Drug effects on pregnancy and male reproduction –
molecular mechanisms and mathematical modeling
Nina Isoherranen
Associate Professor
Department of Pharmaceutics
University of Washington
Abstract:
Research in Dr Isoherranen’s lab focuses on cellular and biochemical
characterization of the CYP26 enzymes and their role in retinoic acid
metabolism and reproductive function. The research also includes
evaluation of drug safety during pregnancy and the role of P450
enzymes in teratogenicity and fetal development. In addition, Dr
Isoherranen’s lab is conducting research on the molecular mechanisms
of enzyme inhibition, the in vitro to in vivo predictions of drug
interactions and the role of metabolites in drug-drug interactions.
Biography:
Dr. Isoherranen received her bachelor’s degree in chemistry and her
master’s degree in Analytical Chemistry in 1998 from the University of
Helsinki, Finland. She obtained a PhD from the Hebrew University of
Jerusalem in 2003 and continued her training as a post-doctoral fellow
with Ken Thummel at the University of Washington. She joined the
Department of Pharmaceutics as an Acting Assistant Professor on
November 2004 and is now an Associate Professor in the Department of
Pharmaceutics at U Washington School of Pharmacy.
Dr. Isoherranen has published over 70 papers and owns several patents.
She is also an Associate Editor for the journal Drug Metabolism and
Disposition. She has received many awards, including the Early Career
Achievement Award from ASPET Division of Drug Metabolism and the
New Investigator Award from International Society for the Study of
Xenobiotics.