Assoc. prof. MVDr. Šimon Vaculín, Ph.D. Department of physiology, Ke Karlovu 4, Praha 2 1. unit 7 weeks Locomotion 2. unit 3 weeks GIT 3. unit 2 weeks Respiration and blood 4. unit 3 weeks Kidney Unit lectures classes seminary (tests, essays) conference Final test/oral exam Ganong WF. Review of medical physiology Silbernagl S, Despopoulos A. Color atlas of physiology Guyton & Hall. Textbook of Medical Physiology Rokyta et al. Practical Courses on Physiology. CD Unit 1 – Locomotion (7 weeks) Running exams Structure Bones of extremities – oral Joints of extremities – oral Axial sceleton – oral skull – oral Function SeminaryTests Final Exams Structure and Function FinalTest Unit 2 – GIT (3 weeks) Running exams Function SeminaryTests Final Exams Structure and Function FinalTest Unit 3 – Respiration and Blood (2 weeks) Running exams Function SeminaryTests Final Exams Structure and Function FinalTest Unit 4 – Kidney (3 weeks) Running exams Function SeminaryTests Final Exams Structure and Function Final Oral Exam Unit 5 – Topography autopsy of extremities Final Exams Structure Final Oral Exam Trials/terms 1st terms – at the end of the unit 2nd term – during winter exam period (17th week) 3th term – during summer exam period 4th term – in September Winter Structure and Function Passing units 1-5 Attendance on classes (80 %) 75-80 % - 5-pages research report on given topic <75 % - not possible to get credit !!! Structure Histological slides – oral examination 1. 2. 3. Winter credit Summer credit Signing for an exam on SIS Terms/trials of Exam Term regular (after obtaining boths credits) Term – 2 weeks after the 1st Term – 2 weeks after the 2nd Physiology humans-animals-plants technical-genaral-medical Actuall interest: neurophysiology Experimental approach (animals) electrophysiological (EEG, surgical (epinephrectomy) pharmacological (naloxon) exercise (ergometer) stimulation (MCS) … substances) clinical (BP, spirometry, hematology) imaging (RTG, PET, fMRI, immunohistology) … EKG, EMG) behavioral (vF, water maze, plantar test) analytical (concentration of Hippocrates (460 – 370 BC), created an intellectual and philosophical atmosphere that laid the foundation for use of animals for experimental Aristoteles (384-322 BC), founder of biology, his dissections demonstrated the internal differences among animals. Erasistratus (304-250 BC) founder of physiology, animal experiments similar to recent experiments. Studied the cerebrum, cerebellum, nerves, and the valves of the heart. Galen (130-200) dissections of all kinds of animals, what he saw mistakenly applied to the human body. left heart and the arteries contained air, the blood being generated in the liver Vesalius (1511-1564) founder of modern anatomy, used animals in public anatomical demonstrations during the Renaissance the first to implement the scientific method to solve biological problems complete fall of Galen's system and a revolution in physiology physics chemistry PHYSIOLOGY or medicine literature economic peace Russian physiologist Heart, liver, circulation, secretion in GIT Psychological secretion – contitioned reflexes Italian patologist Neuroanatomy (AgNO3) Types of Neurones and junctions (G. cells) Nominated for NC 6 times, awarded with Cajal French physiologist and surgeon Transplpantation (vessel suturing) 1912 chicken myocardium lives for 27 years insulin Dog pancreas 1920 isolation of substance containing insulin 1st aplication to diabetic patient Dutch physiologist Registration fo ECG String galvanometry Austrian pathologist Blood groups ABO 1940 discovery of Rh factor Blood transfusion during World War First English physiologist Function of synapse Spinal reflexes Proprioception Neurogram (nerves types A, B, C) Propagation of action potential Registration of electrical changes on nerves English microbiologist Discovery of antibiotics incidentally – bread went to moldy, no grow of bacterias around 1928 publication Milestone in medicine Born in Prague Studied at Medical School of the German University of Prague for their discovery of the course of the catalytic conversion of glycogen Australian physiologist Role of ionts on membrane plasticity Action potential Intracellular recording Honorary Professor of Third Medical Faculty N.P. with Hodgkin and Huxle American physiologists Discovery of G-protein and its role in cell signalization Jiří Procháska (1749-1820) – description and definition of reflexes and synapse Jan Jánský (1873-1921) Discovery of blood groups organs of sense muscles and nerves the ciliary movement of the epithelium of the mucous membrane the structure of the nerve-fibre (axis-cylinder) of the ganglia the glands secreting gastric juice the sympathetic nervous system embryogenesis (discovery of the germinal spot). Purkinje cells, Purkinje fibers demonstrated experimentally the role of thyroid hormones in the metamorphosis of amphibia discovered the protein ferritine was successful in isolating insulin, studied the structure of cells, etc. he became one of the pioneers of experimental neuroendocrinology the discovery of thyreotropin releasing hormone (TRH) demonstrating the existence and isolation of TRH before Schally and Guillemin (who received the Nobel Prize 1977 for this discovery) named amongst these zakladatel experimentální neuroendokrinologie