1 1 Unit Goals • Describe the phases of the cell cycle. • Describe the process of Mitosis. – Describe the functions of mitosis. • Describe the process of Meiosis. – Describe the functions of meiosis. – Explain the consequences of mistakes. 2 2 Cell Size • Why not just one large cell? • Difficult to get nutrients in and waste out 3 3 Phases of The Cell Cycle G1,S, and G2 are known together as Interphase. 4 4 Interphase Regular Cells Somatic cell cycle • G1 phase- Gap phase, cell undergoes growth. • S phase- DNA synthesis Sex cells are called gametes • G2 phase- Gap phase. Preparation for Mitosis. Organelles are produced. • M phase- Cell division (Mitosis and cytokinesis) 5 5 G1 Phase •Cell Grows 6 6 S Phase • Chromosomes Condense • Chromosomes are inherited genetic information • Chromosomes are made up of DNA • Can only be seen when cells are dividing 7 S Phase When a cell divides, its two daughter cells must receive the required number of DNA molecules. • Chromosomes replicateor copy is made • The two copies are • -attached together at a point called a centromere. • -are called sister chromatid. 8 8 9 9 G2 Phase Organelles must be replicated (copied) 9 10 10 M Phase Two parts: 1.Nuclear division – Mitosis 2.Cytoplasmic Division – Cytokinesis 10 11 11 Mitosis • Nuclear Division. • Nucleus divides into two new nuclei Mitosis keeps the number of chromosomes constant from one cell generation to the next. • In eukaryotes, it is the main process by which growth and tissue repair is accomplished. • Mitosis is also the main process by which single-celled and many multi-celled 12 eukaryotes reproduce asexually. 12 4 Steps of Mitosis (PMAT) • Prophase: Chromosomes condense and attach to the spindle fibers at their centromere. • Nuclear Membrane breaks down. 13 13 Steps of Mitosis (PMAT) • Prophase: Centrioles move to opposite sides of the cell and organize the spindle fibers 14 Metaphase: Chromosomes attach to spindle fibers and line up in the middle of the cell 14 15 15 Anaphase: Chromosomes separateMove to opposite sides of the cell 16 16 Telophase • Nuclear Envelope reforms There are now TWO nuclei in one cell! …And they contain the SAME genetic information *SAME NUMBER OF CHROMOSOMES 17 17 18 18 19 19 Cytokinesis • Cytoplasmic division • Each cell gets half of the organelles. • After mitosis: cell pinches in half to form two new cells. 20 20 Cytokinesis • Animal cells pinch. • Cytokinesis in plant cells is different from that in animal cells. 21 21 In plant cells a cell plate forms from the • inside out. 22 23 23 Results of Mitosis and Cytokinesis 24 •Two new cells. •The new cells- called daughter cells- have the same number of chromosomes as the mother cell. 24 24 Results of Mitosis and Cytokinesis • This occurs in all somatic cells in your body. • You have 46 chromosomes in all of your somatic cells-23 pair! 25 25 Mitosis in Onion 26 26 Cells during Mitosis 27 27 28 28 http://www.youtube.com/watch?v=VlN7K1-9QB0&feature=related 29 29 Concept Map Cell Cycle includes M phase (Mitosis) Interphase is divided into G1 phase S phase is divided into G2 phase Prophase Metaphase Anaphase Telophase 30 Meiosis: Reproduction of Sex Cells 30 • Sex cells- Sperm and egg • Process is called Meiosis • Similar to Mitosis Meiosis Introduction Clip 31 31 Meiosis DIPLOID= 2 copies) • Cell divides twice • First division is like mitosis and then the cell divides again to create 4 haploid cells. Not genetically identical! Contains ½ (HAPLOID) of the genetic information. 32 31.2 Not genetically identical! Contains ½ of the genetic information. 33 32 MEIOSIS=CHROMOSOME REDUCTION DIVISION Not genetically identical! Contains ½ of the genetic information. 34 34 Meiosis Meiosis Square Dance • Meiosis is also know as chromosome reduction division. • In Humans, starts with 46 and ends up with 23. • Why? • Fertilization creates the diploid Haploid condition again Diploid 35 35 • Sperm formation- 4 haploid sperm cells are formed. • Egg formation-most of the cytoplasm is used in one cell and the other three disintegrate. One haploid egg cell is formed. 36 36 Meiosis Video Clip 37 37 Crossing Over • Sometime during meiosis the chromosomes can exchange information • This is called Crossing Over • Major source of genetic diversity in the species 38 38 39 39 Prokaryotic Cells • Binary fission • Occurs in Prokaryotic Cells • DNA is copied and then the cell splits in half. 40 40 Regulation of the Cell Cycle • How do cells know when to divide? • When to stop dividing? • Cyclins-proteins that regulate the cell cycle. 41 41 Cancer • Unregulated cell growth. • Can form masses of cells called tumors. 42 REVIEW CLIP 43