IMMUNOLOGY Doc. dr Dušan Popadić Doc. dr Miloš Marković Ass. dr Emina Savić Prof. dr Vera Pravica imunologija@med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija Limfocitic Welcome to Immunology Course Advice • for successful learning • and passing the exam Immunology Course (40 hours) Lectures (12 hrs) Practice (Seminars and Labs 28 hrs) Seminars and Labs during first 14 weeks Lectures during first 12 weeks Seminars, Labs and Lectures are integral parts of the course Student are allowed to be absent on seminar or lab twice during the semester In addition to these 40 hrs to prepare the exam you will need 60 hours of effective work Preparation of colloquium and final exam (45 hrs) Preparation for lectures and practice (15 hrs) Lectures (12 hrs) Practise (seminars and labs 28 hrs) References Basic Immunology: Functions and Disorders of the Immune System - Authors: Abbas AK, Lichtman AH. - Publisher: Elsevier - 3rd edition updated, 2011 .ppt presentations and authorised supplementary material (available on web site) Continuous assessment activities on the course (seminars, labs and lectures) – through activity points presence on lectures noted separately colloquium – partial, after every 4 weeks (5th, 9th and 13th week) Colloquium Test (multiple choice – 1 correct answer out of 4) It consists of 30 questions in total (divided into 3 mini tests) 1 point for each answer, max 30 points 15 minutes per mini test - first: in the 5th week - second: in the 9th week - third: in the 13th week Final exam Final test with combined multiple choice and short answer questions Threshold for a pass is 31 points, max 60 points Final mark in Immunology Final exam mark (60%) Colloquium score (30%) Regularity of course attendance (3%) Activity on seminars and labs (7%) Final mark in Microbiology and Immunology Final mark in Immunology (25%) February session→ Final mark in Microbiology (75%) June session→ Pass in Immunology is a condition for starting the exam in Microbiology Introduction to immune system • Innate and adaptive immunity • Types of adaptive immunity • Properties and phases of adaptive immune response • Central and peripheral lymphoid organs • Lymphocyte recirculation INNATE (Natural) (Native) ADAPTIVE (Aquired) IMMUNITY Principle mechanisms of innate and adaptive immunity Principle mechanisms of innate and adaptive immunity The most important cells of the immune system Chain of events in infection Pathogen(s) enter(s) tissue Pathogen(s) enter(s) tissue Pathogen(s) enter(s) tissue Macrophages recognize (and eliminate) pathogens Macrophages recognize (and eliminate) pathogens Macrophages recognize (and eliminate) pathogens Inflammation is induced and PMNs attracted Inflammation is induced and PMNs attracted Antigen-presenting cells (APCs) capture antigen(s) Antigen-presenting cells (APCs) capture antigen(s) APCs migrate to draining lymph node APCs migrate to draining lymph node APCs migrate to draining lymph node APCs migrate to draining lymph node APCs migrate to draining lymph node APCs migrate to draining lymph node APCs migrate to draining lymph node APCs migrate to draining lymph node APCs migrate to draining lymph node T cells are activated by APCs T cells are activated by APCs T cells are activated by APCs B cell are activated (helped by T cells) B cell are activated (helped by T cells) B cell are activated (helped by T cells) Activated B cells (plasma cells) produce antibodies (Abs) Activated B cells (plasma cells) produce antibodies (Abs) Activated B cells (plasma cells) produce antibodies (Abs) Activated B cells (plasma cells) produce antibodies (Abs) Activated T cells and Abs leave lymph node... ... enter blood stream and... ... enter blood stream and... ... migrate to site of infection ... migrate to site of infection ... migrate to site of infection Activated T cells stimulate phagocytes Activated T cells stimulate phagocytes Activated T cells stimulate phagocytes Activated T cells stimulate phagocytes Abs neutralize pathogens and stimulate phagocytes Abs neutralize pathogens and stimulate phagocytes Abs neutralize pathogens and stimulate phagocytes Abs neutralize pathogens and stimulate phagocytes Abs neutralize pathogens and stimulate phagocytes Pathogen is eliminated http://instruction.cvhs.okstate.edu/vmed5253/immunobiology.swf Principle mechanisms of innate and adaptive immunity Mechanisms of adaptive immunity - acquired throughout a lifetime of an individual - result of previous contact with pathogen - present in vertebrates Properties of adaptive immunity - diversity and specificity - memory - clonal expansion - specialization - autotolerance - stimulation of mechanisms of innate immunity Types of adaptive immunity Phases of adaptive immune response Types of lymphocytes Lymphoid organs Lymph node structure Lymph node structure Recirculation of T lymphocytes The morphology of the spleen Introduction to immune system • Innate and adaptive immunity • Types of adaptive immunity • Properties and phases of adaptive immune response • Central and peripheral lymphoid organs • Lymphocyte recirculation 1. Innate immunity is also called a. phagocytes and NK cells 2. Mechanisms of innate immunity mediate b. humoral and cellular immunity 3. First line of defence of innate immunity is provided by c. B and T lymphocytes 4. Cells of innate immunity are d. natural or native immunity 5. Cells of adaptive immunity are e. diversity, specificity and memory 6. Types of adaptive immunity are f. 7. Important properties of adaptive immune cells are g. early defence against infectious agents 8. Human central (primary) lymphoid organs are h. epithelial barriers 9. Human peripheral (secondary) lymphoid organs are i. peripheral lymphoid organs j. lymph nodes, spleen and MALT 10. Primary adaptive immune response begins in 1._____ 2._____ d. g. 3._____ 4._____ h. a. bone marrow and thymus 5._____ 6._____ 7._____ c. b. e. 8._____ 9._____ f. j. 10.____ i.