Biology
Name: ____________________________Per.: ____
DNA, RNA, & Replication Worksheet
DNA Structure
1. What type of macromolecule is DNA?
2. What are the monomer units (building blocks) of DNA?
3. What term is given to the shape of the DNA molecule?
4. What are the three components of a nucleotide?
5. What part(s) of the nucleotide make up the backbone (sides) of the DNA molecule?
6. What part(s) of the nucleotide make up the rungs (middle) of the DNA molecule?
DNA vs. RNA: Fill in the table below.
Bases
Sugar
DNA
mRNA
DNA Replication
7. What is the purpose of DNA replication?
8. What is the end result of DNA replication?
Relative Size &
Number of Strands
Location
Long or short?
Nucleus? ________
____ strands
Cytoplasm? ______
Long or short?
Nucleus? ________
____ strands
Cytoplasm? ______
Biology
9.
Name: ____________________________Per.: ____
In DNA Replication:
A pairs with ________
and C pairs with __________
10. In Protein Synthesis (RNA):
A pairs with ________ and
C pairs with __________
Directions: Below are five (3) different DNA sequences:

In the original DNA row of each table, rewrite the sequence in the form of three (3) bases per box.
This will help you for when you move on to the steps to Protein Synthesis on the next assignment.
DNA sequence #1: ACCGTAGGTCGAAAT
Original
DNA
New Copy of
DNA
ACC
TGG
DNA sequence #2: TACCGAGCTAGCTAT
Original
DNA
New Copy of
DNA
DNA sequence #3: CTCATTTGACTAACC
Original
DNA
New Copy of
DNA
7.
The model of DNA below is ready to be copied. Compared to the original double
helix, evaluate the copies made during three attempts of DNA replication. List any
errors with the replication if they occurred:
Biology
A
T
C
C
G
T
G
Replication #1
T
A
G
G
AND
C
A
C
Replication #2
A
T
T
A
C
G
C
G
G
C
T
A
G
C
AND
A
T
C
A
G
T
G
T
A
G
G
C
A
C
A
T
C
C
G
T
G
T
A
G
G
C
A
C
A
T
T
A
C
G____
Name: ____________________________Per.:
C
G
G
C
List problems if any:
T
A
_______________________
G
C
_______________________
_______________________
_______________________
_______________________
_______________________
List problems if any:
_______________________
_______________________
_______________________
_______________________
_______________________
_______________________
8. Complete the diagram on the left. Then circle the areas in the diagram on the right that
show a genetic mutation.
DNA Correctly Copied
A
G
C
T
A
T
A
DNA Incorrectly Copied
A
G
C
T
A
T
A
9.
__
A
G
C
T
A
T
A
T
C
G
A
T
G
T
G
G
C
T
A
C
A
T
C
G
A
T
A
T
Explain how the mutations might have been caused in the diagram above.
_______________________________________________________________________
__
_______________________________________________________________________
__
_______________________________________________________________________