THE SCIENCE SHOW FOCUS ON HEALTH ANSWER KEY TSIALIS APOSTOLOS Episode 1: Sexually Transmitted Diseases Previewing KEY QUESTIONS 1. Venereal diseases 2. Prevention 3. The etymology of the term is: Gk, gone + rhoia, flow, i.e., discharge of semen. The ancient Greeks mistakenly thought that this discharge was leakage of semen. MEDICAL TERMS 1.chlamydia 2.gonorrhea 3.endometriosis 4.salpingitis 5.herpes genitalis 6.condyloma acuminatum Intensive Viewing AIDS I. 1) 5 to 10 million people 2) In 138 countries 3) blood, sexual secretions II. toilet seats kisses coughs dishes __ unsafe sex caresses clothing __ razors __ syringes III. When the AIDS virus reaches the blood the immune system tries to neutralize it by producing antibodies. These molecules normally attach themselves to viruses and bacteria notifying their presence to the immune system’s killer cells. However, the AIDS virus outmaneuvers this strategy. It manages to do so by attacking the lymphocytes, cells that play the role of generals in the battle the organism wages against foreign bodies. IV. The Aids virus spots a lymphocyte, it attaches itself to it. It then injects a copy of its genetic material into the nucleus of the lymphocyte. The virus genetic material really represents the directions for fabrication. Concealed in e lymphocytes these directions are invulnerable to the immune system’s attacks. V. When the lymphocytes reproduce they pass on a copy of them to their descendants. In most people who are infected, the AIDS virus’ genetic material will remain hidden for months or even for years. The antibodies the organism produces during the first attack are the only clue to the presence of the virus. Tests to detect the AIDS virus infection are based on the presence of these antibodies in the blood. People having such antibodies are said to be HIV positive. Most people who are HIV positive have no symptoms for several years. However they can unwillingly transmit through their blood or sexual secretions, the virus and the lymphocytes, which have incorporated the AIDS virus’ genetic material. GONORRHEA 1) bacteria 2) mucous 3) irritation, swelling, redness 4) pus, swelling, pain 5) a) vaginal, pain b) discharge, sensation CHLAMYDIA 1) sterility 2) In the cervix 3) endometriosis 4) salpingitis 5) The accumulated pus and scar formation in the fallopian tubes renders the spermatozoa incapable of fertilizing the ovum. HERPES GENITALIS Symptoms painful blisters fever stiffness headaches Factors too much exposure to the sun pants worn too tightly stress menstruation CONDYLOMA ACUMINATUM 1) podophyllin 2) cold 3) LAZER Focus on Language PERIPHERAL VOCABULARY 1.conversely 2.divulge 3.insidious 4.forestall 5.judicial 6.repercussion 7.pronounced 8.besiege 9.abstinence 10.subside 11.relapse(into) 12.incubation 13. stave off 14.notably 15.screen 16.intercourse ADJECTIVES 1-f 2-d 3-b 4-i 5-h 6-a 7-g 8-e 9-j 10-c PHRASAL VERBS 1.have done it without you 2.run down 3.put across 4.had made it up 5.come round GRAMMAR CHECK Answers will vary ANALYSING MEDICAL WORDS AND WORD PARTS I. 1.gland 2.cancer, cancerous 3.to cut 4.kidney 5.disease 6.brain 7.joint 8.heart 9.nose 10.bone II. 1.leuk-o-cyte 2.dermat-itis white blood cell inflammation of the skin Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 2 3.inguin-al 4.axill-ary 5.post-nat-al 6.tachy-pnea 7.onc-o-logy 8.psych-osis 9.epiderm-oid 10.poly-neur-itis pertaining to the groin pertaining to the armpit pertaining to after birth rapid breathing study of tumors abnormal condition of the mind resembling epidermis inflammation of many nerves Post-viewing RELATED READING 1. It’s purpose is to share of information regarding the development, delivery, evaluation, production and implementation of AIDS vaccines and immunotherapies. 2. Several of the women took a break from the sex trade and, upon returning, became infected with HIV -- leading researchers to question how long any protection may last. 3. A typical vaccine presents a marker of the virus, bacteria or fungus to educate the immune system, showing it what the enemy looks like. Then when the disease appears and the marker is present again, the immune system recognizes it as an enemy and launches an all-out attack, blocking infection. This is an antibody response; it occurs before cells are infected. A cellular immune response kills cells that are already infected. IN YOUR OWN WORDS 1. to activate, to stir up, to serve as the activating influence of; i.e. to spark interest 2. fulfillment, accomplishment, the carrying into effect 3. done, made, provided, occurring, etc. in or for the meantime; provisional, temporary. 4. withstanding the action or effect; that is not overcome by some disease or drug 5. assured, certain 6. that overwhelms, overthrows, overturns, or submerges utterly; so powerful as to overcome utterly by strength of numbers, influence, etc. 7. a downward trend or financial loss, as on an investment 8. to conceal Episode 2: CANCER Previewing Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 3 KEY QUESTIONS 1. In men: prostate, stomach, lung; in women: breast, cervix, ovaries 2. Environmental agents (heavy metals, chemicals, viruses), hereditary factors, physical condition, diet, stress. 3. Chemotherapy, surgery, radiation therapy MEDICAL TERMS 1.hormone therapy 2.monoclonal antibodies (MOAB) 3.cobalt 60 4.porphyrin 5.lymph node 6.photochemotherapy 7.remission 8.life expectancy 9.virus 10.oncogene 11.chemotherapy 12.metastasis Intensive Viewing THE DEVELOPMENT OF CANCER 1–4–7–2–5–3–8–6 DIVISION OF CELLS Genes are like small electric switches. They can be turned on or off. However, most genes are only turned on for a short period in a person’s life and then put to sleep. Therefore, at any given moment only a small number of a cell’s genes are functioning. It sometimes happens though that some of the cell’s dormant genes are activated. Their sudden awakening disrupts the activities of the cell. The cell becomes incapable of performing the tasks assigned to it and starts dividing chaotically. It has turned into a cancer cell. GETTING THE MAIN IDEA I. 1) skin, testis, breast, uterus, bladder 2) intestine, stomach, lung II. heavy metals, chemical products, viruses and also hereditary factors, general physical condition, diet, stress. III. 1.chemotherapy 2.surgery 3.radiation therapy IV. 1.surgical removal 2.radiation therapy 3.chemotherapy COMMON TREATMENTS OF CANCER I. 1.T 2.F 3.T II. 1.YES 2.NO 3.YES III. Radiation Therapy is based on the sensitivity of living cells to rays beamed by radioactive bodies such as cobalt 60. The radiation penetrates the cells and sections DNA. The genes become inoperative. The X-rayed cells loose their capacity to divide and die. IV. 1. They primarily attack rapidly dividing cells such as cancer cells. Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 4 2. nausea, hair-loss METASTASES Metastases are secondary cancers that originate from the main cancer site. They are formed from the cancer cells that have separated naturally from the originated tumor. These cells are spread through the blood or lymphatic system – network of vessels throughout the body. These vessels are lined with lymph glands or nodes, which filter out the cancer cells. Most of these cells die but sooner or later one of them will survive causing a new cancer to develop. PHOTOCHEMOTHERAPY I. Photochemotherapy is based on the use of a natural chemical compound of the human body, porphyrin. Small amount of this compound - close to blood hemoglobin - is produced normally by all body cells. Cancer cells when applied with a chemical substance called aminolevulinic acid produced greater quantities of porphyrin than healthy cells. Porphyrin also has the property of becoming toxic in the presence of light. II. The main advantages of photochemotherapy are: little risk of the treatment damaging the body’s healthy cells, greater control of the drug due to the use of a light beam, and elimination of porphyrin by the body within a few hours. MONOCLONAL ANTIBODIES 1. T 2. F 3. T 4. T Focus on Language PERIPHERAL VOCABULARY 1.unbearable 2.delve into 3.recapitulate 4.rigorous 5.assign to 6.enigma 7.drain 8.harbor 9.hereditary 10.detach 11.foster 12.restrain 13. attenuate 14.originate 15.spare 16.tenatious 17.detection 18.amalgamate 19.proliferate 20.by leaps and bounds SURGICAL PROCEDURES IN CANCER TREATMENT 1. fulguration 2. electrocauterization 3. exenteration 4. incisional biopsy 5. excisional surgery 6. cryosurgery ABBREVIATIONS 3, 9, 1, 10, 6, 8, 2, 7, 4, 5 GRAMMAR CHECK assigned (adj.), spreading (adj.), ensuring (adv.), affecting (adv.) ANALYSING MEDICAL WORDS AND WORD PARTS I. 1.tumor, mass 2.process of visual examination 3.removal 4.bodies 5.abnormal condition 6.breakdown, destruction 7.formation 8.little 9.record 10.suture Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 5 II. 1.crani-o-tomy 2.laryng-eal 3.palat-o-plasty 4.sub-mandibul-ar 5.hepat-o-megaly 6.stomat-itis 7.olig-uria 8.colp-o-rrhaphy 9.mammo-plasty 10.myel-o-gram incision of the skull pertaining to the voice box surgical repair of the roof of the mouth pertaining to the lower law enlargement of the liver inflammation of the mouth scanty urination suture of the vagina surgical repair of the breast record (x-ray) of the spinal cord Post-viewing RELATED READING 1. Body Mass Index 2. People who are obese can benefit from doing some moderate activity and reduce their excess risk of pancreatic cancer. Walking at a moderate pace every day is something you can build into your lifestyle and most everyone can do. IN YOUR OWN WORDS 1. to make less or smaller; to lessen; to reduce in magnitude or degree 2. an offender, one guilty of a fault or offence 3. not intense, violent, or rigorous 4. to bring about as a result, cause to follow as a consequence, entail, bring on 5. to look carefully into or through; to view in detail; to examine 6. to entangle, involve, commit 7. (or regimen) a particular course of diet, exercise, or mode of living 8. to incorporate, frame, raise, by gradual means Episode 3: THE BRAIN Previewing KEY QUESTIONS 1. Answers will vary. Suggested answer: loosing teeth – loosing money, seeing yourself in a mirror – announcement of a wedding. 2. All three are diseases of the brain. 3. Medical purposes: diagnosis of various forms of epilepsy or coma, location of cerebral injuries or tumors. As a research instrument in order to assess the effectiveness of certain therapies or to study phenomena like sleep and dreams. MEDICAL TERMS 1.electroencephalogram (EEG) 2.psychoanalysis 3.axon 4.neurotransmitter 5.cerebral cortex 6.cerebellum 7.corpus callosum 8.limbic system 9.schizophrenia Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 6 10.Parkinson’s disease 11.cranium 12.beta waves 13.alpha waves 14.delta waves 15.theta waves 16.epilepsy 17.biopsy 18.tumor Intensive Viewing DREAMS 1. F (more than 4) 2. F (less than 100) 3. F (10 minutes) 4. T rapidly, F (40%) 5. F (eyes move INTERPRETATION OF DREAMS The first scientific attempts at interpreting dreams go back about one hundred years to Sigmund Freud. Freud believed that a dream of a diving and swimming related to the womb. By a reversal process common in our subconscious the dive would mean rather the immergence from water, hence, birth. From his part, Carl Jung, one of Freud’s followers believed that water symbolized the archetypal mother rather than the dreamer’s real mother. For Jung, the color of the water, its temperature, every detail distinguishing the choice of one symbol over another was meaningful. The theories of master and student were soon to become irreconcilable. For Freud the motivating force behind dreams was sexuality. Young found Freud’s view too limiting. Dreams might just as well originate in a collective unconscious, built through the ages that gives all mankind its psychological heritage. THE BRAIN I. 1. T 2. F (left) 3. F (right) 4. F (they work together) II. 1. The center of vision … is isolated at the back of the head. 2. All tactile information is … gathered by the skin, muscles, joints and tendons. 3. The frontal cortex … regulates our impulses. 4. The cerebellum … is responsible for the coordination of movement. 5. It is believed that memory … is spread throughout the brain. NEUROTRANSMITTERS The brain is a world in itself. It consists of some 50 to 100 billion nerve cells called neurons. To exchange information the neurons send nerve impulses through their main prolongations, the axons. A little like a tree sends its sap from its trunk to all its branches. On the axons and their branches are located the neuron-to-neuron contacts. It is in these tiny swellings that the brain’s chemical messengers the neurotransmitters are found. The neurotransmitters take over the impulse and relay it to an other neuron. Owning to these neurotransmitters each neuron can establish contact with thousands of other neurons. During the past few years, scientists have discovered over forty different kinds of neurotransmitters. They each have a crucial role in orchestrating nerve impulse exchanges. Too much dopamine could cause schizophrenia and a deficiency of the same neurotransmitter could bring on Parkinson’s disease. Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 7 EEG 1. The EEG registers the brain’s electric currents. 2. Alpha waves are typical of relaxation and daydreaming states. 3. Beta waves are produced when a person is active. 4. Theta waves immerge when we fall asleep. 5. Delta waves are those of dreams. MRI 3-5–1–6–7–2-4 Focus on Language PERIPHERAL VOCABULARY 1.reflect on 2.monitor 3.unravel 4.assimilate 7.superfluous 8.predominate 9.intervene 10.intrigue 13.prolongation 14.relay 15.deficiency 16.amplification 19.circumvent 20.impact 21.spin 22.resonate 23.exquisite 5.nocturnal 6.veritable 11.defective 12.tactile 17.affliction 18.feeble 24.impulse PARTS OF THE BRAIN AND THEIR FUNCTIONS 5–4–1–2–6-3 ABBREVIATIONS 2, 6, 7, 1, 10, 8, 4, 5, 3, 9 GRAMMAR CHECK 1) have you worked 2) I’ve worked 3) I worked 4) were you 5) I moved 6) I’ve had 7) I had 8) I sold 9) I came ANALYSING MEDICAL WORDS AND WORD PARTS I. 1.back, again 2.away from 3.against 4.short 5.good, normal 6.half 7.large 8.bad 9.many 10.beyond II. 1.pro-gnosis 2.hyper-glycemia 3.dia-gnosis 4.peri-cardi-um 5.epi-gastr-ic 6.di-ure-tic 7.anti-angin-al 8.an-alges-ic 9.dys-phag-ia before knowledge; a prediction about the outcome of treatment excessive amount of sugar in the blood complete knowledge the membrane surrounding the heart pertaining to above the stomach a drug that promotes kidneys to excrete urine a drug that prevents chest pain due to ischemia an agent that relieves pain difficult swallowing Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 8 10.sub-cutane-ous pertaining to under the skin Post-viewing RELATED READING 1. In children, the content of the nightmare may be influenced by daytime experiences such as television viewing, movies, or scary real-life events. In adults, there is a less specific association between nightmares and daytime events. 2. In cases when nightmares persist longer than 6 weeks or remain unexplained. 3. Follow a regular energetic fitness routine, using aerobic exercises if possible. IN YOUR OWN WORDS 1. acting against or in opposition to, opposing, contrary, antagonistic 2. cessation of use or provision of a drug; spec. the interruption of doses of an addictive drug, with resulting craving and physical reactions 3. the mental connection between. an object and ideas that have some relation to it, link 4. case history, the patient’s complete medical background 5. to cease to continue; to cease, stop 6. to evaluate (a person or thing); to estimate (the quality, value, or extent of) again 7. to use improperly, to make a bad use of; to take (a drug) for a purpose other than a therapeutic one. 8. requiring or utilizing free oxygen in the air for metabolic purposes; involving the presence of air Episode 4: GENETICS Previewing KEY QUESTIONS 1. Genetic inheritance. 2. Due to a congenital defect 3. A test whose aim is to detect possible diseases or predispositions. MEDICAL TERMS 1.nucleotide 2.chromosome 3.graft 4.implant 5.insecticide 6.mutation 7.embryo 8.polyunsaturated 9.in vitro 10.handicapped 11.DNA 12.eugenics Intensive Viewing DNA 1. molecule 2. genetic inheritance 3. identical 4. genes, nucleotides, chromosomes CLONING Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 9 1. a. First, it involves taking the nucleus of a cell from a body of a living being. b. The nucleus is then introduced into a female sexual egg, a non-fertilized egg whose nucleus was previously removed. c. The egg divides and it can be implanted in the uterus. 2. In 1978 GENETIC ENGINEERING The DNA molecule carrier of the genetic inheritance of all species can be cut, sliced and edited much like the shots of a film. Genetic engineering of this kind requires the use of restriction enzymes, which select and cut DNA molecules in two. A gene can thus be extracted from a DNA molecule and grafted to another DNA molecule previously sliced by the same enzyme. We thus create a transgenic species that is to say a new species from the combination of the genetic inheritance of existing species. Genetic manipulation can also be applied to bacteria and even to more complex beings like mice and man. CROSSBREEDING 1. Nowadays the genes of a plant cell can be altered to produce a mature plant. 2. In vitro reproduction from an engineered plant cell can yield several thousand identical plants. 3. With animals researchers lack precision when they attempt to place a new gene to a designated site of the DNA molecule. 4. The foreign gene transplanted randomly on the DNA molecule produced unpredictable results. 5. Man has at his disposal the means to force the hand of nature. 6. Long before genetics mutations were part of the normal process of evolution. IN VITRO CONCEPTION For the time being the sorcerer’s apprentices are playing God, ideas rushing through their heads. Who knows for instance how the association of in vitro fertilization with DNA recombination would turn out? This child has 3 mothers, his genetic mother, his surrogate mother and his adopted mother. The egg was taken from Suzan, the sperm from John. Barbara carried the fetus and Dian adopted the baby. There are thousands of test tube babies living all around the world. In vitro conception is modern medicine’s answer to insurmountable fertility problems. This solution however raises problems of a moral and legal nature that frequently neither the partners involved nor the courts are able to deal with. But the innovative potential of genetic engineering may soon create ethical and legal challenges that are far greater. EUGENICS 1.S 2.I 3.N 4.I 5.N 6.S 7.N 8.I 9.N 10.S Focus on Language PERIPHERAL VOCABULARY 1.array 2.diversity 3.universal 4.define 5.inheritance 6.elongate 7.diminutive 8.authentic 9.homologus 10.fuse 11.identical 12.remarkable 13.overrun Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 10 14.vigilance 15.profitable 16.adaptable 17.insurmountable 18.eradicate 19.flaw 20.traits NOUNS FROM VERBS to modify to assess to bypass to radiate to train to consult to circulate to vaccinate modification assessment bypass radiation training consultation circulation vaccination to practice to screen to inject to scan to prescribe to inflame to fail to ail practice screen injection scan prescription inflammation failure ailment PHRASAL VERBS 1.’m done in 2.came out 3.made for 4.would have come up 5.make out GRAMMAR CHECK 1. Sexual reproduction is the union of x nuclei of a female sex cell and a male sex cell that results in the creation of a new individual. 2. Identical twins are formed from the fertilization of a single egg cell by a single sperm. 3. The transformation of a normal cell to a cancerous one is only partially understood at x present time. The key to x understanding the process of x malignant transformation lies in the operation of the DNA of a cell. 4. Causes of x cancer not only come from the environment but may also originate within the body. ANALYSING MEDICAL WORDS AND WORD PARTS 1.gastr-itis 2.gynec-o-logy 3.nephr-ectomy 4.in-cis-ion 5.erythr-o-cyte 6.iatr-o-genic 7.ped-iatr-ics inflammation of the stomach study of female (women’s diseases) removal of the kidney process to cut into (a part of the body) red blood cell pertaining to produced by treatment pertaining to treatment of children (combining vowel o has been dropped between ped- and iatr-) 8.gastr-o-enter-o-logy study of the stomach and intestines 9.cyt-o-logy study of cells 10.bi-opsy process of viewing life Post-viewing Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 11 RELATED READING 1. Because many of the qualities that interest us about humans involve many genes in many locations and , in most cases, we don’t yet know enough to alter our genes intelligently or intentionally. 2. No, there is no evidence that people have suffered any harm so far, although it would be difficult to document a hazard to the general population. 3. Yes, because the information about the presence of a diseased gene can very easily be used against a person by employers or insurance companies.. IN YOUR OWN WORDS 1. open to discussion; debatable, questionable; disputed 2. non-professional, not expert, esp. with reference to law and medicine 3. that which is involved or implied in something else 4. to meddle or interfere with (a thing) so as to misuse, alter, corrupt, or pervert it 5. presenting a clear course; free from difficulties 6. belonging to the intrinsic nature of that which is spoken of; intrinsic, essential 7. to prove or support (something) by documentary evidence 8. work composed of pieces or fragments put together, esp. in an incongruous manner Episode 5: DRUG DEPENDENCY Previewing KEY QUESTIONS 1. Answers will vary. 2. According to some researchers nicotine creates a dependency as powerful as heroine because it acts directly on the dopamine neurons in the brain. 3. The level of toxicity of chemical contaminants, like drugs, mainly consumed by man, which become more dangerous when mixed with other drugs may be increased and even multiplied through combinations.. MEDICAL TERMS 1.cirrhosis 2.toxicity 3.drug 4.synergy 5.acetaldehyde 6.caffeine 7.dopamine 8.narcotic Intensive Viewing Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 12 THE FUNCTION OF THE BRAIN The brain functions through billions of cells called neurons. Consisting of a cellular body and elongated fibers, neurons are connected together into vast networks. The information that flows through these networks is transmitted in two different ways. On the neurons, the signals are conveyed through electric currents. When these currents reach the end of the neurons they cause chemical substances called neurotransmitters to be secreted. The neurotransmitters make contact with the next neuron, thereby creating a new electric current. Neurotransmitters play a vital role in our brain. Depending on their chemical nature and abundance, they enhance or diminish the signals transmitted from one neuron to the next, and thus regulate all activity in every region of the brain. In the brain every neurotransmitter is assigned precise functions. For example, one of the brains most important functions – satisfying vital needs – appears to be associated with the neurotransmitter called dopamine. 1. They consist of a cellular body and elongated fibers. 2. Through electric currents. 3. By making contact with the next neuron. 4. Satisfying vital needs COCAINE I. When a person absorbs cocaine for instance, the drug reaches the brain quickly. It causes an increase in the amount of dopamine present in the neurons. This functional modification of the brain creates intense euphoria. After a while the effect disappears but the brain remembers the euphoric sensation. Haunted by the memory the person then feels something is lacking – a need, a feeling similar to being hungry. That feeling can only be alleviated by consuming cocaine again. In time, the vicious circle intensifies. The need to take drugs can replace the vital needs and even becomes stronger than the need to eat for instance. II. 1.a.T b.T 2.F 3.F 4.F 5.T 6.F ALCOHOL I. In small amounts alcohol: In high doses alcohol: stimulates the nervous system slows the reflexes heightens the reflexes upsets coordination creates a feeling of well being blurs memory reduces fatigue lowers concentration II. 1. No, because if they stop consuming alcohol, they will experience a series of violent withdrawal symptoms. Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 13 2. No, because they are genetically predisposed. 3. No, they just don’t experience the same euphoria as others. 4. No, the presence of this enzyme causes alcohol to produce greater euphoria and this makes people who have it more susceptible to alcoholism. 5. No, they enable alcoholics to share their experiences and thus help each other. THE CONTAMINATION OF OUR PLANET I. A number of chemical pollutants contaminating the environment endanger living beings because like drugs they are foreign to the normal processes of life. To determine how these substances act, toxicologists use a colony of living cells. Normally, the liver eliminates toxic substances absorbed by animals and man. The liver cell’s response to these agents enables the toxicologists to predict the response of entire organisms. Their studies have indicated that many toxic substances act on the membrane, which surrounds cells. This is the case of heavy metals like mercury, lead and cadmium. The membrane is not merely a protective layer. Equipped with tiny pumps, it regulates the flow of many substances into and out of the cells. The constant pumping action of this membrane enables the cells to maintain a different chemical composition than that of their ambient environment. That composition is essential to maintaining their vital processes. In weak concentrations heavy metals do not destroy the cells. But they can prevent the membrane pumps from functioning normally. they chemical pollutants, Their toxicologists, it membrane, that composition, their cells, they heavy metals. II. Genotoxic agents attack the long molecules of DNA, which constitute genes. They cause chemical changes in the basic units of these vital molecules. The changes are liable to result in mutations, that is, permanent changes to the structure of the genes. Scientists believe that some mutations can cause a healthy cell to become a cancer cell. The list of mutagenic and carcinogenic agents that can cause these mutations is a long one. It includes pesticides, heavy metals, emissions from combustion and cooking reactions and many others. Focus on Language PERIPHERAL VOCABULARY 1.intoxication 2.awareness 3.boost 4.ambient 5.vital 6.enhance 7.alleviate 8.induce 9.horrendous 10.illicit 11.deterioration 12.susceptibility 13.predisposed 14.universal 15.disrupt 16.hazardous 17.liable to 18.jeopardize 19.juvenile 20.deliquency FORMAL VS. INFORMAL SPEECH 1.got hammered 2.teens 3.kids 4.Fag ends 5.snifter Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 14 PHRASAL VERBS 1.Did you do well 2.’ll make application to 3.is made up 5.came up against 4.is being done up GRAMMAR CHECK 1. The nervous circuits are affected from drugs. 2. Drinking has long been practiced as part of a normal social life. 3. The biosphere as a whole is being threatened by massive intoxication. 4. An excellent operation was performed by the surgeon. 5. Severe health problems will be caused by the chronic use of a drug. ANALYSING MEDICAL WORDS AND WORD PARTS 1.hydr-o-phobia 2.my-oma 3.hem-o-stasis 4.lapar-o-tomy 5.arteri-ole 6.pleur-o-dynia 7.nephr-o-pathy 8.ot-algia (more commonly used than ot-o-dynia) 9.isch-emia 10.amni-o-centesis Post-viewing RELATED READING 1. It should be but and not butt, however the writer wants to simultaneously ask (But Why?) and provide the answer (Butt = cigarette butt, i.e. because of smoking). 2. Smoking increases risk of melanoma and nonmelanoma skin cancer and perhaps increases those skin cancer risks as well. 3. Number of subjects : 33 Men : 21 Women : 12 Nonsmokers Men : 10 Women : 9 Smoking patterns : 10 to 20 cigarettes a day for 3 to 25 years Results : Protein MMP-1 levels higher for smokers Conclusion : Smokers get a double whammy – once from the sun and again from tobacco, since both trigger this skin-destructive MMP-1 Α.Π.Θ. – ΙΑΤΡΙΚΗaction. ΣΧΟΛΗ 15 IN YOUR OWN WORDS 1. nonsmoker 2. to send, put, or hit in a forceful way 3. rear end 4. the action or process of deteriorating, of growing or making worse 5. smoking habits 6. the final analysis or determining factor; the point, the crux of the argument; 7. to increase a pain, the virulence of (disease), the bitterness of (feeling, speech, etc.); to embitter, aggravate 8. occurring, existing, or done before the usual, proper, or appointed time Episode 6: PHARMACOLOGY Previewing KEY QUESTIONS 1. Answers will vary. 2. E.g. Thalidomide, a mild sleeping pill became popular as because it had no side effects, during the sixties. At that time a number of women took the drug during their pregnancy, and gave birth to children with congenital malformations. 3. Ten years MEDICAL TERMS 1.ointment 2.tranquilizer 3.bronchitis 4.insulin 5.prostaglandin 6.hypothalamus 7.nausea 8.lactose 9.starch 10.thalidomide 11.side effect 12.antacid Intensive Viewing INTRODUCTION Drugs Illnesses aspirin sleeping pill tranquilizer antibiotic ointments cancer bronchitis ASPIRIN I. Let’s take aspirin. Of all the drugs based on acetylsalicylic acid it is the most widely consumed. It is estimated that each year some 100 billion aspirins under various Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 16 trademarks are taken worldwide. Like most drugs aspirins are taken orally. Once swallowed, they enter the stomach where they begin to dissolve. Here they run into their first obstacle, the stomach’s high acidity. Fortunately, owing to its chemical composition the aspirin is able to withstand this acidity, which is not the case with some other drugs. Insulin, for example, must be injected into the muscle because if it went through the stomach it would be completely inactivated. The aspirin then travels to the intestine. From there it enters the bloodstream, which carries it through the system in less than one minute. So the aspirin spreads to every part of our body including the organs that don’t need it. II. 1. Drugs can be administered orally, by suppository, by injection, locally. 2. Aspirin reduces pain, fever, inflammations. 3. Prostaglandins are chemical substances. 4. Fever comes from the presence of prostaglandins in the hypothalamus. 5. An aspirin will have effect as long as there is sufficient quantity in the body. III. 1.F 2.T 3.F 4.NG 5.F 6.T 7.F 8.NG 9.T 10.F THE MANUFACTURING OF DRUGS 1. a. by simulating how the body and drug interact b. by maximizing the efficiency of molecules whose action is already known c. by accelerating research on an active molecule 2. 10% 3. 10 years 4. a. the drug’s chemical compound b. the way it is to be taken c. psychological factors related to marketing 5. a. lactose b. cellulose c. starch 6. 120$ million SIDE EFFECTS Despite precautions some drugs are like time bombs, their side effects only showing up several years after they are taken. This is what happened with thalidomide. During the sixties thalidomide became popular as a mild sleeping pill because it had no side effects. At that time a number of women took the drug during their pregnancy, and gave birth to children with congenital malformations. The pharmaceutical industry Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 17 is required to give a high priority to drug safety but at the same time it is under ever increasing pressure to find solutions. Cancer is a good example. It is one of pharmacologists’ greatest challenges and a prime target for new drugs. The drugs currently used to treat cancer permeate our entire system. Via the blood stream they reach both the malignant cells and the cells of all our other organs liver, kidneys, intestines, muscles; a little like a circular distributed door to door. And that’s where the problem lies. While the substances used in chemotherapy do kill the malignant cells, these are not the only ones they kill, hence the known side effects: hair loss, nausea. HOMING DRUGS 1.two 2.antigen 3.20.000 to 100.000 4.1000, 1000 5.second, solid foreign 6.containing, absorbed, decomposes, released 7.limitations Focus on Language PERIPHERAL VOCABULARY 1.engrave 2.abate 3.assimilate 4.remedy 5.concoct 6.component 7.expedient 8.permeat 9.homing 10.complement 11.capacity 12.druggist 13.solid 14.decompose 15.pour ADMINISTRATION OF DRUGS 1.topical 2.oral 3.intradermal 4.intrathecal 5.intramuscular 6.rectal 7.intravenous 8.inhalation ABBREVIATIONS 3, 6, 7, 5, 10, 9, 4, 2, 1, 8 GRAMMAR CHECK The diaphragm is a muscle that separates the abdominal and thoracic cavities. Acromegaly is an endocrine disorder, which is caused by an excessive amount of growth hormone. A psychiatrist is a specialist who treats mental and nervous disorders. A neurologist is a specialist who deals with the structure and functions of the nervous system. PLURALS varices, bursae, apices, metastases, bullae, ova, nuclei, epiphyses, bronchi, atria, coccyges, bacteria ANALYSING MEDICAL WORDS AND WORD PARTS 1. ocul/ : oculist, ocular, oculistics 2. blephar/: blepharitis, blepharoptosis Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ opt/ : optician, optometrist palpebr/: palpebral, palpebration 18 3. 4. 5. 6. lacrim/: lacrimation, lacrimatory kerat/: keratoplasty, keratitis cor/ : corectasis, corectomy phac/ : phacoemulsification dacry/: dactyorrhea, dacryoadenitis corne/: corneosclera, corneoiritis pupill/ : papillary, pupilloscope phak/ : phakitis, phakomatosis Post-viewing RELATED READING 1. Aspirin. 2. Drowsiness and fast or deep breathing IN YOUR OWN WORDS 1. together with 2. without obvious cause 3. of old age 4. extreme, pronounced 5. throw up, empty the contents of the stomach 6. adapt oneself to, get used to 7. annoying, troublesome 8. extreme nervousness, a state of emotional and (often) physical tension; agitation Α.Π.Θ. – ΙΑΤΡΙΚΗ ΣΧΟΛΗ 19