Adolescent/Young Adult Brain Development And Drugs Dean Blumberg, PhD, LMFT, CADC Kaiser CDRP, San Francisco dean.blumberg@kp.org 1 OBJECTIVES Review: Adolescent brain development Gender differences Effects of substance abuse and chemical dependency on adolescent development Substance abuse prevention for parents 2 THE JOURNEY Storm and Stress: Not always (Offer and Offer, 1975) 3 3 Pathways (rides) through adolescence (Caviola & Kane- Caviola, 1989,) : (1) The Kiddy Roller Coaster – continuous growth group (23%) - well-adjusted teens who meet the demands of this stage. (2) Go For a Ride or 2 on the Big Roller Coaster surgent growth group (35%) comprised of reasonably well-adjusted youngsters, who may have difficulty coping with unexpected 4 trauma. 3 Pathways (rides) through adolescence (Caviola & Kane- Caviola, 1989,) : (3) Go For the Biggest, Scariest Roller Coaster You Can Find - tumultuous growth group (42%) characteristic of the adolescent turmoil hypothesized by the ‘storm and stress’ theorists. 5 Which One? (1) The Kiddy Roller Coaster (2) Go For a Ride or 2 on the Big Roller Coaster (3) Go For the Biggest, Scariest Roller Coaster 6 THE TASKS Individuation and Separation 7 Identity Development EXPLORATION “Sex, Drugs and Rock ‘n Roll” Hip Hop” “Teenagers define their identity through risk-taking . . .” - Shedler and Block “. . . balance exploration with commitment to formulate a sense of 8 identity.” (Trad, 1994) Identity Development Exploration – Oppositional as a Transitional Step “not trusting adults” to develop identity When CD: pseudoindividuation (Haley) 9 Identity Development EXPLORATION – Neurological Basis The reward/pleasure system. Dopamine (DA) is the final neurotransmitter. 10 Identity Development EXPLORATION – Neurological Basis Dopamine (DA) is depleted in teens’ reward system. Because DA has migrated to help develop the prefrontal cortex 11 Identity Development EXPLORATION – Neurological Basis Teens often need more stimulating activities to get the same kick as adults get. • DA increases w/high risk-taking in the nucleus accumbens (NAc). (Strauch,97; Galvin, et. al., 2006) 12 Identity Development EXPLORATION – Neurological Basis NAc Activity in response to rewards : (Galvan, A., et al., 2005 and Galvan, A., et al., 2006) • Adults: Corresponds to level of reward. • Children: The same despite level of reward. “. . . Kids were happy to play the game . . .” • Teens: All-or-Nothing - High to high rewards. Low to moderate and low rewards. 13 Identity Development EXPLORATION – Neurological Basis Evolutionary basis: • Explorers for the tribe • Broaden the gene pool? One Consequence: More susceptible to substance abuse & chemical dependence. 14 Neurological Development Phases of Growth DEVELOPING POTENTIAL DEVELOPING ABILITIES BECOMING CONSISTENT & EFFICIENT (childhood – 11/12 y.o.) (puberty – 19 y.o.) (19 – 26 y.o.) 15 Neurological Development Developing Potential – Childhood - Prepuberty Brain thickening – Dendrite Growth • Grey matter over-production until 11 y.o.- girls & 12 y.o. boys • 4 million dendrites/neuron Brain highly receptive to new information & skills Primed to acquire new skills 16 Neurological Development Developing abilities Puberty – 19 y.o. Pruning and Shaping • Developing abilities 17 Neurological Development Developing abilities Puberty – 19 y.o. “Use It or Lose It” “You are hard-wiring your brain in adolescence. Do you want to hard-wire it for sports and playing music and doing math . . . or for lying on the couch in front of the TV?” Jay Giedd, MD, NIMH 18 Neurological Development Developing abilities “Use It or Lose It” 15 – 19 y.o. 19 Neurological Development Phases of Growth 19 – 26 y.o.: Myelination • Becoming consistent and efficient 20 Neurological Development Becoming consistent & efficient – 19 – 23 -> 26 y.o. Electrical charge travels 100x times faster on a myelinated axon than on unmyelinated one. Speeds and smoothes signals • Less jumping to unintended neuron > 200 miles per hour 21 Neurological Development Intelligence & Skills Don’t use it, you lose it = • less dendrites. • less myelination SO messages travel slower = 22 Neurological Development Intelligence & Skills More dendrites/connections + Thicker myelination/faster message travels = INTELLIGENCE! 23 Neurological Development Direction of Growth Growth begins at the back and moves to the front of the brain. 24 25 Neurological Development Growth 26 Neurological Development Frontal lobes The brain’s so-called chief executive. Fully developed frontal lobes = grown-up. Executive functioning: planning, organization, decision making, emotional processing, response inhibition 27 Neurological Development Frontal lobe The brain’s chief executive. The human frontal lobe comprises: 30% 28 Neurological Development Frontal lobe Dogs? 7% 29 Neurological Development Frontal lobe Cats? 3% 30 Neurological Development Executive Functioning Onset of puberty begins remodeling. • DA migrates to frontal lobes as part of development DA involved in ability to recognize when something is important and take action 31 Neurological Development Executive Functioning This growth spurt and pruning of synapses leads to relative inefficiency in circuitry. For ex.: • Speed can identify emotions drops by as much as 20%. • Returns to normal levels only at age 18 or older. (McGivern, 2002) 32 Neurological Development Executive Functioning Younger teens use the more crocodile like amygdala part of their brain to process emotions. (Yurgelun-Todd, 1999) 33 Neurological Development Executive Functioning Often misread facial expressions. • For ex., frequently mislabel fear as anger. 34 Neurological Development PreFrontal Cortex Impulse Control-The Brain’s Police 35 Neurological Development Amygdala Lots of connections between amygdala and prefrontal cortex (PC) “Do something part of the brain” 36 Neurological Development PreFrontal Cortex Amygdala: Robust @ 9 weeks old • Neg. emotions have a more powerful and longer impact than positive emotions so can survive. 37 Neurological Development Amygdala Hormonal Influence Due to surge in hormones: amygdala hyperactive Hyperactive amygdala + not-fully developed prefrontal cortex = “the roller coaster” Not uncommon for early adolescents to experiment with SDB like cutting as part of general exploration, to get some temp. pain relief and increase DA in reward pathway. 38 TMI? Too Much Information? 39 Neurological Development The Low Road The amygdala, reward pathway and other emotional centers along w/the “reptilian,” automatic brain responses comprise the FAST MOVING, LOW-ROAD of the brain. The “GO” part of the brain. 40 Neurological Development The High Road The cortex, particularly the frontal cortex, is the “thinking brain” that is SLOW MOVING, HIGHROAD of the brain. the 41 Neurological Development PreFrontal Cortex The “STOP” part of the brain: 42 Neurological Development PreFrontal Cortex 15 y.o. brain does not have the biological machinery to inhibit impulses in the service of long-range planning. • One reason teens can “flip out” @ a moments notice “Adolescents make a lot of decisions that the average 9 yr. old would say [were] a dumb thing to do.” Ronald E. Dahl, MD, Univ. of Pittsburgh Medical Center, NYAS Magazine 2003 43 Neurological Development Phineas Gage Syndrome 1848-Phineas Gage first taught us about the frontal lobes: impulse control and personality. He was a foreman of a railroad construction crew laying tracks in Vermont. He was honest, reliable, hardworking, smart and respectful, a very likeable guy. Tamping down a dynamite charge when it exploded. It launched a 13 lb., 4 ½ foot tamping rod through his left cheek and out the top of his head. It didn't kill him. He remained conscious. Phineas became a belligerent, cursing, dishonest schemer. Sometimes, teens PFCs stop working . . . 44 Neurological Development PreFrontal Cortex Immortality and Omnipotence • Rates of mortality in youth ages 10–24, by cause: Motor vehicle accidents - 32% Unintentional injuries - 12% Homicide - 15% Suicide - 12% All other causes - 29% 45 Neurological Development PreFrontal Cortex Adolescent dilemma: “ . . . want to be adults and they’re exposed to a semiadult culture, but they don’t have the prefrontal cortex to regulate those adult behaviors.” (Giedd, MD) 46 Neurological Development PreFrontal Cortex Adolescent dilemma: “They have the passion and the strength but no brakes and . . . may not get good brakes until . . . twentyfive.” (Giedd, MD) 47 Neurological Development PreFrontal Cortex Parents, teachers and therapists task: “Sometimes need to act as though they are their teenagers’ “frontal cortex . . . talking through possibilities and options. They have to function like a surrogate set of frontal lobes, an auxiliary problem solver.” 48 Neurological Development Sleep effects • Sleep cycle-circadian rhythm Night owls to guard the cave, keep the fire going? • Too little sleep impairs a teenager’s thinking ability and can cause a variety of problems . . . • Teenagers are most sleep-deprived segment of pop. 49 Neurological Development Sleep effects •Most adol. need to sleep ~9 hours. • Dendrites grow during sleep, if you get enough sleep. • Get enough sleep, all neurons fire and rehearse learning. Also, can’t learn if tried to learn too much the day before. 50 Cognitive Development Formal Operations Use of logic hypothesis development and validation through experimentation (Brisbon & Chambers). “Capacity to engage in propositional thinking, go beyond the here and now to understand abstract concepts . . .” (Caviola & Kane- Caviola, 1989, 17) Ex. of hypothesis testing looking for honesty: – Teen who called in early AM 12 step members who didn’t seem sincere re/giving their #’s. 51 Cognitive Development Formal Operations Decision making/problem solving Predicting the probable outcomes of behavior Weighing options and selecting alternatives 52 Cognitive Development Formal Operations Females: 14 -16 y. o. Males: 16 – 18 y. o. Full ethical/moral: ~ 24 – 26 y.o. 53 Cognitive Development Formal Operations Abstraction/Ideals Teen hypocrisy: “To an adolescent expressing an ideal is equal to living up to it.” (Caviola & KaneCaviola, 1989, 18) “Hypercritical of parents, . . . able to imagine the perfect parents or perfect family and now realizing that yours is not perfect makes for a critical, argumentative adolescent.” (Caviola & KaneCaviola, 1989, 17) “At a certain point, many teenagers start a rash of lying, . . . a way of solving problems and could again point back to the development of the frontal 54 lobes.” 119 Hormonal Changes Hormones with feet. Terrible 2's in big bodies.- Lack of impulse control. • Puberty is developing 2 yrs. earlier in girls-and somewhat earlier, in boys than 100 yrs. ago. Speculation that puberty/menses is starting earlier in girls due to hormones in food. • Increase in thrill-seeking behavior . . . “an engine w/o a driver.” (Strauch, 96) 55 Hormonal Changes Poor parental relations: High testosterone sons - more likely to engage in risky behavior, e.g., skipping school, sex, lying, drinking, and stealing. Low testosterone sons - more likely depressed. Low testosterone daughters - who had poor relations with their mothers - more likely to do risky things. Low testosterone daughters who had bad relations with their fathers - more likely depressed. (Strauch,142) With good relationships, high and low testosterone levels don’t matter at all. 56 Gender Differences 80% of women and 20% of men have similar brain architecture: Better better designed for info. processing, language development and relational skills. 57 Gender Differences 80% of men and 20% of women have similar brain architecture: Built for action, motor skills, spatial reasoning, problem solving. 58 Gender Differences Boys Are From Pluto Uranus Boys are ‘‘wired’’ to act on their emotions rather than work through them with language. Boys have more Cerebrospinal fluid (CSF): The main purpose of CSF appears to be to cushion the brain in the case of trauma to the cranium 59 Gender Differences The Hemispheres The brains of men consistently show more hemispheric asymmetry than women • Men’s left hemisphere ‘‘looks’’ different from the right; function more independently. • Women’s two hemispheres are essentially indistinguishable either by MRI or at 60 autopsy Gender Differences Connecting the Hemispheres Corpus Collusum (CC): Use both hemispheres for abstract thinking, communication, writing, multitasking. • Women’s CC: Freeway • Men’s CC: Dirt road 61 Gender Differences Stress Women under stress: release Oxytocin, cuts off connection to amygdala. • One reason can have a child again; doesn’t let burn into the HC. Oxytocin: female more susceptible to caring, nurturing, and connection/ bonding 62 Gender Differences Stress Men under stress produce testosterone = ACTION! • Boys are nearly twice as likely to report having been in a physical fight and nearly 5x as likely to have carried a weapon. 63 Gender Differences Stress When do male brains produce “the cuddle hormone,” Oxytocin? 64 Gender Differences Stress Under sexual conditions. 65 Gender Differences Two recommendations for boys Give an adolescent male some time to get ready to discuss how he is feeling. • For example, if a parent needs to talk to a boy about his poor report card, it is better to say to him, ‘‘I’d like to talk to you about your report card when you are ready,’’ rather than confront him without warning. Boys also may have an easier time ‘‘unlocking’’ their emotions if they are allowed to move around. • Taking a walk or shooting baskets while discussing tough issues is likely to be more rewarding than 66 sitting him down on the couch. Gender Differences Middle-school girls who ate with their families at least 5x/week were much less likely to use alcohol, tobacco or marijuana 5 years later. Boys: No association between family meals and substance-using behavior. Girls could be picking up on subtle reinforcing messages from family members — signals that boys may tend to miss. Journal of Adolescent Health , August 2008, Pages 151-156 67 Gender Differences RISK TAKING & SELF-ESTEEM • Risk taking - correlated to high selfesteem • Boy’s brain: produces testosterone • • Primed to take risks w/little thought, Girl’s brain: produce oxytocin • Help girls take a risk by putting into a relationship/caring context 68 Risk of Developing Chemical Dependency Due to brain development, adolescent brain is very susceptible to CD: • Increased receptor sites 50% more receptors for nicotine Adol. rats given typical nicotine of daily smoker produced 2x the nicotine receptors in VTA (craving) 69 Risk of Developing Chemical Dependency Decreased DA in reward pathway Poor impulse control (prefrontal cortex) Psychological stress Stress can reduce DA receptor sites Lower susceptibility to negative side effects: sedation, motor problems, hangovers, etc., 70 71 Alcohol Dependence Onset Past-year DSM-IV Alcohol Dependence by Age in the United States Source: NIAAA 2001-2002 NESARC data (18-60+ years of age) and SAMHSA 2003 NSDUH (12-17 years of age) Drug Dependence Onset Hazard rates for age at onset of DSM-IV drug abuse and dependence Compton, W. M. et al. Arch Gen Psychiatry 2007;64:566-576. Copyright restrictions may apply. Chemical Dependency: Risks Inherited predisposition (genetics) Childhood trauma or abuse* Unwanted sexual involvement before age 13* Mental Illness: depression, anxiety, personality disorder (teen or other family member)* Attention Deficit Hyperactive Disorder (ADHD) Learning disabilities/school failure Parental discord or divorce* Parental substance abuse* * Subjected to teasing, bullying Acne and/or obesity Other than heterosexual orientation Social rejection Onset of drug use before age 16 Enabling environment Ignorance Using energy drinks Rothman, Emily F., Edwards, Erika M., Heeren, Timothy, Hingson, Ralph W. Adverse Childhood Experiences Predict Earlier Age of Drinking Onset: Results From a Representative US Sample of Current or Former Drinkers Pediatrics 2008 122: e298-e304 74 FIGURE 6 Association of age of initiation of alcohol use and lifetime dependence (meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for dependence at some point in one's life) Masten, A. S. et al. Pediatrics 2008;121:S235-S251 Data source: 2001–2002 National Epidemiologic Survey on Alcohol and Related Conditions.7 Copyright ©2008 American Academy of Pediatrics Chemical Dependency: Resilience Factors No family history of addiction Good mental health Academic competence Positive relationship with an adult Family eats dinner together 5 days/wk Positive peer group participation Participation in sports Participation in music, drama or dance Involvement in faith-based activities Taking care of pets Volunteer activities Social acceptance Environment disapproves of drug use Immediate, appropriate scaled consequences for alcohol/drug use. 76 Early intervention for alcohol/drug use Impact of Chemical Dependency Teens who drink avg of 2 drinks/day for 2 yrs. or weekend binge drinking for 1 yr.: 10% smaller HC and recall 10% less • = to at least one grade lower Adult rats need 2x as much beer as an adol. rat for equivalent amt. of HC damage (Strauch, 177) 77 Impact of Chemical Dependency MARIJUANA: 16 y.o. 2 year history of daily abuse Normal underside surface view of prefrontal and temporal lobe activity © 2006 Amen Clinics Inc 78 Neurogenic Denial MARIJUANA: 18 y.o. 3 year history of 4x/week Normal underside surface view of prefrontal and temporal lobe activity © 2006 Amen Clinics Inc 79 The Need to Deny Chemical Dependency The PET-scan images to show the brain’s response to the avalanche of dopamine in the nucleus accumbens of people with dependencies. To relieve the chronic stimulation of its neurons, the nucleus accumbens simply reduces the number of dopamine receptors that they have. In these images of the brain, the red areas indicate large numbers of dopamine receptors. These images show that people who are alcoholic, obese, or cocaine-dependent have fewer dopamine receptors than normal people do. 80 Impact of Chemical Dependency MARIJUANA & Memory: 16 y.o. 2 year history of daily abuse underside surface view of prefrontal and temporal lobe activity © 2006 Amen Clinics Inc 81 Impact of Chemical Dependency MARIJUANA & Virtual Novelty Instant Interest & Fun, BUT . . . Leads to More Boredom So, want to use more Memory & learning problems Slower Reactions Pilots 24 hrs. later 82 Marijuana & Cancer 70% increased risk of testicular cancer* associated with current marijuana use The risk is particularly elevated for: Current, at least weekly use or Use that began in adolescence. * approx 1 in 36,266 or 7,500 people in USA/yr. Rate increasing 3 – 6%/yr for past ~ 50 yrs. 83 5-HT levels in monkey after MDMA (two 5 mg/kg daily for 4 days) • Result: -long-term loss of 5HT fibers in monkeys 2 weeks 7 years (caudate nucleus) (Hatzidimitriou et al., J. Neurosci. 19 [1999] 5092) -some recovery Image courtesy of Dr. GA Ricaurte, Johns Hopkins University Bloomberg School of Medicine Impact of Chemical Dependency Teen heavy smokers: 4x more likely to develop depression with in a year. 15x greater risk of developing panic attacks as adults. • Anxiety levels were no higher than others to begin with . . . Possibly due to respiratory prob. which can trigger panic attacks. After a few years of smoking , lung capacity is reduced, smokers take in less oxygen, and exhale less carbon dioxide. Carbon dioxide in the blood stimulates breathing and too much of it sends a signal to the brain that it’s suffocating, setting off a false alarm and a panic attack. (Strauch,184) 86 Impact of Chemical Dependency Delayed or Arrested Development • The phenomena of early stage physical symptoms with middle and late stage emotional impairment. • Liquid Courage Ex.: Empathy Difficulties - Rely on drugs for coping so delayed development of relationship coping skills. • Difficulty understanding other’s point of view. • Narcissism? 87 Impact of Chemical Dependency Use drugs or drink: Short term gain, long term pain Don't go for the easy, quick high: Short term pain, long term gain! 88 Prevention Goals I. Education II. Commitment to not drink/use drugs and drive or ride with others who are intoxicated III. Support primary objective of no ATOD use under 21 89 Parents’ Perceptions of Teen Alcohol Use Drank alcohol at least 1x in past yr. Source: Pride Surveys National Summary for Parents, 2004-05 90 Parents’ Perceptions of Teen Drug Use Used a drug at least 1x in past yr. Source: Pride Surveys National Summary for Parents, 2004-05 91 Prevention LOVE, LIMITS & LISTENING Don’t: • Lecture • Nag • Preach or • Give unwanted advice Don’t Inflict Help! 92 Prevention LISTEN, LISTEN, LISTEN • Bite your tongue • They need you to hold up the mirror . . . • Adolescence: Learner’s permit on life • Mistakes are an opportunity to learn 93 Prevention LISTEN, LISTEN, LISTEN CONT’D: Teens need you to respect their “No’s,” before they will give you a “Yes.” DON’T INFLICT HELP! Earn the right to ask 1 time: • “Would you like to know what I think?, Would you like a suggestion?,” etc. 94 Prevention LISTEN, LISTEN, LISTEN CONT’D: If don’t want your advice/opinion: • “You’ve got a good head on your shoulders, I’m sure you’ll figure it out . . .” • “I trust you to know when to ask for help when you need it . . .” • “I have faith in you . . .” 95 Prevention LISTEN, LISTEN, LISTEN CONT’D: Positive One on One Time** – Break the coercion “log jam.” – Spend positive time with your teen first. – Take a sabbatical from teaching, judging, lecturing, directing, correcting, etc. – 15-20 min. 3-4x per week. – Let your teen choose something enjoyable or Notice when your teen is doing a fun activity, approach, make positive comments, and stick around ** From “Your Defiant Teen,” Barkley, Robin, & Benton, 2007 96 Prevention LIMITS: • + and – consequences • Written down They need “No's” to develop selfdiscipline No limits = DDD •Discipline Deficit Disorder D. Walsh, PhD 97 August 4, 2008 Vol. 17, Issue 31 Percentage of South Dakota Students Reporting Heavy Drinking in 9th and 11th Grades, by Permissiveness of Household Permissive Household Nonpermissive (n=313)Household ( 100% 74% 80% 76% 60% 40% 27% 20% 8% 0% Heavy Drinking Heavy in 9th Drinking Grade in 11th Gr *Data are from a sample of 3,687 7th grade students recruited from 48 South Dakota schools in 1997-1998, with follow-up assessments conducted in grades 8, 9, 10, and 11. Nonpermissive households (n=397, 10.3% weighted) were defined as parents being “very upset” to know that their child drank alcohol or used marijuana, knowing “all of the time” where to find their child, and telling the child “all of the time” what time to be home. Permissive households (n=313, 10.2% weighted) were defined as having at least three of these four characteristics: parents being “not at all” or “a little” upset to know that their child drank alcohol or used marijuana, knowing “sometimes” or less often their child’s whereabouts, and telling the child “sometimes” or less often what time to be home. The remaining 79.5% (n=2,977) of the sample were from households that fell in between these two extremes in terms of permissiveness and were not analyzed. SOURCE: Adapted by CESAR from Tucker, J.S., Ellickson, P.L., and Klein, D.J., “Growing Up In a Permissive Household: What Deters At-Risk Adolescents from Heavy Drinking?,” Journal of Studies on Alcohol and Drugs 69(4):528-534,2008. For more information, contact Dr. Joan S. Tucker at joan_tucker@rand.org. Prevention LIMITS: When angry, don’t act, take a break, and think about what you want to do. • “When you feel like taking the wind out of his sails . . . take your sails out of his wind.” • Mirror neurons Apologize when you make a mistake Let them get the last word 99 Prevention Giving Effective Commands – Make sure you mean it – Make it simple, direct, in a business like tone, not a question (there is no choice) – Tell what to do rather than what not to do – Make sure you have teen’s full attention – If giving time limit, give teen a timer to use. – Give limited choices. ** Start off w/things you know they’ll do: go to the mall, have another dessert 100 Prevention If can only do one of the 3 L’s: LOVE 101 Selected References The Primal Teen, Barbara Strauch Marijuana: What’s a Parent to Believe?, Timmen Cermak Why Do They Act That Way? A Survival Guide to the Adolescent Brain for You and Your Teen, David Walsh Inside the Teenage Brainhttp://www.pbs.org/wgbh/pages/frontline/shows/teenbrain/i nterviews/giedd.html 102 Don't panic. You can do this. http://timetoact.drugfree.org/ 103 Safe Drinking Guidelines for Adults Moderate Drinking is… For Men: no more than 2/day, 14/week or 5 drink tolerance For Women/Elderly: no more than 1/day, 7/week or 4 drink tolerance (M) 2 - 14 - 5 (W) 1 - 7 - 4 (NIAAA, 2000) 104 Prevention 105 Neurological Development Direction of Growth Occipital, parietal and temporal lobes largely mature in older adolescents. • Parietal – logic and spatial reasoning. • Temporal – language. 106