THE 32nd NAITO CONFERENCE ON
Biological basis of
mental functions and disorders
PROGRAM
ABSTRACTS
October 18-21, 2011
Yatsugatake Royal Hotel
Oizumi-Kogen, Yamanashi, Japan
I
Organizing
Committee
Chair
Toru Nishikawa
Graduate School of Medical and Dental Science,
Tokyo Medical and Dental University, Japan
Committee
Masabumi Minami
Graduate School of Pharmaceutical Sciences,
Hokkaido University, Japan
Tsuyoshi Miyakawa
Institute for Comprehensive Medical Science,
Fujita Health University, Japan
Toru Takumi
Graduate School of Biomedical Sciences,
Hiroshima University, Japan
Takeo Yoshikawa
RIKEN Brain Science Institute, Japan
General Secretary
Hiroyuki Mitsui
Executive Director, The Naito Foundation
Correspondence: All correspondence should be addressed to Conference Secretariat
The 32nd Naito Conference on Biological basis of mental functions and
disorders
The Naito Foundation
42-6, Hongo 3, Bunkyo, Tokyo, 113-0033, Japan
TEL: +81-3-3813-3005
FAX: +81-3-3811-2917
E-mail: conference@naito-f.or.jp
Sponsor: The Naito Foundation
II
PREFACE
Welcome to The Naito Conference.
The Naito Foundation was established in 1969 by the late Toyoji Naito (Former President of The
Naito Foundation and Former Emeritus Chairman of Eisai Co., Ltd.) to promote fundamental
researches concerning the prevention and treatment of human diseases.
One of the objectives of The Naito Foundation is to provide selective support to basic research yet
been sufficiently supported in Japan, and to hold symposia or conferences concerning such investigations to stimulate and encourage the scientists engaged in such basic researches.
The following 31 Conferences have been held since the 1st Naito Conference in 1991.
Three Conferences on Protein Translocation in the Cell, 1991-1993
Three Conferences on Neuro-Immuno-Endocrine Networks, 1994-1996
The Conference on Morphogenesis Program: Patterning of Muticellular Organisms, 1995
The Gordon Naito-Conference on Structure and Biological Function of Glycolipids and
Sphingolipids, 1996
The Conference on Bioactive Natural Products and Their Mode of Action [I]: Chemical and
Biological Basis for the Diversity of Marine Life, 1997
The Conference on Molecular Biological Approaches for Intractable Diseases [I], 1998
The Conference on Structural Genomics: Passage to Drug Development, 1999
The Conference on Bioactive Natural Products and Their Mode of Action [II]: Regulation of Plant
Life Cycle at Molecular Level, 1999
The Conference on Molecular Biological Approaches for Intractable Diseases [II], 2000
The Conference on Bioactive Natural Products and Their Mode of Action [III]: Insect Bioactive
Molecules and Their Modes of Action, 2001
The Conference on Molecular Biological Approaches for Intractable Diseases [III], 2002
The Conference on Innate Immunity in Medicine and Biology [I], 2003
The Conference on Molecular Basis for Maintenance and Differentiation of Stem Cells [I], 2004
The Conference on Innate Immunity in Medicine and Biology [II], 2005
The Conference on Molecular Basis for Maintenance and Differentiation of Stem Cells [II], 2006
The Conference on Innate Immunity in Medicine and Biology [III], 2007
The Conference on Nuclear Dynamics and RNA [I], 2008
The Conference on Chemical Biology [I], 2008
The Conference on Molecular Basis for Maintenance and Differentiation of Stem Cells [III], 2008
The Conference on Nuclear Dynamics and RNA [II], 2009
The Conference on Chemical Biology [II], 2009
The Conference on Osteobiology, 2009
The Conference on Membrane Dynamics and Lipid Biology [I], 2010
The Conference on Glycan Expression and Regulation [I]: Functions and Disease Mechanisms,
2010
The Conference on GLIA WORLD!
Dynamic Function of Glial Cells in the Brain!
, 2010
The Conference on Membrane Dynamics and Lipid Biology [II]: Domains, Droplets and Diseases,
2011
Glycan Expression and Regulation [II]: Metabolites, Stress Response, Microdomains, and Beyond,
2011
III
The Naito Foundation has designated “Biological basis of mental functions and disorders” as one of
the latest subject to stimulate researchers in the rapidly expanding research field, and decided to
support active and young investigators who are being engaged in these subjects.
The Naito Conference on “Biological basis of mental functions and disorders” has been framed under the guidance of committee organized by Drs. Masabumi Minami (Hokkaido University),
Tsuyoshi Miyakawa (Fujita Health University), Toru Nishikawa (Tokyo Medical and Dental University), Toru Takumi (Hiroshima University) and Takeo Yoshikawa (RIKEN Brain Science Institute).
The 32nd Naito Conference is held at Yatsugatake Royal Hotel, JAPAN on October 18th-21st, 2011
in order to discuss the recent progress in many subjects of Biological basis of mental functions and
disorders.
It is the sincere hope of The Naito Foundation that all participants will enjoy this Naito Conference
and find it fruitfu1 for you.
October 18 (Tue), 2011
The Naito Foundation
42!
6, Hongo 3, Bunkyo, Tokyo
l13!
0033, Japan
IV
ABSTRACTS
OF
ORAL PRESENTATION
Presenters
Gary ASTON-JONES
Overseas
Department of Neurosciences, Medical University of South
Carolina, USA
Douglas BLACKWOOD
Division of Psychiatry, University of Edinburgh, UK
Joshua A. GORDON
Department of Psychiatry, Columbia University, USA
Thomas R. INSEL
National Institute of Mental Health, National Institute of
Health, USA
Peter W. KALIVAS
Department of Neurosciences, Medical University of South
Carolina, USA
Pat LEVITT
Zilkha Neurogenetic Institute, Keck School of Medicine of
University of Southern California, USA
Alea MILLS
Cold Spring Harbor Laboratory, USA
Robert PAWLAK
Department of Cell Physiology and Pharmacology,
University of Leicester, UK
Joseph S. TAKAHASHI
Howard Hughes Medical Institute, USA
Lawrence WILKINSON
Schools of Psychology and Medicine, Cardiff University,
UK
Catharine WINSTANLEY
Department of Psychology, University of British Columbia,
Canada
VI
Presenters
Teiichi FURUICHI
Japan
Faculty of Science and Technology, Tokyo University of
Science, Japan
Kaoru INOKUCHI
Graduate School of Medicine and Pharmaceutical Sciences,
University of Toyama, Japan
Nobumasa KATO
Department of Psychiatry, Karasuyama Hospital, Showa
University School of Medicine, Japan
Tadafumi KATO
Laboratory for Molecular Dynamics of Mental Disorders,
RIKEN Brain Science Institute, Japan
Masabumi MINAMI
Department of Pharmacology, Graduate School of
Pharmaceutical Sciences, Hokkaido University, Japan
Tsuyoshi MIYAKAWA
Division of Systems Science, Institute for Comprehensive
Medical Science, Fujita Health University, Japan
Shigeru MORINOBU
Department of Psychiatry and Neurosciences, Hiroshima
University, Japan
Toshitaka NABESHIMA
Department of Chemical Pharmacology, Meijo University
Graduate School of Pharmaceutical Sciences, Japan
Shuh NARUMIYA
Kyoto University Graduate School of Medicine, Japan
Toru NISHIKAWA
Graduate School of Medical and Dental Sciences, Tokyo
Medical and Dental University, Japan
Michio NOMURA
Graduate School of Education, Kyoto University, Japan
Ichiro SORA
Department of Biological Psychiatry, Tohoku University
Graduate School of Medicine, Japan
Toru TAKUMI
Graduate School of Biomedical Sciences,
Hiroshima University, Japan
Takeo YOSHIKAWA
Laboratory for Molecular Psychiatry, RIKEN Brain Science
Institute, Japan
Mitsuhiro YOSHIOKA
Department of Neuropharmacology, Graduate School of
Medicine, Hokkaido University, Japan
VII
October 18 (Tue)
15:00-17:00
Registration
17:20-17:30
Opening Remarks: Toru NISHIKAWA
Plenary Lecture
Chair: Toru NISHIKAWA
Rethinking mental illness
17:30-18:30
National Institute of Mental Health, National Institute of Health, USA
Thomas R. INSEL
18:40-20:00
Welcome Reception
VIII
October 19 (Wed)
Breakfast
7:00-8:30
Session A: Molecular basis of schizophrenia
Chairs: Tsuyoshi MIYAKAWA, Joshua A. GORDON
Molecular mechanisms of adolescence-dependent onset
of schizophrenia
9:00-9:30
A-1
Graduate School of Medical and Dental Sciences, Tokyo Medical and
Dental University, Japan
Toru NISHIKAWA
Schizophrenia and fatty acids
9:30-10:00
A-2
RIKEN Brain Science Institute, Japan
Takeo YOSHIKAWA
Circuit mechanisms underlying schizophrenia
predisposition in 22q11 model mice
10:00-10:30
A-3
Department of Psychiatry, Columbia University, USA
Joshua A. GORDON
Coffee Break
10:30-11:00
Immature dentate gyrus as a candidate
endophenotype of psychiatric disorders
11:00-11:30
A-4
Division of Systems Science, Institute for Comprehensive Medical
Science, Fujita Health University, Japan
Tsuyoshi MIYAKAWA
The role of DISC1 in schizophrenia
11:30-12:00
A-5
Division of Psychiatry, University of Edinburgh, UK
Douglas BLACKWOOD
12:00-14:00
Lunch
IX
Session B: Molecular basis of anxiety and
mood disorders
Chairs: Takeo YOSHIKAWA, Robert PAWLAK
Regulation of fear memory formation
14:00-14:30
B-1
Graduate School of Medicine and Pharmaceutical Sciences,
University of Toyama, Japan
Kaoru INOKUCHI
Control of anxiety by extracellular proteolysis
in the amygdala
14:30-15:00
B-2
Department of Cell Physiology and Pharmacology, University of
Leicester, UK
Robert PAWLAK
Prospects for epigenetic research of major depression
15:00-15:30
B-3
Department of Psychiatry and Neurosciences,
Hiroshima University, Japan
Shigeru MORINOBU
Coffee Break
15:30-16:00
Clock genes, clock cells and clock circuits
16:00-16:30
B-4
Howard Hughes Medical Institute, Department of Neuroscience,
UT Southwestern Medical Center, USA
Joseph S. TAKAHASHI
Neurobiology of bipolar disorder
16:30-17:00
B-5
Laboratory for Molecular Dynamics of Mental Disorders,
RIKEN Brain Science Institute, Japan
Tadafumi KATO
17:30-19:00
19:00-21:00
Dinner
Poster Session [I]
X
October 20 (Thu)
Breakfast
7:00-8:30
Session C: Molecular basis of developmental
disorders
Chairs: Toru TAKUMI, Pat LEVITT
A mouse model of 15q duplication syndrome towards
understanding of molecular pathophysiology of autism
9:00-9:30
C-1
Graduate School of Biomedical Sciences, Hiroshima University, Japan
Toru TAKUMI
Enhanced secretion of BDNF by CADPS2 is critical
for proper brain development and behavior
9:30-10:00
C-2
Tokyo University of Science, Japan
Teiichi FURUICHI
At the core of autism: models of 16p11.2 copy
number variations
10:00-10:30
C-3
Cold Spring Harbor Laboratory, USA
Alea MILLS
Coffee Break
10:30-11:00
Asperger syndrome as a key model of social
dysfunction
11:00-11:30
C-4
Department of Psychiatry, Karasuyama Hospital, Showa University
School of Medicine, Japan
Nobumasa KATO
The clinical-basic interface for discovering autism
pathophysiology
11:30-12:00
C-5
Zilkha Neurogenetic Institute, Keck School of Medicine of University
of Southern California, USA
Pat LEVITT
12:00-14:00
Lunch
XI
Session D: Molecular basis of abuse and
negative emotion
Chairs: Masabumi MINAMI, Gary ASTON-JONES
The glutamate homeostasis hypothesis of addiction
14:00-14:30
D-1
Department of Neurosciences, Medical University of South Carolina,
USA
Peter W. KALIVAS
Molecular neuropsychopharmacology of
psychostimulants
14:30-15:00
D-2
Department of Biological Psychiatry, Tohoku University Graduate
School of Medicine, Japan
Ichiro SORA
Physiological function of new drug dependence-related
molecule, Shati
15:00-15:30
D-3
Department of Chemical Pharmacology, Meijo University Graduate
School of Pharmaceutical Sciences, Japan
Toshitaka NABESHIMA
Coffee Break
15:30-16:00
Seeking reward: Overdoing it with orexin neurons
16:00-16:30
D-4
Department of Neurosciences, Medical University of South Carolina,
USA
Gary ASTON-JONES
Role of the BNST in pain-induced aversion
16:30-17:00
D-5
Department of Pharmacology, Graduate School of
Pharmaceutical Sciences, Hokkaido University, Japan
Masabumi MINAMI
17:30-19:00
19:00-21:00
Dinner
Poster Session [II]
XII
October 21 (Fri)
Breakfast
7:00-8:30
Session E: Molecular basis of impulsivity and
aggression
Chairs: Toru NISHIKAWA, Lawrence WILKINSON
Translational models for assaying impulse control:
waiting, choosing and stopping
9:00-9:30
E-1
Schools of Psychology and Medicine, Cardiff University, UK
Lawrence WILKINSON
Prostaglandin-mediated control of stress responses
9:30-10:00
E-2
Kyoto University Graduate School of Medicine, Japan
Shuh NARUMIYA
Exploring the molecular mechanisms underlying
different aspects of impulsivity using rodent models
10:00-10:30
E-3
Department of Psychology, University of British Columbia, Canada
Catharine WINSTANLEY
Coffee Break
10:30-11:00
Impulsivity and infra-limbic cortex
11:00-11:30
E-4
Department of Neuropharmacology, Graduate School of Medicine,
Hokkaido University, Japan
Mitsuhiro YOSHIOKA
Biological and psychological basis of impulsive behavior
11:30-12:00
E-5
Graduate School of Education, Kyoto University, Japan
Michio NOMURA
12:00-12:15
Announcement
12:15-12:20
Closing Remarks: Takeo YOSHIKAWA
12:20-13:00
Lunch
XIII