Supply Chain Risk Management and Hospital Inventory: Effects of System Affiliation David Zepeda, Northeastern University, Boston, MA, (617) 373-3549, d.zepeda@neu.edu Gilbert Nyaga, Northeastern University, Boston, MA, (617) 373-2116, g.nyaga@neu.edu Gary Young, Northeastern University, Boston, MA, (617) 373-2528, ga.young@neu.edu ABSTRACT In this study we propose a supply chain risk management (SCRM) approach in health care supply chains. Utilizing detailed data from hospitals in the State of California, we investigated inventory cost in hospital operations under conditions of uncertainty in supply due to existing supply chain infrastructure and uncertainty in demand due to service mix variety. We also examined the potential moderating effects of hospital system affiliation that potentially affect a managers’ confidence in their supply chain. Our results suggest that weaker supply chain infrastructure and greater service mix uncertainty are associated with greater inventory accumulation. As a risk buffering approach, results suggest that hospitals mitigate supply chain risk by risk pooling through small hospital system affiliation. Key words: health care services; hospital operations; supply chain risk management; inventory management