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SYLLABUS
GENERAL VIROLOGY - MULTIPLICATION OF VlRUSES
Bacteriology/Oncology/Plant Pathology 640
FALL SEMESTER, 2009
1:20 pm Mon, Wed, Fri, Room 125 McArdle Laboratory
Paul Ahlquist
Professor
841A Bock Labs; Tel, 263-5916; Email: ahlquist@wisc.edu
Office hours: Monday and Wednesday 2:10-3:00 PM
Robert Kalejta
Assoc. Professor
635A Bock Labs; Tel, 265-5546; Email: rfkalejta@wisc.edu
Office hours: Monday and Wednesday 2:10-3:00 PM
Bryan Sibert
Discussion Leader
827B Bock Labs; Tel, 265-9742 or 502-432-3104; Email: sibert@wisc.edu
Office hrs by email or appointment; Exam review sessions will be arranged
DATE
TOPIC
(Sessions in regular type are by Ahlquist, in italics by Kalejta)
Wed., Sept.2
Fri., Sept. 4
Mon., Sept. 7
Wed., Sept. 9
Fri., Sept. 11
Mon., Sept. 14
Wed., Sept. 16
Fri., Sept. 18
Mon., Sept. 21
Wed., Sept. 23
Fri., Sept. 25
Course Introduction / Why and how we study viruses
Viruses in the real world: Ebola
Labor Day – no lecture
Ebola discussion / virus structure and assembly
dsRNA viruses
dsRNA viruses
Picornaviruses
Picornaviruses
Alphaviruses
Alphaviruses
Coronaviruses / SARS
Mon., Sept. 28
Wed., Sept. 30
Fri., Oct. 2
Mon., Oct. 5
Wed., Oct. 7
Fri., Oct. 9
Mon., Oct. 12
Wed., Oct. 14
Fri., Oct. 16
Mon, Oct. 19
Wed, Oct. 21
Fri., Oct. 23
Exam 1 (100 pts)
Retroviruses/HIV
Retroviruses/HIV
Retroviruses/HIV
Retroviruses/HIV
Papillomavirus
Papillomavirus/Adenovirus
Adenovirus
Herpesviruses
Herpesviruses
Herpesviruses
Exam 2 (100 pts)
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DATE
TOPICg
Mon, Oct. 26
Wed., Oct. 28
Fri., Oct. 30
Mon., Nov. 2
Wed., Nov. 5
Fri., Nov. 6
Mon., Nov. 9
Wed., Nov. 11
Fri., Nov. 13
Mon, Nov. 16
Wed., Nov. 18
Fri., Nov. 20
Rhabdoviruses
Rhabdoviruses
Rhabdoviruses / Orthomyxoviruses
Orthomyxoviruses
Orthomyxoviruses
Pandemic flu preparations
Genetic variability in viruses
RNA interference - discovery and mechanisms
RNA interference - antiviral effects and viral modulation of RNAi
Plant viruses - initiation and spread of infection
Plant resistance responses: relation to animal innate immunity
Exam 3 (100 pts)
Mon. Nov. 23
Wed., Nov. 25
Fri., Nov. 27
Mon., Nov. 30
Wed., Dec. 2
Fri., Dec. 4
Mon., Dec. 7
Wed., Dec. 9
Fri., Dec. 11
Mon. Dec 14
Antiviral Drugs
Intrinsic immunity
Thanksgiving recess, no class
Innate immunity
Innate immunity
Adaptive immunity (B. Sibert)
Vaccines
(B. Sibert)
Poxviruses: virus modulation of immunity; virus control by vaccination
Emerging viruses
Course Review and Discussion
Tues. Dec 22
Comprehensive Final Exam (150 points)
10:05 am – 12:05 pm
125 McArdle
[The final covers the last 9 lectures (~75 pts)
plus comprehensive questions on earlier material (~75 pts).]
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Suggested Texts and References
Principles of Virology: Molecular Biology, Pathogenesis, and Control (Third Edition, 2009)
Flint, S. J., Enquist, L. W., Racaniello, V. R. & Skalka, A. M. ASM Press.
Fields Virology (Fifth Edition, 2007)
Knipe, D. and P. Howley (editors). Lippincott, Williams and Wilkins.
Selected Websites
"All the Virology on the WWW"
http://www.virology.net/
Universal Virus Database of the International Committee on Taxonomy of Viruses
http://www.ncbi.nlm.nih.gov/ICTVdb/index.htm
NCBI Viral Genomes Resource
http://www.ncbi.nlm.nih.gov/genomes/VIRUSES/viruses.html
Virus World - Structures and Images (UW-Madison Institute for Molecular Virology)
http://rhino.bocklabs.wisc.edu/cgi-bin/virusworld/virustable.pl?
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Grading
 Grading is based on exam performance.
 There are three hour exams (100 points each) plus a comprehensive final exam (150 points) for
a total of 450 points.
 Separate curves are used for graduate and undergraduate students.
 Examples of prior year exams can be found on the course website. To access this, log on to the
MyUW portal at http://my.wisc.edu/ and click on your academic tab. In the list for current courses,
this course should contain a link for "library/reserve."
Sample Distribution of Test Scores and Letter Grades in Previous Years
The following grades and scores are listed for illustration only and do not necessarily reflect how
grades will be given this year.
Year
Graduate
2008
2007
2006
2005
2004
2003
2002
Undergrad
2008
2007
2006
2005
2004
2003
2002
Graduate
2008
2007
2006
2005
2004
2003
2002
Undergrad
2008
2007
2006
2005
2004
2003
2002
A
86
84
82
83
83
81
84
84
82
79
81
% of total course points required for indicated grade
AB
B
BC
C
D
83
70
63
55
43
81
70
78
68
79
68
63
55
78
69
66
61
79
70
66
64
80
68
55
80
78
75
74
75
81
A
13
6
5
14
10
10
13
2
5
6
4
57
56
59
64
64
50
40
53
51
55
48
Number of students with indicated grade
AB
B
BC
C
5
15
3
2
2
8
2
6
5
12
2
5
10
1
2
7
14
7
2
13
22
1
1
3
2
3
1
8
67
67
65
65
63
68
68
5
6
5
4
3
3
4
D
1
1
2
2
1
1
3
5
1
3
3
4
1