Research in the
School of Dentistry
.
School of Dentistry
1888
First class enrolled
3 year program
22 students
.
4 faculty
Dr. Edith White followed the gold rush to the
Yukon
School Statistics
• Student body
–
–
–
–
–
–
98 DDS students/class
10 PASS students/2 classes
24 BS dental hygiene students/class
10 MS dental hygiene students/class
9 dental therapy students/class
92 residents in 8 advanced
education programs
• Faculty
– 116 full-time
– 181 adjunct
• Professional and support staff
– 232 total
Clinical services
Moos Tower – open to the public
377 clinical operatories
95,514 patient visits per year
Outreach sites: 15,000 patient visits
Northpoint Health & Wellness Cntr
Center (N. Mpls)
CUHCC (S. Mpls)
Walker Dental Clinic (S. Mpls)
Hibbing
Willmar
Howard, South Dakota
Mobile Dental Unit
Continuing Dental Education:
154 courses per year
7,349 practitioners
Research Training
Graduate Program in Oral Biology
MinnCResT (NIDCR T32)
Positions:
11 post-doc
7 pre-doc
.
Ph.D. students advised by SOD faculty:
Ph.D. oral biology - 13
Other Ph.D. – 5
Summer Research Opportunities
18
Graduate Program in Oral Biology
40th Anniversary in 2009
14 grad students
32 Faculty
School of Dentistry
. of
Department of Veterinary Biosciences, College
Veterinary Medicine
Department of Medicine, Medical School.
Department of Microbiology
Department of Neuroscience, School of Medicine
Department of Pediatrics and Department of
Genetics, Cell Biology and Development
Department of Pharmaceutics, College of Pharmacy
Director: Mark Herzberg T32DE007288-14
Neuroscience
Microbiology and Immunology
Cancer Biology
Developmental Biology, Molecular Genetics,
and Stem Cells
Clinical Research
.
Translational Genetics and Communications
Disorders
Genomics, Proteomics, Structural Biology, and
Computational Biology
Nanotechnology, Materials Sciences, and
Tissue Engineering
Summer Research
Director: Joel Rudney, Asst. Dean Res.
DDS (DH) students
20 students / year
10 week full-time program
.
Presentations at national and regional meetings
$600,000 fundraising campaign to stabilize
funding
Research Funding
NIH institutes:
NIDCR
NIDA
NCI
NIAID
NIGMS
NINDS
ORWH
NSF
HRSA/MN
Corporate:
3M
ORMCO
Dentscare
Amgen
ARRA funding:
. (2)
R01 subcontr
R21
R01 supplement
NSF subcontr.
GO grant IHI/SON
Funding Sources FY09
NIDCR
Other NIH Institutes
Subcontracts
Non-federal
9%
32%
17%
.
42%
$ 4,574,143
Total: $Total:
6,278,002
Funding Increase Jun-Nov 2009
$3,000,000
June
$2,500,000
$ 4.5M
November $ 6.3M
ARRA: $862,265
$2,000,000
$1,500,000
$1,000,000
$500,000
$0
NIDCR
Other NIH Inst
Subcontracts
Non-federal
21 Funded SOD investigators
Research Areas
Bone Biology
Neuroscience, Pain
Microbiology, Virology
Salivary Proteins
Cell Biology
Biomaterials
Dental Materials
Imaging
Immunology
Periodontal and Systemic Disease
Temporomandibular joint disease
Orthodontics
Endodontics
Dental Implants
Oral Surgery
Oral Cancer
Developmental Biology
Public Health, Preventive Care
Director: Louis Mansky
Investigators:
School of Dentistry - 5
School of Medicine - 15
College of Pharmacy - 3
School of Public Health - 2
College of Veterinary Science - 5
Mayo Clinic - 13
Bacteriophage phi29
1966: Bacteriophage phi29 is identified by Bernard Reilly and Dwight
Anderson from soil sample obtained on St. Paul Campus
2009: R01DE003606-39 Morphogenesis of bacteriophage phi29
Shelley Grimes
.
Director: Alex Siu-Lun Fok
Works closely with manufacturers to
develop and test new dental products
and materials in the areas of
biomaterials, biomechanics and nanotechnology.
3M support since 1991
.
Virtual Dental Patient: interactive 3D
computer rendition of a dental patient.
Artificial Mouth: replicates the effects of
a year of chewing in one day
(“chews” 300,000 per day)
Exhibited in Smithsonian Inst.
Shape Optimization of Dental
Restorations
An interdisciplinary project
involving engineers and dental
scientists.
92% of fractured teeth have
been previously restored
Shape optimization based on
finite element analysis and
biological adaptive growth
process led to significant
reduction in the stress levels at
the tooth–restoration interface.
Conventional
Optimized
Oral Health Clinical Research
Center
Director: Bryan Michalowicz
Founded 1990, $2.5 M NIH grant
Multi-purpose research clinic consisting of 10 dental
operatories
Translate advances in the basic and applied
sciences to the clinical setting
Test new technologies in dental care or delivery
Periodontitis and systemic disease
5U01DE014338-06, Michalowicz (PI)
EFFECTS OF PERIODONTAL
THERAPY ON PRETERM BIRTH
Treatment of periodontitis in pregnant
women improves periodontal disease
and is safe but does not significantly
alter rates of preterm birth, low birth
weight, or fetal growth restriction.
1UO1 DE018902, Engebretson (PI)
DIABETES AND PERIODONTICS TRIAL
Determine if periodontal treatment improves glycemic
control in type II diabetics with moderate to advanced
periodontitis
Launched 2002
NIDCR contract $ 5.9 M
Jim Fricton (PI)
Sandra Myers (Repository)
Lois Kehl (Neuroscience)
John Look (Registry)
•
A variety of therapeutic approaches have
evolved for the relief of TMJD symptoms.
Implants have been used primarily to
replace the articular disc of the joint and the
condylar head of the mandible. Long-term
success and functioning of these implants
remains a major problem.
A neural pathway for itch
Steve Davidson, Xijing Zhang, Sergey G
Khasabov, Donald A Simone & Glenn J
Giesler Jr
Department of Neuroscience,
Department of Diagnostic and Biological
Sciences.
Nature Neuroscience 12, 544 - 546 (2009)
“scratching the cutaneous receptive field of
primate STT neurons produced inhibition
during histamine-evoked activity but not
during spontaneous activity or activity
evoked by a painful stimulus, suggesting
that scratching inhibits the transmission of
itch in the spinal cord in a state-dependent
manner.”
News stories carried by NYT,
BBC, Reuters, MPR
A look ahead
A diverse research program
Stabilize funding:
Review of Summary Statements
Grant Writers Club
Research Incentive Plan
Organize research themes
Meet the Program Director
Increased collaboration to reach critical
mass