POSTERS HDA AND THE REPLISOME IN ESCHERICHIA COLI Baxter, Jamie C. and Mark D. Sutton State University of New York at Buffalo ENHANCING THE EFFECTIVENESS OF CHEMOTHERAPEUTIC AGENTS BY INHIBITING PRO-MUTAGENIC DNA SYNTHESIS Berdis, Anthony J. and Andrea I. Ramos Department of Pharmacology and the Comprehensive Cancer Center, Case Western Reserve University, Cleveland OH 44106 THE COORDINATION AND MANAGEMENT OF DNA REPLICATION, REPAIR AND TRANSLESION SYNTHESIS BY THE E. COLI BETA SLIDING CLAMP. Heltzel, Justin, Rob Maul and Mark Sutton State University of New York at Buffalo LOCALIZATION OF MSH2-MSH3 ON Saccharomyces cerevisiae GENOME Kumar, Charanya and Jennifer A. Surtees Dept. of Biochemistry, State University of New York at Buffalo, Buffalo,NY 14214 THE TARGETING MECHANISM OF TN7 TO DISCONTINUOUS DNA REPLICATION Li, Zaoping, Adam Parks and Joseph Peters Department of Microbiology, Cornell University, Ithaca, NY 14853 CRYSTAL STRUCTURES OF MONOMERIC, DIMERIC AND TRIMERIC PCNA: +PCNA-RING ASSEMBLING AND OPENING Ling, Hong, Vladena Hlinkova, Guangxin Xing, Jacob Bauer &Yoon Jung Shin Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1 DNA REPLICATION-DRIVEN DM1 (CTG)n•(CAG)n INSTABILITY AT AN ECTOPIC CHROMOSOMAL SITE IN HUMAN CELLS Liu, Guoqi 1, Xiaomi Chen 1, John Bissler 2, Richard Sinden 3, and Michael Leffak 1 1 Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio 45435, 2 Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45220, 3 Department of Biological Sciences, Florida Institute of Technology, Melbourne, Florida 329013 IS DBF4 A LONG-LOST BRCT FAMILY MEMBER? Matthews, Lindsay 1, Andrew Duong1, Ajai Prasad2, Bernard Duncker2 and Alba Guarné1. 1) Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON. 2) Department of Biology, University of Waterloo, Waterloo, ON. MUKBFE: A COMPLEX RELATIONSHIP REGULATING CHROMOSOME CONDENSATION AND SEGREGATION Menzies, Stuart 1,*, Melanie Gloyd1,*, Rodolfo Ghirlando2 and Alba Guarné1. 1) Department of Biochemistry, McMaster University, Hamilton (ON); 2) Laboratory of Molecular Biology, NIDDK, NIH, Bethesda (MD). YEAST MISMATCH REPAIR PROTEIN MSH1P AND MITOCHONDRIAL BASE EXCISION REPAIR Pogorzala, Leah and Elaine A. Sia, PhD University of Rochester, Rochester, NY MUTATIONS TO DBF4 MOTIF C WEAKEN INTERACTION WITH MCM2 BUT ENHANCE ASSOCIATION WITH RAD53 CONFERRING INCREASED RESISTANCE TO GENOTOXIC AGENTS IN SACCHAROMYCES CEREVISIAE. Prasad, Ajai A., Darryl R. Jones, Philip K. Chan, and Bernard P. Duncker University of Waterloo, Waterloo, ON, Canada N2L 3V5 GCN5 IS A POSITIVE REGULATOR OF ORIGINS OF DNA REPLICATION Rehman,Muhammad Attiq, Maria Espinosa, and Krassimir Yankulov Department of Molecular and Cellular Biology, University of Guelph, ON, Canada KINETIC ANALYSIS OF ARGININE-FINGER MOTIF FUNCTION IN SACCAROMYCES CEREVISIAE CLAMP LOADER Sakato, Miho and Manju Hingorani Department of Molecular Biology and Biochemistry, Wesleyan University, Connecticut 06459 MCM2 REQUIRES NUCLEOTIDE TO REGULATE MCM4/6/7 Stead, Brent E., Christopher J. Brandl and Megan J. Davey Department of Biochemistry, Schulich School of Medicine and Dentistry University of Western Ontario, London, ON Canada, N6A 5C1 ARCHAEAL LIGASE IS A HOMODIMERIC PROTEIN THAT CIRCULARIZES SINGLE-STRANDED DNA AND RNA Takagi. Yuko 1, Christopher Torchia1, and C.Kiong Ho1,2 Department of Biological Sciences1 and Microbiology and Immunology2 State University of New York at Buffalo, Buffalo, NY 14260 REQUIREMENTS FOR THE DNA DAMAGE CHECKPOINT PROTEIN HUS1 IN THE MOUSE MAMMARY GLAND Yazinski, Stephanie A., Peter Westcott, Kelly Ong, and Robert S. Weiss Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853 LUNG CANCER INDUCTION BY WIDESPREAD OVEREXPRESSION OF RIBONUCLEOTIDE REDUCTASE IN TRANSGENIC MICE Xu, Xia, Jennifer L. Page, Houchun Liu, Sarah Lagedrost, Young Lu, Alexander Yu. Nikitin, and Robert S. Weiss. Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA ANALYSIS OF S. CEREVISIAE MISMATCH REPAIR PROTEIN MSH2-MSH6 INTERACTIONS WITH DNA Zhai, Jie and Manju Hingorani Department of Molecular Biology and Biochemistry, Wesleyan University, Connecticut 06459