Drug
I
INTRODUCTION
Drug, substance that affects the function of living cells, used in medicine to
diagnose, cure, prevent the occurrence of diseases and disorders, and prolong
the life of patients with incurable conditions.
Since 1900 the availability of new and more effective drugs such as antibiotics,
which fight bacterial infections, and vaccines, which prevent diseases caused
by bacteria and viruses, has increased the average American’s life span from
about 60 years to about 75 years. Drugs have vastly improved the quality of
life. Today, drugs have contributed to the eradication of once widespread and
sometimes fatal diseases such as poliomyelitis and smallpox.
II
CLASSIFICATION
Drugs can be classified in many ways: by the way they are dispensed——over
the counter or by prescription; by the substance from which they are derived—
plant, mineral, or animal; by the form they take—capsule, liquid, or gas; and
by the way they are administered—by mouth, injection, inhalation, or direct
application to the skin (absorption). Drugs are also classified by their names.
All drugs have three names: a chemical name, which describes the exact
structure of the drug; a generic or proprietary name, which is the official
medical name assigned by the United States Adopted Name Council (a group
composed of pharmacists and other scientists); and a brand or trade name
given by the particular manufacturer that sells the drug. If a company holds
the patent on a drug—that is, if the company has the exclusive right to make
and sell a drug, then the drug is available under one brand name only. After
the patent expires, typically after 17 years in the United States, other
companies can also manufacture the drug and market it under the generic
name, or give it a new brand name.
Another way to categorize drugs is by the way they act against diseases or
disorders: chemotherapeutic drugs attack specific organisms that cause a
disease without harming the host, while pharmocodynamic drugs alter the
function of bodily systems by stimulating or depressing normal cell activity in a
given system. The most common way to categorize a drug is by its effect on a
particular area of the body or a particular condition.
A
Endocrine Drugs
Endocrine drugs correct the overproduction or underproduction of the body’s
natural hormones. For example, insulin is a hormone used to treat diabetes.
The female sex hormones estrogen and progesterone are used in birth control
pills. Estrogen may be given as a replacement therapy to relieve uncomfortable
symptoms associated with menopause including sweating, hot flashes, and
mood swings. Estrogen replacement therapy may also delay some long-term
consequences of menopause including osteoporosis and atherosclerosis.
B
Anti-infective Drugs
Anti-infective drugs are classified as antibacterials, antivirals, or antifungals
depending on the type of microorganism they combat. Anti-infective drugs
interfere selectively with the functioning of a microorganism while leaving the
human host unharmed.
Antibacterial drugs, or antibiotics—sulfa drugs, penicillins, cephalosporins, and
many others—either kill bacteria directly or prevent them from multiplying so
that the body’s immune system can destroy invading bacteria. Antibacterial
drugs act by interfering with some specific characteristics of bacteria. For
example, they may destroy bacterial cell walls or interfere with the synthesis of
bacterial proteins or deoxyribonucleic acid (DNA)—the chemical that carries the
genetic material of an organism. Antibiotics often cure an infection completely.
However, bacteria can spontaneously mutate, producing strains that are
resistant to existing antibiotics.
Antiviral drugs interfere with the life cycle of a virus by preventing its
penetration into a host cell or by blocking the synthesis of new viruses.
Antiviral drugs may cure, but often only suppress, viral infections; and flareups of an infection can occur after symptom-free periods. With some viruses,
such as human immunodeficiency virus (HIV), which causes acquired
immunodeficiency syndrome (AIDS), antiviral drugs can only prolong life, not
cure the disease.
Vaccines are used as antiviral drugs against diseases such like mumps,
measles, smallpox, poliomyelitis, and influenza. Vaccines are made from either
live, weakened viruses or killed viruses, both of which are designed to
stimulate the immune system to produce antibodies, proteins that attack
foreign substances. These antibodies protect the body from future infections by
viruses of the same type (see Immunization).
Antifungal drugs selectively destroy fungal cells by altering cell walls. The cells’
contents leak out and the cells die. Antifungal drugs can cure, or may only
suppress, a fungal infection.
C
Cardiovascular Drugs
Cardiovascular drugs affect the heart and blood vessels and are divided into
categories according to function. Antihypertensive drugs reduce blood pressure
by dilating blood vessels and reducing the amount of blood pumped by the
heart into the vascular system. Antiarrhythmic drugs normalize irregular
heartbeats and prevent cardiac malfunction and arrest.
D
Drugs that Affect the Blood
Antianemic drugs, such as certain vitamins or iron, enhance the formation of
red blood cells. Anticoagulants like heparin reduce blood-clot formation and
ensure free blood flow through major organs in the body. Thrombolytic drugs
dissolve blood clots, which can block blood vessels and deprive the heart or
brain of blood and oxygen, possibly leading to heart attack or stroke.
E
Central Nervous System Drugs
Central nervous system drugs—that is, drugs that affect the spinal cord and
the brain—are used to treat several neurological (nervous system) and
psychiatric problems. For instance, antiepileptic drugs reduce the activity of
overexcited brain areas and reduce or eliminate seizures.
Antipsychotic drugs are used to regulate certain brain chemicals called
neurotransmitters, which do not function properly in people with psychoses,
major mental disorders often characterized by extreme behaviors and
hallucinations, such as in schizophrenia. Antipsychotic drugs can often
significantly alleviate hallucinations and other abnormal behaviors.
Antidepressant drugs reduce mental depression. Antimanic drugs reduce
excessive mood swings in people with manic-depressive illness, which is
characterized by behavioral fluctuations between highs of extreme excitement
and activity and lows of lethargy and depression. Both types of drugs act by
normalize chemical activity in the emotional centers of the brain. Antianxiety
drugs, also referred to as tranquilizers, treat anxiety by decreasing the activity
in the anxiety centers of the brain.
Sedative-hypnotic drugs are used both as sedatives to reduce anxiety and as
hypnotics to induce sleep. Sedative-hypnotic drugs act by reducing brain-cell
activity. Stimulatory drugs, on the other hand, increase neuronal (nerve cell)
activity and reduce fatigue and appetite.
Analgesic drugs reduce pain and are generally categorized as narcotics and
non-narcotics. Narcotic analgesics, also known as opioids, include opium and
the natural opium derivatives codeine and morphine; synthetic derivatives of
morphine such as heroin; and synthetic drugs such as meperidine and
propoxyphene hydrochloride. Narcotics relieve pain by acting on specific
structures, called receptors, located on the nerve cells of the spinal cord or
brain. Non-narcotic analgesics such as aspirin, acetaminophen, and ibuprofen
reduce pain by inhibiting the formation of nerve impulses at the site of pain.
Some of these drugs can also reduce fever and inflammation.
General anesthetics, used for surgery or painful procedures, depress brain
activity, causing a loss of sensation throughout the body and unconsciousness.
Local anesthetics are directly applied to or injected in a specific area of the
body, causing a loss of sensation without unconsciousness; they prevent
nerves from transmitting impulses signaling pain (see Anesthesia).
F
Anticancer Drugs
Anticancer drugs eliminate some cancers or reduce rapid growth and spread.
These drugs do not affect all cancers but are specific for cancers in certain
tissues or organs such as the bladder, brain, liver, or bones. Anticancer drugs
interfere with specific cancer-cell components. For example, alkylating agents
are cytotoxic (cell-poisoning) drugs that alter the DNA of cancer cells. Vinca
alkaloids, chemicals produced by the periwinkle plant, prevent cancer cell
division.
G
Other Drugs
Many other categories of drugs also exist, such as anti-inflammatory,
antiallergic, antiParkinson (see Parkinson Disease), antiworm (see Anthelmintic
Drugs), diuretic, gastrointestinal, pulmonary, and muscle-relaxant drugs. Often
a drug in one category can also be used for problems in other categories. For
example, lidocaine can be used as a local anesthetic or as a cardiac drug.
III
HOW DRUGS MOVE THROUGH THE BODY
The effect of a drug on the body depends on a number of processes that the
drug undergoes as it moves through the body. All these processes together are
known as pharmacokinetics (literally, “motion of the drug”). First in these
processes is the administration of the drug after which it must be absorbed
into the bloodstream. From the bloodstream, the drug is distributed throughout
the body to various tissues and organs. As the drug is metabolized, or broken
down and used by the body, it goes through chemical changes that produce
metabolites, or altered forms of the drug, most of which have no effect on the
body. Finally, the drug and its metabolites are eliminated from the body.
A
Administration
Depending on the drug and its desired effect, there are a variety of
administration methods. Most drugs are administered orally—that is, through
the mouth. Only drugs that will not be destroyed by the digestive processes of
the stomach or intestines can be given orally. Drugs can also be administered
by injection into a vein (intravenously), which assures quick distribution
through the bloodstream and a rapid effect; under the skin (subcutaneously)
into the tissues, which results in localized action at a particular site as with
local anesthetics; or into a muscle (intramuscularly), which enables rapid
absorption through the many blood vessels found in muscles. An intramuscular
injection may also be given as a depot preparation, in which the drug is
combined with other substances so that it is slowly released into the blood.
Inhaled drugs are designed to act in the nose or lungs. General anesthetics
may be given through inhalation. Some drugs are administered through drugfilled patches that stick to the skin. The drug is slowly released from the patch
and enters the body through the skin. Drugs may be administered topically—
that is, applied directly to the skin; or rectally—absorbed through an enema
(an injection of liquid into the rectum) or a rectal suppository (a pellet of
medication that melts when inserted in the rectum).
B
Absorption
Absorption is the transfer of a drug from its site of administration to the
bloodstream. Drugs that are inhaled or injected enter the bloodstream more
quickly than drugs taken orally. Oral drugs are absorbed by the stomach or
small intestine and then passed through the liver before entering the
bloodstream.
C
Distribution
Distribution is the transport of a drug from the bloodstream to tissue sites
where it will be effective, as well as to sites where the drug may be stored,
metabolized, or eliminated from the body. Once a drug reaches its intended
destination, the drug molecules move from blood through cellular barriers to
various tissues. These barriers include the walls of blood vessels, the walls of
the intestines, the walls of the kidneys, and the special barrier between the
brain and the bloodstream that acts as a filtration system to protect the brain
from exposure to potentially harmful substances.
The drug molecules move from an area of high drug concentration—the
bloodstream—to an area of low drug concentration—the tissues—until a
balance between the two areas is reached. This process is known as diffusion.
When a drug reaches its highest concentration in the tissues, the body begins
to eliminate the drug and its effect on the body begins to diminish. The time it
takes for the level of a drug to fall by 50 percent is known as the drug’s halflife. Depending on the drug, this measurement can vary from a few minutes to
hours or even days. For example, if a drug’s highest concentration level in the
blood is 1 mg/ml and this level falls to 0.5 mg/ml after five hours, the half-life
of the drug is five hours. A drug’s half-life is used to determine frequency of
dosage and the amount of drug administered.
Distribution of a drug may be delayed by the binding of the drug to proteins in
the blood. Because the proteins are too large to pass through blood vessel
walls, the drug remains in the blood for a longer period until it is eventually
released from the proteins. While this process may increase the amount of
time the drug is active in the body, it may decrease the amount of the drug
available to the tissues.
D
Metabolism and Elimination
While circulating through the body, a drug undergoes chemical changes as it is
broken down in a process called metabolism, or biotransformation. Most of
these changes occur in the liver, but they can take place in other tissues as
well. Various enzymes oxidize (add oxygen to), reduce (remove oxygen from),
or hydrolyze (add water to) the drug. These changes produce new chemicals or
metabolites that may continue to be medically active in the body or may have
no activity at all. A drug may be broken down into many different metabolites.
Eventually, most drugs or their metabolites circulate through the kidney,
where they are discharged, or eliminated, into the urine. Drugs can also be
excreted in the body’s solid waste products, or evaporated through
perspiration or the breath.
E
Dose-Response Relationship
The extent of the body’s response to a drug depends on the amount
administered, called the dose. At a low dose, no response may be apparent. A
higher dose, however, may produce the desired effect. An even higher dose
may produce an undesirable or harmful response. For example, to relieve a
headache most adults require two tablets of aspirin. A half tablet may provide
no relief from pain while ten tablets may cause burning pain in the stomach or
nausea.
The doses prescribed by physicians are those recommended by each drug’s
manufacturer to produce the best therapeutic, or medically beneficial,
responses in the majority of patients. However, doses may need to be adjusted
in certain individuals. For example, a person may be born without the enzyme
required to metabolize a particular drug while other individuals may suffer
from lung disorders that prevent them from absorbing inhaled drugs. Factors
such as alcohol consumption, age, the method of drug administration, and
whether or not the individual has taken the drug previously can affect an
individual’s response to a drug.
F
Receptors
Drugs interact with cell receptors, small parts of proteins that control a
multitude of chemical reactions and functions in the body. Receptors have a
specific, chemical structure compatible only with certain drugs or endogenous
compounds—substances that originate within the body such as hormones and
neurotransmitters. This relationship can be compared to that of a lock and key:
A drug molecule—the “key”—attaches briefly to its specific receptor—the “lock”
that only this molecule can open. The lock-and-key combination of the drug
and receptor results in a cascade of chemical events. The extent of the
response is determined by the number of receptors activated. Stimulation of
only a few receptors may not produce a response while stimulation of a certain
number of receptors is needed to produce the desired effect.
IV
THERAPEUTIC RESPONSES AND ADVERSE REACTIONS
The same receptors can be found in different tissues and organs in the body,
but receptors produce different responses depending on their location. As a
result, a specific drug can affect the body in more than one way. Desirable
effects are called therapeutic or beneficial responses. Undesirable or harmful
effects are called adverse reactions. Some adverse reactions, or side effects,
can be predicted. The most common side effects are drowsiness, headache,
sleeplessness, nausea, and diarrhea. Other reactions, such as those that occur
only in specific individuals for unexpected reasons, called idiosyncratic
reactions, and those that occur with the triggering of the body’s immune
system, called allergic reactions, are less predictable.
Drug toxicity, or poisoning, can occur when drugs are given in too large a dose
or when individuals take a particular drug over a long period of time—the drug
may build up to dangerous levels in the kidneys and liver and damage these
organs. For some drugs, such as those used to treat epilepsy, the difference
between therapeutic and toxic concentrations is small. Physicians constantly
monitor the precise levels of such drugs in an individual’s bloodstream to
prevent drug poisoning.
Other drugs, such as those used to treat cancer, are known to have toxic
effects; however, the benefits outweigh the risks—that is, treatment without
them may result in death.
A
Drug Interactions
When taken together, drugs can interact with one another and produce
desirable or undesirable results. Some drugs have an additive effect—that is,
they increase the effect of other drugs. For example, alcoholic beverages
intensify the drowsiness-producing effect of some sedatives. Drugs that
displace, or take the place of other drugs present in blood proteins, make the
displaced drugs more active in the body, increasing their effect. Other drugs
have a reducing effect—that is, they interfere with the action of drugs already
present in the body. For example, antacids prevent antibiotics from being
absorbed by the stomach. Some drugs combine with other drugs to create a
substance that has no medical benefit. In some cases, however, drug
interactions can produce desirable results. Doctors have found that using three
drugs to fight AIDS is more effective than one drug used alone.
Drugs are most effective when properly prescribed by physicians and taken
correctly by patients. Missing doses, taking drugs at the wrong time of the day
or with instead of before meals, and stopping drug use too soon can markedly
reduce the medical benefits of many drugs.
V
DRUG ABUSE
Drug abuse is characterized by taking more than the recommended dose of
prescription drugs such as barbiturates without medical supervision, or using
government-controlled substances such as marijuana, cocaine, heroin, or other
illegal substances. Legal substances, such as alcohol and nicotine, are also
abused by many people. Abuse of drugs and other substances can lead to
physical and psychological dependence (see Drug Dependence).
Drug abuse can cause a wide variety of adverse physical reactions. Long-term
drug use may damage the heart, liver, and brain. Drug abusers may suffer
from malnutrition if they habitually forget to eat, cannot afford to buy food, or
eat foods lacking the proper vitamins and minerals. Individuals who abuse
injectable drugs risk contracting infections such as hepatitis and HIV from dirty
needles or needles shared with other infected abusers. One of the most
dangerous effects of illegal drug use is the potential for overdosing—that is,
taking too large or too strong a dose for the body’s systems to handle. A drug
overdose may cause an individual to lose consciousness and to breathe
inadequately. Without treatment, an individual may die from a drug overdose.
Drug addiction is marked by a compulsive craving for a substance. Successful
treatment methods vary and include psychological counseling, or
psychotherapy, and detoxification programs—medically supervised programs
that gradually wean an individual from a drug over a period of days or weeks.
Detoxification and psychotherapy are often used together.
The illegal use of drugs was once considered a problem unique to residents of
poor, urban neighborhoods. Today, however, people from all economic levels,
in both cities and suburbs, abuse drugs. Some people use drugs to relieve
stress and to forget about their problems. Genetic factors may predispose
other individuals to drug addiction. Environmental factors such as peer
pressure, especially in young people, and the availability of drugs, also
influence people to abuse drugs.
VI
HISTORY
Humans have always experimented with substances derived from minerals,
plants, and animal parts to treat pain, illness, and restore health. In ancient
Egypt, physicians prescribed figs, dates, and castor oil as laxatives and used
tannic acid to treat burns. The early Chinese and Greek pharmacies included
opium, known for its pain-relieving qualities, while Hindus used the cannabis
and henbane plants as anesthetics and the root of the plant Rauwolfia
serpentina, which contains reserpine, as a tranquilizer.
A school of pharmacy established in Arabia from 750 to 1258 AD discovered
many substances effective against illness, such as burned sponge (which
contains iodine) for the treatment of goiters—a noncancerous enlargement of
the thyroid gland, visible as a swelling at the front of the neck. In Europe, the
15th century Swiss physician and chemist Philippus Aureolus Paracelsus
identified the characteristics of numerous diseases such as syphilis, a chronic
infectious disease usually transmitted in sexual intercourse, and used
ingredients such as sulfur and mercury compounds to counter the diseases.
During the 17th and 18th centuries, physicians treated malaria, a disease
transmitted by the bite of an infected mosquito, with the bark of the cinchona
tree (which contains quinine). Heart failure was treated with the leaves of the
foxglove plant (which contains digitalis); scurvy, a disease caused by vitamin C
deficiency, was treated with citrus fruit (which contains vitamin C); and
smallpox was prevented using inoculations of cells infected with a similar viral
disease known as cowpox. The therapy developed for smallpox stimulated the
body’s immune system, which defends against disease-causing agents, to
produce cowpox- and smallpox-specific antibodies.
In the 19th century scientists continued to discover new drugs including ether,
morphine, and a vaccine for rabies, an infectious, often fatal, viral disease of
mammals that attacks the central nervous system and is transmitted by the
bite of infected animals. These substances, however, were limited to those
occurring naturally in plants, minerals, and animals. A growing understanding
of chemistry soon changed the way drugs were developed. Heroin and aspirin,
two of the first synthetic drugs created from other elements or compounds
using chemical reactions, were produced in the late 1800s. This development,
combined with the establishment of a new discipline called pharmacology, the
study of drugs and their actions on the body, signaled the birth of the modern
drug industry.
VII
DRUG DEVELOPMENT
Today most drugs are synthesized by chemists in the laboratory. Synthetic
drugs are better controlled than those occurring naturally, which ensures that
each dose imparts the same effect. Some new synthetic drugs are developed
by modifying the structure of existing substances. These new drugs are called
analogues. For example, prednisone is an analogue of the hormone cortisone
(see Hydrocortisone). Because scientists can selectively alter the drug’s
structure, analogues may be more effective and cause fewer side effects than
the drugs from which they were derived.
One of the newer methods for developing drugs involves the use of gene
splicing, or recombinant DNA (see Genetic Engineering). In drug research, this
technique joins the DNA of a specific type of human cell to the DNA of a second
organism, usually a harmless bacterium, to produce a recombinant (or
“recombined”) DNA. The altered organism then begins to produce the
substance produced by the human cell. This substance is extracted from the
bacteria and purified for use as a drug.
The first drug produced in this manner was the hormone insulin in 1982, which
was created in large quantities by inserting the human insulin gene in
Escherichia coli (E. coli) bacteria. Since 1982 other genetically engineered
drugs for humans have been developed, including tissue plasminogen activator
(tPA), an enzyme used to dissolve blood clots in people who have suffered
heart attacks, and erythropoetin, a hormone used to stimulate the production
of red blood cells in people with severe anemia.
Because of the great expense and time involved, most new drugs are created
by large, well-funded pharmaceutical companies. From idea to production, the
development of a new drug can take up to ten years and cost about $200
million. The process usually starts with the idea that an existing chemical
substance has therapeutic value or that the structure of an existing drug can
be modified for new clinical uses. Out of 10,000 chemicals tested in a
laboratory, only one may eventually become a drug.
Once drug researchers have determined that a new substance may have
medical value, an elaborate testing program begins. The drug is tested first on
small animals such as rats and mice, and then on larger animals such as
monkeys and dogs. If these tests indicate that the new drug is effective
against its intended target—such as a particular disease—and shows an
acceptably low level of toxicity, the drug company requests permission from
the Food and Drug Administration (FDA), an agency of the U.S. Department of
Health and Human Services, to test the drug in humans.
If the agency approves the request, clinical trials on humans can begin. These
experiments are usually divided into three phases, each of which can last from
several months to several years. In the first phase, the drug is tested on a
small number of healthy individuals to determine its effect on the body. The
second phase tests the drug on a small number of people who have the
disease or disorder the drug manufacturer hopes the drug will treat. These
individuals are divided into two groups: those who receive the drug and those
who receive a placebo, or inactive compound. Neither the investigating
physicians nor the members of the test group know who is receiving the drug
or who is receiving the placebo. This technique, called a double-blind study,
ensures that no one consciously or unconsciously influence the drug’s effect.
The third phase tests the drug on a much larger group of people and
determines specific doses, possible interactions with other drugs, responses
related to gender, and other information used for drug labeling. At the end of
the third phase, a drug manufacturer compiles the results of the clinical trials
and submits them to the FDA in a new product application. If the drug has been proven effective and
safe, and its benefits outweigh any risks, the agency approves the drug for marketing. FDA approval of a
new drug may take up to 18 months; however, the agency is working to reduce the time to 12 months
for most drugs and 6 months for highly effective drugs that treat previously incurable conditions.
VIII
DRUG REGULATION
Because drugs can produce harmful effects when manufactured or taken
improperly, most governments control drug development as well as
availability. In the United States, the FDA determines how drugs are produced
and how they are sold. Drugs that can be sold over the counter (OTC)—that is,
without a prescription from a physician—are called proprietary drugs. They are
considered safe for unsupervised use by the general population. Drugs that
must be prescribed by physicians and dispensed by pharmacists are known as
ethical drugs. Their use is monitored closely by medical personnel.
The FDA regulates the sale and manufacture of drugs in the United States as
outlined in applicable laws enacted over the past century. Legal standards for
composition and preparation of drugs in the United States are found in the
publication known as the United States Pharmacopeia (USP). Drugs that can be
abused, such as the powerful narcotic heroin, are regulated by the Drug
Enforcement Administration (DEA) of the U.S. Department of Justice to ensure
that they are not prescribed or sold illegally.
Before 1900 any individual could sell a drug and claim it offered therapeutic
benefits without medical proof. This changed after 1906 with the passage of
the Pure Food and Drug Act, which required drug manufacturers to state the
content, strength, and purity of each drug they produced. The Pure Food and
Drug Act ended the practice of including morphine, cocaine, and heroin in
drugs without the public’s knowledge. In 1914 the U.S. legislature began to
strictly regulate the trade of narcotics with the enactment of the Harrison
Narcotic Act; in 1937 the government added marijuana to this list of controlled
substances (the Marijuana Tax Act).
The Federal Food, Drug, and Cosmetic Act was enacted in 1938 requiring that
new drugs be safe for humans; however, it did not require that manufacturers
prove their drugs’ effectiveness. It would be 24 years before legislation was
passed that would require proof of the efficacy of new drugs (the KefaverHarris Amendments, 1962). Enforcement of this law was entrusted to the FDA.
Two laws enacted in the 1960s strengthened the FDA’s efforts to reduce drug
abuse. The Drug Abuse Control Amendments of 1965 provided penalties for
the illegal sale or possession of stimulants, sedatives, and hallucinogens, and
the Narcotic Addict Rehabilitation Act of 1966 set up a federal program for
addicts that provided them with the option of receiving treatment for their drug
problems in place of a prison sentence.
In 1970 the Comprehensive Drug Abuse Prevention and Control Act established
rules for manufacturing and prescribing habit-forming drugs. It stipulated that
physicians can prescribe all drugs, but a special license is required to prescribe
drugs with a high abuse potential. This license is issued by the Drug
Enforcement Administration.
The Anti-Drug Abuse Acts, signed into law in 1986 and 1988, set up funding
for the treatment of drug abuse and for the creation of law-enforcement
programs to fight the illegal sale of drugs. These acts also detailed severe
punishments for individuals selling and possessing drugs illegally. Harsh
penalties for using anabolic steroids (hormones that promote the storage of
protein and the growth of tissue that are sometimes abused by competitive
athletes) were included in the 1988 act, along with the requirement that all
alcoholic beverages be labeled with warnings about alcohol’s potentially
dangerous effect on the body. The 1988 act also established the Office of
National Drug Control Policy to develop an action plan that would involve the
public, as well as private agencies, in eliminating the illegal sale of drugs; in
helping individuals who use drugs to stop; and in preventing nonusers from
ever starting to use drugs.
The U.S. government and its regulatory agencies continually monitor the
development and use of all drugs sold in the United States to ensure that the
American public has access only to drugs that are safe and effective. Recently,
the FDA introduced legislation requiring warning labels on all over-the-counter
medication after research indicated that the nonaspirin pain reliever
acetaminophen can cause liver damage when taken in high doses with large
quantities of alcohol.