1st Lecture Hall 08:00 - 08:30 Registration 08:30 - 08:40 Opening Remarks Minister Wen-Ta Chiu/Department of Health and welfare 08:40 - 09:00 Welcome Speech Superintendent Wen-Neng Ueng/Chang Gung Memorial Hospital Superintendent Fang-Yue Lin/Taipei Veterans General Hospital Keynote Lecture Moderator: Academician Cheng-Wen Wu/National Yang-Ming University 09:00 - 09:30 Novel Signaling Pathways and Target Cancer Therapy. Academician Mien-Chie Hung/The University of Texas MD Anderson Cancer Center, USA Session: Lung Cancer Moderator: Academician Cheng-Wen Wu/National Yang-Ming University 09:30 - 09:55 hRAB37 GTPase, a Novel Metastasis Suppressor in Lung Cancer Prof. Yi-Ching Wang/National Cheng Kung University 09:55 - 10:20 Investigation of Stemness Signature and Tumor-initiating Property in Malignant Cancer Prof. Shih-Hwa Chiou/National Yang-Ming University 10:20 - 10:45 Anti-cancer Stem Cell Drug Discovery via Connectivity Map Prof. Chi-Ying Huang/National Yang-Ming University 10:45 - 11:05 Coffee Break Moderator: Dr. Chih-Yi Chen/China Medical University Hospital 11:05 - 11:30 Updates of Pathology and Molecular Diagnosis in Lung Cancer Prof. Teh-Ying Chou/Taipei Veterans General Hospital 11:30 - 11:55 Updates in Chemotherapy and Targeted Therapy for Non-small Cell Lung Cancer Dr. Chong-Jen Yu/National Taiwan University Hospital 11:55 - 12:20 Surgical Treatment for Early Stage Non-small Cell Lung Cancer- Factors Affect the Failure Pattern and Survival Outcomes Dr. Yu-Chung Wu/Taipei Veterans General Hospital 12:20 - 13:30 Lunch Keynote Lecture Moderator: Prof. Jaw-Ching Wu/Taipei Veterans General Hospital; National Yang-Ming University 13:30 - 14:00 Mechanistic Insights from Functional Genomics Studies of Hepatocellular Carcinoma Metastasis Dr. Xin Wei Wang/National Cancer Institute, USA Session: HCC Progression Mechanism and Treatment Strategy Moderators: Academician Ding-Shinn Chen/National Taiwan University Hospital; Prof. Rong-Nan Chien/Chang Gung Memorial Hospital and Chang Gung University College of Medicine Keelung 14:00 - 14:25 Mechanisms of Early and Late Postoperative Recurrence of HCC and Mechanism-targeted Therapy Prof. Jaw-Ching Wu/Taipei Veterans General Hospital; National Yang-Ming University 14:25 - 14:50 Molecular Classification and Stratified Medicine in Liver Cancer Dr. Augusto Villanueva/Institute of Liver Studies, London, UK 14:50 - 15:15 Taiwan Research Biosignature Network on Hepatocellular Carcinoma (TARGET-HCC) Dr. Chi-Ling Chen/National Taiwan University Hospital 15:15 - 15:35 Coffee Break Moderators: Academician Ding-Shinn Chen/National Taiwan University Hospital; Prof. Rong-Nan Chien/Chang Gung Memorial Hospital and Chang Gung University College of Medicine Keelung 15:35 - 16:00 The Duality Tracer Principle of PET in Hepatocellular Carcinoma Prof. Garrett CL Ho/Hong Kong Sanatorium and Hospital, China 16:00 - 16:25 Surgical and Non-surgical Treatments for Hepatocellular Carcinoma Progression or Metastasis Prof. Shi-Ming Lin/Chang Gung Memorial Hospital 16:25 - 16:50 Mechanism-Based Targeted Therapy for Hepatocellular Carcinoma: Present and Future Dr. Chiun Hsu/National Taiwan University 16:50 - 17:10 Award Ceremony President and Academician Kung-Yee Liang/National Yang-Ming University 17:10 - 17:20 Closing Remarks 2nd Lecture Hall Keynote Lecture Moderator: Prof. Ming-Hsul Tsai/China Medical University Hospital 09:00 - 09:30 Comprehensive Genomic Characterization of Head and Neck Squamous Cell Carcinoma Prof. Jeffrey N Myers/The University of Texas MD Anderson Cancer Center, USA Session: From Genomics to Clinical applications (I) Moderators: Academician Jacqueline Whang-Peng /Taipei Medical University; Academician Pei-Jer Chen /National Taiwan University Hospital 09:30 - 09:55 Regulation of stemness gene expression and tumorigenicity by an endogenous matrix metalloproteinase inhibitor RECK Prof. Wen-Chun Hung/National Health Research Institutes 09:55 - 10:20 The Role of Chromatin Modifiers in Hypoxia-induced Epithelial-mesenchymal Transition. Prof. Kou-Juey Wu/National Yang-Ming University 10:20 - 10:45 Characterizing the Migration and Non-migrating Cancer Stem Cells Dr. Muh-Hwa Yang/Taipei Veterans General Hospital 10:45 - 11:05 Coffee Break Moderators: Academician Jacqueline Whang-Peng /Taipei Medical University; Academician Pei-Jer Chen /National Taiwan University Hospital 11:05 - 11:30 Mind the gap: From Research Finding to Clinical Reality in the Setting of Hereditary Colorectal Cancer. Prof. Nicholas Hawkins/University of New South Wales, Australia 11:30 - 11:55 Too Good is no Good: Double-edged Story of DNA Repair Proteins in Breast Prof. Shyng-Shiou Yuan/Kaohsiung Medical University Chung-Ho Memorial Hospital 12:20 - 13:30 Lunch Keynote Lecture Moderator: Prof. Hwei-Fang Tien/National Taiwan University Hospital 13:30 - 14:00 Recent advances of Acute Lymphoblastic Leukemia. Prof. Ching-Hon Pui/St. Jude Children’s Research Hospital Session: From Genomics to Clinical Applications (II) Moderators: President and Academician Hsing-Jien Kung /National Health Research Institutes; Prof. Hsin-Chen Lee/National Yang-Ming University Hospital 14:00 - 14:25 Biomarker to Identify Aristolochic Acid-related Diseases. Prof. Arthur P. Grollman/Stony Brook University, USA 14:25 - 14:50 Aristolochic Acid and Urothelial Carcinoma. Dr. Chung-Hsin Chen/National Taiwan University Hospital 14:50 - 15:15 The Role of Nicotinic Receptor Involved in Smoking-induced Breast Cancer Formation and its Prevention. Prof. Yuan-Soon Ho/Taipei Medical University 15:15 - 15:35 Coffee Break Moderators: President and Academician Hsing-Jien Kung /National Health Research Institutes; Prof. Hsin-Chen Lee/National Yang-Ming University Hospital 15:35 - 16:00 Targeting AR and Akt Signaling Pathways for Treatment of Advanced Prostate Cancers Prof. Chih-Pin Chuu/National Health Research Institutes 16:00 - 16:25 A Molecular Link Between Tissue Architecture, Wnt Pathway, Cancer Stemness and Aggressiveness in Glandular Cancers Prof. Kelvin Kun-Chih Tsai/National Health Research Institutes 3rd Lecture Hall Session: Brain Tumor 09:00 - 9:20 AT/RT: An Enigmatic Disease in Children. Dr. Tai-Tong Wong/Cheng Hsin General Hospital 09:20 - 10:00 Childhood Embryonal Brain Tumor Classification - a Moving Molecular Target. Dr. Annie Huang/University of Toronto, Canada 10:00 - 10:30 Small RNA Sequencing in Brain Tumor MicroRNA Study. Prof. Hsei-Wei Wang/National Yang-Ming University 10:30 - 11:00 Intra-operative Monitoring in Brain Tumor Surgery. Prof. Tsui-Fen Yang/National Yang-Ming University 11:00 - 11:10 Coffee Break 11:10 - 11:40 Intraoperative MRI with integrated functional navigation guidance for brain tumor surgery. Prof. Jin-song Wu/ 11:40 - 12:10 Surgical Treatment of Insula Tumors. Dr. Sanford P.C. Hsu/Taipei Veterans General Hospital 12:10 - 13:30 Lunch 4th Lecture Hall Session: Gastric and Intestinal Cancer Moderator: Prof. Emeritus Jaw-Town Lin/ National Taiwan University; President, The Gastroenterological Society of Taiwan 09:30 - 09:55 MicroRNAs and Gastric Cancer. Dr. Su-Shun Lo/National Yang-Ming University Hospital 09:55 - 10:20 Tumor Associated Macrophages and Gastric Cancer. Dr. Yan-Shen Shan/National Cheng Kung University Hospital 10:20 - 10:45 Biomarkers in Colorectal Cancer Dr. Hsiang-Lin Tsai/Kaohsiung Medical University Chung-Ho Memorial Hospital 10:45 - 11:05 Coffee Break Moderator: Superintendent Su-Shun Lo/National Yang-Ming University Hospital 11:05 - 11:30 Helicobacter Pylori and Gastric Cancer. Dr. Ming-Shiang Wu/National Taiwan University Hospital 11:30 - 11:55 Identification of Aurora Kinase A as an Unfavorable Prognostic Factor and Potential Treatment Target for Gastrointestinal Stromal Tumor. Dr. Chun-Nan Yeh/Chang Gung Memorial Hospital 11:55 - 12:20 Significance of Notch Signaling Pathway in Gastric Cancer. Prof. Tien-Shun Yeh/National Yang-Ming University 12:20 - 13:30 Lunch Session: Lymphoma Moderator: Prof. Tseng-tong Kuo/Chang Gung Memorial Hospital 14:00 - 14:25 New Advances in Peripheral T-cell Lymphomas. Prof. Philippe Gaulard/CHU Henri-Mondor, Paris-Est University School of Medicine in Créteil, France 14:25 - 14:50 Genomic Profiling of T-cell Lymphoma and its Clinical Implications. Prof. Bin-Tean Teh/National Cancer Center Singapore 14:50 - 15:15 Follicular Lymphoma in Taiwan: a Low Frequency of t(14;18) with Grade 3A Tumors More Closely Related to Grade 3B than to Low-grade Tumors. Prof. Shih-Sung Chuang/Chi Mei Medical Center 15:15 - 15:35 Coffee Break Moderator: Prof. Po-Min Chen/Taipei Veterans General Hospital; National Yang-Ming University 15:35 - 16:00 Functional Imaging in Lymphoma. Prof. Alain Rahmouni/CHU Henri-Mondor, Paris-Est University School of Medicine in Créteil, France 16:00 - 16:25 The Many Faces of Cutaneous Lymphoma: A Taiwan Experience and a Study of Cutaneous Plasmacytosis. Prof. Tseng-tong Kuo/Chang Gung Memorial Hospital 16:25 - 16:50 Hematopoietic Stem Cells Transplantation for Lymphoma. Dr. Ming Yao/National Taiwan University Hospital