OBJECTIVES INNATE VERSUS ADAPTIVE RESPONSE I N N AT E ADAPTIVE • • • • • • ANTIBODY STRUCTURE WHAT IS AN ANTIBODY?? BUT WHAT IS AN ANTIGEN??? • SUMMARY ANTIBODY FUNCTIONS • • • • NEUTRALIZATION OPSONIZATION COMPLEMENT AGGLUTINATION • • • • ABO BLOOD GROUPS THERE ARE LOTS OF TYPES OF ANTIBODIES • • • • • IgG IgA IgM IgE IgD OBJECTIVES QUESTION Which immunoglobulin can cross the placenta? ANSWER IgG QUESTION If you mix a person with type A blood and anti-A antibodies, will agglutination occur? ANSWER Yes QUESTION What is the difference between neutralization and opsonization? ANSWER Neutralization – antibody binds a toxin and makes it harmless Opsonization – antibody binds an antigen and targets it for phagocytosis LAB TODAY • Today you will be simulating the Ouchterlony test. • This test is performed on an agar plate • Antigen and antibodies are placed in well and allowed to diffuse. • If an interaction occurs between an antibody/antigen, then a white line appears.