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and Sapling Learning . . .
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THE MOST BALANCED COVERAGE of biology and
chemistry of any one-semester biochemistry text
3
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IN ONE SEMESTER. The coverage you want.
The relevance your students need.
The most balanced
coverage of biology
and chemistry
The best instructor
and student support
supplement package
The highest-quality
book at the lowest
possible price
NOW AVAILABLE with Sapling Learning Online
Homework System!
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The most balanced
COVERAGE OF BIOLOGY AND CHEMISTRY
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Dear Professor,
Oxford University Press is proud to announce the July 2011 publication of Biochemistry: The
Molecular Basis of Life, Fifth Edition, by Trudy McKee and James R. McKee.
As publisher for this trusted and respected textbook—now in its second edition with Oxford
University Press—we would like to extend our warmest regards to our friends in the biochemistry community and to guarantee that the fifth edition and the supplements that accompany it
will be ready and available in July, in plenty of time for fall classes.
The fifth edition of McKee & McKee again provides the right balance between chemical and
biological principles, for the coverage you want and the relevance your students need in a onesemester course. We are proud to announce a new partnership with Sapling Learning, which
will make available to McKee adopters a fantastic online homework system. This system makes
assigning and grading homework a snap. Teaching and learning biochemistry will be easier and
more efficient than ever before.
As a Not-For-Profit publisher, Oxford University Press USA is uniquely situated to offer the
highest-quality scholarship at the lowest possible prices. Sapling Learning’s commitment to
high-quality content, customer service, and low prices makes them a perfect fit in this endeavor.
We invite you to take a guided tour of the new edition and the two advance chapters provided
here. We believe you will find that Trudy and James McKee and Oxford University Press have
prepared a new edition of exceptional quality and value for your students.
Sincerely,
Jason Noe
Senior Editor
Oxford University Press
Jason Kramer
Marketing Manager
Oxford University Press
Table of Contents FOR THE GUIDED TOUR
“ This is the best
one-semester
biochemistry book
available.”
— RANDOLPH A. COLEMAN,
COLLEGE OF WILLIAM & MARY
SAPLING LEARNING ONLINE HOMEWORK SYSTEM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
OVERVIEW. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
INSTRUCTOR AND STUDENT SUPPLEMENTS PACKAGE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
ILLUSTRATED WALK-THROUGH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
ENDORSEMENTS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
SCHOOLS ADOPTING MCKEE & MCKEE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
ANNOTATED TABLE OF CONTENTS FOR THE FIFTH EDITION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
SAMPLE CHAPTERS FROM THE FIFTH EDITION: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
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NOW AVAILABLE WITH
SAPLING LEARNING ONLINE HOMEWORK SYSTEM
NEW! Online Homework System from Sapling Learning
Oxford University Press has partnered with Sapling Learning to produce an
online homework and instructional solution for the Biochemistry: The Molecular
Basis of Life textbook. The text that presents the coverage you need with the
relevance your students want is now available with the most powerful online
homework system in the industry.
The goals of the partnership between Oxford University Press and Sapling
Learning are to:
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Sapling Learning Benefits
This online homework system is a powerful and effective tool for your biochemistry courses.
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Interested in a live demonstration?
Go to www.oup.com/us/mckee and
follow the “Click here” link.
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HERE’S HOW IT WORKS
1. Adopt McKee & McKee’s Biochemistry, The Molecular Basis of Life, 5E
2. Access Sapling’s Biochemistry Online Homework System correlated with text
3. Get a 40% discount off Sapling Online Homework System when packaged with text!
For information on all package options,
flip to the inside back cover.
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McKee/McKee
Biochemistry: The Molecular Basis of
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Principles of Biochemistry, 4E
$181.20
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IN ONE SEMESTER: THE COVERAGE YOU WANT.
THE RELEVANCE YOUR STUDENTS NEED.
Biochemistry: The Molecular Basis of Life is the ideal text for students who do not specialize in biochemistry but who require a strong grasp of biochemical principles. The goal of this edition has been
to enrich the coverage of chemistry while better highlighting the biological context. Once concepts and
problem-solving skills have been mastered, students are prepared to tackle the complexities of science,
modern life, and their chosen professions.
“The integration of biochemical facts
into a meaningful biological context
is a wonderful goal, particularly for
a one-semester course. I applaud
the increased chemistry content,
particularly the addition of the four
mentioned enzyme mechanisms.
The revised problem sets will certainly enhance the value of the text.”
—C. Martin Lawrence,
Montana State University
Chemical and Biological Principles in Balance
Designed from the start for a one-semester survey course, McKee & McKee
introduces students to the fascinating world of biochemical principles with just
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neither too deep nor too shallow a fashion, helping students to see not just the
details but also the bigger picture that connects these fields.
Real-World Relevance
From new chapter-opening vignettes through vivid in-chapter essays and fully
integrated coverage, the authors consistently connect important biochemical
principles to the worlds of medicine, nutrition, agriculture, bioengineering, and
forensics. Students will understand both the relevance of biochemistry and the
latest developments in the field.
Superior Problem-Solving Program
“The authors recognize the continued
need to be current and relevant—a
fact often ignored by other authors.
I have been lecturing on macromolecular crowding for years—it is a
topic often completely ignored or
given short shrift.”
—Kenneth O. Willeford,
Mississippi State University
The fifth edition includes 20 percent more end-of-chapter problems—already
doubled in the previous edition—now approximately 60 per chapter and the most
in any textbook. The expanded problem sets span a range of difficulty and applications, from basic practice problems to more challenging integrative exercises.
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provide students with the opportunity to put their knowledge into action, right
where new concepts are introduced. New with this edition, Sapling Learning’s
Online Homework System is a powerful and effective tool for your course.
Currency
The fifth edition has been fully updated to include recent discoveries, including
new discussions of epigenetics and the epigenome and the contribution of dietary
fructose to the current epidemics of obesity and type II diabetes. Other enhanced
coverage concerns protein folding, glucose transport mechanisms, macromolecular crowding, RNAi, gene silencing, molecular chaperones, and biotechnology,
to keep students up to date and poised for further study.
Simple, Clear Illustrations
With dozens of new and enhanced figures, now also expanded and re-labeled for
lecture display, the fifth edition of McKee & McKee incorporates a superior art
program designed to help students develop a strong visual grasp of biochemical
processes.
YOU CAN HAVE IT ALL IN ONE SEMESTER.
4
A POWERFUL TEACHING PACKAGE
The fifth edition of Biochemistry: The Molecular Basis of Life is accompanied by a variety of ancillary materials for both
instructors and students, including an all-new online homework system from Sapling Learning (see page 5 for details).
Please visit the companion website (www.oup.com/us/McKee) to access lecture and assessment resources and interactive
student study aids.
FOR INSTRUCTORS
‡All text images in enhanced electronic format: Instructors who adopt the fifth
edition of McKee & McKee gain access to every illustration, photo, figure caption,
and table from the text in high-resolution electronic format. Labels have been enlarged
and multi-part figures have been broken down into separate components, for clearer
projection in large lecture halls. Images are available on both the Instructor’s Resource
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‡Test Bank for Instructors: Written by the authors, the Test Bank includes more than
700 questions that are provided as editable Word files that can be easily customized.
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‡Lecture Notes Slides for each chapter of the text::ULWWHQE\6HDQ&ROHPDQ
(University of the Ozarks), this set of more than 1100 editable lecture notes slides
makes preparing lectures faster and easier than ever. Available in PowerPoint format
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website.
FOR STUDENTS
‡Student Study Guide and Solutions Manual: Written by authors Patricia DePra and
Michael G. Sehorn (Clemson University), this manual provides the solutions to all of
the exercises from the text. Each and every solution has been independently checked
for accuracy by a panel of expert reviewers. (ISBN 9780199730971)
‡ Web Quizzes: Students seeking an online resource to test their knowledge of
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questions written by Dan Sullivan (University of Nebraska at Omaha). Students
receive a feedback summary with each graded quiz.
‡Interactive 3-D Molecules:
7RGG&DUOVRQGrand Valley
State University) has created
more than 300 interactive 3-D
molecules in JMOL format.
Students can manipulate and
study individual molecules
and their structures, take selfguided concept tutorials, and
test their molecule-recognition
abilities by working through
the all-new interactive selfquizzes.
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A ROBUST BIOCHEMISTRY LEARNING SYSTEM
Chapter-Opening Vignettes
All new to this edition, these vignettes
grab student attention from the start and
connect biochemical principles and discoveries to such subjects as human disorders, climate change, and the nature
of life itself.
Biochemistry in Perspective essays
show students the real-world relevance
of the biochemical processes they are
studying. The fifth edition includes nine
new essays, each of which begins with
an engaging, thought-provoking question and ends with a concept summary
statement to help students see the big
picture. These and more than two dozen
additional essays from past editions are
also available online.
Biochemistry in the Lab boxes introduce
both classic and modern experimental
techniques, reinforcing the fact that the
best way to learn science is by doing
science!
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summaries, suggested readings, and
key-word lists provide students with
pedagogical support, reinforcing what
they have learned and guiding them
toward further inquiry. Frequent inFKDSWHU.H\&RQFHSWEXOOHWSRLQWVDQG
links to Web resources complete the
step-by-step learning system.
6
An unparalleled problem-solving
system provides multiple opportunities and methods for developing
strong quantitative and analytical
skills. These include hundreds of
in-chapter Questions based on realworld applications and end-of-chapter Review and Thought Questions.
Vivid and accurate figures illuminate
the text discussion, visually illustrating
important concepts and processes.
7
A highly trusted textbook
“I have always appreciated the balance in previous editions, and the
inclusion of more chemistry (enzyme
mechanisms) is great! Increased
relevance is important, too! I appreciate the inclusion of systems biology topics and macromolecular
crowding. Essays and boxes add just
the right flavor to the text to make it
really come alive in a practical kind
of way. It is the best one-semester
biochemistry book available.”
—Randolph A. Coleman,
College of William & Mary
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a biological context is excellent. I welcome the increased depth of
chemistry coverage emphasizing the most important reactions. I also
welcome the increased connection between biochemistry and human
biology. This edition is evolving beautifully. . . . From what I’ve
seen, I prefer the new McKee textbook to the book that I am curUHQWO\XVLQJµ
—Christine A. Hrycyna, Purdue University
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and disorders to the understanding of key biochemical concepts. My
students appreciate the ‘Biochemistry in Perspective’ essays in each
chapter. Once again McKee has done a fabulous job of providing clear
illustrations. I feel the fifth edition has done very well in balancing
both the chemical and biological concepts. The revisions will make
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—Anjuli Datta, Pennsylvania State University
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context to me is the most important goal. In this manner students can
derive the connection between the facts and how they lead to elucidating the principle of the topic being introduced. I like the style: it
begins with very simple down-to-earth discussion and gradually gets
into the more complex and sophisticated aspects. The vignettes at the
beginning of the chapters and the use of Thought Questions at the
end are very appealing. The introduction and discussion of a disease
directly related to the topic being discussed will stimulate students’
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—Ralph A. Stephani, St. Johns University
“I love the vignettes because I teach
with a lot of examples from my
personal scientific and educational
experience. This type of thing often
helps to get the students to understand where a given topic fits into
the real-world situation.”
—Ruth E. Birch,
St. Louis University
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end of the chapters. I like that they are increasing the chemistry. I
really like the format of the questions at the end of the chapter. They
start out easy and build up in complexity. The Thought Questions
push the students to look at the big picture. My students really like
the Biochemistry in the Lab sections. They get excited about the conQHFWLRQWRFXUUHQWUHVHDUFKµ
—Tamara L., Hendrickson, Wayne State University
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and biology. This text is really interesting to read and nicely illustrated. I like most the idea that biochemical reactions should be shown
integrated in the context of the cellular anatomy and functions. The
proposed revisions about RNA interference and chromate code give
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—Max Sokolov, West Virginia University
8
Schools Adopting McKee & McKee
Arizona State University Main
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University of Alabama in Huntsville
Auburn University at Montgomery
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University of Alabama, The
Ball State University
Miami University
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Michigan Technological University
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Baylor University
Middle Tennessee State University
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Bellevue University
Minnesota State University, Mankato
University of Delaware
Benedictine University
Mississippi State University
University of Findlay, The
Bloomsburg University of
Pennsylvania
Monmouth University
University of Kentucky
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University of Maine at Presque Isle
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Nebraska Wesleyan University
University of Memphis
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University, Pomona
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University of Michigan-Ann Arbor
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Sacramento
Northwestern Oklahoma State
University
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University of New England
Pennsylvania State University—
University Park
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at Wilmington
University of Rhode Island
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DePaul University
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South Dakota State University
University of Minnesota-Duluth
University of Nebraska at Omaha
University of Texas, Permian Basin
University of West Alabama
Southwest Missouri State University
Washington State University
Vancouver
Southwest Texas State University
Wayne State University
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Governors State University
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East Tennessee State University
Farleigh Dickinson University
Fordham University
Iowa State University
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Texas Tech University
University of Alabama at
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West Virginia University
Western New Mexico University
Wichita State University
Worcester Polytechnic Institute
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CONTENTS FOR MCKEE & MCKEE, FIFTH EDITION
1. BIOCHEMISTRY:
AN INTRODUCTION
Cytoskeleton: An expanded section
introduces the concept of intraflagellar
transport.
1.1 What is Life?
Ribosomes
1.2 Biomolecules
Functional Groups of Organic
Biomolecules
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1.3 ,VWKH/LYLQJ&HOOD&KHPLFDO
Factory?
Biochemical Reactions
Energy
NEW! Biochemistry in
Perspective: Primary Cilia
and Human Disease: A new
box describes how defects in
the structural and functional
properties of primary cilia
contribute to human disease.
Overview of Metabolism
Biochemistry in the Lab: Cell
Technology
Biological Order
Available Online
1.4 Systems Biology
Biochemistry in Perspective:
Organelles and Human Disease
Emergence
Robustness
3. WATER: THE MATRIX OF
Modularity
Biochemistry in the Lab:
An Introduction
2. LIVING CELLS
2.1 Basic Themes
Water
Biological Membranes
Self-Assembly
Molecular Machines
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Signal Transduction
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Plasma Membrane
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Pili and Flagella
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Plasma Membrane
Endoplasmic Reticulum
Golgi Apparatus
Nucleus
Vesicular Organelles
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The Hydrophobic Effect Revisited
4.3 The Role of ATP
Biochemistry in Perspective:
Nonequilibrium Thermodynamics
Available Online
Biochemistry in Perspective: The
Extremophiles: Organisms that Make
a Living in Hostile Environments
5. AMINO ACIDS, PEPTIDES,
AND PROTEINS
5.1 Amino Acids
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Biologically Active Amino Acids
Modified Amino Acids in Proteins
3.1 Molecular Structure of Water
3.2 Noncovalent Bonding
Ionic Interactions
Hydrogen Bonds
Van der Waals Forces
3.3 Thermal Properties of Water
3.4 Solvent Properties of Water
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Structuring, and Sol-Gel Transitions
Hydrophobic Molecules and the
Hydrophobic Effect
Amphipathic Molecules
Osmotic Pressure
3.5 Ionization of Water
Acids, Bases and pH
Buffers
Physiological Buffers
Amino Acid Stereoisomers
NEW! Biochemistry in
Perspective: Cell Volume
Regulation and Metabolism:
A new box describes the relationship between metabolic pathways
and cell volume changes triggered by osmotic imbalances.
Titration of Amino Acids
Amino Acid Reactions
5.2 Peptides
5.3 Proteins
Protein Structure
The Folding Problem: An updated
section describes molecular
chaperone-assisted protein folding.
Fibrous Proteins
Globular Proteins
5.4 Molecular Machines
Motor Proteins
NEW! Biochemistry in
Perspective: Spider Silk and
Biomimetics: A new box describes
the structural properties of spider
silk fibers and the efforts of scientists to manufacture artificial
spider silk.
Biochemistry in the Lab: Protein
Technology
Available Online
Available Online
Peroxisomes
Biochemistry in Perspective: Water,
Abiotic Stress, and Compatible Solutes
4. ENERGY
4.1 palette
Thermodynamics
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First Law of Thermodynamics
Second Law of Thermodynamics
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LIFE
Mitochondria
Plastids
4.2 Free Energy
Biochemistry in Perspective: Protein
Poisons
Biochemistry in Perspective: Myosin:
A Molecular Machine
Biochemistry in the Lab: Protein
Sequence Analysis: The Edman
Degradation
6. ENZYMES
6.1 Properties of Enzymes
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6.3 Enzyme Kinetics
Michaelis-Menten Kinetics
Lineweaver-Burk Plots
Multisubstrate Reactions
Enzyme Inhibition
Enzyme Kinetics, Metabolism and
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Organic Reactions and the Transition
State
The Roles of Amino Acids in Enzyme
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Effects of Temperature and pH on
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6.5 Enzyme Regulation
Homoglycans
Heteroglycans
7.4 Glycoconjugates
Proteoglycans
Glycoproteins
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NEW! Biochemistry in the Lab:
Glycomics: A new box describes
the major technologies used
to determine the structure of
complex carbohydrate molecules.
Available Online
NEW! Biochemistry in
Perspective: Conversion of
Fischer Monosaccharide
Structure onto Haworth Structure
8. CARBOHYDRATE
METABOLISM
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The Reactions of the Glycolytic
Pathway
NEW! Biochemistry
in Perspective: Alcohol
Dehydrogenase: A Tale of Two
Organisms: A new box describes
the remarkable ability of the
yeast Saccaromyces cerevisiae
to synthesize ethanol, and the
properties of human alcohol
dehydrogenases.
Available Online
Biochemistry in Perspective:
Fermentation: An Ancient Heritage
9. METABOLISM I: THE CITRIC
ACID CYCLE
9.1 Oxidation-Reduction Reactions
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Aerobic Metabolism
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8.1 Glycolysis
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Perspective: Turbo Design
Can Be Dangerous: A new box
describes why turbo design
pathways must be rigorously
controlled.
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Allosteric Regulation
NEW! Biochemistry in
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NEW! The Citric Acid Cycle and
Human Disease
The Fates of Pyruvate
The Energetics of Glycolysis
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Regulation of Glycolysis
Biochemistry in Perspective:
The Evolutionary History of the
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8.2 Gluconeogenesis
Gluconeogenesis Reactions
Gluconeogenesis Substrates
Gluconeogenesis Regulation
8.3 The Pentose Phosphate Pathway
10. METABOLISM II: ELECTRON
TRANSPORT AND OXIDATIVE
PHOSPHORYLATION
8.4 Metabolism of Other Important
Sugars
10.1 Electron Transport
Available Online
Fructose Metabolism
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Biochemistry in Perspective: Enzymes
and Clinical Medicine
8.5 Glycogen Metabolism
Biochemistry in Perspective: Quantum
Tunneling and Catalysis
Glycogenolysis
Glycogenesis
Regulation of Glycogen Metabolism
7. CARBOHYDRATES
7.1 Monosaccharides
Monosaccharide Stereoisomers
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Reactions of Monosaccharides
Important Monosaccharides
Monosaccharide Derivatives
7.2 Disaccharides
7.3 Polysaccharides
NEW! Biochemistry in
Perspective: Saccharomyces
Cerevisiae and the Crabtree
Effect: A new box describes the
metabolic mechanism whereby
yeast cells convert glucose
into ethanol molecules that kill
competitor microbes.
NEW! Electron Transport:
The Fluid State Model vs.
the Solid-State Model: A new
section describes the structural
and functional properties of the
respirasome.
Electron Transport Inhibitors
10.2 Oxidative Phosphorylation
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ATP Synthesis
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Uncoupled Electron Transport
11
10.32[\JHQ&HOO)XQFWLRQDQG
Oxidative Stress
12. LIPID METABOLISM
Reactive Oxygen Species
12.1 Fatty Acids, Triacylglycerols,
and the Lipoprotein Pathways: An
expanded discussion focuses on the
distribution of triacylglycerols to the
body’s tissues after digestion, the triacylglycerol cycle, and glycerogenesis.
Antioxidant Enzyme Systems
Antioxidant Molecules
Biochemistry in Perspective:
Myocardial Infarct: Ischemia and
Reperfusion: An expanded reading
describes the damage caused by the
reintroduction of oxygen after blood
flow interruption in heart muscle.
Available Online
Biochemistry in Perspective: Hans
Krebs and the Citric Acid Cycle.
11. LIPIDS AND MEMBRANES
11.1/LSLG&ODVVHV
Fatty Acids
The Eicosanoids: An expanded discussion of the eicosanoids describes their
biological functions and roles
in human disease.
Triacylglycerols
Wax Esters
Phospholipids
Phospholipases: A new section
describes the functions of phospholipases.
13.4 The Light-Independent Reactions
The Calvin Cycle: The Calvin cycle
reactions are expanded to include the
ribulose-1,5- bisphosphate carboxylase
mechanism.
Photorespiration
Fatty Acid Degradation
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Acid
13.5 Regulation of Photosynthesis
Fatty Acid Oxidation: Double Bonds
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Fatty Acid Biosynthesis: The structural
and functional properties of fatty acid
synthase are updated to reflect recent
research. A new table compares the
details of fatty acid b-oxidation and
synthesis.
Biochemistry in Perspective:
Photosynthesis in the Deep
Regulation of Fatty Acid Metabolism
in Mammals: An expanded discussion
places fatty acid metabolism regulation
in the context of AMPK control of the
body’s biochemical pathways.
Biochemistry in the Lab:
Photosynthetic Studies
Lipoprotein Metabolism: The
Endogenous Pathway: A new section
focuses on the transport of synthesized
lipid molecules from the liver to the
body’s tissues.
/LJKW&RQWURORI3KRWRV\QWKHVLV
Available Online
Biochemistry in Perspective:
Starch and Sucrose Metabolism
14. NITROGEN METABOLISM I:
SYNTHESIS
14.1 Nitrogen Fixation
The Nitrogen Fixation Reaction
Nitrogen Assimilation
12.2 Membrane Lipid Metabolism
14.2 Amino Acid Biosynthesis
Phospholipid Metabolism
Amino Acid Metabolism Overview
Sphingolipids
Sphingolipid Metabolism
Reactions of Amino Groups
Sphingolipid Storage Diseases
12.3 Isoprenoid Metabolism
Synthesis of the Amino Acids
Isoprenoids
Cholesterol Metabolism: A new section describes the effects of selected
drugs on the cholesterol biosynthetic
pathway.
14.3 Biosynthetic Reactions Involving
Amino Acids
Lipoproteins
11.2 Membranes
Membrane Structure: A new section
describes the structural and functional
properties of the red blood cell membrane protein AE1.
Membrane Function
NEW! Biochemistry in
Perspective: Botulism and
Membrane Function: A new
box describes how botulinum
toxin causes muscle paralysis by
preventing membrane fusion
in nerve cells.
Available Online
Biochemistry in Perspective:
Glucose-6-Phosphate Dehydrogenase
Deficiency
Biochemistry in Perspective:
Atherosclerosis: The revised box
describes how LDLs trapped in
arterial walls become depleted of
antioxidants and then contribute to
atherosclerotic damage.
Biochemistry in Perspective:
Biotransformation
13. PHOTSYNTHESIS
13.1 Chlorophyll and Chloroplasts:
A revised introduction provides a more
detailed overview of oxygenic photosynthesis in chloroplasts.
13.2 Light
13.3 Light Reactions: The Z-scheme is
updated to reflect recent research.
Photosystem II and Water Oxidation
Photosystem I and NADPH Synthesis
12
Photophosphorylation
2QH&DUERQ0HWDEROLVP
Glutathione: A newly rewritten section focuses on the roles of this vitally
important intracellular reducing agent.
Neurotransmitters
Nucleotides
Biochemistry in Perspective:
Gasotransmitters
Available Online
Biochemistry in Perspective:
The Amine Neurotransmitters:
GABA and Serotonin
Biochemistry in Perspective:
Heme and Chlorophyll Biosynthesis
15. NITGROGEN METABOLISM II:
DEGRADATION
15.1 Protein Turnover: A newly
revised section focuses on the ubiquitin
proteasomal and autophagy lysosomal
systems.
fructose to the current epidemics of
obesity and metabolic syndrome.
DNA Recombination
Deamination
Urea Synthesis
Available Online
Transcription in Prokaryotes
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Biochemistry in Perspective:
Mammalian Hormones and the
Hormone Cascade System
Transcription in Eukaryotes: The structural and functional properties of RNA
pol II are updated.
15.2$PLQR$FLG&DWDEROLVP
&DWDEROLVPRI$PLQR$FLG&DUERQ
Skeletons
15.3 Degradation of Selected
Neurotransmitters
17. NUCLEIC ACIDS
15.4 Nucleotide Degradation
17.1 DNA
3XULQH&DWDEROLVP
DNA Structure: The Nature of
Mutation: A newly revised and
expanded discussion describes
mutation types and several classes
of mutagens.
3\ULPLGLQH&DWDEROLVP
Biochemistry in Perspective: Disorders
of Amino Acid Catabolism
Available Online
Biochemistry in Perspective: Gout
DNA Structure: The Genetic Material
DNA Structure: Variations on a Theme
18.2 Transcription
18.3 Gene Expression
Gene Expression in Prokaryotes
Gene Expression in Eukaryotes: A new
section describes posttranscriptional
gene silencing.
Biochemistry in Perspective: Genomics
Biochemistry in Perspective:
Carcinogenesis: A new section outlines
the roles of tumor suppressors.
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19. PROTEIN SYNTHESIS
Genome Structure
19.17KH*HQHWLF&RGH
16. INTEGRATION OF
METABOLISM
17.2 RNA
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Transfer RNA
Ribosomal RNA
The Aminoacyl-tRNA Synthease
Reaction
16.1 Overview of Metabolism
Messenger RNA
19.2 Protein Synthesis
16.2 Hormones and Intercellular
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Noncoding RNA
Prokaryotic Protein Synthesis
17.3 Viruses
Eukaryotic Protein Synthesis:
Eukaryotic translation initiation is
updated. New sections describe mitochondrial posttranslational protein
import and mTOR-mediated translation control.
Biochemistry in Perspective:
Heme Biotransformation
Peptide Hormones: An expanded section provides a more detailed description of how insulin binding to its
receptor alters intracellular processes.
Growth Factors
Steroid and Thyroid Hormone
Mechanisms
16.3 Metabolism in the Mammalian
Body: Division of Labor: New emphasis is placed on glucose transport
mechanisms in the body’s organs.
Gastrointestinal Tract
Liver
Bacteriophage T4: A Viral Lifestyle
Biochemistry in the Lab: Nucleic Acid
Methods
NEW! Biochemistry in
Perspective: Epigenetics and the
Epigenome: Genetic Inheritance
Beyond DNA Base Sequences:
A new box provides an accessible
introduction to a mechanism that
alters gene expression during
development.
NEW! Biochemistry in
Perspective: Trapped Ribosomes:
RNA to the Rescue: A new box
describes the tactics used by
living organisms to release
ribosomes attempting to translate
truncated mRNAs without stop
codons.
Adipose Tissue
Biochemistry in Perspective: HIV:
An updated boxed reading describes
the infective mechanism of HIV.
Biochemistry in Perspective: ContextDependent Coding Rearrangement
Brain
Available Online
Biochemistry in the Lab: Proteomics
Kidney
Biochemistry in Perspective:
A Short History of DNA Research:
the Early Days
Available Online
Muscle
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The Feeding Phase
The Fasting Phase
Feeding Behavior
Biochemistry in Perspective: Diabetes
Mellitus: An extensively revised
description of diabetes explains the
causes and consequences of this
metabolic disease.
Biochemistry in Perspective: Obesity
and the Metabolic Syndrome: The box
is revised to reflect recent research,
including the contribution of dietary
Biochemistry in Perspective: EF-Tu:
A Motor Protein
18. GENETIC INFORMATION
18.1 Genetic Information: Replication,
Repair, and Recombination
DNA Replication: Expanded sections
describe the functions of the prokaryotic and eukaryotic DNA polymerases.
DNA Repair: An updated and
expanded section describes transcription-associated, mismatch, and doublestrand repair.
13
SAMPLE
CHAPTERS
5 and 8
14
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