Drug Transport & Drug Delivery Systems, SDU (5ECTS), fall 2015 recommended reading draft
last updated july 8th 2015
Topic
Preformulation &
Solid state
Teacher
Annette BauerBrandl
Keywords
Acid base properties, solubility,
solvation, salt selection; partitioning
and distribution revisited;
Recommended reading
Solid state
Polymorphism, amorphous state,
crystal energy, solid state-limited
solubility, crystal engineering,
industrial crystallization;
Recommended basic knowledge (for repetition!)
Aulton’s pharmaceutics. The design and
manufacture of medicines 4th Edition. Churchill
Livingstone/Elsevier, 2013,
chapter 2: pp 126-134
chapter 20: pp 314-324
chapter 23: pp 382-390
Steffansen et al. (eds), Molecular
Biopharmaceutics. Pharmaceutical Press 2009.
Chapters 2.1 and 2.5
Lecture notes
Chemical
structure and
bioavailability
properties of drug
candidates
Elisabeth
Christiansen
Predicting the absorption of new
structures (Lipinski´s rule of 5); in silico
methods; chemical strategies to
improve absorption (bio-isosteric
replacement, prodrugs);
Drug-like properties. Edward H. Kerns and Li Di.
Elsevier, 2008 (e-book available at SDU-library)
Chapter 5: pp 43-47
Chapter 8.3: pp 92-98
Lecture notes
Topic
Skin as biological
barrier
Transdermal
delivery
Teacher
Judith Kuntsche
Keywords
Models to study skin permeability;
transdermal patches
Recommended reading
In vitro diffusion
cells
Hanady Akram Bibi
Franz cell studies
Aulton’s pharmaceutics. The design and
manufacture of medicines
4th Edition. Churchill Livingstone/Elsevier, 2013,
chapter 39: pp. 683-685.
Steffansen et al.(eds), Molecular
Biopharmaceutics. Pharmaceutical Press 2009.
Chapter 3.2.1 and 3.2.2 (pp 135-141)
Calculation of flux and Papp
Buccal & mucoadhesive dosage
forms
Judith Kuntsche
Buccal & muco-adhesive dosage forms
Topic
Intestinal
permeability
screening
Teacher
Martin Brandl
Preclinical
evaluation of
carrier-mediated
transport
Bente Steffansen
Keywords
Approaches to assess / predict
uptake from gastro-intestinal tract, in
vitro and in situ; Caco-2, HT-29,
PAMPA, PVPA-model
Biopharmaceutics classification
system
Membrane transporters in drug
delivery. Methods to characterize
transporter-mediated permeability.
Preclinical investigation of drug/druginteraction on transporters
Aulton’s pharmaceutics. The design and
manufacture of medicines
4th Edition. Churchill Livingstone/Elsevier, 2013,
chapter 39: pp. 679-683; 685-696.
Buccal drug delivery. J.D. Smart. Expert Opin.
Drug Del. 2 (2005) 507-517.
The basis and underlying mechanisms of
mucoadhesion.
J.D. Smart. Adv. Drug Del. Rev. 57 (2005) 15561568.
Recommended reading
Aulton’s pharmaceutics. The design and
manufacture of medicines
4th Edition. Churchill Livingstone/Elsevier, 2013,
chapter 21: pp. 334-342 & 353-354
Steffansen et al. (eds), Molecular
Biopharmaceutics. Pharmaceutical Press 2009.
Chapter 3.7 pp 225-239
Steffansen et al., Molecular Biopharmaceutics.
Pharmaceutical Press 2009. pp 153-173 & 193223
Nice to know: Maeda K and Sugiyama Y (2013)
Transporters biology in drug approval: regulatory
aspects, Mol Aspects Med. 34, 711-8
Topic
Formulations for
poorly soluble
drugs
Micro- &
nanoparticles
Teacher
Martin Brandl
Keywords
Formulations for poorly soluble
drugs:
Nano-crystals, amorphous solid
dispersions, S(M/N)EDDS, microemulsions, lipolysis, FaSSiF, FeSSiF,
Solubility-/permability-interplay
Recommended reading
Buckley et al. European Journal of Pharmaceutical
Sciences 50 (2013) 8–16
Lecture notes
Modified release
oral dosage forms
Annette BauerBrandl
Modified-release oral drug delivery
Aulton’s pharmaceutics. The design and
manufacture of medicines
4th Edition. Churchill Livingstone/Elsevier, 2013,
chapter 31: pp. 550-565.
Biopharmacy &
pharmacokinetics
Carsten Uhd Nielsen
Pharmacokinetics; in vitro in vivo
correlation
Aulton’s pharmaceutics. The design and
manufacture of medicines
4th Edition. Churchill Livingstone/Elsevier, 2013,
Chapter 21: pp 344-354
chapter 22: pp. 355-366.
Clinical aspects of
drug transport
Kim Brösen
The interplay of drug absorption,
disposition, metabolism and
excretion; examples
Brøsen et. Al (eds): Basal og Klinisk Farmakologi,
5. Udgave pp 58-63
Topic
Inhalative dosage
forms
Teacher
Martin Brandl
Recommended reading
Blood-brainbarrier
Carsten Uhd Nielsen
Keywords
Physical and physiological aspects of
drug deposition in the airways
Pharmacopeial methods
Formulations and technologies MDI,
DPI, nebulizer
BBB, pathways for CNS-drugs and
drug delivery to the brain
Liposomes
Martin Brandl
Aulton’s pharmaceutics. The design and
manufacture of medicines
4th Edition. Churchill Livingstone/Elsevier, 2013,
chapter 37: pp. 634-656. And lecture notes.
Begley, D.J. Delivery of therapeutic agents to the
central nervous system: The problems and the
possibilities (2004) Pharmacology and
Therapeutics, 104 (1), pp. 29-45.
M. Brandl Liposomes as drug carriers: a
technological approach
In: Biotechnology Annual Review. M.R. El-Gewely,
editor
Volume 7: pp 59-85. Elsevier 2001
Lecture notes