Transdermal Magnesium
Chloride Treatment of
Fluoroquinolone Side Effects
An ongoing emergency experiment
George Eby and Karen Eby
http://george-eby-research.com
Austin, Texas
Introduction
Fluoroquinolone (and Quinolone) Effects
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Serious side effects are known but incidences are rarely reported in
medical literature
Yet, http://google.com - “fluoroquinolone” + “side effects” yields
114,000 pages
Side effects - both immediate and long delayed (>1 year) symptom
onset with potential for permanent injury with no known treatment
Main side effects: Tendon ruptures and fibromyalgia-like symptoms
Binding to DNA is mediated by magnesium ions
Concentrates in skin and can photosensitize skin
Depletes magnesium
More specifically to side effects: Causes peripheral neuropathy,
chronic pain, depression and other neuropsychiatric illnesses including
insomnia, irritability, suicidal ideation, suicide, heart problems, skin
problems (photosensitivity), Pseudomembranous colitis (bacterial
infection of colon), Rhabdomyolysis, Stevens-Johnson syndrome,
lowered seizure threshold, hypoglycemia, kidney stones and damage to
all internal organs and outright death.
Methods and Procedures
Role of Transdermal Magnesium Chloride
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Magnesium chloride inactivates
fluoroquinolones (see warning
label on package inserts)
Topically applied to skin,
33% magnesium chloride
should bind with and neutralize
fluoroquinolones concentrated
in skin and perhaps body.
Rapidly replaces depleted
magnesium systemically to
levels perhaps not achievable
with oral magnesium
Magnesium is a neuronal calcium channel blocker, like Lyrica
Magnesium has sedating properties and helps induce sleep
Mental Illnesses associated with Increasingly
Severe Neuronal Magnesium Deficiency
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From : http://george-eby-research.com/html/depressionanxiety.html a 180 page report on magnesium and depression
containing a magnesium and fluoroquinolone toxicity discussion.
Results
Case History # 1
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A 32-year old, 5’3” 110 pound woman became toxic from prescribed 500
mg 2 t/d – 10 days ciprofloxacin after several days treatment. Symptoms
included (cold water felt like boiling water), extreme pain in overworked
right arm, severe Achilles’ heel tendon pain, insomnia, pain in all joints
and limbs, vision impairment, irritability and depression. Before and after
intoxication, blood panel was normal and fever was not present.
Topical treatment with 33% magnesium chloride morning and evenings
over both legs rapidly induced 14 to 16 hour sleep each day. After 10
days treatment with topical magnesium chloride, her symptoms ended,
except for irritability and tendon pain.
She remained neurologically symptom free for 5 months but relapsed
from severe social/physiological stress becoming very irritable, depressed
with suicidal ideation, and full body, severe chronic pain.
Retreatment with topical magnesium for 10 days chloride terminated all
complaints including tendon pain and irritability.
Results
Case History # 2
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A 51 year-old 5’ 6” 140 pound woman (non perimenopausal and
nonmenopausal) suffered from fibromyalgia-like symptoms
including depression and full body chronic pain with tendon pain
in all limbs (including toes and fingers) and vision impairment
for 7 years after administration of ciprofloxacin during breast
cancer surgery.
Oral magnesium (500 mg / day) for two years slightly reduced
symptomology, but did not eliminate them and did not improve
sleep.
Topical 33% magnesium chloride application (lower legs and
arms) in evening rapidly and greatly improved sleep and
terminated multi-year paresthesia (asleep feeling) in fingers.
Topical application for _____ days, resulted in __________
Conclusions / Hypotheses
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Magnesium is not only depleted during fluoroquinolone
intoxication, but magnesium homeostasis is hypothesized to be
permanently down regulated (genetically?) to a level sometimes
inconsistent with good mental or physical health
Fluoroquinolone side effects are hypothesized to be very common,
and severe side effects are much more common than previously
believed, perhaps due to magnesium malnutrition
Stress [psychological, physical, environmental, metabolic
(including MSG and calcium)] is hypothesized to trigger relapses
Topical magnesium chloride or other parenteral means of
administering magnesium to higher than normal (+0.9 mMol)
levels is hypothesized to be effective as treatment and prophylaxis
for fluoroquinolone toxicity and should be investigated