Ruff CT, Morrow DA, Jarolim P, Ren F, Contant CF, Kaur A, Curtis SP, Laine L, Cannon
CP, Brune K. Evaluation of NT-proBNP and High Sensitivity C-Reactive Protein for
Predicting Cardiovascular Risk in Patients with Arthritis Taking Longterm Nonsteroidal
Antiinflammatory Drugs. J Rheumatol. 2011 Apr 1.
Hess A, Axmann R, Rech J, Finzel S, Heindl C, Kreitz S, Sergeeva M, Saake M, Garcia M,
Kollias G, Straub RH, Sporns O, Doerfler A, Brune K, Schett G. From the Cover: Blockade of TNF-α rapidly inhibits pain responses in the central nervous system. Proc Natl Acad
Sci U S A. 2011 Mar 1;108(9):3731-6. Epub 2011 Jan 18.
----------------------------------------------------------------------------------------------------------------
Brune K, Renner B, Hinz B. Using pharmacokinetic principles to optimize pain therapy. Nat
Rev Rheumatol. 2010 Oct;6(10):589-98.
Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai
F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz
S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong
D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner
A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ,
Woolf CJ, Penninger JM. A genome-wide Drosophila screen for heat nociception identifies
α2δ3 as an evolutionarily conserved pain gene. Cell. 2010 Nov 12;143(4):628-38.
Brune K. [Cardiovascular complications with cyclooxygenase inhibitors : Myths and facts]. Z
Rheumatol. 2010 Oct;69(8):712, 714-8.
Brune K, Stammschulte T. [Transdermal fentanyl: what if doctor and pharmacist fail?].
MMW Fortschr Med. 2010 Apr 15;152(15):41, 43.
Oldenhof J, Hochberg M, Schiff M, Brune K. Effect of maximum OTC doses of naproxen sodium or acetaminophen on low-dose aspirin inhibition of serum thromboxane B2. Curr Med
Res Opin. 2010 Jun;26(6):1497-504.
Stammschulte T, Brune K. [Drug safety problems in association with the use of opioid containing patches for the management of pain]. Dtsch Med Wochenschr. 2010
Apr;135(17):870-3.
Renner B, Zacher J, Buvanendran A, Walter G, Strauss J, Brune K. Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery-
-a pilot study. Naunyn Schmiedebergs Arch Pharmacol. 2010 Feb;381(2):127-36.
Heindl-Erdmann C, Axmann R, Kreitz S, Zwerina J, Penninger J, Schett G, Brune K, Hess A.
Combining functional magnetic resonance imaging with mouse genomics: new options in pain research. Neuroreport. 2010 Jan 6;21(1):29-33.
Mandery K, Bujok K, Schmidt I, Wex T, Treiber G, Malfertheiner P, Rau TT, Amann KU,
Brune K, Fromm MF, Glaeser H. Influence of cyclooxygenase inhibitors on the function of the prostaglandin transporter organic anion-transporting polypeptide 2A1 expressed in human gastroduodenal mucosa. J Pharmacol Exp Ther. 2010 Feb;332(2):345-51.

2
Neubert A, Lukas K, Leis T, Dormann H, Brune K, Rascher W. Drug utilisation on a preterm and neonatal intensive care unit in Germany: a prospective, cohort-based analysis. Eur J Clin
Pharmacol. 2010 Jan;66(1):87-95.
----------------------------------------------------------------------------------------------------------------
Zopf Y, Rabe C, Neubert A, Janson C, Brune K, Hahn EG, Dormann H. Gender-based differences in drug prescription: relation to adverse drug reactions. Pharmacology.
2009 ;84(6):333-9.
Brune K, Renner B, Maas R. Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous. Dtsch Med Wochenschr. 2009
Sep;134(36):1771-3.
Schiff M, Hochberg MC, Oldenhof J, Brune K. Platelet inhibitory effects of OTC doses of naproxen sodium compared with prescription dose naproxen sodium and low-dose aspirin.
Curr Med Res Opin. 2009 Aug 13.
Renner B, Brune K. Are Myocardial Infarctions and Death in Healthy Individuals Associated
With the Use of Cyclooxygenase Inhibitors? Clin Pharmacol Ther. 2009 May 6.
Brune K, Hinz B, Otterness I. Aspirin and acetaminophen: should they be available over the counter? Curr Rheumatol Rep. 2009 Feb;11(1):36-40.
Hinz B, Renner B, Cheremina O, Besz D, Zolk O, Brune K. Lumiracoxib inhibits cyclooxygenase 2 completely at the 50 mg dose: is liver toxicity avoidable by adequate dosing?
Ann Rheum Dis. 2009 Feb;68(2):289-91.
----------------------------------------------------------------------------------------------------------------
Hinz B, Brune K. Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology. Trends Pharmacol Sci. 2008 Aug;29(8):391-7.
Zopf Y, Rabe C, Neubert A, Gaßmann KG, Rascher W, Hahn EG, Brune K, Dormann H.
Women encounter ADRs more often than do men. Eur J Clin Pharmacol. 2008
Oct;64(10):999-1004..
Heindl C, Hess A, Brune K. Refinement and reduction in animal experimentation: options for new imaging techniques. ALTEX. 2008;25(2):121-5.
Brune K, Katus HA, Moecks J, Spanuth E, Jaffe AS, Giannitsis E. N-terminal pro-B-type natriuretic Peptide concentrations predict the risk of cardiovascular adverse events from antiinflammatory drugs: a pilot trial. Clin Chem. 2008 Jul;54(7):1149-57.
Hinz B, Cheremina O, Besz D, Zlotnick S, Brune K. Impact of naproxen sodium at over-thecounter doses on cyclooxygenase isoforms in human volunteers. Int J Clin Pharmacol Ther.
2008 Apr;46(4):180-6.
Brune K. [Randomized double blind study on traditional Chinese medicine. evidence remains questionable] MMW Fortschr Med. 2008 Jan 24;150(3-4):7.

3
Knabl J, Witschi R, Hösl K, Reinold H, Zeilhofer UB, Ahmadi S, Brockhaus J, Sergejeva M,
Hess A, Brune K, Fritschy JM, Rudolph U, Möhler H, Zeilhofer HU. Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature. 2008 Jan 17;451(7176):330-4.
Hinz B, Renner B, Brune K. Drug insight: cyclo-oxygenase-2 inhibitors--a critical appraisal.
Nat Clin Pract Rheumatol. 2007 Oct;3(10):552-60; quiz 1 p following 589.
Brune K, Niederweis U. [From willow bark to the coxibs. Development of antiphlogistic analgesics] Schmerz. 2007 Aug;21(4):318, 320-8, 330.
Polykandriotis E, Tjiawi J, Euler S, Arkudas A, Hess A, Brune K, Greil P, Lametschwandtner
A, Horch RE, Kneser U. The venous graft as an effector of early angiogenesis in a fibrin matrix. Microvasc Res. 2008 Jan;75(1):25-33.
Hinz B, Cheremina O, Brune K. Acetaminophen (paracetamol) is a selective cyclooxygenase-
2 inhibitor in man. FASEB J. 2008 Feb;22(2):383-90.
----------------------------------------------------------------------------------------------------------------
Eberl S, Renner B, Neubert A, Reisig M, Bachmakov I, König J, Dörje F, Mürdter TE,
Ackermann A, Dormann H, Gassmann KG, Hahn EG, Zierhut S, Brune K, Fromm MF. Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies. Clin Pharmacokinet. 2007 ;46(12):1039-49.
Heindl C, Brune K, Renner B. Kinetics and functional characterization of the glycine receptor alpha2 and alpha3 subunit. Neurosci Lett. 2007 Dec 11;429(1):59-63.
Brune K. [Lumiracoxib taken off the market in Australia. What does that mean for our patients? (interview by Dr. Judith Neumaier)] MMW Fortschr Med. 2007 Sep 27;149(39):6.
Brune K. Persistence of NSAIDs at effect sites and rapid disappearance from side-effect compartments contributes to tolerability. Curr Med Res Opin. 2007 Dec;23(12):2985-95.
Hinz B, Renner B, Brune K. Drug insight: cyclo-oxygenase-2 inhibitors--a critical appraisal.
Nat Clin Pract Rheumatol. 2007 Oct;3(10):552-60; quiz 1 p following 589.
Nitsche A, Zhang M, Clauss T, Siegert W, Brune K, Pahl A. Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors. BMC Immunol. 2007 Aug 31;8:18.
Brune K, Nitschmann S. [Liver toxicity of paracetamol] Internist (Berl). 2007
Sep;48(9):1036-8.
Ernst-Stecken A, Jeske I, Hess A, Rödel F, Ganslandt O, Grabenbauer G, Sauer R, Brune K,
Blümcke I. Hypofractionated stereotactic radiotherapy to the rat hippocampus. Determination of dose response and tolerance. Strahlenther Onkol. 2007 Aug;183(8):440-6.
Brune K, Niederweis U. [From willow bark to the coxibs. Development of antiphlogistic analgesics] Schmerz. 2007 Aug;21(4):318, 320-8, 330. German.

4
Häupl T, Burmester GR, Giannitsis E, Rohrlach T, Spanuth E, Parsch H, Brune K. N-terminal prohormone brain natriuretic peptide: a biomarker for detecting cardiovascular risks in patients with rheumatoid arthritis or osteoarthritis? Ann Rheum Dis. 2007 Jun;66(6):838-9.
Brune K, Furst DE. Combining enzyme specificity and tissue selectivity of cyclooxygenase inhibitors: towards better tolerability? Rheumatology (Oxford). 2007 Jun;46(6):911-9.
Renner B, Clarke G, Grattan T, Beisel A, Mueller C, Werner U, Kobal G, Brune K. Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen. J Clin Pharmacol.
2007 Jun;47(6):715-26.
Hinz B, Cheremina O, Bachmakov J, Renner B, Zolk O, Fromm MF, Brune K. Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic. FASEB J. 2007 Aug;21(10):2343-51.
Brune K. Do case control studies on coxibs tell us anything new? Rheumatology (Oxford).
2007 May;46(5):730.
Puljic R, Benediktus E, Plater-Zyberk C, Baeuerle PA, Szelenyi S, Brune K, Pahl A.
Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF. Eur
J Pharmacol. 2007 Feb 28;557(2-3):230-5.
Hinz B, Brune K. [Pain therapy with antipyretic analgesics] Orthopade. 2007 Jan;36(1):23-31.
Hinz B, Brune K. Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective
COX-2 inhibitors, paracetamol and pyrazolinones. Handb Exp Pharmacol. 2007;(177):65-93.
Hess A, Sergejeva M, Budinsky L, Zeilhofer HU, Brune K. Imaging of hyperalgesia in rats by functional MRI. Eur J Pain. 2007 Jan;11(1):109-19.
----------------------------------------------------------------------------------------------------------------
Polykandriotis E, Horch RE, Arkudas A, Labanaris A, Brune K, Greil P, Bach AD, Kopp J,
Hess A, Kneser U. Intrinsic versus extrinsic vascularization in tissue engineering. Adv Exp
Med Biol. 2006 ;585:311-26.
Neubert A, Dormann H, Weiss J, Criegee-Rieck M, Ackermann A, Levy M, Brune K,
Rascher W. Are computerised monitoring systems of value to improve pharmacovigilance in paediatric patients? Eur J Clin Pharmacol. 2006 Nov;62(11):959-65.
Pahl A, Bauhofer A, Petzold U, Cnota PJ, Maus J, Brune K, Szelenyi S. Synergistic effects of the anti-cholinergic R,R-glycopyrrolate with anti-inflammatory drugs. Biochem Pharmacol.
2006 Dec 15;72(12):1690-6.
Werner U, Lamprecht C, Werner D, Schaefer S, Wuttke H, Hinz B, Fromm MF, Brune K.
Valdecoxib does not interfere with the CYP2D6 substrate metoprolol. Int J Clin Pharmacol
Ther. 2006 Sep;44(9):397-400.
Baumjohann D, Hess A, Budinsky L, Brune K, Schuler G, Lutz MB. In vivo magnetic resonance imaging of dendritic cell migration into the draining lymph nodes of mice. Eur J
Immunol. 2006 Sep;36(9):2544-55.

5
Kneser U, Polykandriotis E, Ohnolz J, Heidner K, Grabinger L, Euler S, Amann KU, Hess A,
Brune K, Greil P, Stürzl M, Horch RE. Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Tissue Eng. 2006 Jul;12(7):1721-31.
Zeilhofer HU, Brune K. Analgesic strategies beyond the inhibition of cyclooxygenases.
Trends Pharmacol Sci. 2006 Sep;27(9):467-74.
Crofford LJ, Breyer MD, Strand CV, Rushitzka F, Brune K, Farkouh ME, Simon LS.
Cardiovascular effects of selective COX-2 inhibition: is there a class effect? The International
COX-2 Study Group. J Rheumatol. 2006 Jul;33(7):1403-8.
Pahl A, Szelenyi S, Brune K. Hypoxia induced chemokine expression in nasal epithelial cells: development of an in vitro model for chronic rhinosinusitis. ALTEX. 2006;23(2):59-63.
Cheremina O, Brune K, Hinz B. A validated high-performance liquid chromatographic assay for determination of lumiracoxib in human plasma. Biomed Chromatogr. 2006
Oct;20(10):1033-7.
Zimmermann WH, Melnychenko I, Wasmeier G, Didié M, Naito H, Nixdorff U, Hess A,
Budinsky L, Brune K, Michaelis B, Dhein S, Schwoerer A, Ehmke H, Eschenhagen T.
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.
Nat Med. 2006 Apr;12(4):452-8.
Hinz B, Dormann H, Brune K. More pronounced inhibition of cyclooxygenase 2, increase in blood pressure, and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxib. Arthritis Rheum. 2006 Jan;54(1):282-91.
Rösch S, Ramer R, Brune K, Hinz B. R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. J Pharmacol Exp Ther. 2006 Mar;316(3):1219-28.
Eichele K, Weinzierl U, Ramer R, Brune K, Hinz B. R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells. Pharm Res. 2006 Jan;23(1):90-4.
Schmidt A, Brune K, Hinz B. Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography. Biomed Chromatogr. 2006
Apr;20(4):336-42.
----------------------------------------------------------------------------------------------------------------
Wunder S, Brune K. [Medication in a physicians network: modern treatment with no increase in costs?] MMW Fortschr Med. 2005 Apr 7;147 Suppl 1:13-9. German.
Rösch S, Ramer R, Brune K, Hinz B. Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases. Biochem Biophys Res Commun. 2005 Dec
16;338(2):1171-8.

6
Hinz B, Rösch S, Ramer R, Tamm ER, Brune K. Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism. FASEB J. 2005 Nov;19(13):1929-31.
Lamprecht C, Werner U, Werner D, Schaefer S, Renner B, Fromm M, Brune K. Effect of selective cyclooxygenase-2 inhibitors on heart rate in healthy young men. Am J Cardiol. 2005
Jun 15;95(12):1531-2.
Cheremina O, Bachmakov I, Neubert A, Brune K, Fromm MF, Hinz B. Simultaneous determination of oxycodone and its major metabolite, noroxycodone, in human plasma by high-performance liquid chromatography. Biomed Chromatogr. 2005 Dec;19(10):777-82.
Brune K. COX-2 selective inhibitors--they are still the best treatment for many patients!
Swiss Med Wkly. 2005 Mar 19;135(11-12):163-5.
Chialda L, Zhang M, Brune K, Pahl A. Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia.
Respir Res. 2005 Apr 15;6:36.
Egger T, Dormann H, Ahne G, Pahl A, Runge U, Azaz-Livshits T, Neubert A, Criegee-Rieck
M, Gassmann KG, Brune K. Cytochrome p450 polymorphisms in geriatric patients: impact on adverse drug reactions--a pilot study. Drugs Aging. 2005;22(3):265-72.
Reinold H, Ahmadi S, Depner UB, Layh B, Heindl C, Hamza M, Pahl A, Brune K, Narumiya
S, Müller U, Zeilhofer HU. Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype. J Clin Invest. 2005 Mar;115(3):673-9.
Hinz B, Chevts J, Renner B, Wuttke H, Rau T, Schmidt A, Szelenyi I, Brune K, Werner U.
Bioavailability of diclofenac potassium at low doses. Br J Clin Pharmacol. 2005 Jan;59(1):80-
4.
Werner U, Werner D, Hinz B, Lambrecht C, Brune K. A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasma. Biomed Chromatogr. 2005 Mar;19(2):113-8.
Brune K. [Treatment of musculoskeletal pain] Med Monatsschr Pharm. 2005 Jan;28(1):19-23.
----------------------------------------------------------------------------------------------------------------
Wunder S, Brune K. [Drug prescribing in practitioner networks--improved treatment at no extra cost?] MMW Fortschr Med. 2004 Dec 16;146(51-52):43-4.
Werner D, Wuttke H, Fromm MF, Schaefer S, Eschenhagen T, Brune K, Daniel WG, Werner
U. Effect of amiodarone on the plasma levels of metoprolol. Am J Cardiol. 2004 Nov
15;94(10):1319-21.
Brune K, Zacher J. [Cardiovascular risk: a class effect of coxibs? How to manage patients taking Vioxx?] MMW Fortschr Med. 2004 Oct 14;146(42):10, 12. German.
Hinz B, Ramer R, Eichele K, Weinzierl U, Brune K. R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts. Biochem Biophys Res Commun. 2004 Nov 12;324(2):621-6.

7
Neubert A, Dormann H, Weiss J, Egger T, Criegee-Rieck M, Rascher W, Brune K, Hinz B.
The impact of unlicensed and off-label drug use on adverse drug reactions in paediatric patients. Drug Saf. 2004;27(13):1059-67.
Hinz B, Ramer R, Eichele K, Weinzierl U, Brune K. Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. Mol Pharmacol. 2004 Dec;66(6):1643-51.
Brune K. [New evaluation by the EU approval committee. Benefits of cox-2 inhibitors outweigh possible risks (interview by Dr. Thomas Meissner)] MMW Fortschr Med. 2004 Feb
26;146(9):47.
Brune K, Hinz B. The discovery and development of antiinflammatory drugs.
Arthritis Rheum. 2004 Aug;50(8):2391-9.
Hinz B, Brune K. Pain and osteoarthritis: new drugs and mechanisms. Curr Opin Rheumatol.
2004 Sep;16(5):628-33.
Dormann H, Neubert A, Criegee-Rieck M, Egger T, Radespiel-Tröger M, Azaz-Livshits T,
Levy M, Brune K, Hahn EG. Readmissions and adverse drug reactions in internal medicine: the economic impact. J Intern Med. 2004 Jun;255(6):653-63.
Brune K, Hinz B. Selective cyclooxygenase-2 inhibitors: similarities and differences. Scand J
Rheumatol. 2004;33(1):1-6.
Brune K. Replacement and refinement of animal experimentation in drug research has been and will be a permanent and necessary process. ALTEX. 2004;21(1):38-41.
Ullmann S, Hage T, Draheim R, Egerland U, Oelmüller U, Brune K, Pahl A. RNA-based drug screening using automated RNA purification and real-time RT-PCR1. J Biomol Screen. 2004
Mar;9(2):95-102.
Dormann H, Criegee-Rieck M, Neubert A, Egger T, Levy M, Hahn EG, Brune K.
Implementation of a computer-assisted monitoring system for the detection of adverse drug reactions in gastroenterology. Aliment Pharmacol Ther. 2004 Feb 1;19(3):303-9.
Brune K. Safety of anti-inflammatory treatment--new ways of thinking. Rheumatology
(Oxford). 2004 Feb;43 Suppl 1:i16-20.
--------------------------------------------------------------------------------------------------------------
Zeilhofer HU, Brune K. A role for cyclooxygenase-1 in neuropathic pain? Anesthesiology.
2003 Nov;99(5):1043-4.
Ramer R, Weinzierl U, Schwind B, Brune K, Hinz B. Ceramide is involved in r(+)methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells. Mol
Pharmacol. 2003 Nov;64(5):1189-98.

8
Hinz B, Rau T, Auge D, Werner U, Ramer R, Rietbrock S, Brune K. Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac. Clin
Pharmacol Ther. 2003 Sep;74(3):222-35.
Werner U, Werner D, Rau T, Fromm MF, Hinz B, Brune K. Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans. Clin Pharmacol Ther. 2003
Aug;74(2):130-7.
Egger T, Dormann H, Ahne G, Runge U, Neubert A, Criegee-Rieck M, Gassmann KG, Brune
K. Identification of adverse drug reactions in geriatric inpatients using a computerised drug database. Drugs Aging. 2003;20(10):769-76.
Schmidt A, Schwind B, Gillich M, Brune K, Hinz B. Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatography. Biomed Chromatogr. 2003 Jun;17(4):276-81.
Hinz B, Auge D, Rau T, Rietbrock S, Brune K, Werner U. Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography. Biomed Chromatogr. 2003 Jun;17(4):268-75.
Depner UB, Reinscheid RK, Takeshima H, Brune K, Zeilhofer HU. Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor. Eur J Neurosci. 2003 Jun;17(11):2381-7.
Diener HC, Brune K, Gerber WD, Pfaffenrath V, Straube A; Deutsche Migräne- und
Kopfschmerz-Gesellschaft. [Therapy of the acute migraine attack and migraine prophylaxis.
Recommendation of the "Deutsche Migräne- und Kopfschmerz-Gesellschaft]. Schmerz. 2000
Aug;14(4):269-83. German.
Pfaffenrath V, Brune K, Diener HC, Gerber WD, Göbel H. [Treatment of tension-type headache. Recommendation of the German Migraine and Headache Society]. Schmerz. 1998
Apr 20;12(2):156-68; discussion 169-70. German.
Brune K, Hinz B. [2-Arylpropionic acids. Role in pain therapy]. Schmerz. 1998 Dec
9;12(6):383-8. German.
Hinz B, Ramer R, Brune K. Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamide. Adv Exp Med Biol. 2003;525:145-52.
Szelenyi I, Brune K. Unconventional therapies in asthma. Drugs Today (Barc). 2001
Oct;37(10):651-664.
Brune K. [Self experimentation and in vitro research will not suffice: a plea for more refinement]. ALTEX. 2003;20(1):48-50. German.
Dormann H, Criegee-Rieck M, Neubert A, Egger T, Geise A, Krebs S, Schneider T, Levy M,
Hahn E, Brune K. Lack of awareness of community-acquired adverse drug reactions upon hospital admission : dimensions and consequences of a dilemma. Drug Saf. 2003;26(5):353-
62.

9
Thomeczek C, Lampert U, Brune K, Hasenbring M, Krämer J, Niebling W, Raspe H, Stäbler
A, Steudel WI, Willburger RE, Zeilhofer HU, Kirchner H, Ollenschläger G; Expertenkreis
"Akuter Rückenschmerz" der Arztlichen Zentralstelle Qualitätssicherung. [Acute backache guideline clearing process. Methodology and results of formal evaluation]. Z Orthop Ihre
Grenzgeb. 2003 Jan-Feb;141(1):11-7. German.
Hinz B, Brune K, Pahl A. 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. Biochem Biophys Res Commun. 2003 Mar 7;302(2):415-20.
--------------------------------------------------------------------------------------------------------------
Szelenyi I, Brune K. Herbal remedies for asthma treatment: between myth and reality. Drugs
Today (Barc). 2002 Apr;38(4):265-303.
Gühring H, Hamza M, Sergejeva M, Ates M, Kotalla CE, Ledent C, Brune K. A role for endocannabinoids in indomethacin-induced spinal antinociception. Eur J Pharmacol. 2002
Nov 15;454(2-3):153-63.
Simon LS, Smolen JS, Abramson SB, Appel G, Bombardier C, Brater DC, Breedveld FC,
Brune K, Burmester GR, Crofford LJ, Dougados M, DuBois RN, Fitzgerald GA, Frishman
W, García Rodríguez LA, Hochberg MC, Kalden JR, Laine L, Langman MJ, Prescott SM, van de Putte LB, Whelton A, White WB, Willaims GH. Controversies in COX-2 selective inhibition. J Rheumatol. 2002 Jul;29(7):1501-10.
Schuster J, Ates M, Brune K, Gühring H. The cannabinoids R(-)-7-hydroxy-delta-6-tetrahydrocannabinol-dimethylheptyl (HU-210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice. Neurosci Lett. 2002 Jul 5;326(3):196-
200.
--------------------------------------------------------------------------------------------------------------
Hinz B, Brune K. New insights into physiological and pathophysiological functions of cyclooxygenase-2. Curr Opin Anaesthesiol. 2000 Oct;13(5):585-90.
----------------------------------------------------------------------------------------------------------------
Szelenyi I, Geisslinger G, Polymeropoulos E, Paul W, Herbst M, Brune K. The real gordian knot: racemic mixtures versus pure enantiomers. Drug News Perspect. 1998 Apr;11(3):139-60.
----------------------------------------------------------------------------------------------------------------
Ionac M, Parnham MJ, Plauchithiu M, Brune K. Oxaceprol, an atypical inhibitor of inflammation and joint damage. Pharmacol Res. 1996 Jun;33(6):367-73.
Ionac M, Bordos D, Geisslinger G, Brune K. [An experimental model of the microsurgical cannulation of the thoracic duct in the rat]. Chirurgia (Bucur). 1996 May-Jun;45(3):147-9.
Romanian.

10
----------------------------------------------------------------------------------------------------------------
Brune K, Bickel D, Peskar BA. Gastro-protective effects by extracts of Petasites hybridus: the role of inhibition of peptido-leukotriene synthesis. Planta Med. 1993 Dec;59(6):494-6.
----------------------------------------------------------------------------------------------------------------
Zeilhofer HU, Swandulla D, Geisslinger G, Brune K. Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons. Eur J Pharmacol. 1992 Mar
17;213(1):155-8.
----------------------------------------------------------------------------------------------------------------
Szelenyi I, Brune K. Possible role of oxygen free radicals in ethanol-induced gastric mucosal damage in rats. Dig Dis Sci. 1988 Jul;33(7):865-71.
----------------------------------------------------------------------------------------------------------------
Szelenyi I, Brune K. Possible role of sulfhydryls in mucosal protection induced by aluminum hydroxide. Dig Dis Sci. 1986 Nov;31(11):1207-10.
Lanz R, Polster P, Brune K. Antipyretic analgesics inhibit prostaglandin release from astrocytes and macrophages similarly. Eur J Pharmacol. 1986 Oct 14;130(1-2):105-9.
----------------------------------------------------------------------------------------------------------------
Schneider E, Brune K. Distribution of fentanyl in rats: an autoradiographic study. Naunyn
Schmiedebergs Arch Pharmacol. 1985 Dec;331(4):359-63.
----------------------------------------------------------------------------------------------------------------
Brune K. Prostaglandins and the mode of action of antipyretic analgesic drugs. Am J Med.
1983 Nov 14;75(5A):19-23.
Brune K, Alpermann H. Non-acidic pyrazoles: inhibition of prostaglandin production, carrageenan oedema and yeast fever. Agents Actions. 1983 Jun;13(4):360-3.
----------------------------------------------------------------------------------------------------------------
Brune K, Peskar BA. Paracetamol does not potentiate the acetylsalicylate inhibition of prostaglandin release from macrophages. Eur J Pharmacol. 1980 Dec 5;68(3):365-7.
Brune K, Kälin H, Rainsford KD, Wagner K. Dexamethasone inhibits the release of prostaglandins and the formation of autophagic vacuoles from stimulated macrophages. Adv
Prostaglandin Thromboxane Res. 1980;8:1679-84.
----------------------------------------------------------------------------------------------------------------
Kälin H, Brune K. Effects of colchicine on the microvascular endothelium in response to acute inflammation. Bibl Anat. 1979 ;(17):66-71.

11
Brune K, Rainsford KD, Peskar BA. Prostaglandin release from macrophages: modulation by anti-inflammatory drugs. Agents Actions Suppl. 1979;(6):159-65.
Brune K, Wagner K. The effects of protein/nucleic acid synthesis inhibitors on the inhibition of prostaglandin release from macrophages by dexamethasone. Agents Actions Suppl.
1979;(4):73-9.
Peskar BA, Brune K. Prostaglandin D2: the prevailing prostaglandin in an acute inflammation. Agents Actions Suppl. 1979;(4):260-6.
----------------------------------------------------------------------------------------------------------------
Peskar BA, Glatt M, Anhut H, Brune K. Effect of imidazole on prostaglandin and thromboxane accumulation in urate arthritis. Eur J Pharmacol. 1978 Aug 15;50(4):437-41.
Brune K, Glatt M, Kälin H, Peskar BA. Pharmacological control of prostaglandin and thromboxane release from macrophages. Nature. 1978 Jul 20;274(5668):261-3.
Rainsford KD, Brune K. Selective cytotoxic actions of aspirin on parietal cells: a principal factor in the early stages of aspirin-induced gastric damage. Arch Toxicol. 1978 Apr
27;40(2):143-50.
----------------------------------------------------------------------------------------------------------------
Whitehouse MW, Rainsford KD, Ardlie NG, Young IG, Brune K. Alternatives to aspirin, derived from biological sources. Agents Actions Suppl. 1977 ;(1):43-57.
Brune K. Biodistribution of salicylates: a clue to the understanding of some effects and side effects. Agents Actions Suppl. 1977;2:163-77.
----------------------------------------------------------------------------------------------------------------
Brune K, Graf P, Glatt M. Inhibition of prostaglandin synthesis in vivo by nonsteroid antiinflammatory drugs: evidence for the importance of pharmacokinetics. Agents Actions. 1976
Feb;6(1-3):159-64.
Brune K, Glatt M. Proceedings: Effects of microtubular inhibitors on capillaries and endothelial cells. Arzneimittelforschung. 1976;26(6):1236-7.
Brune K, Glatt M, Graf P. Mechanisms of action of anti-inflammatory drugs. Gen Pharmacol.
1976;7(1):27-33.
Glatt M, Wagner K, Brune K. The effects of antiinflammatory doses of colchicine on prostaglandin content in inflamed tissue. Adv Prostaglandin Thromboxane Res. 1976;1:111-5.
----------------------------------------------------------------------------------------------------------------
Graf P, Glatt M, Brune K. Acidic nonsteroid anti-inflammatory drugs accumulating in inflamed tissue. Experientia. 1975 Aug 15;31(8):951-3.

12
----------------------------------------------------------------------------------------------------------------
Glatt M, Peskar B, Brune K. Leukocytes and prostaglandins in acute inflammation.
Experientia. 1974 Nov 15;30(11):1257-9.
Brune K, Glatt M. The avian microcrystal arthritis. IV. The impact of sodium salicylate, acetaminophen and colchicine on leukocyte invasion and enzyme liberation in vivo. Agents
Actions. 1974 Apr;4(2):101-7.
Brune K, Glatt M. The avian microcrystal arthritis. 3. Invasion and enzyme-release from leukocytes at the site of inflammation. Agents Actions. 1974 Apr;4(2):95-100.
----------------------------------------------------------------------------------------------------------------
Floersheim GL, Brune K, Seiler K. Colchicine in avian sodium urate and calcium pyrophosphate microcrystal arthritis. Agents Actions. 1973 May;3(1):20-3.
----------------------------------------------------------------------------------------------------------------
Floersheim GL, Brune K. Tolerance to skin allografts by immunosuppressive "pulse" of methylhydrazine derivatives and antilymphocyte serum. Transplant Proc. 1971 Mar;3(1):688-
92.
Brune K, Schneeberger J, Bättig P. [Continuous arteriovenous cross-circulation between unanesthesized rats]. Z Gesamte Exp Med. 1971;155(1):13-9. German.
Floersheim GL, Brune K. The haematological response to the immunosuppressive methylhydrazine derivates procarbazine and Ro 4-6824. Acta Haematol. 1971;46(2):92-105.
----------------------------------------------------------------------------------------------------------------
Brune K, Floersheim GL. Selective effects of heterospecific antilymphocyte sera on graft and host components in graft-versus-host reactions. Agents Actions. 1970 Mar;1(3):112-4.
----------------------------------------------------------------------------------------------------------------
Brune K. [Mechanism of a heterologous, cutaneous Graft-Versus-Host reaction in mice]. Z
Gesamte Exp Med. 1969 Sep 19;151(1):74-88. German.