MODULE SPECIFICATION TEMPLATE MODULE DETAILS Module title Module code Credit value Level Mark the box to the right of the appropriate level with an ‘X’ Intermediate Chemistry 1 CH211 20 points Level 4 Level 5 X Level 6 Level 0 (for modules at foundation level) Level 7 Level 8 Entry criteria for registration on this module Pre-requisites Successful completion of CH110, CH111 and CH112 (or equivalent) Specify in terms of module codes or equivalent Co-requisite modules N/A Specify in terms of module codes or equivalent Module delivery Mode of delivery Taught Other X Distance Placement Pattern of delivery Weekly X Block Other Online When module is delivered Semester 1 X Semester 2 Throughout year Other Brief description of module Students build on their knowledge of organic, inorganic and physical chemistry from level 1. The module focuses on chemical and physical content and/ or aims equilibria, chemical kinetics and their application for biological systems Overview (max 80 words) and transition metals; their uses, coordination chemistry, and complex formation, together with the spectroscopy and magnetochemistry of their complexes. The module covers both theoretical and practical aspects of transition metal chemistry. Module team/ author/ Dr Marcus Dymond, Dr Gerry Gallacher, Dr Peter Cragg, Dr Ian Wright, Dr coordinator(s) Irina Savina School Pharmacy and Biomolecular Sciences Site/ campus where Moulsecoomb delivered Course(s) for which module is appropriate and status on that course Course BSc Pharmaceutical and Chemical Sciences BSc Chemistry Status (mandatory/ compulsory/ optional) Compulsory Compulsory MODULE AIMS, ASSESSMENT AND SUPPORT Aims Learning outcomes To extend students knowledge and understanding of organic, physical and inorganic chemistry At the end of this module, students are expected to: 1. 2. Describe physical properties and chemical reactivities of ethers, aldehydes, ketones, phenols and anilines Outline, by using curly arrows, the mechanism of electrophilic aromatic substitution and relate the mechanism to energy 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. Content diagrams. Suggest ways of synthesising simple disubstituted benzene derivatives. Assess the number of stereoisomers for a given constitutional formula. Predict the preferred conformation of some simple substituted cyclohexanes and relate this to reactivity Correctly name transition metal complexes and draw structures given named complexes Give examples of transition metal complexes with coordination numbers from 2 to 9. Illustrate the different isomers of octahedral and square planar complexes with uni-, bi-, or tri-dentate ligands. Understand and draw phase diagrams Understand the difference between ideal and real solutions Recognise and use basic equations of chemical thermodynamics and kinetics Discuss the concepts of activity coefficients Perform a selection of lab experiments related to the above theory safely in the laboratory Organic Chemistry: Properties, nomenclature, synthesis and reactivity of: ethers, benzene (electrophilic aromatic substitution), phenol, aniline, arenes, aldehydes, ketones, conjugated aldehydes and conjugated ketones. Stereochemistry, (diastereoisomers, meso forms, 2n stereoisomers, resolution, epimers, epimerisation). Introduction to the conformation and reactivity of substituted cyclohexanes Inorganic Chemistry: Nomenclature of transition metal - ligand complexes, coordination chemistry - structures of transition metal compounds, isomers of square planar and octahedral complexes, Jahn-Teller distortions. Physical Chemistry: Fugacity, activity and activity coefficients, Heterogeneous equilibria, liquid-liquid, liquid-solid, and solid-solid equilibria, phase diagrams, Gibbs phase Rule, 1 component and 2 component systems The following practical experiments are representative: Fischer esterification Stereochemistry of electrophilic addition to alkenes Electrophilic aromatic substitution. Friedel-Crafts acylation Sodium borohydride reduction of an aldehyde Distribution between immiscible solvents Determination of standard electrode potential Distillation of a binary liquid mixture Elevation of boiling point The vapour pressure of a volatile liquid Reversible electrochemical cells The use of GLC to determine the activity coefficient of a nonelectrolyte. The preparation and analysis of potassium tris(oxalato)ferrate (II) trihydrate K3[Fe(C2O4)3].3H2O The comparative determination of cobalt by titrimetic and gravimetric procedures. The titrimetric determination of aluminium by means of 8- hydroxyquinoline Preparation of sodium peroxoborate and analysis of hydrogen peroxide content. Learning support Current editions of: Atkins, P., de Paula, J. Atkins’ Physical Chemistry, Oxford University Press. Pavia, D.L., Lampman, G.M., Kriz, G.S. Introduction to Spectroscopy, Harcourt. Hollas, J.M. Modern Spectroscopy, Wiley. Anslyn, E.V., Dougherty, D.A., Modern Physical Organic Chemistry, University Science Books, USA. Peter Atkins, Tina Overton, Jonathan Rourke, Mark Weller, and Fraser Armstrong Inorganic Chemistry, Oxford University Press Clayden, J., Greeves, N., Warren, S., and Wothers, P., Organic Chemistry Oxford University Press. K.P.C. Vollhardt, and N.E. Schore W.H.Freeman, Organic Chemistry CH211 Laboratory Scripts and Lecture Handouts Teaching and learning activities Details of teaching and learning activities A mixture of lectures, seminars and problem sessions, laboratory exercises, private study. Allocation of study hours (indicative) Study hours Where 10 credits = 100 learning hours SCHEDULED This is an indication of the number of hours students can expect to spend in scheduled teaching activities including lectures, seminars, tutorials, project supervision, demonstrations, practical classes and workshops, supervised time in workshops/ studios, fieldwork, external visits, and work-based learning. 74 GUIDED INDEPENDENT STUDY All students are expected to undertake guided independent study which includes wider reading/ practice, follow-up work, the completion of assessment tasks, and revisions. 126 PLACEMENT The placement is a specific type of learning away from the University that is not work-based learning or a year abroad. TOTAL STUDY HOURS 200 Assessment tasks Details of assessment for this module Types of assessment task1 Student performance will be assessed through an end of module exam (2 hour) (end of Semester 1) (learning objectives 1 to 12) and ten laboratory reports (learning objective 13). % weighting Indicative list of summative assessment tasks which lead to the award of credit or which are required for progression. (or indicate if component is pass/fail) WRITTEN Written exam 60 COURSEWORK Written assignment/ essay, report, dissertation, portfolio, project output, set exercise 40 1 Set exercises, which assess the application of knowledge or analytical, problem-solving or evaluative skills, are included under the type of assessment most appropriate to the particular task. Oral assessment and presentation, practical skills assessment, set exercise PRACTICAL EXAMINATION INFORMATION Area examination board Chemistry and Pharmaceutical Sciences External examiners Name Position and institution Date appointed Date tenure ends Dr I Pulford Senior Lecturer, University of Glasgow 01/10/09 31/12/14 QUALITY ASSURANCE Date of first approval 1991 Only complete where this is not the first version Date of last revision 2010 Only complete where this is not the first version Date of approval for this version September 2013 Version number 6 Modules replaced Specify codes of modules for which this is a replacement Available as free-standing module? Yes No X