CURRICULUM VITAE August 28, 2015 Merab Lomia, M.D., Ph.D. Address: 1, Field House Close, Ascot, SL5 9LT, Berkshire, UK Citizenship: 1) United Kingdom 2) Georgia Phone: +44751 6906500 Email: lomiamer@yahoo.com Website: www.asthma.ge Summary: 2 patents in the field of drug development, 29 years of experience in clinical and experimental medicine and neurology, 17 years of experience in pharmacovigilance, 17 years of experience in clinical trials Education: 01.08.1979 – 01.08.1985: Medical Doctor’s Degree, Tbilisi State Medical University, Faculty of Internal Medicine 01.08.1985 – 31.08.1986: Specialty training in Neurology, Department of Neurological Diseases, Central University Hospital, Tbilisi, Georgia 01.11.1988 – 01.11.1991: Postgraduate Doctoral Study, Tbilisi State Medical University, and Beritashvili Institute of Physiology 24.09.1993 – PhD Degree Career and professional experience: 03.05.2011 – till now: Drug Safety Physician, Medical Reviewer, Eli Lilly Erl Wood Centre, Windlesham, Surrey, UK Providing medical technical expertise in evaluation of individual adverse events; supporting the case management staff in ensuring appropriate follow-up; reviewing assessments of listedness based on global and specific requirements and being accountable for the medical assessment of the information within the case report; training and mentorship to Global Patient Safety case managers with respect to the medical aspects of the management, pharmacovigilance expertise through surveillance teams meetings, discussion and training programs; safety related training programs and presentations. Creation and implementation of Multi-tab Access Program for proper listedness evaluation of Lilly and non-Lilly products and for fast access to other frequently used websites, documents and programs. 04.05.2010 – 20.03.2011: Senior Clinical Safety Associate, ICON, Eastleigh, UK Document and process Serious Adverse Event Reports, spontaneously reported adverse events, and other medically related information per study specific procedures, provide input and review relevant safety tracking systems, perform safety review of clinical data (case report forms) and patient labs, completion of quality control feedbacks forms, attend sponsor and project team meetings and teleconferences. Clinical and postmarketing studies experience. 05.06.2008 – 19.02.2010: Clinical Safety Associate, Novartis Horsham Research Centre, Horsham, UK. Responsible for the accurate data entry of Serious Adverse Events /Post Marketing Events and the evaluation on non-expeditable reports within agreed timeframes, in compliance with IMS business rules, standard operating procedures and regulatory requirements. 23.12. 2004 – 15.10.2007: Senior Medical Advisor, Pharmacovigilance Dept., Georgian Drug Agency, Tbilisi, Georgia. Responsible for the risk management and risk minimization plans, monitoring of spontaneous adverse events registration system, medical and scientific review, analyzing and interpretation of AE reports and aggregate 1 data reviews. Registration, medical review and analyzing of positive side effects of drugs. Coordination of SAE activities for assigned projects. See also ‘Pharmacovigilance experience’ on page 3. 10.11.1998 – 13.10.2007 (part-time): Medical Advisor, Chief Neurologist, “Rea” Medical Rehabilitation Centre for Chronic Disorders, Tbilisi, Georgia. Implementation and monitoring of new methods of pharmacotherapy of neurological and neurogenic disorders. Pharmacotherapy of bronchial asthma as neurogenic inflammatory disorder. PI, clinical trials (see ‘Clinical trials’ on page 3). Daily clinical work with patients, clinical rounds and consultations. 08.01.1997 – 22.12.2004 (till 12 October 1998 – part-time): Pharmacovigilance Specialist, National Drug Monitoring Center of Pharmacovigilance, Tbilisi, Georgia. Implementation and monitoring of spontaneous adverse events registration system, medical and scientific review, analyzing and interpretation of AE reports, training of physicians and nurses concerning adverse event reporting. See also ‘Pharmacovigilance experience’ on page 3. 02.10.1993 – 12.10.1998 - Research Scientist Doctor and Lecturer, Neurological Department, Scientific Research Institute of Pediatrics, Tbilisi, Georgia. Clinical research studies in child neurology. EEG-computer topography (brain-mapping) and clinical observational study of antagonists of opiate analgetics for therapy of tics, Tourette syndrome and nocturnal enuresis. Daily and on-duty clinical work with in- and out-patients. Taught post-graduate courses for registrars and fellow physicians in neuropharmacology. 01.12.1991 – 01.10.1993 – Senior Medical Investigator, Neurological Department, Scientific Research Institute of Pediatrics, Tbilisi, Georgia. EEG-computer topography (brain-mapping), in children with neurological disorders. Daily and on-duty clinical work with in- and out-patients. 01.11.1988 – 01.12.1991 – Postgraduate Doctoral Study (Doctoral fellowship), jointly in Neurological Department, Tbilisi State Medical University, and in Department of Metabolic Maintenance of the Brain Functions, I. Beritashvili Institute of Physiology, Georgian Academy of Sciences, Tbilisi, Georgia. Study title: Experimental use of fluorochemical “artificial blood” in therapy of various experimental models of acute cerebral ischemia. Models of brain ischemia in rabbits and rats. 31.08.1986 – 01.11.1988 - Neurologist, Senaki district Mendzhi State Hospital, Georgia. Medical practice of wide range of out-patients with neurological disorders. Treatment of neurological patients. Neurological consultations for non-neurological patients. Daily and on-duty clinical work. 01.08.1985 – 31.08.1986 – Specialty training in Neurology, Department of Neurological Diseases, Central University Hospital, Tbilisi, Georgia. Patents: In the field of drug development: 1) EU, USA (application): WO 0066096, New Indication for Use of Antiepileptic Agents and Medicines. http://www.wipo.int/pctdb/en/wo.jsp?wo=2000066096 2) Georgia: P 2487, New indication for 5-carbamoyl-5H-dibenz(b,f)azepine, its derivatives and analogues P 2612, New indication for use of antiepileptic agents and medicines Awards: Silver Sponsorship from European Respiratory Society (ERS) for the attendance at the European Respiratory Society Annual Congress, 2006, Copenhagen, Denmark Silver Sponsorship from ERS for the attendance at the European Respiratory Society Annual Congress, 2005, Glasgow, UK Award from the Soros Foundation for the participation in the Salzburg-Cornell Seminar in Neurology, Salzburg, Austria, 1996, and for the Internship, C. Doppler Landesnervenklinik, Salzburg, Austria, 1999. Knowledge of languages: Fluent in Georgian, English, Russian 2 IELTS (Academic level): Overall Band Score: 7. Listening: 7, Reading: 7, Writing: 6, Speaking: 7. Test Report Form No: 06GE000097LOMM001A Teaching and lecturing experience: 1997-2007: Lectures in pharmacovigilance for registrar physicians and pharmacists. Training of physicians in hospitals and out-patients clinics (adverse events (AE) forms completion, etc). 1995-2007: Taught post-graduate courses for resident physicians, fellow physicians and nurses, during the Georgian Diabetic Camp Summer sessions, Bakuriani, Georgia (Neurological complications of diabetes, type1). 1993 – 1998: Taught Post-graduate courses for resident physicians, fellow physicians and nurses, Scientific Research Institute of Pediatrics, Tbilisi, Georgia (Pharmacotherapeutic aspects of child neurology) 1989 – 1991: Seminars in neurology for medical students, Tbilisi State Medical Institute/University Scientific Consultant of Doctoral Fellow (PhD Student): 1997 - 1999- Manana Pruidze, Beritashvili Institute of Physiology, Title of doctoral dissertation: “EEGactivity in adult patients with bronchial asthma” (1999). Reviewer of medical journals: Respiratory Medicine, http://www.sciencedirect.com/science/journal/09546111 The Journal of Neurology, Neurosurgery, and Psychiatry, http://jnnp.bmj.com Pharmacovigilance experience: - - risk assessment risk management, risk minimization plans, medical input into PSURs and other periodic reports, ICRs and aggregate data review medical and scientific expertise for regulatory documents coordination of AE and SAE activities for assigned projects adhering to current regulations and FDA, EMEA and ICH guidelines relating to ADR monitoring AE and ADR reporting plans for National Drug Monitoring Center of Pharmacovigilance and Georgian Drug Agency management of case-handling process, medical and scientific analysis and review of AE reports AE forms in hospitals and out-patients stations: instructions for the completion (CIOMS Form, etc.) medical review of AE and SAE information received from research sites preparing and submitting of expedited safety reports to pharmaceutical companies, ethic committees and national regulatory authority (till 2004 - Pharmacological Committee of Georgia, Ministry of Health) SUSAR and annual reporting review for clinical trials consulting of healthcare system authorities in pharmacovigilance training of physicians and nurses concerning adverse event reporting management of data entry into safety database, ARGUS, ARIS Global generation of queries to sites for follow-up information for Georgian Drug Agency presentations of AE reporting at hospital and pharmaceutical company meetings Standard Operational Procedures (SOP) for Georgian Drug Agency review of pharmacovigilance publications and information sources to keep updated on current regulations Therapeutic Area/Lab Experience: Oncology - Phase III, IV, multi country Diabetes - Phase III, IV, multi country Bronchial Asthma, COPD - Phase III, IV, multi country Endocrinology - Phase III, IV, multi country Neurology - Phase III, IV, multi country Cardiology - Phase III, IV, multi country Psychiatry - Phase III, IV, multi country Transplantology - Phase III, IV, multi country Urology - Phase III, IV, multi country Infections - Phase III, IV, multi country Viral Hepatitis - Phase III, IV, multi country 3 Clinical trials: Links to registered clinical trials: http://www.clinicaltrials.gov/ct/search?term=Lomia&submit=Search Research experience: Until 2007 I worked with Z. Chapichadze, MD, PhD (Drug Agency, Ministry of Health, Tbilisi, Georgia), M. Pruidze, MD, PhD (Centre of Chinese Medicine, Tbilisi, Georgia), and T. Tchelidze, MD (CRO “Evidence”, Tbilisi, Georgia), and other members of the scientific group “Neuroasthma” (www.asthma.ge/neuroasthma.htm). In 1993 we found that in patients with trigeminal neuralgia and bronchial asthma, carbamazepine and valproates reduced the severity of asthma symptoms. Since 1994 we performed observational clinical studies and double-blind placebo-controlled randomized trials concerning use of antiasthmatic drugs for treatment of bronchial asthma. Our trials showed high antiasthmatic activity of antiepileptic drugs in adults and in children with asthma. In collaboration with Prof. V. Maloletnev, MD, PhD (Department of Human Psychophysiology, Beritashvili Institute of Physiology, Tbilisi, Georgia), we also investigated the frequency of EEG and neurological signs in patients with asthma, and frequency of breath-holding spells in anamnesis of children with asthma. In experimental studies we investigated the influence of antiepileptic drugs on Herxheimer microshock and anaphylactic shock in Guinea pigs. We received the silver sponsorship for presenting of our data in ERS Congresses from European Respiratory Society in 2004 and 2005. Since 2004 I worked in Georgian Drug Agency as Pharmacovigilance Senior Consultant. In 1997 – 2004 I worked as Senior Specialist in National Drug Monitoring Center of Pharmacovigilance, Tbilisi, Georgia, in collaboration of Dr. Zaza Chapichadze, MD, PhD, and Prof. Nicholas Gongadze, MD, PhD. Refer to previous section “Pharmacovigilance Experience”. In 1998 - 1999 I worked in scientific cooperation with Prof. Sh. Bibileishvili, MD, PhD (Sarajishvili Institute of Experimental and Clinical Neurology, Tbilisi, Georgia), and investigated the epidemiology, clinical signs and the outcome in patients with ischemic stroke and sleep apnea. In 1995 - 1997 in collaboration with Prof. N. Mitagvaria, PhD (Dept. of Metabolic Maintenance of the Brain Functions, Beritashvili Institute of Physiology, Tbilisi, Georgia), I examined the surface tension of blood during cerebral ischemia and discovered that blood surface tension was increased in patients with ischemic stroke. In 1994 - 1995 I worked in scientific collaboration with K. Gambashidze, MD, PhD (Department of Pathophysiology, Tbilisi State Medical University), and researched rheological properties of blood, including surface tension of blood, in rats with Walker carcinoma and in mice with Erlich carcinoma. We also investigated the influence of non-ionogenic surfactants on blood rheology and on survivability of experimental animals. In 1993 - 1998 I worked in the Scientific Research Institute of Pediatrics (Tbilisi, Georgia) and researched EEG-computer topography (brain-mapping) in children with tic hyperkinesia, Tourette syndrome and nocturnal enuresis. We also use antagonists of opiate analgetics for therapy of tics, Tourette syndrome and nocturnal enuresis, and performed observational studies in this direction. We established that naloxone can reduce frequency and intensity of tics, and also can reduce the frequency of episodes of night enuresis. We also found that EEG disturbances in these children are frequent, but non-specific. 1988 - 1993: My PhD thesis was related to experimental use of fluorochemical “artificial blood” in therapy of experimental models of acute cerebral ishemia. Experimental studies were performed under supervision of Prof. N. Mitagvaria, PhD (Department of Metabolic Maintenance of the Brain Functions, Beritashvili Institute of Physiology, Tbilisi, Georgia), resulting in the possibility of clinical implementation of these findings under supervision of Prof. A. Lachkepiani, MD, PhD (Neurological Dept, Tbilisi State Medical Institute/University). We studied several models of ishemia in rabbits and rats and found that fluorochemical blood substitutes improved rheological properties of blood, microcirculation and brain supply with oxygen during brain ischemia. We supposed that it was possible to use fluorochemical blood substitutes in wide range of urgent clinical conditions, in which mechanisms cerebral ischemia plays important role. We 4 were unable to continue these studies due to the collapse of the Soviet Union and, therefore, to the loss of supply of necessary materials. Computer skills: SPSS for Windows (statistical program), MS Word, Excel, PowerPoint, Adobe Photoshop, web-design (www.asthma.ge ) Oral presentations at the international meetings: 15th Congress of European Respiratory Society, Copenhagen, Denmark, 2005: see www.asthma.ge/trileptal.ppt , or http://www.erseducation.org/pages/default.aspx?id=335&idBrowse=13598&det=1 List of publications: Book: Children with Disabilities: Educational, Psychological and Medical Aspects of Social Integration (in Georgian, with co-authors). Tbilisi, 2002, 290p. Dissertation: “Experimental use of perfluorochemical gas-carrying blood substitute during acute brain ischemia” (in Georgian, Eng. abstr). Tbilisi, 1993, 254p. See # 25 in: http://www.nplg.gov.ge/ec/en/dis/catalog.html?pft=biblio&from=21&rnum=10&udc=616.8 Articles in peer-review and international journals: Lomia M. Bronchial asthma as neurogenic paroxysmal inflammatory disease: Do some antiepileptic drugs have antiasthmatic properties? Medical Hypotheses, 2007, vol. 69, no. 4, pp. 858 – 859. http://www.medicalhypotheses.com/article/PIIS0306987707001454/abstract , or doi:10.1016/j.mehy.2007.02.004 Lomia M, Tchelidze T, Pruidze M. Bronchial asthma as neurogenic paroxysmal inflammatory disease: a randomized trial with carbamazepine. Respir Med, 2006, vol.100, no.11, pp. 1988-1996. http://www.resmedjournal.com/article/PIIS095461110600103X/abstract , or doi:10.1016/j.rmed.2006.02.018 Lomia M, Chapichadze Z, Pruidze M, Platonov P. Efficacy of monotherapy with carbamazepine and valproic acid in patients with bronchial asthma: Is asthma a neurological disease? The Internet Journal of Neurology, 2005, v.4, #1. http://ispub.com/IJN/4/1/6172 Articles in Georgian and Russian journals: Chapichadze Z, Chelidze T, Lomia M. affective respiratory paroxysms in the anamnesis of children with bronchial asthma (Eng. abstr.)[ in Russian]. Allergology and Immunology, vol. 7, № 5, 2006, pp. 610-611. Lomia M. Effects of antiepileptic drugs on anaphylactic shock and on Herxheimer microshock in Guinea pigs. Bull. Georg. Acad. Sci., 2006, vol.173, №3, pp. 605-607. http://www.science.org.ge/moambe/173_3/Summuru_173-3.htm (Then find “Lomia”) Lomia M, Ratiani R, Chelidze T. Severe persistent bronchial asthma: high efficacy of carbamazepine. Bull. Georg. Acad. Sci, 172, №2, 2005. http://www.science.org.ge/moambe/New/pub15/172_2/172_2.htm#Lomia, (Then find “Lomia”) Lomia M. Bronchial asthma as neurogenic paroxysmal disease: high antiasthmatic efficacy of carbamazepine in double-blind placebo-controlled trial. Bull. Georg. Acad. Sci, 169, №2, 2004. http://www.science.org.ge/moambe/New/pub15/169_2/169_2.html (Then find “Lomia”) Lomia M. EEG and neurological symptoms, learning disability and AD/HD in children with bronchial asthma. Journal of Education and Rehabilitation for Children with Disabilities. 2002, no.1 (1), pp. 37-40. Lomia M, Pruidze M. Correlation of EEG and clinical signs in patients with bronchial asthma. Messenger Georg. Acad. Sci (Biol), 2000, 26 (4-6): 411-415. Lomia M. EEG and neurological symptoms in adult patients with bronchial asthma. In: 2nd Convention of Georgian Physiologists. Proceedings. Tbilisi, 2000, pp. 98-100. Lomia M, Pruidze M, Kharatishvili I. Frequency of neurological symptoms and pathological reflexes in bronchial asthma and their correlation with severity of disease. Georgian Medical News, 1997, no.11 (32), pp.27-29. 5 Pruidze M, Lomia M, Kharatishvili I. Neurological symptoms in adults with bronchial asthma (Eng. abstr.) [in Georgian]. Sakartvelos Sameditsino Moambe [Georgian Medical Messenger], 1997, no. 4, pp.23-26. Lomia M, Pruidze M, Kharatishvili I. Neurological and EEG-computer topographic studies in adults with bronchial asthma. Georgian Medical News, 1997, no.10 (31), pp.29-31. Lomia M, Pruidze M, Kharatishvili I. Neurological symptoms and reflexes in children with bronchial asthmatic attacks. Georgian Medical News, 1997, no. 6 (27), pp.34-35. Lomia M, Daraselia M. The frequency of pediatric neurological pathology in Republic of Georgia [in Georgian] (Eng. abstr., Rus. abstr.) Sakartvelos Sameditsino moambe [Georgian Medical Messenger], 1996, no.3-4, pp. 67-70. Lomia M, Mamisashvili V, Mchedlishvili N, Kumsishvili T. Influence of "artificial blood" on brain tissue metabolic supply and basic microcirculatory mechanisms [in Georgian] (Eng. abstr., Rus. abstr). Sakartvelos Pediatri [Pediatrist of Georgia], 1992, no.2, pp. 10-15. Lomia M. The influence of fluorocarbon gas-carrying "artificial blood" on brain tissue pO2 in normal conditions and during ischemia [in Georgian] (Eng. abstr., Rus abstr). Bull. Georg. Acad. Sci, 1991, vol. 141, no.2, pp.413-416. Lomia M, Cheishvili M. Use of oxygen-carrying "artificial blood" during brain ischemia (review) [in Georgian]. Sakartvelos Sameditsino Moambe [Georgian Medical Messenger], 1991, no.5-6, pp.32-35. Abstracts of international conferences: Lomia M, Pruidze M, Chapichadze Z, T. Tchelidze T. Bronchial asthma as neurogenic inflammatory and paroxysmal disease – efficacy of antiepileptic drug diphenine in asthma therapy. Abstracts of 16th Congress of European Respiratory Society, Minich, Germany, 2006. Eur Respir J 2006; 28: Suppl. 50, 316s. http://lrp.ersnet.org//abstract_print_06/files/152.pdf Lomia M, Tchelidze T, Pruidze M. Efficacy of antiepileptic drugs diphenine and carbamazepine in pharmacotherapy of children with bronchial asthma: is asthma a neurogenic inflammatory disease? Abstracts of 16th Congress of European Respiratory Society, Minich, Germany, 2006. Eur Respir J 2006; 28: Suppl. 50, 204s. http://lrp.ersnet.org//abstract_print_06/files/107.pdf Lomia M, Pruidze M, Chapichadze Z. Bronchial asthma as neurogenic paroxysmal inflammatory disease high efficacy of antiepileptic drug oxcarbazepine in asthma monotherapy. Abstracts of 15th Congress of European Respiratory Society, Copenhagen, Denmark, 2005. Eur Respir J 2005; 26: Suppl. 49, 466s. http://www.ers-education.org/events/international-congress/copenhagen-2005.aspx?idParent=13591 Lomia M, Pruidze M, Chapichadze Z. Bronchial asthma as neurogenic paroxysmal disease - high effectiveness of carbamazepine in asthma monotherapy. Abstracts of 14th Congress of European Respiratory Society, Glasgow, UK, 2004. Eur. Respir. J, 2004, vol. 24, suppl. 48, 221s. http://www.erseducation.org/events/international-congress/glasgow-2004.aspx?idParent=16821 Lomia M, Pruidze M, Chapichadze Z. Efficacy of monotherapy with anticonvulsive drugs topiramate and carbamazepine in bronchial asthma: is asthma a neurological disease? Abstracts of 14th Congress of European Respiratory Society, Glasgow, UK, 2004. Eur. Respir. J, 2004, vol. 24, suppl. 48, 130s. http://www.ers-education.org/events/international-congress/glasgow-2004.aspx?idParent=16270 Bibileishvili E, Lomia M, Bibileishvili Sh. Sleep apnea and ischemic stroke. Abstracts of the 10th European Stroke Conference. Lisbon, Portugal, May 16-19, 2001. Cerebrovasc Dis. 2001; 11 Suppl 4: 93. http://www.archive.eurostroke.org/Lisbon/Li%20risk_etiology.asp (then find “Lomia”) Bibileishvili E, Lomia M, Bibileishvili Sh. Sleep apnea as a riskfactor in the development of ischemic stroke. 11th meeting of the European Neurological Society. 21-25 April, 2001, Paris, France. Abstracts. J Neurol. 2001, 248. Suppl 2: 126. http://www.blackwell-synergy.com/doi/abs/10.1111/j.14681331.2004.00920.x?journalCode=ene Shota Bibileishvili, Merab Lomia, Shota Bibileishvili. Desynchronosis of hemocoagulation an the localization of the pathological focus in patients with ischemic stroke. Abstracts From the 6th International 6 Symposium on ASTT. Stroke 2000;31;2890. http://stroke.ahajournals.org/cgi/reprint/31/11/2881.pdf (then find “Lomia”) Eteri Bibileishvili, Merab Lomia, Eteri Bibileishvili. Relationship between a biorhythm hemostasis chance and the character of vascular pathology in case of ischemic stroke. Abstracts From the 4th World Stroke Congress. Stroke 2000;31;2801. http://stroke.ahajournals.org/cgi/reprint/31/11/2768.pdf (then find “Lomia”) Lomia M, Pruidze M, Kharatishvili I. EEG-computer topography in adult patients with bronchial asthma. In: Materials of Black Sea Countries 2nd International Conference “Advances of Clinical and Theoretical Medicine and Biology.” Trabzon, Turkey, 2000. Lomia M, Kharatishvili I. Effectiveness of naloxone in the treatment of nocturnal enuresis in children. Proceedings of 4th EFNS Congress, Lisbon, Portugal, 07-11 September 1999. European Journal of Neurology 1999, vol.6, suppl.3, p. 44. Lomia M, Daraselia M. Metoclopramide and naloxone in treatment of tics. Posters of 5th International Congress of Parkinson’s Disease and Movement Disorders, NY, October 14-18, 1998. Movement Disorders, 1998, vol.13, suppl. 2, p. 203. Kharatishvili I, Lomia M, Pruidze M. Frequency of neurological signs in adults with bronchial asthma. Abstracts of “Interasma’97”, Annual Meeting Western Europe Chapter, Las Palmas, Canary Island, Spain, December 3-5, 1997. Journal of Investigational Allergology and Clinical Immunology, 1997, no.5, p.543 Lomia M, Kharatishvili I, Pruidze M. Lack of correlation between frequency of neurological symptoms and severity of bronchial asthma. Abstracts of “Interasma’97”, Annual Meeting Western Europe Chapter, Las Palmas, Canary Island, Spain, December 3-5, 1997. Journal of Investigational Allergology and Clinical Immunology, 1997, no.5, p.543 Lomia M. Increase of blood surface tension during acute ischemic stroke. Proceedings of EFNS Prague Meeting, June 4-8, 1997. European Journal of Neurology, 1997, vol 4, suppl 1, p. S102. Lomia M. Effectiveness of metoclopramide in treatment of tic hyperkinesia in children. Proceedings of EFNS Prague Meeting, June 4-8, 1997. European Journal of Neurology, 1997, vol 4, suppl 1, p. S101-S102. Lomia M, Mitagvaria N. Experimental use of perfluorochemical gas-carrying blood substitute during brain ischemia. Proceedings of EFNS Prague Meeting, June 4-8, 1997. European Journal of Neurology, 1997, vol 4, suppl 1, p.S101 Lomia M, Kharatishvili I. EEG computer topography in children with tic hyperkinesia. In: The 4th International Conference of Baltic Child Neurology Association (BCNA), Tartu, Estonia, May 25-28, 1997: programme and abstracts. Tartu, 1997. p 59. Lomia M.B. Effectiveness of opioid antagonists in the treatment of tic hyperkinesia and nocturnal enuresis in children. Abstracts of symposia and free communications. 5th Meeting of ENS, 17-21 June, 1995, Munich, Germany. Journal of Neurology, 1995, vol. 242, no.6, suppl.2, p. S61. www.springerlink.com/index/Y35L117687712T12.pdf Abstracts of Georgian conferences: Lomia M, Chapichadze Z, Tchelidze T, Pruidze M. High efficacy of antiepileptic drug carbamazepine in pharmacotherapy of bronchial asthma: Is bronchial asthma a neurogenic inflammatory disease? Abstracts of 1st International Congress of the Georgian Respiratory Association. Tbilisi, Georgia, May 31-June 2, 2007. Georgian Respiratory Journal, 2007, 3: Suppl. 1, p. 99 Lomia M. Some features and problems of adequate neurological assistance for contingent of disable children [in Georgian]. In: Inclusive and Special Education Problems in National Program of EFA of Georgia. Materials of National Seminar, 25-29 November, Tbilisi 2002, pp. 46-49. UNESCO, Tbilisi, 2003. Pruidze M, Lomia M, Mandzhgaladze N. Disturbances of brain bioelectric activity in patients with bronchial asthma and their correlation with other asthmatic clinical symptoms [in Georgian]. In: Actual problems of medicine. Materials of Conference, dedicated to memory of Simeon Kipshidze. Tbilisi 1997, pp. 35-38 7 Lomia M, Mandzhgaladze N, Pruidze M. Neurological investigations in children with bronchial asthma [in Georgian]. In: Actual problems of medicine. Materials of Conference, dedicated to memory of Simeon Kipshidze. Tbilisi, 1997, pp. 25-27 Lomia M. Experimental use of oxygen-carrying fluorocarbon blood substitute during brain ischemia, provoked by head trauma [in Georgian]. In: Actual problems of military medicine. Materials of scientific conference. Tbilisi, 1995, pp.114. Lomia M.B. Influence of non-ionogenic surfactant "Proxanol P-268" on CBF and arterial pressure in normal rats and in animals with acute brain ischemia [in Georgian]. In: Actual problems of military medicine. Materials of scientific conference. Tbilisi, 1995, pp.25-27. Gambashidze K, Lomia M, Khutsishvili G, Tsibadze A. Change of mechanical resistance of red blood cells in rats during implanted Walker carcinoma after treatment by non-ionogenic surfactant "Proxanol P-268” and alpha-tocoferol. In: Materials of Georgian Physiologists Conference, dedicated to 60th anniversary of Georgian Physiological Society Foundation. Tbilisi, 1995, p.178. Lomia M, Gambashidze K. Surface tension of blood and red blood cells' deformability in mice during growth of implanted Erlich carcinoma. In: Materials of Georgian Physiologists Conference, dedicated to 60th anniversary of Georgian Physiological Society Foundation. Tbilisi, 1995, p.93. Lomia M.B. The influence of pyrogenicity of gas-carrying perfluorochemical blood substitute on oxygen supply of brain tissue (Eng. abstr.) [in Georgian]. In: Actual Problems of Pediatrics. Issue of articles, dedicated to 30th Anniversary of Georgian Pediatric Institutes Foundation. Tbilisi, 1991, pp.254-259. Samushia O.S, Lomia M.B. Modern aspects of therapy of brain ischemia (Eng. abstr.). Proc. of 21st Scientific Conference of Young Physicians. Telavi, 1991, pp.96-97. Lomia M.B. Use of gas-carrying fluorocarbon "artificial blood” during cerebral ischemia and other vascular diseases (Eng. abstr.). Proc. of 21st Scientific Conference of Young Physicians. Telavi, 1991, pp.96-97. Lomia M.B. Use of fluorochemical "artificial blood” for the treatment of brain ischemia (Eng. abstr.). Proc. of 20th Republican Scientific Conference of Young Physicians. Bakuriani, Tbilisi, 1991, pp.96-97. Lomia M.B. Copper concentration in blood during infantile cerebral paralysis [in Russian]. In: Proc. of 47th Conf. of Tbilisi State Medical Institute I.Takaishvili Medical Society. Tbilisi, 1984, pp.97-98. You can find additional information and links to my published papers and Internet scientific publications on my website: www.asthma.ge 8