1. What portion of the developing embryonic mesoderm gives rise to the gonadal or genital ridge?
A.Intermediate mesoderm
B.Lateral plate mesoderm
C.Paraxial mesoderm
D.Somatic mesoderm
E.Splanchnic mesoderm
2.
Which of the following is not involved in the development of the testes?
A.Genital ridge
B.SRY gene
C.Testis-determining factor
D.X-chromosome
E.Y-chromosome
3. Which of the following genotypes is characteristic of individuals with Klinefelter syndrome?
A.46 XY
B.47 XXY
C.45 YO
D.46 YY
E.45 XO
4. Which of the following phenotypes is NOT characteristic of individuals with Turner syndrome?
A.Inverted nipples
B.High-arched palate
C.Shield-like chest
D.Short statue
E.Small penis
F.Web neck
5.
Which of the following serve as the developmental site of the primordial or primitive germ cells?
A.Dorsal mesentery
B.Gonadal ridge
C.Intermediate mesoderm (mesenchyme)
D.Mesothelium
E.Urogenital ridge
F.Yolk sac
6. Which of the following is derived from the gonadal cords?
A.Interstitial cells of Leydig
B.Primary spermatocytes
C.Seminiferous tubules
D.Spermatids
E.Spermatogonia
7. The ductus (vas) deferens and epididymis are derived from the:
A.Gonadal cords
B.Interstitial mesenchyme
C.Mesonephric duct
D.Mesonephric tubules (ductules)
E.Ureteric bud
8. Which of the following cells or tissues is responsible for the production of anti-müllerian hormone?
A.Interstitial cells of Leydig
B.Primary spermatocytes
C.Spermatids
D.Spermatogonia
E.Sustentacular cells of Sertoli
9. Which of the following stimulates the sustentacular cells of Sertoli to produce anti-müllerian hormone?
A.Estrogen
B.Follicle-stimulating hormone

C.Human chorionic gonadotrophin
D.Interstitial cells of Leydig
E.Testosterone
10. In what stage of cell division is the female gamete of the primary follicle found?
A.Prophase of mitosis
B.Metaphase of mitosis
C.Prophase I of meiosis
D.Metaphase I of meiosis
E.Prophase II of meiosis
F.Metaphase II of meiosis
11. Which of the following forms the uterovaginal primordium?
A.Cloaca
B.Mesonephric duct
C.Paramesonephric duct
D.Urogenital sinus
E.Urorectal septum
12. Which of the following is responsible for producing a hormone that promotes degeneration of the paramesonephric ducts?
A.Intersitial cells of Leydig
B.Primordial follicle
C.Spermatogonium
D.Sustentacular cells of Sertoli
E.Uterovaginal primordium
13. What hormone is responsible for further development of the mesonephric ducts?
A.Anti-müllerian hormone
B.Follicle-stimulating hormone
C.Human chorionic gonadotrophin hormone
D.Testis-determining factor
E.Testosterone
14. Which of the following structures gives rise to the seminal vesicle?
A.Mesonephric duct
B.Paramesonephric duct
C.Urogenital sinus
D.Ureter
E.Ureteric bud
15. Which of the following structures gives rise to the prostate gland?
A.Mesonephric duct
B.Paramesonephric duct
C.Urogenital sinus
D.Ureter
Ureteric bud
16. Which of the following structures gives rise to the uterine tubes, uterus and upper vagina?
A.Mesonephric duct
B.Paramesonephric duct
C.Urogenital sinus
D.Ureter
E.Ureteric bud
17. Which of the following structures gives rise to a bicornate uterus?
A.Mesonephric duct
B.Paramesonephric duct
C.Urogenital sinus
D.Ureter
E.Ureteric bud

18. Which of the following structures gives rise to a hydrocele?
A.Gubernaculum testis
B.Mesonephric duct
C.Paramesonephric duct
D.Process vaginalis
E.Tunica albuginea
19. Which of the following structures fuses to form the spongy urethra?
A.Corpus cavernosa penis
B.Glans penis
C.Process vaginalis
D.Scrotal raphe
E.Urethral or urogenital folds
20. Which of the following structures fails to fuse in an individual with hypospadias?
A.Glandular plate
B.Glans penis
C.Labioscrotal swellings
D.Scrotal raphe
E.Urethral or urogenital folds
21. Which of the following structures gives rise to the labia minora?
A.Glandular plate
B.Glans clitoris
C.Labioscrotal swellings
D.Urethral groove
E.Urogenital folds
F.Urorectal septum
22. Which of the following hormones is responsible for the clinical condition of female pseudohermaphrodism?
A.Anti-müllerian hormone
B.Cortisol
C.Estradiol
D.Interstitial cell-stimulating hormone
E.Müllerian inhibiting substance
F.Progesterone
G.Testosterone
23. What is responsible for the female phenotype in androgen-insensitivity syndrome?
A.Anti-müllerian hormone
B.Dehydroisoandrosterone
C.Estradiol
D.Follicle-stimulating hormone
E.Interstitial cell stimulating hormone
F.Progesterone
G.Testosterone

Answers:
1 (6) A
2. (17) D
3. (18) B
4. (19) E
5. (24) F
6. (31) C
7. (32 C
8. (33) E
9. (34) C
10. (39) C
11. (43) C
12. (47) D
13. (48) E
14. (54) A
15. (55) C
16. (66) B
17. (72) B
18. (80) D
19. (92) E
20. (96) E (The glandular plate may also fail to develop or join the spongy urethra).
21. (103) E
22. (107) G
23. (111) C