“The Power to Detect and Create: Ethical Challenges Emerging from DNA Technology and Genetics: The Impact of Genetics on Jewish Living and Jewish Ethics” at the Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center at Bar-Ilan University With The Center for Bioethics, Columbia University College of Physicians & Surgeons, New York, NY; the Ludwig & Erica Jesselson Institute for Advanced Torah Studies and the Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel; Albert Einstein College of Medicine, Bronx, NY; Touro College of Osteopathic Medicine, New York, NY. 25-26 Sivan, 5770 Monday and Tuesday, June 7-8, 2010 Monday, June 7, 2010 08:00 – 08:30 Registration and Coffee 08:30 – 09:00 Welcoming Remarks 09:00 – 9:45 Dr. John Loike, Director for Special Programs for the Center for Bioethics and Co-Director for Graduate Studies in the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons Professor Uri Nir, Dean, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University Rabbi Professor Daniel Sperber, President, Jesselson Institute for Advanced Torah Studies, Bar-Ilan University Session I- Overview of DNA Technology Chair: Dr. John Loike, Columbia University Lecture: Dr. Eric Schon, Professor of Genetics and Development, Columbia University College of Physicians and Surgeons '' Molecular Genetics – The State of the Art" 9:45-10:30 Lecture: Rabbi Shabtai Rappaport, Rosh Bet Midrash, Jesselson Institute for Advanced Torah Studies, Bar-Ilan University: "Applying DNA Technology-in identifying a dead body, in establishing paternity and in criminal investigationsA Halakhic Overview" 10:30 – 10:45 Coffee Break 10:45-12:00 Session II: DNA: Our Genes- Our Destiny Case Study: Can one use pre-implantation genetic diagnosis (PGD) to select for embryos who do not carry the genetic predisposition for late-onset diseases such as cancer, Huntington's Chorea, Alzheimer's disease, and Parkinson's Disease. Panel Discussion Chair: Dr. Shimon Glick, Professor (Emeritus), Ben Gurion University Faculty of Health Sciences Rabbi Dr. Tzvi Weinreb, Executive Vice President Emeritus, Orthodox Union Professor Elon Pras, Director of the Institute of Human Genetics, Sheba Medical Center, Israel Dr. Yanay Ofran, Senior Lecturer, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University Professor Eric Schon, Columbia University 12:00 – 13:30 Lunch Speaker- Dr. John D. Loike, Columbia University: “The Power to Predict: Emerging Technologies in Genetic Testing" 13:45 – 14:30 Lecture- Rabbi Dr. Tzvi Weinreb, Executive Vice President Emeritus, Orthodox Union: "Psychological Dimensions in Genetic Screening: The Implications of Family History and Genetics on the World of Shidduchim" 14:30-14:45 Break 14:45- 15:30 Lecture: Dr. Gil Atzmon, Assistant Professor, Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York: "The Jewish Genome in the Genome Era" 15:30 -16:30 Session III: Designer Babies: The Quest for an Ethical Genome Case Study: Can one use PGD to select for embryos who do not carry the genetic predisposition for specific behavior traits, such as adultery, aggression, sexual preference and spirituality, ("the Frum Gene") Panel discussion Chair: Professor Uri Nir Rabbi Professor Avraham Steinberg, Director of the Center for Medical Ethics at Shaare Zedek Medical Center, Jerusalem Dr. Gary Steinman, Chair of Biochemistry, Touro College of Osteopathic Medicine, New York, NY Rabbi Dr. Tzvi Weinreb 16:45-18:00 Four Small group discussions on specific dilemmas in genetic testing led by: a) Rabbi Shabtai Rappaport and Dr. Eric Schon b) Professor Elon Pras and Rabbi Dr. Michael Abraham c) Dr. Yannay Ofran and Dr. Kenneth Prager d) Dr. Gary Steinman and Rabbi Tzvi Weinreb Tuesday, June 8, 2010 08:30 – 09:00 Coffee Session IV- Genetics Part II 9:00-9:45 Welcome - Professor Moshe Kaveh, President, Bar Ilan University Introduction: Rabbi Shimon Altshul, Director, Jesselson Institute, Bar Ilan University Lecture: Rabbi Shabtai Rappoport: "Halakha, Genetics, and Marriage" 9:45-10:30 Panel Discussion: Creating a Modern Golem New biotechnologies are being developed that will present new challenges in halakha. For example: Synthetic biology- the capability to alter existing life forms or create new life forms; Stem cell and DNA technology- enabling scientists to alter animals to express human-like organs. Animals have been engineered that produce human sperm and human eggs, and there is the theoretical possibility to engineer cows or sheep that contain human-like uterus. Finally, there is talk among scientists to use the newly sequenced DNA of the Neanderthal man to modify human stem cells to contain Neanderthal-like DNA. Could these cells eventually be used to engineer gamete- like cells and create a living Neanderthal- like human that is gestated in a human being? Chair- Dr. Kenneth Prager, Professor of Clinical Medicine; Director, Clinical Ethics; Chairman, Medical Ethics Committee, Columbia University Rabbi Shabtai Rappaport Israel Belfer, PhD student, Science, Technology and Society program (STS) at Bar Ilan University, Machon HaGavoah LaTorah Professor Ron Goldstein, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University Professor Moshe Idel, Max Cooper Professor of Jewish Thought at the Hebrew University of Jerusalem 10:30 – 10:45 Coffee Break 10:45 – 12:00 Moot Court- Privacy Rights in Genetics Case- Rabbi Cohen is a childless Mohel who was hired to do milah on the newborn son of a leading Hassidic Rebbe, a leading charismatic personality. After the milah, the mohel takes the foreskin of the baby and brings it to a laboratory in Israel that specializes in stem cell technology and fertility. Scientists in the lab can utilize technologies in cell and molecular biology to convert the cells from the orlah into sperm like cells and use them to fertilize the egg of the wife of the mohel and implants the newly formed embryo into the wife of the mohel. Nine months later she delivers a healthy baby boy whose genetic father is the nine- month old son of the Rebbe. What are the legal and halachic ramifications? Moderator: Dr. Kenneth Prager Judge Neal Hendel, the Supreme Court of Israel Rav Michael Abraham, Ram, Jesselson Institute for Advanced Torah Studies, Bar Ilan Umiversity 12:00 – 13:30 Lunch –Invited Speaker-Professor Amihood Amir, Professor of Computer Science at Bar-Ilan University and Research Professor at Johns Hopkins University: "Genetic Archaeology“ 13:30- 14:30 Lecture: Dr. Ruth Fischbach, Professor of Bioethics and Director and Co-founder of the Center for Bioethics, Columbia University: "Autism- The Ethics of Genetic Research on Autism" 14:30-14:45 Break 14:45-16:00 Concluding Session: Challenges, Opportunities and Questions Moderator: TBA Summing Up the Conference The major issues as they emerge from the conference 16:00-17:00 Future Issues, Dr. John Loike Halakha, Rabbi Prof. Daniel Sperber Ethics, Rabbi Shimon Altshul Genetics, Prof. Uri NIr Small Group discussions Genetics and Privacy - Dr. Gil Atzmon and Rabbi Abraham Autism – Dr. Ruth Fischbach and Rabbi Sperber Designer Babies – Professor Ron Goldstein and Dr. Rabbi Steinberg --------------- This Conference is also sponsored by: The Yavneh Founders:Rabbi Nachum and Yaakov Meir Shapiro Jewish Ethics Program International Academic Friends of Israel The Henry, Bertha and Edward Rothman Foundation The Jewish Press Jerry Wartski Conference Participants-Israel Rabbi Dr. Michael Abraham, Ram, Jesselson Institute for Advanced Torah Studies, Bar Ilan University Rabbi Shimon Altshul, Director,The Ludwig and Erica Jesselson Institute for Advanced Torah Studies(RA),Bar Ilan University, Ramat Gan, Israel Professor Amihood Amir, Professor of Computer Science at Bar-Ilan University and Research Professor at Johns Hopkins University: Israel Belfer, PhD student, Science, Technology and Society program (STS) at Bar Ilan University; Machon HaGavoah LaTorah Prof. Shimon Glick, Professor (Emeritus), Ben Gurion University Faculty of Health Sciences Professor Ron Goldstein, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University Professor Moshe Idel, Max Cooper Professor of Jewish Thought at the Hebrew University of Jerusalem Judge Neal Hendel, the Supreme Court of Israel Professor Uri Nir, Dean, Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University Yanay Ofran, Ph.D., Systems Biology and Functional Genomics, Bar-Ilan University, Ramat Gan, Israel. Elon Pras, MD, PhD, Director of the Institute of Human Genetics at the Sheba Medical Center, Israel. Rabbi Shabtai Rappaport, Rosh Bet Midrash, Ludwig and Erica Jesselson Institute for Advanced Torah Studies, Bar-Ilan University, Ramat Gan, Israel. Rabbi Daniel Sperber, Ph.D., President of the Ludwig and Erica Jesselson Institute of Advanced Torah Studies of Bar Ilan University, Bar-Ilan University, Ramat Gan, Israel, Israel Prize Recipient, 1992 Avraham Steinberg, M.D., Rabbi, Department of Pediatrics, Shaare Zedek Medical Center, Director of The Center for Medical Ethics at Shaare Zedek Medical Center, Editor in Chief of Encyclopedia Talmudit, Jerusalem, Israel. Conference Participants-US Dr. Gil Atzmon, Assistant Professor, Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York Ruth L. Fischbach, Ph.D., M.P.E., Professor of Bioethics and Director of the Center for Bioethics, Department of Psychiatry, Columbia University College of Physicians and Surgeons and Department of Sociomedical Sciences at the Columbia University Mailman School of Public Health, New York, NY John D. Loike, Ph.D. Director for Special Projects, Columbia University's Center for Bioethics, Co-Director for Graduate Studies, Department of Physiology, Columbia University College of Physicians and Surgeons, New York, NY Kenneth Prager, M.D., F.A.C.P., Professor of Clinical Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, College of Physicians and Surgeons, Director, Clinical Ethics and Chairman, Medical Ethics Committee, Columbia University Medical Center, New York, NY. Eric Schon, Ph.D. Professor of Genetics and Development, Columbia University College of Physicians and Surgeons Gary Steinman, M.D., Ph.D. Professor and Chair of Biochemistry, Touro College of Osteopathic Medicine, New York, NY Rabbi Dr. Tzvi Weinreb, Executive Vice President Emeritus, Orthodox Union, Clinical Psychologist