CSE 599 Lecture 7: Information Theory, Thermodynamics and Reversible Computing What have we done so far? Theoretical computer science: Abstract models of computing Turing machines, computability, time and space complexity Physical Instantiations 1. Digital Computing Silicon switches manipulate binary variables with near-zero error 2. DNA computing Massive parallelism and biochemical properties of organic molecules allow fast solutions to hard search problems 3. Neural Computing Distributed networks of neurons compute fast, parallel, adaptive, and fault-tolerant solutions to hard pattern recognition and motor control problems R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 1 Overview of Today’s Lecture Information theory and Kolmogorov Complexity What is information? Definition based on probability theory Error-correcting codes and compression An algorithmic definition of information (Kolmogorov complexity) Thermodynamics The physics of computation Relation to information theory Energy requirements for computing Reversible Computing Computing without energy consumption? Biological example Reversibe logic gates Quantum computing (next week!) R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 2 Information and Algorithmic Complexity 3 principal results: Shannon’s source-coding theorem The main theorem of information content A measure of the number of bits needed to specify the expected outcome of an experiment Shannon’s noisy-channel coding theorem Describes how much information we can transmit over a channel A strict bound on information transfer Kolmogorov complexity Measures the algorithmic information content of a string An uncomputable function R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 3 What is information? First try at a definition… Suppose you have stored n different bookmarks on your web browser. What is the minimum number of bits you need to store these as binary numbers? Let I be the minimum number of bits needed. Then, 2I n I log2 n So, the “information” contained in your collection of n bookmarks is I0 = log2 n R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 4 Deterministic information I0 Consider a set of alternatives: X = {a1, a2, a3, …aK} When the outcome is a3, we say x = a3 I0(X) is the amount of information needed to specify the outcome of X I0(X) = log2X We will assume base 2 from now on (unless stated otherwise) Units are bits (binary digits) Relationship between bits and binary digits B = {0, 1} X = BM = set of all binary strings of length M I0(X) = logBM= log2M= M bits R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 5 Is this definition satisfactory? Appeal to your intuition… Which of these two messages contains more “information”? “Dog bites man” or “Man bites dog” R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 6 Is this definition satisfactory? Appeal to your intuition… Which of these two messages contains more “information”? “Dog bites man” or “Man bites dog” Same number of bits to represent each message! But, it seems like the second message contains a lot more information than the first. Why? R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 7 Enter probability theory… Surprising events (unexpected messages) contain more information than ordinary or expected events “Dog bites man” occurs much more frequently than “Man bites dog Messages about less frequent events carry more information So, information about an event varies inversely with the probability of that event But, we also want information to be additive If message xy contains sub-parts x and y, we want: I(xy) = I(x) + I(y) Use the logarithm function: log(xy) = log(x) + log(y) R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 8 New Definition of Information Define the information contained in a message x in terms of log of the inverse probability of that message: I(x) = log(1/P(x)) = - log P(x) First defined rigorously and studied by Shannon (1948) “A mathematical theory of communication” – electronic handout (PDF file) on class website. Our previous definition is a special case: Suppose you had n equally likely items (e.g. bookmarks) For any item x, P(x) = 1/n I(x) = log(1/P(x)) = log n Same as before (minimum number of bits needed to store n items) R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 9 Review: Axioms of probability theory Kolmogorov, 1933 P(a) >= 0 P(l) = 1 P(a + b) = P(a) + P(b) where a is an event where l is the certain event where a and b are mutually exclusive Kolmogorov (axiomatic) definition is computable Probability theory forms the basis for information theory Classical definition based on event frequencies (Bernoulli) is uncomputable: na P( a) = lim n n R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 10 Review: Results from probability theory Joint probability of two events a and b: P(ab) Independence Events a and b are independent if P(ab) = P(a)P(b) Conditional probability: P(a|b) = probability that event a happens given that b has happened P(a|b) = P(ab)/P(b) P(b|a) = P(ba)/P(a) = P(ab)/P(a) e j ej P ba P a We just proved Bayes’ Theorem: P ab = P b P(a) is called the a priori probability of a P(ab) is called the a posteriori probability of a R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 11 Summary: Postulates of information theory 1. Information is defined in the context of a set of alternatives. The amount of information quantifies the number of bits needed to specify an outcome from the alternatives 2. The amount of information is independent of the semantics (only depends on probability) 3. Information is always positive 4. Information is measured on a logarithmic scale Probabilities are multiplicative, but information is additive R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 12 In-Class Example Message y contains duplicates: y = xx Message x has probability P(x) What is the information content of y? Is I(y) = 2 I(x)? R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 13 In-Class Example Message y contains duplicates: y = xx Message x has probability P(x) What is the information content of y? Is I(y) = 2 I(x)? I(y) = log(1/P(xx)) = log[1/(P(x|x)P(x))] = log(1/P(x|x)) + log(1/P(x)) = 0 + log(1/P(x)) = I(x) Duplicates convey no additional information! R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 14 Definition: Entropy The average self-information or entropy of an ensemble X= {a1, a2, a3, …aK} F 1 I 1 I F H X = E log H P( x ) K= Paa flogG HPaa fJ K K k =1 k k E expected (or average) value R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 15 Properties of Entropy 0 <= H(X) <= I0(X) Equals I0(X) = logXif all the ak’s are equally probable Equals 0 if only one ak is possible Consider the case where k = 2 X = {a1, a2} P(a1) = ; P(a2) = 1– H X = log F1 I 1 log 1 H K 1 = log 1 log1 R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 16 Examples Entropy is a measure of randomness of the source producing the events Example 1 : Coin toss: Heads or tails with equal probability H = -(½ log ½ + ½ log ½) = -(½ (-1) + ½ (-1)) = 1 bit per coin toss Example 2 : P(heads) = ¾ and P(tails) = ¼ H = -(¾ log ¾ + ¼ log ¼) = 0.811 bits per coin toss As things get less random, entropy decreases Redundancy and regularity increases R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 17 Question If we have N different symbols, we can encode them in log(N) bits. Example: English - 26 letters 5 bits So, over many, many messages, the average cost/symbol is still 5 bits. But, letters occur with very different probabilities! “A” and “E” much more common than “X” and “Q”. The log(N) estimate assumes equal probabilities. Question: Can we encode symbols based on probabilities so that the average cost/symbol is minimized? R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 18 Shannon’s noiseless source-coding theorem Also called the fundamental theorem. In words: You can compress N independent, identically distributed (i.i.d.) random variables, each with entropy H, down to NH bits with negligible loss of information (as N) If you compress them into fewer than NH bits you will dramatically lose information The theorem: Let X be an ensemble with H(X) = H bits. Let Hd (X) be the entropy of an encoding of X with allowable probability of error d Given any > 0 and 0 < d < 1, there exists a positive integer No such that, for N > No, e j N 1 H X H N d R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 19 Comments on the theorem What do the two inequalities tell us? 1 N Hd X H N ej The number of bits 1 N Hd X that we need to specify outcomes x N ej with vanishingly small error probability d does not exceed H + If we accept a vanishingly small error, the number of bits we need to specify x drops to N(H + ) H 1 N Hd X N ej The number of bits 1 N that we need to specify outcomes x Hd X N ej with large allowable error probability d is at least H – R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 20 Source coding (data compression) Question: How do we compress the outcomes XN? With vanishingly small probability of error How do we assign the elements of X such that the number of bits we need to encode XN drops to N(H + ) Symbol coding: Given x = a3 a2 a7 … a5 Generate codeword (x) = 01 1010 00 Want Io((x)) ~ H(X) Well-known coding examples Zip, gzip, compress, etc. The performance of these algorithms is, in general, poor when compared to the Shannon limit R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 21 Source-coding definitions A code is a function : X B+ B = {0, 1} B+ the set of finite strings over B B+ = {0, 1, 00, 01, 10, 11, 000, 001, …} (x) = (x1) (x2) (x3) … (xN) A code is uniquely decodable (UD) iff : X+ B+ is one-to-one A code is instantaneous iff No codeword is the prefix of another (x1) is not a prefix of (x2) R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 22 Huffman coding Given X = {a1, a2, …aK}, with associated probabilities P(ak) Given a code with codeword lengths n1, n2, …nk The expected code length n = K Pk nk k =1 No instantaneous, UD code can achieve a smaller n than a Huffman code n= K Pk nk H X 1 k =1 R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 23 Constructing a Huffman code Feynman example: Encoding an alphabet Code is instantaneous and UD: 00100001101010 = ANOTHER Code achieves close to Shannon limit H(X) = 2.06 bits; n = 2.13 bits 1 R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 24 Information channels Input x Output channel H(X) entropy of input ensemble X I(X;Y) is the average mutual information between X and Y Definition: Channel capacity y I(X;Y) what we know about X given Y a f I X;Y = H X H X Y af = P xy log xy P( xy ) P( x ) P( y ) a f = H Y H Y X The information capacity of a channel is: C = max[I(X;Y)] The channel may add noise Corrupting our symbols R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 25 Example: Channel capacity Problem: A binary source sends equiprobable messages in a time T, using the alphabet {0, 1} with a symbol rate R. As a result of noise, a “0” may be mistaken for a “1”, and a “1” for a “0”, both with probability q. What is the channel capacity C? Channel is discrete and memoryless X R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing Y 26 Example: Channel capacity (con’t) Assume no noise (no errors) T is the time to send the string, R is the rate The number of possible message strings is 2RT The maximum entropy of the source is Ho = log(2RT ) bits The source rate is (1/T) Ho = R bits per second The entropy of the noise (per transmitted bit) is Hn = qlog[1/q] + (1–q)log[1/(1–q)] The channel capacity C (bits/sec) = R – RHn = R(1 – Hn) C is always less than R (a fixed fraction of R)! We must add code bits to correct the received message R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 27 How many code bits must we add? We want to send a message string of length M We add codebits to M, thereby increasing its length to Mc How are M, Mc, and q related? M = Mc(1 – Hn) Intuitively, from our example Also see pgs. 106 – 110 of Feynman Note: this is an asymptotic limit May require a huge Mc R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 28 Shannon’s Channel-Coding Theorem The Theorem: There is a nonnegative channel capacity C associated with each discrete memoryless channel with the following property: For any symbol rate R < C, and any error rate > 0, there is a protocol that achieves a rate >= R and a probability of error <= In words: If the entropy of our symbol stream is equal to or less than the channel capacity, then there exists a coding technique that enables transmission over the channel with arbitrarily small error Can transmit information at a rate H(X) <= C Shannon’s theorem tells us the asymptotically maximum rate It does not tell us the code that we must use to obtain this rate Achieving a high rate may require a prohibitively long code R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 29 Error-correction codes Error-correcting codes allow us to detect and correct errors in symbol streams Used in all signal communications (digital phones, etc) Used in quantum computing to ameliorate effects of decoherence Many techniques and algorithms Block codes Hamming codes BCH codes Reed-Solomon codes Turbo codes R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 30 Hamming codes An example: Construct a code that corrects a single error We add m check bits to our message Can encode at most (2m – 1) error positions Errors can occur in the message bits and/or in the check bits If n is the length of the original message then 2m – 1 >= (n + m) Examples: If n = 11, m = 4: 24 – 1= 15 >= (n + m) = 15 If n = 1013, m = 10: 210 – 1= 1023 >= (n + m) = 1023 R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 31 Hamming codes (cont.) Example: An 11/15 SEC Hamming code Idea: Calculate parity over subsets of input bits Four subsets: Four parity bits Check bit x stores parity of input bit positions whose binary representation holds a “1” in position x: Check bit c1: Bits 1,3,5,7,9,11,13,15 Check bit c2: Bits 2,3,6,7,10,11,14,15 Check bit c3: Bits 4,5,6,7,12,13,14,15 Check bit c4: Bits 8,9,10,11,12,13,14,15 The parity-check bits are called a syndrome The syndrome tells us the location of the error R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing Position in message binary decimal 0001 1 0010 2 0011 3 0100 4 0101 5 0110 6 0111 7 1000 8 1001 9 1010 10 1011 11 1100 12 1101 13 1110 14 1111 15 32 Hamming codes (con’t) The check bits specify the error location Suppose check bits turn out to be as follows: Check c1 = 1 (Bits 1,3,5,7,9,11,13,15) Error is in one of bits 1,3,5,7,9,11,13,15 Check c2 = 1 (Bits 2,3,6,7,10,11,14,15) Error is in one of bits 3,7,11,15 Check c3 = 0 (Bits 4,5,6,7,12,13,14,15) Error is in one of bits 3,11 Check c4 = 0 (Bits 8,9,10,11,12,13,14,15) So error is in bit 3!! R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 33 Hamming codes (cont.) Example: Encode 10111011011 Code position: Code symbol: Codeword: 15 14 13 12 11 10 9 8 7 6 5 4 3 2 1 1 0 1 1 1 0 1 c4 1 0 1 c3 1 c2 c1 1 0 1 1 1 0 1 1 1 0 1 1 1 0 1 Notice that we can generate the code bits on the fly! What if we receive 101100111011101? c4 = 1 101100111011101 c3 = 0 101100111011101 c2 = 1 101100111011101 c1 = 1 101100111011101 The error is in location 1011 = 1110 R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 34 Kolmogorov Complexity (Algorithmic Information) Computers represent information as stored symbols Not probabilistic n the Shannon sense) Can we quantify information from an algorithmic standpoint? Kolmogorov complexity K(s) of a finite binary string s is the single, natural number representing the minimum length (in bits) of a program p that generates s when run on a Universal Turing machine U K(s) is the algorithmic information content of s Quantifies the “algorithmic randomness” of the string K(s) is an uncomputable function Similar argument to the halting problem How do we know when we have the shortest program? R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 35 Kolmogorov Complexity: Example Randomness of a string defined by shortest algorithm that can print it out. Suppose you were given the binary string x: “11111111111111….11111111111111111111111” (1000 1’s) Instead of 1000 bits, you can compress this string to a few tens of bits, representing the length |P| of the program: For I = 1 to 1000 Print “1” So, K(x) <= |P| Possible project topic: Quantum Kolmogorov complexity? R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 36 5-minute break… Next: Thermodynamics and Reversible Computing R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 37 Thermodynamics and the Physics of Computation Physics imposes fundamental limitations on computing Computers are physical machines Computers manipulate physical quantities Physical quantities represent information The limitations are both technological and theoretical Physical limitations on what we can build Example: Silicon-technology scaling Major limiting factor in the future: Power Consumption Theoretical limitations of energy consumed during computation Thermodynamics and computation R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 38 Principal Questions of Interest How much energy must we use to carry out a computation? The theoretical, minimum energy Is there a minimum energy for a certain rate of computation? A relationship between computing speed and energy consumption What is the link between energy and information? Between information–entropy and thermodynamic–entropy Is there a physical definition for information content? The information content of a message in physical units R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 39 Main Results Computation has no inherent thermodynamic cost A reversible computation, that proceeds at an infinitesimal rate, consumes no energy Destroying information requires kTln2 joules per bit Information-theoretic bits (not binary digits) Driving a computation forward requires kTln(r) joules per step r is the rate of going forward rather than backward R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 40 Basic thermodynamics First law: Conservation of energy (heat put into system) + (work done on system) = increase in energy of a system DQ + DW = DU Total energy of the universe is constant Second law: It is not possible to have heat flow from a colder region to a hotter region i.e. DQ/T >= 0 Change in Entropy DS = DQ/T Equality holds only for reversible processes The entropy of the universe is always increasing R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 41 Heat engines A basic heat engine: Q2 = Q1 – W T1 and T2 are temperatures T1 > T2 Reversible heat engines are those that have: No friction Infinitesimal heat gradients The Carnot cycle: Motivation was steam engine Reversible Pumps heat DQ from T1 to T2 Does work W = DQ R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 42 Heat engines (cont.) R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 43 The Second Law No engine that takes heat Q1 at T1 and delivers heat Q2 at T2 can do more work than a reversible engine W = Q1 – Q2 = Q1(T1 – T2) / T1 Heat will not, by itself, flow from a cold object to a hot object R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 44 Thermodynamic entropy If we add heat DQ reversibly to a system at fixed temperature T, the increase in entropy of the system is DS = DQ/T S is a measure of degrees of freedom The probability of a configuration The probability of a point in phase space In a reversible system, the total entropy is constant In an irreversible system, the total entropy always increases R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 45 Thermodynamic versus Information Entropy Assume a gas containing N atoms Occupies a volume V1 Ideal gas: No attraction or repulsion between particles Now shrink the volume Isothermally (at constant temperature, immerse in a bath) Reversibly, with no friction How much work does this require? R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 46 Compressing the gas From mechanics work = force × distance force = pressure × (area of piston) volume change = (area of piston) × distance Solving: DW = pDV DW = F Dx F = pA DV = ADx From gas theory The idea gas law: pV = NkT N number of molecules k Boltzmann’s constant (in joules/Kelvin) Solving: W= V2 z V1 FI HK V2 NkT dV = NkT ln V V1 R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 47 A few notes W is negative because we are doing work on the gas:V2 < V1 W would be positive if the gas did work for us Where did the work go? Isothermal compression The temperature is constant (same before and after) First law: The work went into heating the bath Second law: We decreased the entropy of the gas and increased the entropy of the bath R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 48 Free energy and entropy The total energy of the gas, U, remains unchanged Same number of particles Same temperature The “free energy” Fe, and the entropy S both change Both are related to the number of states (degrees of freedom) Fe = U – TS For our experiment, change in free energy is equal to the work done on the gas and U remains unchanged V I F = DF = DU TDS = TDS G J HV K FV I DS = Nk lnG J HV K NkT ln 2 e 1 2 DFe is the (negative) heat siphoned off into the bath 1 R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 49 Special Case: N = 1 Imagine that our gas contains only one molecule Take statistical averages of same molecule over time rather than over a population of particles Halve the volume Fe increases by +kTln2 S decreases by kln2 But U is constant What’s going on? Our knowledge of the possible locations of the particle has changed! Fewer places that themolecule can be in, now that volume has been halved The entropy, a measure of the uncertainty of a configuration, has decreased R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 50 Thermodynamic entropy revisited Take the probability of a gas configuration to be P Then S ~ klnP Random configurations (molecules moving haphazardly) have large P and large S Ordered configurations (all molecules moving in one direction) have small P and small S The less we know about a gas… the more states it could be in and the greater the entropy A clear analogy with information theory R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 51 The fuel value of knowledge Analysis is from Bennett: Tape cells with particles coding 0 (left side) or 1 (right side) If we know the message on a tape Then randomizing the tape can do useful work Increasing the tape’s entropy What is the fuel value of the tape (i.e. what is the fuel value of our knowledge)? R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 52 Bennett’s idea The procedure Tape cell comes in with known particle location Orient a piston depending on whether cell is a 0 or a 1 Particle pushes piston outward Increasing the entropy by kln2 Providing free energy of kTln2 joules per bit Tape cell goes out with randomized particle location R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 53 The energy value of knowledge Define fuel value of tape = (N – I)kTln2 N is the number of tape cells I is information (Shannon) Examples Random tape (I = N) has no fuel value Known tape (I = 0) has maximum fuel value R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 54 Feynman’s tape-erasing machine Define the information in the tape to be the amount of free energy required to reset the tape The energy required to compress each bit to a known state Only the “surprise” bits cost us energy Doesn’t take any energy to reset known bits Cost to erase the tape: IkTln2 joules For known bits, just move the partition (without changing the volume) R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 55 Reversible Computing A reversible computation, that proceeds at an infinitesimal rate, destroying no information, consumes no energy Regardless of the complexity of the computation The only cost is in resetting the machine at the end Erasing information costs energy Reversible computers are like heat engines If we run a reversible heat engine at an infinitesimal pace, it consumes no energy other than the work that it does R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 56 Energy cost versus speed We want our computations to run in finite time We need to drive the computation forward Dissipates energy (kinetic, thermal, etc.) Assume we are driving the computation forward at a rate r The computation is r times as likely to go forward as go backward What is the minimum energy per computational step? R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 57 Energy-driven computation Computation is a transition between states State transitions have an associated energy diagram Assume forward state E2 has a lower energy than backward state E1 “A” is the activation energy for a state transition Thermal fluctuations cause the computer to move between states Whenever the energy exceeds “A” We also used this model in neural networks (e.g. Hopfield networks) R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 58 State transitions The probability of a transition between states differing in positive energy DE is proportional to exp(–DE/kT) Our state transitions have unequal probabilities The energy required for a forward step is (A – E1) The energy required for a backward step is (A – E2) forward rate = Ce A E1 kT , and backward rate = Ce forward rate r =e backward rate A E2 kT E1 E2 kT R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 59 Driving computation by energy differences The (reaction) rate r depends only on the energy difference between successive states The bigger (E1 – E2), the more likely the state transitions, and the faster the computation Energy expended per step = E1 – E2= kTlnr R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 60 Driving computation by state availability We can drive a computation even if the forward and backward states have the same energy As long as there are more forward states than backward states The computation proceeds by diffusion More likely to move into a state with greater availability Thermodynamic entropy drives the computation r n forward rate = 2 backward rate n1 b a f afg a f kT ln r = kT ln n2 ln n1 = S2 S1 T R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 61 Rate-Driven Reversible Computing: A Biological Example Protein synthesis is an example... of (nearly) reversible computation of the copy computation of a computation driven forward by thermodynamic entropy Protein synthesis is a 2-stage process 1. DNA forms mRNA 2. mRNA forms a protein We will consider step 1 R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 62 DNA DNA comprises a double-stranded helix Each strand comprises alternating phosphate and sugar groups One of four bases attaches to each sugar Adenine (A) Thymine (T) Cytosine (C) Guanine (G) (base + sugar + phosphate) group is called a nucleotide DNA provides a template for protein synthesis The sequence of nucleotides forms a code R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 63 RNA polymerase RNA polymerase attaches itself to a DNA strand Moves along, building an mRNA strand one base at a time RNA polymerase catalyzes the copying reaction Within the nucleus there is DNA, RNA polymerase, and triphosphates (nucleotides with 2 extra phosphates), plus other stuff The triphosphates are adenosine triphosphate (ATP) cytosine triphosphate (CTP) guanine triphosphate (GTP) uracil triphosphate (UTP) R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 64 mRNA The mRNA strand is complementary to the DNA The matching pairs are DNA RNA A U T A C G G C As each nucleotide is added, two phosphates are released Bound as a pyrophosphate R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 65 The process R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 66 RNA polymerase is a catalyst Catalysts influence the rate of a biochemical reaction But not the direction Chemical reactions are reversible RNA polymerase can unmake an mRNA strand Just as easily as it can make one Grab a pyrophosphate, attach to a base, and release The direction of the reaction depends on the relative concentrations of the pyrophosphates and triphosphates More triphosphates than pyrophosphates: Make RNA More pyrophosphates than triphosphates: Unmake RNA R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 67 DNA, entropy, and states The relative concentrations of pyrophosphate and triphosphate define the number of states available Cells hydrolyze pyrophosphate to keep the reactions going forward How much energy does a cell use to drive this reaction? Energy = kTlnr = (S2 – S1)T ~ 100kT/bit R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 68 Efficiency of a representation Cells create protein engines (mRNA) for 100kT/bit 0.03µm transistors consume 100kT per switching event Think of representational efficiency What does each system get for 100kT? Digital logic uses an impoverished representation 104 switching events to perform an 8-bit multiply Semiconductor scaling doesn’t improve the representation We pay a huge thermodynamic cost to use discrete math R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 69 Example 2: Computing using Reversible Logic Gates Two reversible gates: controlled not (CN) and controlled controlled not (CCN). A CCN gate A CN gate A A A' B B' C C' A' B B' A 0 0 1 1 B 0 1 0 1 A’ 0 0 1 1 B’ 0 1 1 0 A 0 0 0 0 1 1 1 1 B 0 0 1 1 0 0 1 1 C 0 1 0 1 0 1 0 1 A’ 0 0 0 0 1 1 1 1 B’ C’ 0 0 0 1 1 0 1 1 0 0 0 1 1 1 1 0 CCN is complete: we can form any Boolean function using only CCN gates: e.g. AND if C = 0 R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 70 Next Week: Quantum Computing Reversible Logic Gates and Quantum Computing Quantum versions of CN and CCN gates Quantum superposition of states allows exponential speedup Shor’s fast algorithm for factoring and breaking the RSA cryptosystem Grover’s database search algorithm Physical substrates for quantum computing R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 71 Next Week… Guest Lecturer: Dan Simon, Microsoft Research Introductory lecture on quantum computing and Shor’s algorithm Discussion and review afterwards Homework # 4 due: submit code and results electronically by Thursday (let us know if you have problems meeting the deadline) Sign up for project and presentation times Feel free to contact instructor and TA if you want to discuss your project Have a great weekend! R. Rao, Week 3: Information Theory, Thermodynamics, and Reversible Computing 72