Confidential Draft Project Jaguar Presentation to the Board of Directors May 10, 2014 Goldman Stanley Table of Contents Executive Summary 3 Jaguar Valuation 5 Potential Strategic Partners 25 Process Recommendations 38 Appendix 43 Goldman Stanley 2 Executive Summary Goldman Stanley 3 Executive Summary As of May 9, 2014, Jaguar’s share price and valuation multiples have more than doubled over the last twelve months Even at its current levels, however, Jaguar is still undervalued relative to peer specialty pharmaceutical companies, and on an intrinsic, cash-flow basis Given its prominence in the market, the record healthcare M&A activity in the first half of this year, and the soaring interest in “tax inversion” deals, Jaguar could make for an attractive acquisition candidate Such a strategy would allow Jaguar to maximize shareholder value, expand its geographic reach and distribution channels, and acquire more resources for future research & development efforts and/or M&A activity Given Jaguar’s unique attributes, we believe a purchase premium above 50%, implying a share price of ~$200+, is possible with the proper positioning and process We recommend a highly targeted process focused on the most likely (“Tier 1”) potential partners, along with an outreach to Tier 2 potential partners while discussions with Tier 1 partners are ongoing Goldman Stanley 4 Jaguar Valuation Goldman Stanley 5 Valuation Summary – Operating Scenarios Base Case Management Case $2.0 billion in FY 20 $4.2 billion in FY 21 $300 million / year $377 million / year FY 20 FY 21 Annual Price Increases Through Peak Revenue CAGR of 6%; max of ~$79,000 in FY 21 CAGR of 11%; max of ~$122,000 in FY 21 Xyrem Market Penetration Increases from 7% in FY 13 to 19% in FY 23 Increases from 7% in FY 13 to 24% in FY 23 EBITDA Margins Steady between 54-56% until generics enter Steady between 55-57% until generics enter Peak Xyrem Revenue Xyrem Revenue After Peak Xyrem Generics Entrance Year Goldman Stanley 6 Summary of Valuation Implications #1 Implied Valuation Jaguar appears to be undervalued by 50%+ in the Management Case and 1020% in the Base Case #2 Comparable Companies Also point to the same result – Jaguar trades below the median EV / EBITDA multiple of peer companies #3 Discounted Cash Flow (DCF) Analysis Produces the highest implied valuation, primarily because Jaguar’s value is heavily dependent on Xyrem pricing 5-10 years into the future #4 Precedent Transactions Similar M&A deals imply a much lower valuation, but we believe these multiples are less relevant due to the lack of comparable deals Goldman Stanley 7 Base Case Financial Projections ($ USD in Millions except for $ per Share Figures) Income Statement: Revenue: Existing Products: Xyrem Sales: Erwinaze Sales: Defitelio Sales: Other Sales and Royalties: Risk-Adjusted Pipeline Drug Sales: JZP-110 Sales: JZP-386 Sales: Total Revenue: Revenue Growth: Units: $M $M $M $M FY14 $ FY15 578.6 $ 203.4 57.8 142.0 FY16 766.6 $ 234.2 79.8 156.2 Projected FY18 FY19 FY17 FY20 FY21 975.1 $ 1,205.9 $ 1,447.1 $ 1,709.4 $ 1,975.3 $ 266.6 300.7 336.7 346.8 385.8 107.1 140.7 182.0 209.3 240.7 168.7 182.1 193.1 204.7 214.9 FY22 276.3 $ 397.3 276.9 225.6 FY23 301.4 $ 439.6 318.4 234.7 301.4 452.7 366.1 244.0 $M $M $M % 981.8 12.5% 1,236.7 26.0% 1,517.4 22.7% 18.1 1,847.6 21.8% 43.4 2,202.3 19.2% 76.9 2,547.1 15.7% 88.9 2,905.6 14.1% 135.6 1,311.7 (54.9%) 152.3 1,446.4 10.3% 196.1 1,560.5 7.9% Operating Income (EBIT): Operating (EBIT) Margin: $M % 266.7 27.2% 563.2 45.5% 716.8 47.2% 895.2 48.5% 1,088.2 49.4% 1,286.5 50.5% 1,477.1 50.8% 549.9 41.9% 616.9 42.6% 674.2 43.2% Net Income: Effective Tax Rate: $M % 877.5 18.0% $ 1,054.8 18.0% $ 1,211.2 18.0% Diluted Shares Outstanding: Diluted Earnings Per Share (EPS): EBITDA: EBITDA Margin: Goldman Stanley $M $ as Stated $M % $ $ $ 178.8 18.0% $ 430.6 18.0% $ 64.4 2.77 $ 67.5 6.38 $ 527.1 $ 53.7% 695.5 $ 56.2% 556.6 18.0% $ 70.6 7.88 $ 719.2 18.0% $ 73.9 9.73 $ 77.4 11.34 $ 81.0 13.02 $ $ 450.9 18.0% $ 505.8 18.0% $ 552.8 18.0% 84.8 14.29 $ 88.8 5.08 $ 92.9 5.44 $ 97.2 5.68 847.8 $ 1,029.8 $ 1,224.0 $ 1,410.1 $ 1,606.8 $ 55.9% 55.7% 55.6% 55.4% 55.3% 665.0 $ 50.7% 734.9 $ 50.8% 795.1 51.0% 8 Management Case Financial Projections ($ USD in Millions except for $ per Share Figures) Income Statement: Revenue: Existing Products: Xyrem Sales: Erwinaze Sales: Defitelio Sales: Other Sales and Royalties: Risk-Adjusted Pipeline Drug Sales: JZP-110 Sales: JZP-386 Sales: Total Revenue: Revenue Growth: Units: $M $M $M $M FY14 $ FY15 FY16 Projected FY18 FY19 FY17 FY20 FY21 FY22 773.7 $ 1,083.1 $ 1,455.7 $ 1,902.2 $ 2,391.3 $ 2,959.2 $ 3,551.1 $ 4,218.7 $ 203.4 234.2 266.6 300.7 336.7 346.8 385.8 397.3 57.8 79.8 107.1 140.7 182.0 209.3 240.7 276.9 142.0 156.2 168.7 182.1 193.1 204.7 214.9 225.6 FY23 376.8 $ 439.6 318.4 234.7 376.8 452.7 366.1 244.0 $M $M $M % 1,176.9 34.9% 1,553.3 32.0% 1,998.0 28.6% 28.5 2,554.3 27.8% 71.7 3,174.8 24.3% 133.2 3,853.2 21.4% 159.8 4,552.3 18.1% 253.1 5,371.6 18.0% 292.7 1,662.1 (69.1%) 387.8 1,827.6 10.0% Operating Income (EBIT): Operating (EBIT) Margin: $M % 380.8 32.4% 754.7 48.6% 1,003.9 50.2% 1,312.6 51.4% 1,657.1 52.2% 2,044.0 53.0% 2,424.9 53.3% 2,870.7 53.4% 739.4 44.5% 825.0 45.1% Net Income: Effective Tax Rate: $M % 792.0 18.0% $ 1,061.5 18.0% $ 1,344.0 18.0% $ 1,675.9 18.0% $ 1,988.4 18.0% $ 2,353.9 18.0% Diluted Shares Outstanding: Diluted Earnings Per Share (EPS): EBITDA: EBITDA Margin: Goldman Stanley $M $ as Stated $M % $ $ $ 272.4 18.0% $ 64.4 4.23 $ 642.0 $ 54.6% 587.6 18.0% $ $ 676.5 18.0% 88.8 26.52 $ 92.9 6.53 $ 97.2 6.96 888.6 $ 1,137.7 $ 1,452.2 $ 1,800.7 $ 2,179.4 $ 2,571.1 $ 3,030.4 $ 57.2% 56.9% 56.9% 56.7% 56.6% 56.5% 56.4% 860.0 $ 51.7% 949.4 52.0% 67.5 8.71 $ 70.6 11.21 $ 73.9 14.36 $ 77.4 17.37 $ 81.0 20.69 $ 84.8 23.45 $ $ 606.3 18.0% 9 Revenue and EBITDA: Management Case vs. Base Case ($ USD in Billions) Revenue Projections $6.0 B $5.4 B $4.6 B $5.0 B $3.9 B $4.0 B $3.2 B Management $2.6 B $3.0 B $2.0 B $2.0 B $1.2 B $1.7 B $1.6 B $1.8 B Base $1.0 B $0.0 B FY14 FY15 FY16 FY17 FY18 FY19 FY20 FY21 FY22 FY23 EBITDA Projections $3.5 B $3.0 B $3.0 B $2.6 B $2.5 B $2.2 B $1.8 B $2.0 B $1.5 B $1.0 B Management $1.5 B $0.6 B $0.9 B $1.1 B $0.9 B $0.9 B Base $0.5 B $0.0 B FY14 FY15 Goldman Stanley FY16 FY17 FY18 FY19 FY20 FY21 FY22 FY23 10 Projected Xyrem Sales – Pricing vs. Patient Growth ($ USD in Millions) Goldman Stanley 11 Valuation Summary – Base Case ($ USD in Dollars as Stated) Jaguar Current Share Price(1): Public Company Comparables: LTM EV / Revenue: 2014-12-31 E EV / Revenue: 2015-12-31 E EV / Revenue: LTM EV / EBITDA: 2014-12-31 E EV / EBITDA: 2015-12-31 E EV / EBITDA: LTM Reported P / E: 2014-12-31 E Reported P / E: 25th to Median 2015-12-31 E Reported P / E: Median to 75th Precedent Transactions: LTM EV / Revenue: LTM EV / EBITDA: Discounted Cash Flow Analysis: 7.0% - 9.0% Discount Rate, (1.0%) – 1.0% Terminal FCF Growth Rate: $0.00 $50.00 $100.00 $150.00 $200.00 $250.00 $300.00 Implied Share Price All market data as of May 9, 2014 Given that Jaguar’s revenue growth, EBITDA growth, and EBITDA margins exceed those of its peer companies, we believe a valuation in the 75th percentile to maximum of the set is justified Goldman Stanley (1) Financial data as of May 9, 2014. 12 Valuation Summary – Management Case ($ USD in Dollars as Stated) Jaguar Current Share Price(1): Public Company Comparables: LTM EV / Revenue: 2014-12-31 E EV / Revenue: 2015-12-31 E EV / Revenue: LTM EV / EBITDA: 2014-12-31 E EV / EBITDA: 2015-12-31 E EV / EBITDA: LTM Reported P / E: 2014-12-31 E Reported P / E: 25th to Median 2015-12-31 E Reported P / E: Median to 75th Precedent Transactions: LTM EV / Revenue: LTM EV / EBITDA: Discounted Cash Flow Analysis: 7.0% - 9.0% Discount Rate, (1.0%) – 1.0% Terminal FCF Growth Rate: $0.00 $50.00 $100.00 $150.00 $200.00 $250.00 $300.00 Implied Share Price All market data as of May 9, 2014 The rest of this discussion will utilize the Management Case projections; these figures imply a valuation closer to $200 per share Goldman Stanley (1) Financial data as of May 9, 2014. 13 Jaguar Comparable Public Companies Specialty Pharmaceutical Companies That Sell Primarily Branded Drugs, with LTM Revenue Between $500 Million and $2 Billion ($ USD in Billions) Comparable Public Companies – Revenue and EBITDA, CY 2014E – CY 2015E(1) $3.0 B $2.5 B $2.0 B CY 2014E $1.5 B CY 2015E $1.0 B $0.5 B $0.0 B $1.4 B $1.2 B $1.0 B $0.8 B $0.6 B CY 2014E $0.4 B CY 2015E $0.2 B $0.0 B ($0.2 B) ($0.4 B) ($0.6 B) Goldman Stanley (1) Financial data as of May 9, 2014. 14 Jaguar Comparable Public Companies Specialty Pharmaceutical Companies That Sell Primarily Branded Drugs, with LTM Revenue Between $500 Million and $2 Billion Comparable Public Companies – Growth and Valuation Multiples, CY 2014E – CY 2015E(1) Revenue Growth, CY 2014E - CY 2015E 120% 111% EBITDA Growth, CY 2014E - CY 2015E 160% 137% 140% 100% 120% 80% 100% 60% 80% 38% 40% 60% 32% 23% 20% 11% 6% 21% 18% 20% 0% 11.6 x 11.6 x 9.7 x 8.0 x 5.9 x 6.0 x 4.1 x 4.0 x 2.0 x NM 22% CY 2015E EBITDA Multiples 14.0 x 10.0 x NM 14% 10% 0% CY 2015E Revenue Multiples 12.0 x 41% 38% 40% 4.8 x 3.4 x 1.9 x 0.0 x Goldman Stanley (1) Financial data as of May 9, 2014. 100.0 x 90.0 x 85.8 x 80.0 x 70.0 x 60.0 x 50.0 x 40.0 x 30.0 x 22.7 x 20.5 x 20.0 x 9.2 x 10.2 x 6.8 x 10.0 x 10.0 x NM 0.0 x 15 Jaguar Precedent Transactions North American Pharmaceutical Sellers with Between $200 Million and $2 Billion In LTM Revenue, Jan. 1, 2009 – May 9, 2014 ($ USD in Millions) Jaguar - Comparable M&A Transactions Acquirer Name Mallinckrodt plc Forest Laboratories Inc. Shire Pharmaceutical Holdings Ireland Limited Salix Pharmaceuticals, Inc. Endo Health Solutions Inc. Akorn, Inc. Valeant Pharmaceuticals International, Inc. TPG Capital, L.P. Novartis AG Takeda Pharmaceuticals U.S.A., Inc. Genomma Lab Internacional SAB de CV Nestlé Health Science S.A. Pfizer Inc. Endo Pharmaceuticals Holdings Inc. Celgene Corporation Astellas US Holding, Inc. Dainippon Sumitomo Pharma America Holdings, Inc. GlaxoSmithKline plc Target Name Questcor Pharmaceuticals, Inc. Aptalis Holdings Inc. ViroPharma Inc. Santarus, Inc. Paladin Labs Inc. Hi-Tech Pharmacal Co., Inc. Medicis Pharmaceutical Corporation Par Pharmaceutical Companies Inc. Fougera Pharmaceuticals Inc. URL Pharma, Inc. Prestige Brands Holdings, Inc. Prometheus Laboratories Inc. King Pharmaceuticals LLC Qualitest Pharmaceuticals Abraxis BioScience, Inc. OSI Pharmaceuticals Inc. Sepracor, Inc. Stiefel Laboratories, Inc. Maximum 75th Percentile Median 25th Percentile Minimum Goldman Stanley Date 2014-04-07 2014-01-08 2013-11-11 2013-11-07 2013-11-05 2013-08-27 2012-09-03 2012-07-16 2012-05-02 2012-04-11 2012-02-21 2011-05-24 2010-10-12 2010-09-28 2010-06-30 2010-05-16 2009-09-03 2009-04-20 Operating Metrics Transaction Transaction Equity Enterprise LTM LTM Value Value Revenue EBITDA $ 5,291 $ 4,802 $ 891 $ 517 2,900 2,900 688 315 4,200 4,097 430 59 2,600 1,980 338 82 1,600 1,348 264 93 640 536 231 48 2,600 2,329 764 191 1,900 1,976 1,035 237 1,525 1,525 429 173 800 800 600 76 834 1,263 403 119 745 659 519 139 3,600 3,225 1,565 349 1,200 1,176 309 58 2,923 2,789 397 (23) 4,000 3,414 441 176 2,600 2,347 1,334 306 3,050 3,450 900 288 $ $ 4,802 3,144 2,154 1,284 536 $ $ 1,565 859 480 399 231 $ $ 517 275 156 78 (23) Valuation Multiples EV / EV / LTM LTM Revenue EBITDA 5.4 x 9.3 x 4.2 x 9.2 x 9.5 x 69.0 x 5.9 x 24.3 x 5.1 x 14.5 x 2.3 x 11.3 x 3.1 x 12.2 x 1.9 x 8.3 x 3.6 x 8.8 x 1.3 x 10.5 x 3.1 x 10.6 x 1.3 x 4.7 x 2.1 x 9.2 x 3.8 x 20.2 x 7.0 x NM 7.7 x 19.4 x 1.8 x 7.7 x 3.8 x 12.0 x 9.5 x 5.3 x 3.7 x 2.1 x 1.3 x 69.0 x 14.5 x 10.6 x 9.2 x 4.7 x 16 Jaguar DCF Analysis – Free Cash Flow Projections ($ USD in Millions) FY14 FY15 FY16 FY17 Projected FY19 FY18 FY20 Unlevered Free Cash Flow Projections: Units: Revenue: Annual Revenue Growth Rate: Operating Income (EBIT): Annual Operating Margin: $M % $M % Less: Taxes, Excluding Effect of Interest: $M (68.5) (135.8) (180.7) Net Operating Profit After Tax (NOPAT): $M 312.3 618.8 823.2 1,076.4 1,358.8 1,676.1 1,988.4 Total Adjustments for Non-Cash Charges: $M 265.3 138.0 137.9 143.7 147.7 139.4 Total Changes in Operating Assets & Liabilities: % Change in Revenue: $M % (32.4) (10.6%) (57.4) (15.2%) (53.3) (12.0%) (67.1) (12.1%) (75.8) (12.2%) Less: Capital Expenditures: % Revenue: $M % (14.1) 1.2% (20.2) 1.3% (28.0) 1.4% (38.3) 1.5% (50.8) 1.6% Annual Unlevered Free Cash Flow: Unlevered Free Cash Flow for Remaining Quarters: Present Value of Free Cash Flow: $M $M $M 531.1 464.7 453.2 679.3 679.3 621.5 879.8 879.8 744.8 Normal Discount Period: Mid-Year Discount Period: Annual Free Cash Flow Growth Rate: Annual EBITDA: Annual EBITDA Growth Rate: Goldman Stanley FY21 FY22 FY23 Normalized FY24 $ 1,176.9 $ 1,553.3 $ 1,998.0 $ 2,554.3 $ 3,174.8 $ 3,853.2 $ 4,552.3 $ 5,371.6 $ 1,662.1 $ 1,827.6 $ 1,919.0 5.0% 10.0% (69.1%) 18.0% 18.1% 21.4% 24.3% 27.8% 28.6% 32.0% 34.9% 964.2 825.0 739.4 2,870.7 2,424.9 2,044.0 1,657.1 1,312.6 1,003.9 754.7 380.8 45.0% 45.1% 44.5% 53.4% 53.3% 53.0% 52.2% 51.4% 50.2% 48.6% 32.4% (236.3) 1,114.6 1,114.6 873.2 (298.3) 1,379.9 1,379.9 1,000.3 (133.1) (148.5) (173.6) 2,353.9 606.3 676.5 790.6 150.3 163.9 124.7 128.5 29.0 (84.7) (12.5%) (87.2) (12.5%) (103.0) (12.6%) 453.0 (12.2%) (21.5) (13.0%) (11.0) (12.0%) (65.5) 1.7% (81.9) 1.8% (102.1) 1.9% (33.2) 2.0% (38.4) 2.1% (38.4) 2.0% (367.9) 1,665.3 1,665.3 1,117.0 (436.5) 1,969.5 1,969.5 1,222.4 (516.7) 2,312.7 2,312.7 1,328.2 1,150.8 1,150.8 611.6 770.3 770.3 350.5 745.1 745.1 366.4 Year Frac. Year Frac. 0.647 0.323 1.647 1.147 2.647 2.147 3.647 3.147 4.647 4.147 5.647 5.147 6.647 6.147 7.647 7.147 8.647 8.147 9.647 9.147 10.647 10.147 % 79.5% 27.9% 29.5% 26.7% 23.8% 20.7% 18.3% 17.4% (50.2%) (35.2%) 3.4% $M % 642.0 50.6% 888.6 38.4% 1,137.7 28.0% 1,452.2 27.6% 1,800.7 24.0% 2,179.4 21.0% 2,571.1 18.0% 3,030.4 17.9% 860.0 (71.6%) 949.4 10.4% 989.1 15.0% 17 Jaguar DCF Analysis – Implied Share Price Calculations ($ USD in Millions except for $ per Share Figures) Terminal Value - Multiples Method: Terminal Value - Perpetuity Growth Method: Baseline Terminal EBITDA Multiple: Baseline Terminal Value: Implied Terminal FCF Growth Rate: 12.0 x $ 11,393.4 1.0% Baseline Terminal FCF Growth Rate: Baseline Terminal Value: Implied Terminal EBITDA Multiple: 1.0% $ 11,393.4 12.0 x PV of Terminal Value: Sum of PV of Free Cash Flows: Implied Enterprise Value: 5,389.6 8,338.5 $ 13,728.1 PV of Terminal Value: Sum of PV of Free Cash Flows: Implied Enterprise Value: 5,389.6 8,338.5 $ 13,728.1 % of Implied EV from Terminal Value: Plus: Cash & Cash-Equivalents(1): $ (1) Plus: Equity Investments : (1) Plus: Other Non-Core Assets, Net : (1) Plus: Net Operating Losses : Less: Total Debt(1): 251.4 Plus: Cash & Cash-Equivalents(1): Less: Noncontrolling Interests : Less: Unfunded Pensions(1): Less: Capital Leases(1): - Plus: Other Non-Core Assets, Net : (1) Less: Restructuring & Other Liab. : Implied Equity Value: 12,834.6 Diluted Shares Outstanding: Implied Share Price from DCF: Premium / (Discount) to Current(1): Exercise Number: Price: 0.604 $ 7.37 0.948 4.00 1.590 26.09 1.164 4.306 $ $ Plus: Equity Investments : (17.6) - (1) Less: Noncontrolling Interests : Less: Unfunded Pensions(1): (17.6) - Less: Capital Leases(1): - Less: Restructuring & Other Liab. (1): Implied Equity Value: Implied Share Price from DCF: (1) Financial data as of May 9, 2014. 71.4 (1,198.6) Less: Preferred Stock(1): 202.27 Dilution: 0.582 0.929 1.385 1.164 4.060 - (1) Plus: Net Operating Losses : Less: Total Debt(1): Diluted Shares Outstanding: Premium / (Discount) to Current(1): Type: Options A: Options B: Options C: RSUs: Total: 251.4 - (1) 63.452 56.3% 39.3% (1) - (1) Goldman Stanley % of Implied EV from Terminal Value: 71.4 (1,198.6) Less: Preferred Stock(1): Type: Options A: Options B: Options C: RSUs: Total: 39.3% Exercise Number: Price: 0.604 $ 7.37 0.948 4.00 1.590 26.09 1.164 4.306 12,834.6 63.452 $ 202.27 56.3% Dilution: 0.582 0.929 1.385 1.164 4.060 18 Jaguar DCF Analysis – Sensitivities ($ USD in Dollars as Stated) Sensitivity - Terminal FCF Growth Rate vs. Discount Rate and Implied Share Price from DCF Analysis: Discount Rate (WACC): Terminal FCF Growth Rate: 20227.2% (2.0%) (1.5%) (1.0%) (0.5%) 0.5% 1.0% 1.5% 2.0% 6.5% $ 207.35 $ 212.35 $ 218.01 $ 224.49 $ 231.96 $ 240.68 $ 250.98 $ 263.34 $ 278.44 7.0% 196.54 200.79 205.58 211.01 217.21 224.37 232.72 242.59 254.43 7.5% 186.76 190.41 194.49 199.08 204.28 210.23 217.09 225.09 234.54 8.0% 177.89 181.03 184.53 188.44 192.84 197.83 203.52 210.10 217.77 8.5% 169.78 172.51 175.53 178.88 182.63 186.84 191.62 197.09 203.39 9.0% 162.34 164.72 167.34 170.23 173.45 177.04 181.08 185.66 190.90 9.5% 155.48 157.57 159.85 162.36 165.14 168.22 171.67 175.54 179.94 10.0% 149.14 150.98 152.98 155.17 157.57 160.24 163.19 166.50 170.22 10.5% 143.26 144.88 146.64 148.55 150.65 152.97 155.52 158.36 161.53 Sensitivity - Terminal EBITDA Multiple vs. Discount Rate and Implied Share Price from DCF Analysis: Discount Rate (WACC): Terminal EBITDA Multiple: 20227.2% 8.0 x 9.0 x 10.0 x 11.0 x 12.0 x 13.0 x 14.0 x 15.0 x 16.0 x 6.5% $ 192.32 $ 200.44 $ 208.56 $ 216.68 $ 224.80 $ 232.92 $ 241.04 $ 249.16 $ 257.28 7.0% 186.25 194.01 201.77 209.53 217.29 225.05 232.81 240.57 248.34 7.5% 180.42 187.84 195.26 202.68 210.10 217.52 224.94 232.36 239.77 8.0% 174.82 181.92 189.01 196.11 203.20 210.30 217.39 224.48 231.58 8.5% 169.45 176.23 183.02 189.80 196.59 203.37 210.16 216.94 223.73 9.0% 164.28 170.77 177.26 183.75 190.24 196.74 203.23 209.72 216.21 9.5% 159.32 165.53 171.74 177.95 184.16 190.37 196.58 202.79 209.00 10.0% 154.54 160.49 166.43 172.38 178.32 184.26 190.21 196.15 202.09 10.5% 149.96 155.65 161.33 167.02 172.71 178.40 184.09 189.78 195.47 Goldman Stanley 19 Other Valuation Considerations Corporate Headquarters in Ireland and Lower Effective Tax Rate Alternative Valuation Methodologies May Provide Additional Insight Into Jaguar’s Intrinsic Value Goldman Stanley Results Implications and Examples Jaguar’s corporate status in Ireland makes it an attractive candidate for a “tax inversion” deal Salix Pharmaceuticals: Reduced tax rate would increase CY2015E Net Income from ~$450 million to ~$567 million, and would add $2 billion to company’s Equity Value and Enterprise Value Effective tax rate of 18% vs. statutory US rate of 35-40% could effectively add billions in value for the right acquirer Premiums Paid analysis for comparable transactions indicates per-share premium of 30-40% in recent deals Implied valuation is significantly higher than multiples analysis from comparable public companies and precedent transactions $2 billion represents $31.52 per share for Jaguar Actavis / Forest Labs: 31% premium paid over average 10-day price prior to deal Mallinckrodt / Cadence: 32% premium paid over average 30-day price Salix / Santarus: 39% premium paid over average 30-day price 20 Jaguar’s Corporate Structure Provides Advantages to Partners Ireland Italy U.S.A. Jaguar Public Limited Company Bermuda Switzerland Jaguar Italy S.p.A. Jaguar, Inc. Jaguar Financing I, Ltd. Jaguar Investments I Limited Gentium S.p.A. Jaguar (EUSA Pharma USA) Inc. Jaguar International III Limited JPI Commercial, LLC Pharmelle LLC Gentium Gmbh AxCell Biosciences Corporation Goldman Stanley Prostagen, Inc. 21 Other Valuation Considerations Jaguar is also trading at a discount to recent stock price highs: One-Year Price History, May 9, 2013 - May 9, 2014 6M $200.00 5M $160.00 Share Price $140.00 4M $120.00 3M $100.00 $80.00 2M $60.00 $40.00 1M Shares Traded (in Millions) $180.00 $20.00 0M $0.00 Volume Traded Share Price Given the stock price run-up over the past year, it may or may not be realistic to aim for the all-time high; however, the valuation methodologies imply that a per-share price in that range is plausible Goldman Stanley 22 Summary Profile of Equity Shareholders Commentary: Gross Common Share Count: 55,751,243(1) Major institutional investors represent approximately 40% of share ownership Largest institutional shareholders include: Putnam: 6,102,213 (10.5%) Fidelity: 5,333,862 (9.2%) Vanguard: 3,162,658 (5.5%) Janus Capital: 2,709,782 (4.7%) Banks / Investment Banks: 4% Individuals / Insiders: 4% Hedge Funds: 9% Insider ownership represents approximately 4% of shares outstanding: Seamus Mulligan (Director): 1,453,305 (2.5%) Bruce Cozadd (CEO): 471,310 (0.8%) Kathryn Falberg (ex-CFO): 95,137 (0.2%) Given the lack of activist investors and the high percentage of shares held by traditional investment managers, the chances of a challenge to a potential deal are low Goldman Stanley Other: 2% Source: Company proxy statements, investor filings, and Capital IQ. (1) As of March 31, 2014 10-Q filing. Investment Managers: 81% 23 Valuation Conclusions #1 “75th Percentile” Valuation is Justified The company’s margins and growth rates exceed those of its peer companies, indicating that it should be valued in-line with the 75th percentile of the comparable company set #2 Goal: $200 / Share This price represents a 50%+ premium to Jaguar’s current share price; greater upside might be possible with a highly complementary partner #3 Discounted Cash Flow (DCF) Analysis Implied value is between $170 and $240 / share, based on a conservative Discount Rate and Terminal Value and Management’s financial projections #4 Premiums Paid Analysis Premiums Paid indicate a median 30-day average price premium of ~40%, implying a per-share value of $190 for Jaguar Goldman Stanley 24 Potential Strategic Partners Goldman Stanley 25 Potential Strategic Partners Size, ability to pay, tax/corporate headquarters status, product/pipeline, and strategic fit should all be considered US-headquartered partners are ideal since tax rates are highest there; several Canadian and Israeli companies could also qualify since tax rates are also higher than those in the UK and Ireland Both branded and generics companies should be considered, in light of recent M&A activity Tier 1 Potential Partners Tier 2 Potential Partners Market Cap: Significantly larger than Jaguar Closer to Jaguar’s size Headquarters and Tax Status: US-based with US corporate tax rates US-based with US corporate tax rates Strategic Fit: Solid product and pipeline fit Solid product and pipeline fit Goldman Stanley 26 Potential Strategic Partners Tier 1 Potential Partners Tier 2 Potential Partners Goldman Stanley 27 Overview of Tier 1 Potential Partners ($ USD in Billions) Potential Partner: Market Cap(1): Debt & NCI(1): $36.3 $8.7 $0.3 $44.7 3.6 x Primarily < $1B acquisitions in the past; rumors of Actavis and Forest Labs $84.6 $32.0 $19.8 $96.8 4.3 x Primarily < $100 million acquisitions, except for $10 billion Onyx deal $81.7 $7.7 $7.1 $82.4 1.7 x Last deals over $1 billion took place 2-3 years ago; smaller recent acquisitions $121.0 $10.1 $6.5 $124.6 1.4 x Last major deal was Pharmasset ($11 billion) two years ago $281.0 $17.3 $29.4 $268.9 0.7 x $62.9 $5.3 $5.2 $63.0 0.8 x Has completed primarily smaller, “tuck-in” M&A deals over the past 2-3 years $160.2 $30.8 $20.5 $170.5 1.9 x Last major deals were 5 years ago; rumors of interest in Cubist Pharmaceuticals $44.0 $17.5 $0.6 $60.9 5.6 x Mostly minor deals except for $8.7 billion acquisition of Bausch & Lomb last year $186.1 $37.5 $33.9 $189.6 1.7 x No major recent deals; announced $10 billion buyback plan last year Goldman Stanley Cash(1): Enterprise Value(1): Leverage Ratio(1): (1) Financial data as of May 9, 2014. Strategic Fit: Ability to Pay: Comments: Typically does only very small “tuck-in” deals 28 Company Profile: Allergan ($ USD in Billions) Business Description Allergan plc develops, manufactures, and distributes generic, branded, biosimilar, and over-the-counter (OTC) pharmaceutical products. It operates in three segments: North American Brands, North American Generics and International, and Anda Distribution. Allergan Headquarters: Employees: Founded: Parsippany, NJ 21,600 1983 Financial Information(1) Market Cap: Cash: Debt, Preferred & NCI: LTM Revenue: LTM EBITDA: CY 2014E Revenue: CY 2014E EBITDA: CY 2015E Revenue: CY 2015E EBITDA: Business Segments and Product Lines $36.3 $0.3 $8.7 $9.4 $2.4 $12.9 $3.8 $13.5 $4.2 One-Year Price History(1) $250.00 16 M Share Price 12 M 10 M 8M $100.00 6M 4M Shares Traded (in Millions) $200.00 Paul Bisaro Executive Chairman Brenton Saunders CEO Maria Hilado CFO James D’Arecca CAO A. Robert Bailey CLO Jonathon Kellerman EVP John Kelly EVP Sigurd Kirk EVP, Bus. Dev. Key Partners North American Brands – Provides patented and off-patent Amgen – Biosimilar versions of trademarked pharmaceutical products primarily under the Dalvance, Bystolic, Canasa, Carafate, Daliresp, Fetzima, Linzess, Namenda, Namenda XR, Saphris, Teflaro, Viibryd, Actonel, Asacol HD, Atelvia, Delzicol, Doryx, Estrace Cream, Enablex, Lo Loestrin Fe, and Minastrin 24 Fe brands. Herceptin, Avastin, Rituxan/Mab Thera, and Erbitux North American Generics and International – Develops, manufactures, and sells generic, branded generic, and OTC pharmaceutical products. Anda Distribution – Distributes generic and brand 14 M $150.00 The company also develops and out-licenses generic pharmaceutical products primarily in Europe through its third-party business, and it sells its generic and brand pharmaceutical products primarily to drug wholesalers, retailers, and distributors. Management Team Ironwood Pharmaceuticals – Commercial development of Linzessfor Sanofi-Aventis Trevena – Development of TRV027 pharmaceutical products primarily to independent pharmacies, pharmacy chains and buying groups, and physician’s offices. $50.00 2M $0.00 Goldman Stanley 0M (1) Financial data as of May 9, 2014. 29 Company Profile: Amgen ($ USD in Billions) Business Description Amgen Inc., a biotechnology company, discovers, develops, manufactures, and delivers human therapeutics worldwide. It focuses on the treatment of illness in the areas of oncology, hematology, inflammation, bone health, nephrology, cardiovascular, and general medicine. Amgen Headquarters: Employees: Founded: California 17,900 1980 Financial Information(1) Market Cap: Cash: Debt, Preferred & NCI: LTM Revenue: LTM EBITDA: CY 2014E Revenue: CY 2014E EBITDA: CY 2015E Revenue: CY 2015E EBITDA: $140.00 14 M $120.00 12 M $100.00 10 M $80.00 8M $60.00 6M $40.00 4M $20.00 2M $0.00 0M Goldman Stanley Chairman & CEO CFO EVP, Operations CAO CIO CCO Neulasta – A pegylated protein to decrease the incidence of infection associated with chemotherapy-induced febrile neutropenia in cancer patients NEUPOGEN – A recombinant-methionyl human granulocyte colony-stimulating factor for reducing the incidence of infection as manifested by febrile neutropenia for patients with nonmyeloid malignancies Key Partners Xencor – Strategic collaboration AstraZeneca, Takeda Pharmaceutical, UCB, Novartis, Bayer Healthcare Pharmaceuticals – Collaborative agreements Enbrel – Treatment for rheumatoid arthritis, plaque psoriasis, and psoriatic arthritis in adult patients Other Products – EPOGEN (Dialysis), Aranesp (anemia), Shares Traded (in Millions) Share Price One-Year Price History(1) Robert Bradway David Meline M. Balachandran Anetta L. Such Diana McKenzie Cynthia Patton The company serves pharmaceutical wholesale distributors; and physicians or their clinics, dialysis centers, hospitals, and pharmacies, as well as consumers. It also develops various products that are in various stages of clinical trials. Business Segments and Product Lines $84.6 $19.8 $32.0 $19.0 $7.6 $20.2 $9.1 $21.4 $11.2 Management Team XGEVA (prevention of skeletal problems), Prolia (osteoporosis), Sensipar/Mimpara (chronic kidney disease), Kyprolis (lung cancer), Nplate (thrombopoietic compound),Vectibix (human monoclonal antibody), and BLINCYTO (leukemia) (1) Financial data as of May 9, 2014. 30 Company Profile: Bristol-Myers Squibb ($ USD in Billions) Business Description Bristol-Myers Squibb Company discovers, develops, licenses, manufactures, markets, distributes, and sells biopharmaceutical products worldwide. Bristol-Myers-Squibb Headquarters: Employees: Founded: New York 25,000 1887 Financial Information(1) Market Cap: Cash: Debt, Preferred & NCI: LTM Revenue: LTM EBITDA: CY 2014E Revenue: CY 2014E EBITDA: CY 2015E Revenue: CY 2015E EBITDA: Business Segments and Product Lines $81.7 $7.1 $7.7 $16.4 $4.3 $15.9 $4.0 $16.0 $3.8 Currently Available Products – Baraclude (Chronic hepatitis B); Daklinza (hepatitis C); Reyataz and Sustiva (HIV); Erbitux (IgG1 monoclonal antibody); Sprycel (multi-targeted tyrosine kinase inhibitor); Yervoy (metastatic melanoma); Abilify (schizophrenia, bipolar mania disorder, and depressive disorder); Orencia (rheumatoid arthritis); Eliquis (stroke prevention in atrial fibrillation) Development-Stage Products – Opdivo (human monoclonal antibody for lung cancer, renal cell cancer, and melanoma – Phase III trials); Beclabuvir (HCV – Phase III trials); Elotuzumab (multiple myeloma – Phase III trials); BMS-663068 (HIV-1) One-Year Price History(1) $60.00 It provides chemically-synthesized drugs or small molecules, and biologics in various therapeutic areas, including virology comprising human immunodeficiency virus infection (HIV); oncology; neuroscience; immunoscience; and cardiovascular. 40 M Share Price 25 M $30.00 20 M 15 M $20.00 10 M Shares Traded (in Millions) $50.00 $40.00 Giovanni Caforio Charles Bancroft Francis Cuss Paul Von Autenried Anne Nielsen Emmanuel Blin Joseph Caldarella CEO CFO CSO CIO CCO SVP SVP/Controller Key Partners Gilead – Licensing agreements and co-development/co-promotion agreements Allergan – Development and commercialization AstraZeneca, Pfizer – Codevelopment and co-promotion agreement FivePrime, Ambrx, Adaptive, The Medicines Company, Tibotec – Co-development agreements 35 M 30 M Management Team $10.00 5M $0.00 Goldman Stanley 0M (1) Financial data as of May 9, 2014. 31 Company Profile: Gilead Sciences ($ USD in Billions) Gilead Sciences Headquarters: Employees: Founded: California 7,000 1987 Financial Information(1) Market Cap: Cash: Debt, Preferred & NCI: LTM Revenue: LTM EBITDA: CY 2014E Revenue: CY 2014E EBITDA: CY 2015E Revenue: CY 2015E EBITDA: One-Year Price History(1) $90.00 50 M $80.00 45 M 35 M 30 M $50.00 25 M $40.00 20 M $30.00 15 M $20.00 10 M $10.00 5M $0.00 0M Goldman Stanley Gilead Sciences, Inc., a biopharmaceutical company, discovers, develops, and commercializes medicines in areas of unmet medical need in North America, South America, Europe, and the AsiaPacific. It focuses on HIV treatment, liver disease, certain cancers, and other conditions such as cystic fibrosis. John Martin Chairman & CEO John Milligan President & COO Robin Washington CFO Norbert Bischofberger CSO Brett Pletcher EVP Muzammmil Mansuri EVP The company markets its products through its commercial teams and/or in conjunction with third-party distributors and corporate partners. HIV-Related – Stribild, Complera/Eviplera, Atripla, Truvada, Viread, Emtriva, Tybost, and Vitekta for treatment in adults Liver Disease – Harvoni, Sovaldi, Viread, and Hepsera Other Products – Zydelig (certain blood cancers); Letairis Key Partners Bristol-Myers Squibb Company, Janssen R&D Ireland, and Japan Tobacco Inc. – Agreements to develop and commercialize various products (pulmonary arterial hypertension); Ranexa (chronic angina); Lexiscan/Rapiscan (pharmacologic stress agent); Cayston (cystic fibrosis); Tamiflu (influenza A and B); AmBisome (fungal infections); Macugen (neovascular age-related macular degeneration) Development-Stage Products – Pipeline drugs include ones 40 M Shares Traded (in Millions) Share Price $60.00 Management Team Business Segments and Product Lines $121.0 $6.5 $10.1 $13.7 $7.1 $24.7 $16.5 $31.2 $23.3 $70.00 Business Description targeted at HIV/AIDS, hepatitis B and hepatitis C, inflammation/oncology, and serious cardiovascular and respiratory conditions (1) Financial data as of May 9, 2014. 32 Company Profile: Johnson & Johnson ($ USD in Billions) Business Description Johnson & Johnson, together with its subsidiaries, researches and develops, manufactures, and sells various products in the health care field worldwide. It operates in three segments: Consumer, Pharmaceutical, and Medical Devices. Johnson & Johnson Headquarters: Employees: Founded: New Jersey 126,500 1885 Financial Information(1) Market Cap: Cash: Debt, Preferred & NCI: LTM Revenue: LTM EBITDA: CY 2014E Revenue: CY 2014E EBITDA: CY 2015E Revenue: CY 2015E EBITDA: $100.00 25 M $80.00 20 M $60.00 15 M $40.00 10 M $20.00 5M $0.00 0M Goldman Stanley Shares Traded (in Millions) Share Price 30 M Consumer – Baby care and oral care products; skin care products such as Aveeno, Clean & Clear, Dabao, Le Petite Marseillais, Lubriderm, Neutrogena; women’s health products such as Stayfree and Carefree; Tylenol, Sudafed, Benadryl, and Zyrtec Pharmaceutical – Various products in immunology, infectious diseases, neuroscience, oncology, and cardiovascular and metabolic diseases Key Partners AstraZeneca, Bristol-Myers Squibb, and GalaxoSmithKline – Various development and distribution agreements for pipeline drugs Takeda Pharmaceutical – Development partnership for small-molecule drugs Medical Devices – Orthopaedic, trauma, and neurological One-Year Price History(1) $120.00 Alex Gorsky Chairman & CEO Dominic Caruso CFO Stephen Cosgrove CAO Paulus Stoffels CSO Joaquin Duato Pharma. Chair The company distributes its products to general public, retail outlets and distributors, wholesalers, hospitals, and health care professionals for prescription use in the professional fields by physicians, nurses, hospitals, and clinics. Business Segments and Product Lines $281.0 $29.4 $17.3 $71.9 $23.7 $74.2 $24.8 $70.2 $23.2 Management Team products; general surgery, and biosurgical and energy products; products to treat cardiovascular disease; infection prevention products; diagnostics products; blood glucose monitoring and insulin delivery products; and disposable contact lenses (1) Financial data as of May 9, 2014. 33 Company Profile: Eli Lilly ($ USD in Billions) Business Description Eli Lilly and Company discovers, develops, manufactures, and sells pharmaceutical products worldwide. It operates through two segments, Human Pharmaceutical Products and Animal Health Products. Eli Lilly Headquarters: Employees: Founded: Indiana 39,135 1876 Financial Information(1) Market Cap: Cash: Debt, Preferred & NCI: LTM Revenue: LTM EBITDA: CY 2014E Revenue: CY 2014E EBITDA: CY 2015E Revenue: CY 2015E EBITDA: Business Segments and Product Lines $62.9 $5.2 $5.3 $22.2 $6.4 $19.4 $4.6 $19.9 $5.3 One-Year Price History(1) 30 M $60.00 25 M $50.00 Share Price 20 M $40.00 15 M $30.00 10 M $20.00 $0.00 Goldman Stanley 5M 0M Pharmaceutical – Endocrinology products to treat diabetes; osteoporosis; human growth hormone deficiency and pediatric growth conditions; testosterone deficiency; neuroscience products; and positron emission tomography imaging of betaamyloid neurotic plaques in adult brains; products for the treatment of non-small cell lung, colorectal, head and neck, pancreatic, metastatic breast, ovarian, bladder, and metastatic gastric cancers, as well as malignant pleural mesothelioma; and cardiovascular products for the treatment of erectile dysfunction and benign prostatic hyperplasia, thrombotic cardiovascular events, and cardiac ischemic complications Animal Health – Cattle feed additives; protein supplements for Shares Traded (in Millions) $70.00 $10.00 Within the Pharmaceutical segment, it provides products for endocrinology, neuroscience, cancer, and other conditions. Within the Animal Health segment, it provides protein supplements, feed additives, and antibiotics for the treatment of various animal infections. Management Team John Lechleiter Derica Rice Donald Zakrowski Jan Lundberg Stephen Fry Melissa Barnes Darren Carroll Chairman & CEO CFO CAO EVP SVP SVP SVP Key Partners Zymeworks – Licensing and collaboration agreement for bispecific cancer immunotherapies AstraZeneca – Co-development and co-commercialization agreement for Alzheimer’s disease treatment Hanmi Pharmaceutical – Licensing and collaboration agreement for autoimmune diseases cows; leanness and performance enhancers for swine, cattle, and poultry; antibiotics to treat respiratory and other diseases in cattle, swine, and poultry; anticoccidial agents for poultry; and chewable tablets that kill fleas and prevent diseases; products to treat chronic manifestations of atopic dermatitis and congestive heart failure in dogs, and chronic allergic dermatitis and kidney diseases in cats (1) Financial data as of May 9, 2014. 34 Company Profile: Merck & Co. ($ USD in Billions) Business Description Merck & Co., Inc. provides health care solutions worldwide. The company offer therapeutic and preventive agents, neuromuscular blocking agents for use in surgery, anti-bacterial products for skin and skin structure infections, and a variety of cancer drugs and vaccines. Merck & Co. Headquarters: Employees: Founded: New Jersey 68,805 1891 Financial Information(1) Market Cap: Cash: Debt, Preferred & NCI: LTM Revenue: LTM EBITDA: CY 2014E Revenue: CY 2014E EBITDA: CY 2015E Revenue: CY 2015E EBITDA: Business Segments and Product Lines $160.2 $20.5 $30.8 $43.6 $15.8 $41.8 $14.7 $39.8 $20.9 60 M $60.00 50 M $50.00 Share Price 40 M $40.00 30 M $30.00 20 M $20.00 $0.00 Goldman Stanley 10 M 0M Shares Traded (in Millions) $70.00 Pharmaceutical – Therapeutic and preventive agents to treat cardiovascular, type 2 diabetes, asthma, nasal allergy symptoms, allergic rhinitis, chronic hepatitis C virus, HIV-1 infection, fungal infections, intra-abdominal infections, hypertension, arthritis and pain, inflammatory, osteoporosis, male pattern hair loss, and fertility diseases; neuromuscular blocking agents for use in surgery; anti-bacterial products for skin and skin structure infections; antidepressants; drugs for cancer patients and vaccines for various diseases Animal Health – Drugs for pneumonia in cattle, horses, and One-Year Price History(1) $10.00 It also offers animal health products and vaccines, antibiotics, ointments, and other drugs to prevent disease. The company serves drug wholesalers and retailers, hospitals, government entities and agencies, physicians, physician distributors, veterinarians, distributors, and animal producers. Management Team Kenneth Frazier Robert Davis Rita Karachun Clark Golestani Michael Holston Willie Deese Richard DeLuca Roger Perlmutter Chairman & CEO CFO SVP EVP & CIO EVP EVP EVP EVP Key Partners AstraZeneca – Partnership to conduct joint phase 1 clinical trials for treating solid cancer tumors Celera – Co-development partnership for new osteoporosis treatment Zymeworks – Co-development partnership for novel bi-specific therapeutic antibodies swine; vaccines for poultry; parasiticide for sea lice in salmon; and antibiotics for, and vaccines against bacterial and viral disease in fish; companion animal products, such as diabetes mellitus treatment drugs and vaccines for dogs and cats; ointments for acute and chronic otitis; anthelmintic products; chewable tablets to kill fleas and ticks in dogs; and products for protection against bites from fleas, ticks, mosquitoes, and sandflies (1) Financial data as of May 9, 2014. 35 Company Profile: Valeant ($ USD in Billions) Valeant Headquarters: Employees: Founded: Quebec 16,800 1983 Financial Information(1) Market Cap: Cash: Debt, Preferred & NCI: LTM Revenue: LTM EBITDA: CY 2014E Revenue: CY 2014E EBITDA: CY 2015E Revenue: CY 2015E EBITDA: 12 M 10 M 8M 6M $40.00 Shares Traded (in Millions) Share Price 14 M $60.00 The Company focuses on eye health, dermatology and neurology therapeutic classes, primarily on branded generics, OTC products and medical devices. The Company operates through two segments: developed markets and emerging markets. It has a direct or indirect sales and marketing presence in over 100 countries. Pharmaceuticals – Solodyn (oral antibiotic), Wellbutrin XL, Jublia, Xenazine (Huntington’s disease), Arestin, Zovirax, Syprine, Elidel, Prolensa, and Duromine Over the Counter – PreserVision (supplement), CeraVe (skin conditions), ReNu Multiplus (contact lenses), Biotrue, Ocuvite, Boston solution, and Artelac (eye drops) Medical Devices – SofLens (disposable contact lenses), Key Partners GlaxoSmithKline – Worldwide collaboration agreement for ezogabine / retigabine (epilepsy) Biovail – Supplier for Xenazine tablets (Huntington’s disease) Kadmon Pharmaceuticals – Development and commercialization agreement for taribavirin and ribavirin 18 M 16 M $80.00 Michael Pearson Chairman & CEO Robert Rosiello CFO Robert Butz VP, Medical Affairs Robert Chai-Onn EVP Deborah Jorn EVP Ari Kellen EVP Anne Whitaker EVP Pavel Mirovsky President (Europe) Calvin Roberts CMO 20 M $120.00 $100.00 Valeant Pharmaceuticals International, Inc. develops, manufactures, and markets pharmaceuticals, over-the-counter products, and medical devices worldwide. PureVision, Akreos and Crystalens, and surgical equipment products, such as the VICTUS femtosecond laser and the Stellaris PC, a vitreoretinal and cataract surgery system One-Year Price History(1) $140.00 Management Team Business Segments and Product Lines $44.0 $0.6 $17.5 $6.6 $3.2 $8.4 $4.0 $10.6 $5.4 $160.00 Business Description Generics – Tobramycin, Cardizem CD (hypertension and angina), Retin-A Micro (acne), and Latanoprost (glaucoma and ocular hypertension) 4M $20.00 $0.00 Goldman Stanley 2M 0M (1) Financial data as of May 9, 2014. 36 Company Profile: Pfizer ($ USD in Billions) Business Description Pfizer Inc. discovers, develops, manufactures, and sells healthcare products worldwide. The company operates through the Global Innovative Pharmaceutical (GIP); Global Vaccines, Oncology and Consumer Healthcare (VOC); and Global Established Pharmaceutical (GEP) segments. Pfizer Headquarters: Employees: Founded: New York 78,300 1849 Financial Information(1) Market Cap: Cash: Debt, Preferred & NCI: LTM Revenue: LTM EBITDA: CY 2014E Revenue: CY 2014E EBITDA: CY 2015E Revenue: CY 2015E EBITDA: One-Year Price History(1) $35.00 250 M Share Price $20.00 $15.00 150 M 100 M $10.00 Shares Traded (in Millions) 200 M $25.00 Global Innovative Pharmaceutical – Develops, registers, and commercializes medicines for therapeutic areas, including inflammation, cardiovascular/metabolic, neuroscience and pain, rare diseases, and women’s/men’s health Bristol-Myers Squibb – Development and commercialization agreement for Eliquis (thromboembolic events) Merck – Collaboration agreement for novel anti-cancer combination regimen products that have lost marketing exclusivity in various markets, generic pharmaceuticals, and sterile injectable and biosimilar development products Saniona – Drug discovery development and collaboration agreement for neurological disorders Philogen – Development and commercialization agreement for antibody and small molecule targeted therapies 50 M Goldman Stanley Key Partners Develops and commercializes vaccines, oncology products, over-the-counter dietary supplements, pain management products, gastrointestinal products, respiratory products, and personal care products $5.00 $0.00 Chairman & CEO CFO & EVP CSO EVP Group SVP CSO Global Vaccines, Oncology, and Consumer Healthcare – Global Established Pharmaceutical – Offers patent-protected $30.00 Ian Read Frank D’Amelio Michael Ehlers Rady Johnson Robert Abraham Morris Birnbaum Its key biopharmaceuticals include Lyrica, Prevnar, Enbrel, Celebrex, Lipitor, Viagra, Zyvox, Sutent, EpiPen, Toviaz, Tygacil, Rapamune, Xalkori, Inlyta, Norvasc, the Premarin family of products, Eliquis, and Xeljanz. Its biotechnology products include BeneFIX, Genotropin, ReFacto, Xyntha, and Enbrel. Business Segments and Product Lines $186.1 $33.9 $37.5 $50.5 $22.4 $49.4 $20.7 $48.3 $20.4 Management Team 0M (1) Financial data as of May 9, 2014. 37 Process Recommendations Goldman Stanley 38 Key Recommendations We recommend engaging in targeted discussions with the Tier 1 candidates and assessing their receptiveness to M&A discussions At the same time, Goldman Stanley will reach out to Tier 2 candidates and introduce Jaguar as a potential partner M&A process with Tier 1 candidates will take significantly longer due to the scale of the companies, so we recommend conducting both processes simultaneously Depending on responses from Tier 1 and Tier 2 candidates, Goldman Stanley and Jaguar may do additional research to determine other potential partners and then approach them Targeted Sell-Side M&A Broad Sell-Side M&A < 5 potential partners 10 – 100 potential partners 6 – 12 months Time required is highly variable Close-ended Iterative process Higher success probability Lower success probability Goldman Stanley 39 Process Recommendations Specialized Negotiations With One Party Highly Targeted Process Targeted Discussions + Broader Search Broad M&A Process Broad Marketing RECOMMENDED Combination of targeted discussions plus broader search conducted in background maximizes success probability and minimizes disruption to Jaguar Additional parties contacted depend on responsiveness of Tier 1 and Tier 2 partners Interested parties would sign NDAs and then proceed into due diligence and valuation discussions with Jaguar Goldman Stanley 40 Targeted Discussions – Roles and Responsibilities Goldman Stanley Determine potential partners Phase I: Organization Phase II: Contact and Marketing Phase III: Business Due Diligence, Synergy Discussions, and Initial Bids Phase IV: Final Negotiations, Confirmatory Diligence, and Signings Finalize projections, CIM, and mgm’t presentation Legal Review draft DA Identify legal issues/concerns Management Board Determine potential partners Determine process and objectives Finalize projections, CIM, and mgm’t presentation Approve Tier 1 and Tier 2 partners to approach Receive process updates Contact partners and negotiate NDAs Assist in NDA negotiations Prepare for management meetings Schedule management meetings Assist in compiling legal diligence items Contact potential partners (if appropriate) Conduct management meetings and solicit bids Assist in reviewing initial bids and follow-up diligence lists for legal items Formulate synergies Receive process updates Attend management meetings Provide input/direction if required Discuss synergies and facilitate diligence Provide input/direction if required Answer diligence requests Review bids from potential partners Negotiate terms of DA with top partners Goldman Stanley Review bids, negotiate terms of DA, and assist with confirmatory diligence Review bids and assist with diligence Review bids and approve agreement, if appropriate Discuss contracts 41 Process Timeline Depending on the responsiveness of Tier 1 and Tier 2 partners, the process may take between 6 and 9 months to complete: Six-Month Timeline: Phase I: Organization Phase II: Contact and Marketing Phase III: Business Due Diligence, Synergy Discussions, and Initial Bids Phase IV: Final Negotiations, Confirmatory Diligence, and Signings Goldman Stanley JUN JUL AUG SEP OCT NOV Phase I Phase II Phase III Phase IV 42 Appendix Goldman Stanley 43 Xyrem and Erwinaze Projections – Management ($ USD in Millions except for $ per Patient Figures) Revenue Assumptions: Units: Xyrem Assumptions: Total Market Size (# Potential Patients) - Xyrem: # Patients On Medication at End of Year: Average # of Patients Throughout the Year: Growth Rate in # of Patients: # People # People # People % % of Market on Xyrem Medication: Post-Toggle % of Market on Xyrem Medication: % % Annual Price Per Patient - Xyrem: Growth Rate in Price per Patient: Post-Toggle Growth Rate in Price per Patient: $ as Stated % % $ $M % $ Xyrem - Revenue: Annual Growth Rate: % of Market on Erwinaze Medication: Annual Price Per Patient - Erwinaze: Growth Rate in Price per Patient: Erwinaze - Revenue: Annual Growth Rate: Goldman Stanley FY15 FY16 FY17 Projected FY18 FY19 FY20 FY21 FY22 FY23 FY14 FY15 FY16 FY17 FY18 FY19 FY20 FY21 FY22 FY23 157,000 157,000 157,000 157,000 157,000 157,000 157,000 157,000 157,000 157,000 12,560 18.2% 15,700 25.0% 18,840 20.0% 21,980 16.7% 25,120 14.3% 28,260 12.5% 31,400 11.1% 34,540 10.0% 37,680 9.1% 37,680 – 8.0% 8.0% Erwinaze Assumptions: Total Market Size (# Potential Patients) - Erwinaze: Average # of Patients on Erwinaze: Growth Rate in # of Patients: FY14 $ as Stated % $M % 14.0% 14.0% 16.0% 16.0% 18.0% 18.0% 20.0% 20.0% 22.0% 22.0% 24.0% 24.0% 24.0% 24.0% 773.7 $ 1,083.1 $ 1,455.7 $ 1,902.2 $ 2,391.3 $ 2,959.2 $ 3,551.1 $ 4,218.7 $ 376.8 $ 35.9% 40.0% 34.4% 30.7% 25.7% 23.8% 20.0% 18.8% (91.1%) 3,600 612 13.3% % 12.0% 12.0% 61,598 $ 68,990 $ 77,269 $ 86,541 $ 95,195 $ 104,715 $ 113,092 $ 122,139 $ 10,000 $ 10,000 15.0% 12.0% 12.0% 12.0% 10.0% 10.0% 8.0% 8.0% 6.0% 6.0% 15.0% 12.0% 12.0% 12.0% 10.0% 10.0% 8.0% 8.0% 6.0% 6.0% FY14 # People # People % 10.0% 10.0% 17.0% FY15 3,600 684 11.8% 19.0% FY16 3,600 756 10.5% 21.0% FY17 3,600 828 9.5% 23.0% FY18 3,600 900 8.7% 25.0% FY19 3,600 900 – 25.0% FY20 3,600 972 8.0% 27.0% FY21 3,600 972 – 27.0% 376.8 – FY22 FY23 3,600 1,044 7.4% 3,600 1,044 – 29.0% 29.0% $ 332,368 $ 342,339 $ 352,609 $ 363,187 $ 374,083 $ 385,305 $ 396,864 $ 408,770 $ 421,033 $ 433,664 3.0% 3.0% 3.0% 3.0% 3.0% 3.0% 3.0% 3.0% 3.0% 3.0% $ 203.4 $ 16.7% 234.2 $ 15.1% 266.6 $ 13.8% 300.7 $ 12.8% 336.7 $ 12.0% 346.8 $ 3.0% 385.8 $ 11.2% 397.3 $ 3.0% 439.6 $ 10.6% 44 452.7 3.0% Jaguar Income Statement – Management Case ($ USD in Millions except for $ per Share Figures) Income Statement: Revenue: Existing Products: Xyrem Sales: Erwinaze Sales: Defitelio Sales: Other Sales and Royalties: Risk-Adjusted Pipeline Drug Sales: JZP-110 Sales: JZP-386 Sales: Total Revenue: Revenue Growth: Units: $M $M $M $M FY14 $ FY15 FY16 Projected FY18 FY19 FY17 FY20 FY21 FY22 773.7 $ 1,083.1 $ 1,455.7 $ 1,902.2 $ 2,391.3 $ 2,959.2 $ 3,551.1 $ 4,218.7 $ 203.4 234.2 266.6 300.7 336.7 346.8 385.8 397.3 57.8 79.8 107.1 140.7 182.0 209.3 240.7 276.9 142.0 156.2 168.7 182.1 193.1 204.7 214.9 225.6 FY23 376.8 $ 439.6 318.4 234.7 376.8 452.7 366.1 244.0 $M $M $M % 1,176.9 34.9% 1,553.3 32.0% 1,998.0 28.6% 28.5 2,554.3 27.8% 71.7 3,174.8 24.3% 133.2 3,853.2 21.4% 159.8 4,552.3 18.1% 253.1 5,371.6 18.0% 292.7 1,662.1 (69.1%) 387.8 1,827.6 10.0% Total Cost of Product Sales: Gross Profit: Gross Margin: $M $M % 111.8 1,065.0 90.5% 147.6 1,405.6 90.5% 189.9 1,808.1 90.5% 242.8 2,311.5 90.5% 301.7 2,873.1 90.5% 366.2 3,487.0 90.5% 432.6 4,119.6 90.5% 510.5 4,861.1 90.5% 158.0 1,504.2 90.5% 173.7 1,653.9 90.5% Operating Expenses: Selling, General, and Administrative: Research and Development: Acquired In-Process Research & Development: Intangible Asset Amortization: Total Operating Expenses: $M $M $M $M $M 376.6 51.1 127.0 129.5 684.2 466.0 58.8 126.2 651.0 614.8 67.6 121.8 804.2 802.8 74.4 121.7 998.9 1,015.9 81.8 118.2 1,216.0 1,252.3 90.0 100.7 1,443.0 1,499.6 94.5 100.7 1,694.8 1,790.5 99.3 100.7 1,990.5 559.9 104.2 100.7 764.7 621.4 106.8 100.7 828.9 Operating Income (EBIT): Operating (EBIT) Margin: $M % 380.8 32.4% 754.7 48.6% 1,003.9 50.2% 1,312.6 51.4% 1,657.1 52.2% 2,044.0 53.0% 2,424.9 53.3% 2,870.7 53.4% 739.4 44.5% 825.0 45.1% Other Income / (Expense): Interest Expense, Net: Losses and Other Items: Goodwill Impairment: Total Other Income / (Expense): $M $M $M $M (48.6) (48.6) (38.1) (38.1) (38.1) (38.1) (18.1) (18.1) (18.1) (18.1) (0.2) (0.2) Income From Continuing Operations (Before Taxes): Tax Provision / (Benefit): Income From Continuing Operations: $M $M $M 332.2 59.8 272.4 716.6 129.0 587.6 965.8 173.8 792.0 1,294.5 233.0 1,061.5 1,639.0 295.0 1,344.0 2,043.8 367.9 1,675.9 Income from Discontinued Operations: $M Net Income: Effective Tax Rate: $M % Diluted Shares Outstanding: Diluted Earnings Per Share (EPS): EBITDA: EBITDA Margin: Goldman Stanley $M $ as Stated $M % $ $ $ 272.4 18.0% $ 64.4 4.23 $ 642.0 $ 54.6% 587.6 18.0% $ $ 1,061.5 18.0% - 2,424.9 436.5 1,988.4 - 2,870.7 516.7 2,353.9 - 739.4 133.1 606.3 - - 888.6 $ 1,137.7 $ 1,452.2 $ 1,800.7 $ 2,179.4 $ 2,571.1 $ 3,030.4 $ 57.2% 56.9% 56.9% 56.7% 56.6% 56.5% 56.4% 860.0 $ 51.7% 949.4 52.0% (1) Financial data as of May 9, 2014. 84.8 23.45 $ $ 606.3 18.0% - 97.2 6.96 81.0 20.69 $ $ 2,353.9 18.0% 825.0 148.5 676.5 92.9 6.53 $ 77.4 17.37 $ $ 1,988.4 18.0% - 88.8 26.52 $ 73.9 14.36 $ $ 1,675.9 18.0% - 676.5 18.0% 70.6 11.21 $ $ 1,344.0 18.0% - $ 67.5 8.71 $ 792.0 18.0% - - 45 Jaguar Comparable Public Companies Specialty Pharmaceutical Companies That Sell Primarily Branded Drugs, with LTM Revenue Between $500 Million and $2 Billion ($ USD in Millions) Operating Statistics Company Name Alexion Pharmaceuticals, Inc. Vertex Pharmaceuticals Inc. BioMarin Pharmaceutical Inc. Salix Pharmaceuticals, Ltd. Cubist Pharmaceuticals, Inc. United Therapeutics Corporation The Medicines Company Capitalization Equity Enterprise Value(1) Value(1) $ 31,143 $ 29,697 15,689 14,079 9,103 8,769 7,988 9,538 5,866 6,038 5,803 4,723 1,699 1,533 Maximum 75th Percentile Median 25th Percentile Minimum $ 31,143 12,396 $ 7,988 5,834 1,699 Jaguar $ Valuation Statistics Company Name Alexion Pharmaceuticals, Inc. Vertex Pharmaceuticals Inc. BioMarin Pharmaceutical Inc. Salix Pharmaceuticals, Ltd. Cubist Pharmaceuticals, Inc. United Therapeutics Corporation The Medicines Company Capitalization Equity Enterprise Value(1) Value(1) $ 31,143 $ 29,697 15,689 14,079 9,103 8,769 7,988 9,538 5,866 6,038 5,803 4,723 1,699 1,533 Maximum 75th Percentile Median 25th Percentile Minimum $ 31,143 12,396 $ 7,988 5,834 1,699 $ 29,697 11,809 $ 8,769 5,381 1,533 Jaguar $ $ 8,196 8,196 LTM $ 1,779 1,002 572 1,116 1,086 1,161 709 Revenue EBITDA Reported Net Income 2014-12-31 2015-12-31 LTM 2014-12-31 2015-12-31 LTM 2014-12-31 2015-12-31 $ 2,171 $ 2,569 $ 697 $ 1,074 $ 1,306 $ 330 $ 472 $ 1,123 574 1,211 (331) (478) 164 (369) (538) 119 655 905 (108) (80) 65 (175) (142) 47 1,649 1,995 281 680 957 77 361 444 1,206 1,483 195 259 295 (0) 26 48 1,255 1,387 445 629 690 250 400 441 775 823 85 70 166 22 (0) 106 $ 29,697 11,809 $ 8,769 5,381 1,533 $ $ $ 1,779 1,138 1,086 856 572 $ $ 923 9,089 9,089 Goldman Stanley $ $ 2,171 1,452 1,206 715 574 $ $ 2,569 1,739 1,387 1,058 823 $ 697 $ 363 195 $ (11) (331) $ 1,177 $ 1,553 $ 423 $ 1,074 $ 655 259 $ (5) (478) 642 $ 1,306 823 295 165 65 $ 889 $ Enterprise Value / Enterprise Value / Revenue (1) EBITDA(1) LTM 2014-12-31 2015-12-31 LTM 2014-12-31 2015-12-31 16.7 x 13.7 x 11.6 x 42.6 x 27.7 x 22.7 x 14.1 x 24.5 x 11.6 x NM NM 85.8 x 15.3 x 13.4 x 9.7 x NM NM NM 8.5 x 5.8 x 4.8 x 34.0 x 14.0 x 10.0 x 5.6 x 5.0 x 4.1 x 31.0 x 23.3 x 20.5 x 4.1 x 3.8 x 3.4 x 10.6 x 7.5 x 6.8 x 2.2 x 2.0 x 1.9 x 18.0 x 21.8 x 9.2 x $ 80 $ 472 $ 380 26 $ (71) (538) 272 $ EBITDA Margin LTM 2014-12-31 2015-12-31 39.2% 49.5% 50.8% (33.0%) (83.3%) 13.5% (18.9%) (12.2%) 7.2% 25.2% 41.3% 48.0% 17.9% 21.5% 19.9% 38.3% 50.1% 49.7% 12.0% 9.1% 20.2% 1,123 443 119 77 47 111.0% 30.6% 21.0% 14.4% 6.1% 136.6% 31.1% 13.7% (62.3%) (181.3%) 39.2% 31.7% 17.9% (3.4%) (33.0%) 50.1% 45.4% 21.5% (1.6%) (83.3%) 50.8% 48.9% 20.2% 16.7% 7.2% 588 32.0% 38.4% 45.8% 54.6% 57.2% P / E Multiple (1) LTM 2014-12-31 2015-12-31 94.4 x 66.0 x 27.7 x NM NM NM NM NM NM NM 22.1 x 18.0 x NM NM NM 23.2 x 14.5 x 13.2 x 76.9 x NM 16.1 x 16.7 x 14.7 x 8.5 x 4.8 x 2.2 x 24.5 x 13.5 x 5.8 x 4.4 x 2.0 x 11.6 x 10.6 x 4.8 x 3.7 x 1.9 x 42.6 x 34.0 x 31.0 x 18.0 x 10.6 x 27.7 x 23.3 x 21.8 x 14.0 x 7.5 x 85.8 x 22.2 x 15.2 x 9.4 x 6.8 x 9.8 x 7.7 x 5.9 x 21.5 x 14.2 x 10.2 x NM (1) Financial data as of May 9, 2014. 330 $ 163 22 $ (88) (369) Projected Projected Revenue EBITDA Growth Growth 18.3% 21.6% 111.0% (134.3%) 38.2% (181.3%) 21.0% 40.6% 22.9% 13.7% 10.5% 9.7% 6.1% 136.6% 94.4 x 85.6 x 76.9 x 50.1 x 23.2 x 66.0 x 44.1 x 22.1 x 18.3 x 14.5 x 27.7 x 20.4 x 17.0 x 15.4 x 13.2 x 30.1 x 13.9 x 46 Jaguar DCF Analysis – WACC Calculation ($ USD in Millions) (1) Discount Rate Calculations - Assumptions : Risk-Free Rate: Equity Risk Premium: Pre-Tax Cost of Debt: Cost of Preferred Stock: 2.62% 7.00% 3.42% – Comparable Companies - Unlevered Beta Calculation: Levered Beta 0.64 0.35 0.92 1.18 0.65 1.44 0.79 (1) Debt $ 93.5 473.4 828.4 1,944.4 945.2 70.3 263.0 Median: 0.79 $ 473.4 Jaguar 1.05 Name Alexion Pharmaceuticals, Inc. Vertex Pharmaceuticals Inc. BioMarin Pharmaceutical Inc. Salix Pharmaceuticals, Ltd. Cubist Pharmaceuticals, Inc. United Therapeutics Corporation The Medicines Company (1) Preferred 8.3% Jaguar - Levered Beta & WACC Calculation: Unlevered Current Capital Structure: "Optimal" Capital Structure: Beta 0.72 0.72 $ - Preferred (1) Debt $ 1,198.6 783.6 Equity (1) Unlevered (1) % Debt Stock % Preferred Value % Equity 0.3% $ – $ 31,142.6 99.7% 2.9% – 15,689.4 97.1% 8.3% – 9,102.5 91.7% 19.6% – 7,987.9 80.4% 13.9% – 5,865.8 86.1% 1.2% – 5,802.8 98.8% 13.4% – 1,699.3 86.6% (1) – $ 7,987.9 Tax Rate 17.0% 20.0% 27.0% 35.0% 27.0% 35.0% 36.0% Beta 0.64 0.34 0.86 1.02 0.58 1.43 0.72 27.0% 0.72 91.7% Equity (1) % Debt Stock % Preferred Value % Equity 12.8% $ – $ 8,196.0 87.2% 8.3% – 8,611.0 91.7% Levered Tax Rate 18.0% 18.0% Cost of Equity Based on Comparables, Current Capital Structure: Cost of Equity Based on Comparables, "Optimal" Capital Structure: Cost of Equity Based on Historical Beta: Beta 0.81 0.77 8.26% 8.03% 9.97% WACC = Cost of Equity * % Equity + Cost of Debt * % Debt * (1 - Tax Rate) + Cost of Preferred Stock * % Preferred Stock WACC, Current Capital Structure: WACC, Current Capital Structure and Historical Cost of Equity: WACC, "Optimal" Capital Structure: 7.56% 9.06% 7.59% Average WACC Produced by All Methods: 8.07% Goldman Stanley (1) Financial data as of May 9, 2014. 47