Female Hormonal Cycle - also known as the MENSTRUAL CYCLE

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Female Hormonal Cycle

MENSTRUAL CYCLE by : S. Rouholamin MD

Reproductive hormones: GnRH

GnRH: decapeptide, by neurons in arcuate nucleus of hypothalamus

Regulate secretion of two hormones: FSH and LH

Pulsatile secretion

Extremely short half-life: only 2-4 min

Gonodotropins

LH &FSH: by ant pituitary gonadotroph cells

Ovarian follicular stimulation

Glycoproteins, alpha &beta subunit

Prolactin

Poly peptide, by ant pituitary lactotroph

Primary trophic factor responsible for the synthesis of milk by breast

PRL secretion is under tonic inhibitory control by hypothalamic secretion of dopamine

PRL stimulation: breast manipulation, drugs, stress, exercise, certain foods

TSH

By ant pituitary thyrotrophs in response to TRH

TRH:by arcuate nucleus ,portal circulation, pituitary

TRH: TSH & PRL release

Hypo- and hyperthyroidism: ovulatory dysfunction

Oxytocin

9 aa peptide, by paraventricular nucleus of hypothalamus

Uterine muscular contraction, breast lactiferous duct myoepithelial contraction

MENSTRUAL CYCLE

Normal cycle length is considered 28 days

 varies from female to female (21-35 days)

Ovarian cycle: 1-follicular ,2-luteal

Uterine cycle: 1-proliferative ,2-secreatory

1 – Follicular phase

Development dominant follicle, mature at midcycle, ovulation

Average length:10-14 days

Variability in length: variations in total cycle length

2-luteal phase

Ovulation to menses

Average length: 14 days

Normal menstrual cycle

21-35 days

2-6 days of flow

Average blood loss:20-60 ml

Hormonal variations

1.

At the beginning of cycle: levels of gonadal steroids are low

2.

Demise of corpus luteum, FSH levels rise, cohort of growing follicles is recruited, rise in estrogen: stimulus for uterine endometrial proliferation

Hormonal variations

3.

Rising estrogen levels: negative feedback on pituitary FSH secretion; growing follicle produce inhibin-B: suppresses pituitary FSH secretion;

Rising estrogen levels: LH initially decreases but late in follicular phase LH levels increased dramatically

Hormonal variations

4.

At the end of follicular phase (just before ovulation) FSH-induced LH receptors on granulosa cells; with LH stimulation, modulate secretion of progesterone

Hormonal variations

5.

After sufficient degree of estrogenic stimulation; pituitary LH surge triggered, proximate cause of ovulation occurs 24 to 36 hours later

Hormonal variations

6.

Estrogen level decreases through the early luteal phase from just before ovulation until midluteal phase, rise again as a result of corpus luteum secretion

Hormonal variations

7.

Progesteron levels rise after ovulation; presumptive sign of ovulation

8.

Progesteron;estrogen and inhibin-A : suppress gonadotropin secretion and new follicular growth

Cyclic changes of the

Endometrium

Decidua functionalis: 2/3 superficial, proliferate and shed each cycle

Decidua basalis: deepest region, source of endometrial regeneration after each menses

1-Proliferative phase

First day of vaginal bleeding :day 1 of the menstrual cycle

Progressive mitotic growth of decidua functionalis, preparation for implantation of embryo

Thin endometrium (1-2 mm); straight, narrow, short endometrial glands become longer, tortuous structures

2-Secretory phase

48 to 72 hours following ovulation, progesteron secretion: eosinophilic protein-rich secretory product in glandular lumen

Postovulatory day 6-7,maximal secretory activity: optimal for implantation of blastocyst

Stromal edema in late secretory phase

2-Secretory phase

2 days before menses:dramatic increases in PMN migrate from vascular system

Menses

Absence of implantations, glandular secretion ceases, irregular break-down of decidua fuctionalis

Destruction of corpus luteum and its productions estrogen and progesteron: cause of shedding

Withdrawal of sex steroids: spiral art spasm, endometrial ischemia, lysosoms breakdown, proteolytic enzymes release

Ovarian follicular development

Fetus:6-7 million in 20 wks

At birth:1-2 million

At puberty:300,000

Release during ovulation:400-500

At menopause:rare

Oogonia: only one final daughter cell (oocyte), three polar body

Oocyte arrested in prophase

(diploten) until time of ovulation

Two-cell two-gonadotropin theory

 with LH stimulation, the ovarian theca cells produce androgens that convert by granulosa cells into estrogens under the stimulus of FSH

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