9 June 2014
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SYLLABUS
GENERAL VIROLOGY - MULTIPLICATION OF VlRUSES
Bacteriology/Oncology/Plant Pathology 640
FALL SEMESTER, 2014
1:20 pm Mon, Wed, Fri, Room 125 McArdle Laboratory
Paul Ahlquist
Professor
841A Bock Labs; Tel: 263-5916; Email: ahlquist@wisc.edu
Office hours: Monday and Wednesday 2:10-3:00 PM
Robert Kalejta
641A Bock Labs; Tel: 265-5546; Email: rfkalejta@wisc.edu
Professor
Office hours: Monday and Wednesday 2:10-3:00 PM
Nathan Sherer
Asst. Professor
501A Bock Labs; Tel: 890-2551; Email: nsherer@wisc.edu
Office hours: Monday and Wednesday 2:10-3:00 PM
Bieneke Bron
Discussion Leader
227-7 Hanson Labs; Tel: 890-0480; Email: gbron@wisc.edu
Office hrs after class or by arrangement. Exam review sessions will be arranged.
DATE
TOPIC
(Sessions in regular type are led by Ahlquist, in italics by Kalejta; in bold by Sherer; others as indicated)
Mon
Wed
Fri
Mon
Wed
Fri
Mon
Wed
Fri
Mon
Wed
Fri
Sept 1
Sept 3
Sept 5
Sept 8
Sept 10
Sept 12
Sept 15
Sept 17
Sept 19
Sept 22
Sept 24
Sept 26
-Labor DayCourse Introduction / Why and how we study viruses
Viruses in the real world: Ebola
Ebola discussion (Sherer) / Icosahedral virion structure
dsRNA viruses
dsRNA viruses
Picornaviruses
Picornaviruses
Alphaviruses
Alphaviruses
Coronaviruses (SARS, MERS, etc.)
Exam 1 (100 pts)
Mon
Wed
Fri
Mon
Wed
Fri
Mon
Wed
Fri
Mon
Wed
Sept 29
Oct 1
Oct 3
Oct 6
Oct 8
Oct 10
Oct 13
Oct 15
Oct 17
Oct 20
Oct 22
Papillomavirus
Papillomavirus/Adenovirus
Adenovirus
Herpesviruses
Herpesviruses
Herpesviruses
Retroviruses/HIV
Retroviruses/HIV
Retroviruses/HIV
Retroviruses/HIV
Exam 2 (100 pts)
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DATE
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TOPIC
Fri
Mon
Wed
Fri
Mon
Wed
Fri
Oct 24
Oct 27
Oct 29
Oct 31
Nov 3
Nov 5
Nov 7
Rhabdoviruses
Rhabdoviruses
Filoviruses
Orthomyxoviruses
Orthomyxoviruses
Orthomyxoviruses
Pandemic flu preparations
Mon
Wed
Fri
Mon
Wed
Nov 10
Nov 12
Nov 14
Nov 17
Nov 19
Plant viruses - initiation and spread of infection
Plant (& invertebrate) resistance responses: RNAi
Plant resistance responses: relation to animal innate immunity
Genetic variability in viruses
Exam 3 (100 pts)
Fri
Mon
Wed
Fri
Mon
Wed
Fri
Mon
Wed
Fri
Nov 21
Nov 24
Nov 26
Nov 28
Dec 1
Dec 3
Dec 5
Dec 8
Dec 10
Dec 12
Antiviral Drugs
Intrinsic immunity
Intrinsic immunity
- Thanksgiving recess, no class Innate immunity
Innate immunity
Adaptive immunity
Vaccines
(Bieneke Bron)
Poxviruses
(Bieneke Bron)
Emerging viruses
Fri
Dec 19
Comprehensive Final Exam (150 points)
7:45 AM – 9:45 AM
125 McArdle
[The final covers the last 9 lectures (~75 pts)
plus comprehensive questions on earlier material (~75 pts).]
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Suggested Texts and References
Principles of Virology: Molecular Biology, Pathogenesis, and Control (Third Edition, 2009)
Flint, S. J., Enquist, L. W., Racaniello, V. R. & Skalka, A. M. ASM Press.
Fields Virology (Fifth Edition, 2007)
Knipe, D. and P. Howley (editors). Lippincott, Williams and Wilkins.
Selected Websites
"All the Virology on the WWW"
http://www.virology.net/
Universal Virus Database of the International Committee on Taxonomy of Viruses
http://www.ncbi.nlm.nih.gov/ICTVdb/index.htm
NCBI Viral Genomes Resource
http://www.ncbi.nlm.nih.gov/genomes/VIRUSES/viruses.html
Virus World - Structures and Images (UW-Madison Institute for Molecular Virology)
http://rhino.bocklabs.wisc.edu/cgi-bin/virusworld/virustable.pl?
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Grading
 Grading is based on exam performance.
 There are three hour exams (100 points each) plus a comprehensive final exam (150 points) for
a total of 450 points.
 Separate curves are used for graduate and undergraduate students.
 Examples of prior year exams can be found on the course website. To access this, log on to the
MyUW portal at http://my.wisc.edu/ and click on your academic tab. In the list for current courses,
this course should contain a link for "library/reserve."
Sample Distribution of Test Scores and Letter Grades in Previous Years
The following grades and scores are listed for illustration only and do not necessarily reflect how
grades will be given this year.
Year
Graduate
2013
2012
2011
2010
2009
2008
2007
2006
2005
A
89
85
87
86
83
86
84
82
83
Undergrad
2013
2012
2011
2010
2009
2008
2007
2006
2005
85
82
82
81
80
84
82
79
81
2013
2012
2011
2010
2009
2008
2007
2006
2005
A
10
7
5
6
14
13
6
5
14
2013
2012
2011
2010
2009
2008
2007
2006
2005
2
4
5
7
5
2
5
6
4
Graduate
Undergrad
% of total course points required for indicated grade
AB
B
BC
C
D
85
75
65
82
72
63
56
82
72
65
81
72
80
70
65
56
83
70
63
55
43
81
70
78
68
79
68
63
55
81
76
75
76
75
80
78
75
70
66
67
67
66
67
67
65
65
63
60
60
60
60
55
52
50
53
45
45
50
40
57
56
Number of students with indicated grade
AB
B
BC
C
4
5
1
4
10
1
1
8
18
3
7
3
2
11
5
1
5
15
3
2
2
8
2
6
5
12
2
4
5
4
1
4
1
3
2
5
9
3
6
3
5
6
5
4
4
3
2
2
2
D
1
1
5
3
2
2
1
5
1
2
2