M. Yusron Hasani
A. Muammar Kadafi
Nira Meirita W.
Putri Indisari
Group 3:
(105090100111037)
(115090101111012)
(115090100111017)
(115090107111021)
JURUSAN BIOLOGI
FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN
ALAM
UNIVERSITAS BRAWIJAYA
MALANG
2013
 Substance
that stimulates the production of
antibodies and can be recognised by a B cell
receptor or antibody, or a T cell receptor.
 Protein, polisakarida or other molecule
 Part of the antigen which comes into contact
with the antigen receptor is called the epitope
or antigenic determinant
ANTIGEN STRUCTURE


linear or sequential epitope is an epitope that
is recognized by antibodies by its linear
sequence of amino acids, or primary structure
Conformational epitope that has a specific
three-dimensional shape and its protein
structure. In contrast, most antibodies
recognize this epitope

Major histocompatibility Complex
 The
binding between antibodies and
antigens has high specificity and affinity
resulting from various structural and
energetic aspects.
 Is
a non covalent bond ( similar
mechanism as lock and key on enzyme
and a substrate )
 Happens
because the molecular structure
of an antibody typical

Pre-natal used IgG as antibody

Post-natal used IgA from colostrum as
antibody


Response to the first exposure to antigen
called primary immune response, mediated
by lympocytes, called naïve lympocytes
Subsequent encounters with the same
antigen lead to responses, called secondary
imune response



First exposure to antigen stimulate primary
imun responses signalling by IgM few days
after exposing.
Time between exposure and appearance of
IgM antigen called the lag phase
In serum, IgG start to be detected 6-7 days
after exposure

When second exposure to antigen occurs,
secondary immune response in which IgM
and IgG levels increased rapidly with a short
lag phase


IgM levels did not exceed the peak levels of
the primary response, but IgG levels rise
much higher and lasts longer
Much better response faster on secondary
immune response