UNIT OF WORK GENETIC (80+40min.) 1.1. Chromosomes, genes, mutations and meiosis 1.2. Meiosis and genetic variation 1.3. Homologous Chromosomes 1.4. The phases of meiosis 1.5. Down’s Syndrome 1.6. Karyotypes (80+40 min.) 2.1. Theoretical Genetic 2.2. Genotype, phenotype and test cross 2.3. Modification of the 3:1 monohybrid ratio Punnet Square 2.4. Human inheritance investigated by pedigree chart 2.5. Sex chromosomes and gender (80+80min) 3.1. Genetic engineering and biotechnology 3.2. The steps of genetic engineering 3.3. Issues raised by genetic engineering 3.4. DNA Profiling 3.5. Human Genome Project 3.6. The new discipline of bioinformatics 3.7. Cloning 3.8. Current uses of genetically modified organisms 3.9. Ethical issues surrounding therapeutic cloning (80+80min.) D:\533581981.doc 4.1. Genetic II- Mendel’s Law 4.2. Dihybrid crosses and gene linkage 4.3. The dihybrid test cross 4.4. Linked Genes 4.5. Polygenes and continuous variation 4.6. Polygenetic inheritance in a plant species Lesson planning sheet 1 Class: 11th grade MEB Date of lesson: 11th grade IB/SL-HL Lesson title: GENETICS ( Define chromosomes Number in class: 20 ,genes mutations, meiosis and genetic variation and their functions) Attainment range of students: Length of lesson: 80 min. Teaching goal (conceptual Behavioral (learning) objectives understanding and strategy) Explain how chromosomes are paired. Distinguish between autosomes and sex Students will be able to define chromosome, genes, mutations, meiosis chromosomes. List the phases of meiosis I and meiosis II and describe the events characteristic of each phase. Define nondisjunction, explain how it can and genetic variation that every person is unique Students will be able to explain how mutation may cause a gene to be defective occur, and describe what can result Describe the causes and symptoms of phases of meiosis Down syndrome separation of homologous chromosomes Explain how and why karyotyping is performed Assessment strategies Links to curriculum Homework ( form key vocabulary and 11th MEB define all unknown words and IB Biology HL 10th or 11th terminology) Questioning Prior teaching/learning Cell division Mitosis and meiosis D:\533581981.doc Common misconceptions Cell cycle Students often seem confused by the difference between a DNA molecule and a chromosome. This is especially problematic when discussing DNA replication. Key vocabulary Homework Chromosomes The phases of meioses ( Students will draw all Genes phases with colorful pen and get understand Alleles process) autosomes Write new terms on vocabulary part in their cell cycle Cell division notebook. (I do not want to exact meaning of dictionary; the main aim is students get familiar centromeres terminology.) chiasma (plural, chiasmata) chromatin chromosome crossing over Students with special needs and support planned Extension activities Down syndrome Homologous chromosomes Cross curricular issues karyotype Psychology lesson ( Learning Ability- Down locus Syndrome) Meiosis Mutations nondisjunction sex chromosome Resources Risks and safety precautions 11th MEB Biology Text Book N/A IB SL-HL Biology Text Book Campbell Biology 7th Edition D:\533581981.doc IGCSE 9,10 Biology Text Book Time Student activity Teacher activity Content notes Take attendance Prepare a presentation Answer the question Setting the class to settle before the lesson. Settle down down First 5 or 10 minutes for Prepare their materials. Asking daily question prepare the students to General admin 10 attend lesson. . Lesson starter 10 Listen to teacher Explain the lesson Teach how students form Ask and answer the Give information about key words booklet. questions chromosomes, genes, Dna, Students usually cannot locus, nucleotides (distinguish separate which structure and shows which one is bigger than other. bigger than other.) D:\533581981.doc 20 Listen to teacher “The phases of meiosis” Take notes Interphase Draw the phases of Prophase meiosis on their Metaphase notebooks. Anaphase (Use PPT for shows their view during the meiosis.) Give some examples Sister chromatids, look like fruit fly. Why centromeres and daughter they are important in chromosomes are important genetic? Lesson core terms and be sure students are able to distinguish them. 30 Watch animation Take notes Show animation about the https://www.youtube.co phases of meiosis and explain m/watch?v=QwmpD0O one more time with B3AQ animation. Ask questions Give time them to write and Answer the questions draw If there is time and it Give post test ( It is about this lesson and main goal is learning what they learn or not) should be minimum 10 minutes, apply test about the lesson useful. Students study the topic before come to lesson. D:\533581981.doc Final plenary 10 Listen Make summary Make a keywords Give homework and explain notebook. how they will do. It is very important for this unit because they will learn so many new Asking and answering words and terminology. Asking and answering questions questions Explaining task is very important, even giving instruction, students cannot read them. Lesson planning sheet 2 Class: 11th grade Date of lesson: Lesson title: Theoretical Genetics ( Gregor Mendel, Number in class: 20 Punnet Square Attainment range of students: Length of lesson: 80 min. D:\533581981.doc Teaching goal (conceptual understanding Behavioral (learning) objectives and strategy) Students will be able to Define genotype, phenotype, allele, define genotype, phenotype, allele, dominant, recessive, codominant allele, dominant, recessive, codominant allele, locus locus Define homozygous, heterozygous, test cross distinguish homozygous, heterozygous, test cross use Punnet Square investigate Gregor Mendel’s work distinguish allele and gene. define genotype phenotype and ratios by completing Punnet square for different characteristics of pea plant Assessment strategies Links to curriculum Homework from last lesson ( The phases of 11th MEB meiosis and key vocabulary) IB Biology Homework ( form key vocabulary and IGCSE 9,10 Biology define all unknown words and terminology) Questioning Prior teaching/learning Common misconceptions From 10th grade they are familiar these Genes contain alleles terms. Alleles contain genes Monohybrid crossing Alleles and genes are the same DNA Replication occurs in prophase D:\533581981.doc Key vocabulary Homework Allele Gregor Mendel life and his works. Codominant allele Worksheet about Punnet square and monohybrid Dominant allele ratio. Genotype Heterozygous Students with special needs and support Homozygous planned Locus Inheritance Nondisjunction Extension activities Monohybrid ratio Read an article about Mendel Phenotype Punnett Square Recessive allele Cross curricular issues Test cross Mathematic ( Monohybrid ratio, calculation ) Resources Risks and safety precautions 11th MEB Biology Text Book N/A IB SL-HL Biology Text Book Campbell Biology IGCSE 9,10 Biology Text Book http://learn.genetics.utah.edu/content/begin/t raits/karyotype/ D:\533581981.doc Time General admin 5 Student activity Teacher activity Content notes Students can look Take attendance Prepare a presentation before each other works. Setting the class to settle down. the lesson. If some of them Collect the homework and give + Collect homework and check did not find some or – to students. one by one. If you give Asking daily question for warm to homework and not check lesson. them, they will not do next of terms, they can learn each other and add their time. vocabulary part. Doing homework is useful for students to understand topic. . Lesson starter 5 Listen to teacher Ask question about previous “Who want to explain genes Ask and answer of lesson. function?” questions Answer students’ questions “Which structure is carrying “Do you have any question about genes?” D:\533581981.doc meiosis?” 15 Listen to teacher Define genetic variation and Students might recall some Take notes mutation. basic genetics, remembering Down’s syndrome that for many traits a person Explain Down syndrome and how is it occurs? receives a separate “signal” from mom and dad. These separate signals for the same Trisomy 21, shows karyotyping of Down Syndrome. 10 Make a Karyotype Answer the Lesson core Explain what nondisjunction is. chromosomes, such as the Shows healthy human karyotypes. freckle. (Teaching tips from Go to computer lab Campbell.) (Every student makes karyotype, http://learn.genetics.utah.edu and not enough computers for all /content/begin/traits/karyoty students, this activity can change pe/ cut and paste activity in Students should come to the Listen to teacher. classroom.) board and solve some During the Theoretical Genetic problems in front of the teachers’ Define genotype, phenotype, other students. It gives explanation, they dominant allele, recessive allele, opportunity to all students be can come to the codominant alleles, locus, self confidant and make board and write homozygous, heterozygous, them aware of the topic and homozygous, carrier and test cross on board and questions. heterozygous shows some example with PPT. Especially if students do not Determine the genotypes and understand topic, they can phenotypes of the offspring of a come to board and teacher monohybrid cross using a Punnett can help him/her. Take notes examples and solve one problem about test crossing. 10 portion of homologous if there is no internet connection questions 20 trait are carried on the same Answer the grid. Punnet Square Activity question and ( Attached ) complete the activity. 10 Give post test (It is about this lesson and main goal is learning what they learn from this lesson.) D:\533581981.doc Pea Plant Punnet Square 5 Listen Give homework Remind homework Final plenary Gregor Mendel’s work Asking and Make summary and finish the answering lesson. Keyword notebook questions Lesson planning sheet 3 Class: 11th grade Date of lesson: Lesson title: Study Pattern of Inheritance Number in class: 20 Attainment range of students: Length of lesson: 80 min. D:\533581981.doc Teaching goal (conceptual understanding Behavioral (learning) objectives and strategy) Students will be able to Explain how the sex chromosomes control gender by referring to the inheritance of X and Y chromosomes in humans. crosses. predict which blood type is inherited. understand how sex is determined and Explain why Mendel’s decision to inherited in humans and patterns of work with peas was a good choice. Define and distinguish between truebreeding organisms, hybrids, the P generation, the F1 generation, and determine the probability of different inheritance of sex-linked genes trace a gene as it is passed down from generation to generation. the F2 generation. Explain how family pedigrees can help determine the inheritance of many human traits. Assessment strategies Links to curriculum Homework 11th MEB Questioning IB Biology Discussion IGCSE 10 grade Prior teaching/learning Common misconceptions Students know Punnet square from previous lesson. Students know blood cells and type names. D:\533581981.doc Key vocabulary Homework Inheritance Reading textbook before come to school Homozygous Terminology notebook Heterozygous Watch video for experiment Allele http://www.youtube.com/watch?v=hOpu4iN5Bh4 Patterns Punnet square Blood Type Students with special needs and support Pedigree planned X-Y sex chromosomes Color Blindness Extension activities Autosomal chromosomes Worksheet Haemophilia Textbook Questions Cross curricular issues Resources Risks and safety precautions 11th MEB Biology Text Book N/A IB SL-HL Biology Text Book Campbell Biology IGCSE 9,10 Biology Text Book http://www.youtube.com/watch?v=hOpu4iN 5Bh4 D:\533581981.doc Time General admin 10 Lesson starter 10 Student activity Teacher activity Content notes Try to find out key Take attendance Prepare a presentation before word and answer Setting the class to settle the lesson questions down They should do problems by Listen to teacher Asking daily question for themselves. Sit in a group and warm to lesson They need to know or learn answer the questions. Check pre knowledge. monohybrid crossing. Listen to teacher Show different pedigree They need to remember Ask and answer of Describe patterns of sex-linked meaning of fertilization, questions. inheritance, noting examples in gametes and offspring. fruit flies and humans. If they do not remember, solve questions about Verbal questions and giving reminds them. pedigree. exercise on board about sex Open text books and linked. D:\533581981.doc 20 Listen to teacher Teach key words; solve Take notes problem, show family tree and sex-linked diseases. Asking questions to students one by one. Show some figures and give different kind of question. Lesson core Explain why sex-linked disorders are expressed much more frequently in 30 Try to understand and men than in women. use terminology. Verbal questions and giving Students have to read Solve the problems with exercise on board about sex textbook before come to Punnet square and linked. school. They have to know conventional pattern. all terminology meaning and Learning genetic what we will do in this diseases. lesson. Learning pedigree and family relationship. 10 Listen Summarize the lesson by Final plenary asking questions. Answer the question. Take notes Give worksheet about Pedigree as homework. board. D:\533581981.doc Homework Family Blood Type pedigree Answer of questions. Answer the question on Make a keywords notebook. Check students’ textbooks. Lesson planning sheet 4 Class: 11th grade Date of lesson: Lesson title: Genetic engineering and Number in class: biotechnology Attainment range of students: Length of lesson: 80 min. Teaching goal (conceptual understanding Behavioral (learning) objectives and strategy) Students will be able to discover ethical issues Outline the use of polymerase chain reaction surrounding the practice of genetic engineering in (PCR) to copy and amplify minute quantities reproductive medicine. of DNA. Students will be able to understand key terms and concepts related to the science of genetic State that gel electrophoresis of DNA is used in DNA profiling. engineering. Define DNA profile Outline the steps of genetic engineering. Students will be able to discuss “Is genetic (Cutting DNA, Making recombinant DNA , engineering a good or bad thing?” ( With ethical Cloning, Screening ) issues ) Assessment strategies Links to curriculum Homework ( form key vocabulary and 11th MEB define all unknown words and terminology) IB Biology Questioning IGCSE 10 grade Handout: Different Perspective on Genetic Engineering. Prior teaching/learning 10th grade DNA structure D:\533581981.doc Common misconceptions Key vocabulary Homework Bioethics Reading textbook before come to school Biotechnology Keyword notebook Deoxyribonucleic acid Research biotechnology benefit and risks for Eugenics discussion. Genetic code Genetic engineering Students with special needs and support PCR planned Cloning Extension activities Worksheet Textbook Questions Cross curricular issues Resources Risks and safety precautions 11th MEB Biology Text Book N/A IB SL-HL Biology Text Book Campbell Biology IGCSE 9,10 Biology Text Book http://www.mcw.edu/bioethicsandmedhuma nities.htm D:\533581981.doc Time General admin 10 Student activity Teacher activity Content notes Try to find out key Take attendance Student should read textbook word and answer Setting the class to settle before come to school. questions down Listen to teacher Asking daily question for Sit in a group and warm to lesson answer the questions. Check pre knowledge. Explain the topic of genetic engineering and asking questions Lesson starter 10 Listen to teacher Discussion about the topic Ask and answer of and ask questions about questions. genetic engineering. Open text books D:\533581981.doc 20 Listen to teacher The steps of genetic If students have Take notes engineering. misconception try to fix 1. Cutting DNA them and teach right way. 2. Making recombinant DNA 3. Cloning 4. Screening http://www.biotechnologyonline. State that gel electrophoresis gov.au/popups/int_dnaprofiling. of DNA is used in DNA 20 html profiling. Find the suspect from internet site. Shows DNA profiling game. Give information about Lesson core bioinformatics. Outline a technique for cloning using differentiated animal cells They had to read before come to school and this lesson. They had to know all terminology meaning and what we will do in this lesson. Asking questions to students one by one. Listen to discussion and ask different questions. 10 Discussion about genetic engineering. Do you worry about eating GM (genetically modified) food? D:\533581981.doc They prepare some documents for discussion. Final plenary 10 Listen Answer the question. Summarize the lesson by Take notes asking questions. Answer of questions. Answer the question on Give worksheet board. Check textbook Check students’ textbooks. questions. Lesson planning sheet 5 Class: 11th grade Date of lesson: Lesson title: The Human Genome Project Number in class: 20 Cloning Attainment range of students: Length of lesson: 80 min. Teaching goal (conceptual understanding Behavioral (learning) objectives and strategy) Explain Human Genome Project and goals Outline outcomes of the sequencing of the complete human genome. Discuss the ethical issues of therapeutic Students will be able to define DNA profile explain cloning understand function of gel electrophoresis investigate cutting, copying and pasting cloning in humans. genes D:\533581981.doc Assessment strategies Links to curriculum Homework from last lesson about discussion 11th MEB Homework ( form key vocabulary and IB Biology define all unknown words and terminology) IGCSE 9,10 Biology Questioning Handout Prior teaching/learning Common misconceptions From previous lesson and mid school Cloning and copying Dolly’s cloning procedure Key vocabulary Homework Cloning Dolly DNA profile Read article about Human Genome Project Electrophoresis Ligase Students with special needs and support Clone planned Therapeutic cloning PCR Extension activities Human Genome Read article about Human Genome Project Gene Transfer Transgenic Plants Resources 11th MEB Biology Text Book IB SL-HL Biology Text Book Campbell Biology IGCSE 9,10 Biology Text Book http://www.genome.gov/10001772 D:\533581981.doc Cross curricular issues Risks and safety precautions Time General admin 10 Teacher activity Content notes Try to find out key Take attendance Prepare a presentation before word and answer Setting the class to settle the lesson questions down . Asking daily question for warm to lesson 10 Lesson starter Student activity Listen to teacher Check homework Ask and answer of Ask questions about DNA questions and DNA Profile D:\533581981.doc Answer students’ questions Try to find misconceptions. 20 Listen to teacher Exploring DNA Take notes The Human Genome Project Outline outcomes of the sequencing of the complete human genome. Discuss the ethical issues of Lesson core therapeutic cloning in 30 Discussion about humans. cloning human with ethical issues. Ask questions Give time them to write and draw Give post test ( It is about this lesson and main goal is learning what they learn or not) 10 Listen Make summary Remind homework Final plenary Give homework Asking and answering Asking and answering Next week students have questions questions exams about first 5 lessons. Lesson planning sheet 6 Class: 11th grade D:\533581981.doc Date of lesson: Lesson title: Genetic II- Mendel’s Law Number in class: Attainment range of students: Length of lesson: 80 min. Teaching goal (conceptual understanding Behavioral (learning) objectives and strategy) Students will be able to 1. Define linkage group. apply and define the Law of Segregation. identify that meiosis reduces the 2. Illustrate Mendel’s Laws: Law of Dominance, Law of Segregation, and chromosome number by half produces sex cells Law of Independent Assortment 3. Use Punnett squares to solve basic chromosomes) 4. Identify and explain Mendel’s Laws identify that meiosis is a process that undergoes 2 divisions Law of Segregation, and Law of Independent Assortment define diploid (complete set of homologous chromosomes) and haploid (half set of problems in genetics. of Genetics: Law of Dominance, identify that meiosis is the process that apply and define genetic terminology. Assessment strategies Links to curriculum Homework 11th MEB Questioning IB Biology Handout IGCSE 10 grade Prior teaching/learning Common misconceptions Students should know the characteristics of a cell. Students should understand DNA and the Central Dogma of Molecular Biology (DNA – RNA – Protein) 1. Students are often confused about how the autosomes work in DNA. 2. Students do not understand the relationship between linage and genes or traits. 3. Students are often confused about Students should understand chromosome migration during cell chromosome structure. division. Students should understand mitosis D:\533581981.doc 4. Students often cannot tell the difference Students should understand the human between homologous chromosome pairs reproductive system and be able to and sister chromatid pairs. understand the question- How do we reproduce? 5. Students do not realize each parent contributes an equal number of chromosomes to their offspring. 6. Students often cannot tell the difference between Mendel’s Law of Segregation and Mendel’s Law of Independent Assortment. Key vocabulary Homework Prophase Reading textbook before come to school Metaphase Keyword notebook Anaphase Example of dihybrid cross Telophase Crossing Over Gametes Mendel’s law Students with special needs and support Independent assortment planned Gene linkage Dihybrid crosses Extension activities Autosomes and sex chromosomes Worksheet Polygenic inheritance Textbook Questions Cross curricular issues Resources 11th MEB Biology Text Book IB SL-HL Biology Text Book Campbell Biology IGCSE 9,10 Biology Text Book D:\533581981.doc Risks and safety precautions Time Teacher activity Content notes Listen to teacher Take attendance Prepare a presentation before Sit in a group and Setting the class to settle the lesson answer the questions. down They should solve problems Asking daily question for by themselves. warm to lesson They need to learn dihybrid Check pre knowledge. crossing. Show a picture of a Teacher can relate this to mother/father and child – Down Syndrome, Klinefelter identify traits of the child Syndrome, or Turner that are common to mother Syndrome General admin 10 Student activity and common to father (cartoon picture) Lesson starter 10 Listen to teacher Discussion about the topic They need to remember Ask and answer of and ask questions about meaning of fertilization, questions. Pedigree and Punnet Square. gametes and offspring. Open text books Verbal questions and giving D:\533581981.doc exercise on board about sex linked. 20 Listen to teacher Take notes Calculate and predict the genotypic and phenotypic ratio of Identify the process of offspring of dihybrid chromosome reduction crosses involving in the production of unlinked autosomal sperm and egg cells genes. during meiosis They had to read before 30 Lesson core Mendel’s law of come to school and this independent lesson. They had to know all assortment. terminology meaning and Dihybrid crosses and what we will do in this gene linkage. lesson. Autosomes and chromosomes. Try to understand and use terminology. Linkage group Solve the problems with Linked genes Punnet square and Offspring of a conventional pattern. Learn genetic diseases. Genetic variety in gametes. D:\533581981.doc dihybrid cross Polygenic inheritance Final plenary 10 Listen Answer the question. Summarize all lesson by Take notes asking questions. Answer of questions. Answer the question on Give worksheet board. Check textbook questions. D:\533581981.doc Check students’ textbooks. Make a keywords notebook.