Review for Genetics final exam. Study powerpoints! Reproduction and Chromosome Transmission Difference in prokaryotic, eukaryotic, and viral chromosomes Prokaryotic cell division Diploid vs haploid Cell cycle parts Mitosis – outcome and purpose, stages Meiosis – reduction and equational division, function of each Comparison of mitosis and meiosis Spermatogenesis vs oogenesis How genetic variation obtained in sexual reproduction Mendelian Inheritance Know general terms such as homozygous, heterozygous, monohybrid cross, etc. Mendel’s Laws Test cross How to do crosses and interpret pedigrees Using probability (not binomial expansions) How to use chi-square analysis Sex Determination and Sex-Linked Traits Sex chromosomes, autosomes Sex-linked problems (nothing fancy here) SRY gene Barr bodies EXTENSIONS OF MENDELIAN INHERITANCE Genetic polymorphism Lethal alleles Incomplete dominance Multiple alleles ABO blood types Gene dosage effects Heterozygote advantage Expressivity Penetrance Sex-limited traits Sex-influenced traits Epistasis Bioinformatics and Genomics Synthetic biology Structural and Functional genomics, proteomics Use of homologies Use of microarrays Transposable elements Alternative mRNA splicing Cytogenetic mapping FISH Linkage mapping Physical mapping Restriction enzymes Molecular markers such as RFLPs, microsatellites, SNPs Haplotypes Contigs in physical mapping LINKAGE AND GENETIC MAPPING IN EUKARYOTES How linkage determined from crossing-over recomb data How to map genes based on recomb data NO trihybrid stuff MEDICAL GENETICS AND CANCER Pedigree analysis (again) Heterogeneity Genetic testing types Genetic screening Terms related to cancer – ie metastatic, malignant, angiogenesis, etc Tumor-suppressor genes You should remember most of this from the last test.