Chapter 3 Biology and Behavior Nature and Nurture •Each of us is a product of our genetics and the environment •Historical views of how characteristics are transmitted Galton (1869) Mendel Watson and Crick (1953) Currently scientists are attempting to figure out the function of the roughtly 30,000 to 60,000 genes that make up the human genome Divisions of the Cell • Mitosis refers to a process by which 2 identical cells are produced • Meiosis refers to a process in 4 cells are produced, with each containing only 23 chromosomes (Figure adapted with permission from Biology: Exploring Life, by G.D. Brum and L.K. McKane, 1989, New York: John Wiley and Sons) Cross-Over During Meiosis • During meiosis, the x-shaped chromosomes line up and intermix, yielding a novel genetic product (Figure adapted with permission from Biology: Exploring Life, by G.D. Brum and L.K. McKane, 1989, New York: John Wiley and Sons) DNA • DNA is the basic genetic material, formed from pairs of base nucleotides – The bases form pairs such as adenosine-thymine or guanine-cytosine – The DNA strand is in the form of a double helix made up of series of base pairs Principles of Heredity • Mendel argued that certain traits are transmitted from parents to child – Each trait is governed by two elements with one from each parent – Phenotype – Genotype – Principle of dominance Mendelian Inheritance Genetic Disorders • Dominant disorders: – Huntington’s chorea • Recessive disorders: – Phenylketonuria (PKU) © 1999 John Wiley and Sons, Inc. Genetic and Environmental Forces •Model Components: Genotype Phenotype Environment •4 relations fundamental to a child’s development Parents’ genotype Child’s genotype Child’s environment Child’s phenotype Child’s genotype Child’s phenotype Child’s phenotype Child’s environment Parents’ Genotype •Terms: Chromosomes DNA Genes Proteins Child’s Genotype Diversity Mutations— Crossing over •Chromosomes Sex Determination by Sex Chromosomes Females XX Males XY—presence of the Y chromosome determines male sex Child’s Genotype Child’s Phenotype •Gene Expression Regulator genes control other genes (puberty, graying hair) •Dominance Patterns Inheritance patterns are complicated with few following Mendel’s simple pattern Alleles Dominance/Recessive genes Homozygous/Heterozygous Mendelian inheritance patterns Above are the Mendelian inheritance patterns for two brown-haired parents who are both heterozygous for hair color. The allele for brown hair (B) is dominant, and that for blond hair (b) is recessive. Note that these parents have three chances out of four of producing children with brown hair. They have two chances in four of producing brown-haired children who carry the gene for blond hair. Common Genetic Traits DOMINANT Brown eyes Normal hair Dark hair Color vision Freckles Dimples © 1999 John Wiley and Sons, Inc. RECESSIVE Blue, gray, or green eyes Baldness (in men) Blond hair Color Blindness No freckles No dimples •Genetic Transmission of Diseases and Disorders Dominant–Recessive Pattern— 2 recessive alleles (PKU, sickle-cell anemia, Tay-Sachs) Dominant gene (Huntington’s disease) Polygenic Inheritance—combination of multiple genes and environment (ADHD, some cancers, schizophrenia) Sex-Linked Inheritance X-linked Disorders are more prevalent in men (hemophilia, color-blindness, male-pattern baldness) Chromosomal Anomalies—more or less than the normal complement of chromosomes (Down syndrome, Kleinfelter syndrome, Turner syndrome) Regulator Gene Defects—which initiate the development of genitalia Child’s Environment Child’s Phenotype •Depending on the environment–genotype relationship numerous phenotypes may result PKU—special diet Parents’ role—highly literate parents may have more books in the home, exposing children to more literature Child’s Phenotype Child’s Environment •For example, the activity level of a child gets differing responses from adults •Children create environments of interest, talents, and personality Behavioral Genetics •The study of how variation results from environmental factors and genetic Research Designs Family studies Twin studies Adoption studies Age-Related Changes in Concordance for MZ and DZ Twins (Figure adapted by permission from “The Louisville Twin Study: Developmental Synchronies in Behavior” by R.S. Wilson, 1983, Child Development, 34, p. 301. Copyright © 1983 by the Society for Research in Child Development). •Heritability A statistical estimate of the proportion of the measured variance on a given trait among individuals in a given population that is attributable to genetic differences among the individuals For example IQ, temperament, and divorce Important restrictions: Heritability applies only to populations, not to individuals Heritability estimates apply only to a particular group living in a particular environment at a particular time High heritability does not imply immutability Heritability estimates tell us nothing about difference between groups Experience and the Brain •Plasticity Experience-expectant plasticity Sensitive periods Experience-dependent plasticity •Plasticity, Brain Damage, and Recovery Recovery depends on Extent of the damage Aspect of the brain developing at time of damage Damage may not be immediate “Worst time” is during prenatal development “Best time” is childhood during synapse generation and pruning Body Growth and Development • Depends on nature and nurture, genetics, and the environment • Nutritional Behavior Breast feeding Food preference Eating disorders Obesity Bulimia Anorexia Nervosa Undernutrition Marasmus (low calories) Kwashiorkor (low protein) • Research has shown links between cognitive development/performance and nutrition Malnutrition and cognitive development Malnutrition, combined with poverty, affects many aspects of development and can lead to impaired cognitive abilities. (From Brown & Pollitt, 1996.)