Parallel Trade in Scandinavia 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. Parallel Trade in Scandinavia Introduction SMART CLUB The supply chain A market, or an ecology The model, animals in the woods Scandinavian population Scandinavian PI markets Norway Sweden Denmark Differences and similarities Pharmacies 14. 15. 16. 17 18 19 20 21 22 23 24 25 26 The underlying process The story Example of a story Price structures Currencies GBP NOK SEK DKK The next few years Next century, the crystal ball References The end, the ecologial approach www.perhamre.com 1 Introduction • A general phenomenon. • Confined to EU and EEA, 16th of July 1998, the Silhouette case in ECJ. www.perhamre.com 2 SMART CLUB • SMART CLUB, an example. • A one stop shop • A wareouse based on parallel import for branded products • The power is in the retail part of the distribution chain www.perhamre.com 3 The supply chain • TRADITIONAL 1. 2. 3. • PI - a detour Manufacturers, or trademark owners Wholesalers Pharmacies PARALLEL DISTRIBUTION – – – – – – Evolution = adaption New steps, 3 new palyers A large detour Discounting Very effective Societal benefit Well adapted to changes www.perhamre.com 4 A market, or an ecology? 1. The patient is not informed, and the decision making process is split in 3 for reimbursed medicine 2. Some criteria for an efficient market: DTC – Direct to Customer Marketing, may be considered an opportunity to empower the customer 1. Large number of non-dominant players 2. Informed customers 3. Rational behaviour 3. The pharmaceutical market is an agglomeration of monopolies www.perhamre.com 5 The model, the animals in the wood • The market may be described as an ecology • The market is governed by natural selection • Dinosaurs • Fat cats • Birds, examples of effective down-sizing www.perhamre.com 6 Scandinavia, population POPULATION MARKET PPP millions 1000 US $ 1998 Norway 4,4 803 Sweden 8,8 2 040 Denmark 5,2 1 010 total 18,4 3 853 www.perhamre.com 7 Scandianavian PI markets Parallel Im port in Scandinavia 12,00 % 10,00 % 8,00 % SWEDEN 6,00 % DENMARK NORWAY 4,00 % 2,00 % 0,00 % 1994 1995 1996 1997 SWEDEN 0,02 % 0,02 % 0,02 % 1,94 % 6,19 % 7,43 % DENMARK 0,16 % 5,40 % 7,55 % 9,78 % 10,57 % 10,25 % NORWAY 0,00 % 0,20 % 1,42 % 3,48 % 7,13 % 7,15 % www.perhamre.com 1998 MAT.6.99 8 Norway, USD PPP • • • • • • • 20 on top in Norway 120 000 000 No 1, Astra Zeneca has decreased turnover No 2, Merck is on a plateau No 3, Glaxo is growing No 4, Pfizer is increasing rapidly No 5, Pharmacia Ujohn grows slowly No 6, Novartis decreases No 7, Paranova, the largest PI company, grows rapidly Astra Zeneca Merck & Co 100 000 000 Glaxo Wellcome Pfizer Pharmacia & Upjohn Nycomed Amersham 80 000 000 Paranova Novo Nordisk A/S Novartis Alpharma 60 000 000 Weifa Johnsen & Johnsen Bristol-Myers Squibb Lilly 40 000 000 SmithKline Beecham Rhone Poulenc Lundbeck Roche 20 000 000 Octapharma American Home 0 1 2 3 4 96-97-98 + MAT June 99 www.perhamre.com 9 Sweden, USD PPP 20 on top in Sweden ASTRAZENECA PHARMACIA & UPJOHN 600 000 000 • The 3 largest companies, AstraZeneca, Pharmacia & Upjohn and Merck are all heavily affected by PI • Cross Pharma is the 6th largest company in Sweden • Medartuum is the 17th largest GLAXO WELLCOME MERCK & CO ROCHE CROSS PHARMA 500 000 000 NOVO NORDISK A/S PFIZER NOVARTIS JOHNSON & JOHNSON 400 000 000 LUNDBECK BRISTOL-MYERS SQB. RHONE POULENC LILLY 300 000 000 BAXTER INT MEDARTUUM AMERICAN HOME HOECHST 200 000 000 FRESENIUS NYCOMED AMERSHAM 100 000 000 0 1 2 3 4 96-97-98 and MAT June 99 www.perhamre.com 10 Denmark, USD PPP • The largest companies are on a plateau • Denmark is the most ”mature” PI market, the change lately are less dramatic than in Sweden • No 4, Orifarm, has a strong growth AtraZeneca 20 on top in Denmark Nycomed Amersham Glaxo Wellcome 140 000 000 Orifarm Pharmacia & Upjohn Pfizer 120 000 000 Paranova Novartis 100 000 000 Merck & Co Johson and Johnson Lundbeck 80 000 000 Statens Serum Inst. Leo SmithKline Beecham 60 000 000 Lillly Novo Nordisk A/S Roche 40 000 000 Bristol-Myers Squibb Schering AG American Home 20 000 000 0 1 2 3 4 96, 97, 98 and MAT June 99 www.perhamre.com 11 -Differences and similarities • Culture – Languages – Political system • Business life – Index of 500 largest/1” inhabitants – Clusters • The national character www.perhamre.com 12 Pharmacies 1. 2. 3. 4. 5. 6. 7. Reference pricing (NB VAT) Generic substitution and empowering Apoteket AB Apokjeden and LIS Amgross Gatekeepers and police Socialised medicine is good, market is … www.perhamre.com 13 The underlying process • Interstate price differentials • Currency fluctations • Cost containment • Pharmacoeconomics, PI is cost minimalisation • DTC www.perhamre.com 14 The story • Media, or what story do you have? • Basic scripts: – Marketing vs bribery – Marketing dementia or flooding – David and Goliath • What is the essence of drama? www.perhamre.com 15 Example of a story ”Wrong use and side effects of parallel import is known by 15% of the health personel” • It is expensive to tell • It tries to belittle the PI industry • It puts shame on those selling PI • Do you think it works? www.perhamre.com 16 Price structures • Denmark – Discounts forbidden – Obligation to sell low cost • Norway – Profit share scheme – Referece pricing • Sweden, one body • Reference pricing • Tenders www.perhamre.com 17 Currencies • The British story • The Euros • Norwegian kroners, 8,12 the 271199 • Swedish kronors • Danske kroner www.perhamre.com 18 GBP R%EURGBP=R, Close(Bid) [Line] Monthly 12Oct88 - 18Feb00 Pr R%EURGBP=R , Close(Bid) 30Nov 99 0.6376 0.83 • The GBP is strong now • PI is booming 0.82 0.81 0.8 0.79 0.78 0.77 0.76 0.75 0.74 0.73 0.72 0.71 0.7 0.69 0.68 0.67 0.66 0.65 0.64 Jan89 Jul Jan90 Jul Jan91 Jul Jan92 Jul Jan93 www.perhamre.com Jul Jan94 Jul Jan95 Jul Jan96 Jul Jan97 Jul Jan98 Jul Jan99 Jul Jan00 19 NOK per Euro • Last year, the krone became weaker • Now it is relatively strong • 261199, it was 8,12 NOK/Euro R%EURNOK=R, Close(Bid) [Line] Monthly 12Oct88 - 18Feb00 Pr R%EURNOK=R , Close(Bid) 30Nov 99 8.1896 8.9 8.8 8.7 8.6 8.5 8.4 8.3 8.2 8.1 8 7.9 7.8 7.7 7.6 7.5 Jan89 Jul Jan90 Jul Jan91 Jul Jan92 Jul Jan93 Jul Jan94 www.perhamre.com Jul Jan95 Jul Jan96 Jul Jan97 Jul Jan98 Jul Jan99 Jul Jan00 20 SEK R%EURSEK=R, Close(Bid) [Line] Monthly 05Dec91 - 26Jan00 Pr R%EURSEK=R , Close(Bid) 30Nov 99 8.6012 9.7 9.6 9.5 9.4 9.3 • Turmoil beginning 1999 • Stabilised now 9.2 9.1 9 8.9 8.8 8.7 8.6 8.5 8.4 8.3 8.2 8.1 8 7.9 7.8 7.7 7.6 7.5 7.4 Jan92 May Sep Jan93 May Sep Jan94 May Sep Jan95 May Sep www.perhamre.com Jan96 May Sep Jan97 May Sep Jan98 May Sep Jan99 May Sep 7.3 Jan00 21 DKK R%EURDKK=R, Close(Bid) [Line] Monthly 10Feb93 - 18Jan00 Pr R%EURDKK=R , Close(Bid) 30Nov 99 7.4336 7.8 • Very strong Jan 96 • Now stable 7.75 7.7 7.65 7.6 7.55 7.5 7.45 7.4 7.35 7.3 7.25 7.2 7.15 7.1 May 93 Sep Jan94 May Sep Jan95 May Sep Jan96 May www.perhamre.com Sep Jan97 May Sep Jan98 May Sep Jan99 May Sep Jan00 22 The next few years • Legal issues, Bayer, Glaxo Wellcome, Paranova, Losec etc. • Price regulation schemes in ES and the UK • Business is opportunistic • PI companies are very effective • Vertical integration • Generics www.perhamre.com 23 Next century, at the speed of light • 2010 and later, Bill Gates • Flow of goods and flow of information • Internet • Do we need wholesalers and pharmacies? www.perhamre.com 24 References 1. 2. 3. 4. 5. Parallel Imports – Effects of the Silhouette Ruling. Swedish Competition Authhority, January 1999. Web site www.kkv.se Pharmaceutical pricing and reimbursement in Europe –1999 Edition, Dr Panos Kanavos, 24th August 1999, by PJB Publications Ltd www.sigma.no www.eaepc.org, catalogue /Members/N-Norway/index.htl Business at the speed of thought – using a digital nervous sytem, Bill Gate, Warner books 1999 www.perhamre.com 25 Final, the ecologial approach • The smallest fish: the world is not just • The middle fish: the world is just sometimes just • The largest fish: the world is just www.perhamre.com 26