Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 Invention Granted Under R.A. 8293 (PCT) 1 INVENTIONS [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2007/502139 [22] Date Filed: 28/09/2007 [54] Title: METHODS, COMPOSITIONS AND FORMULATIONS FOR PREVENTING OR REDUCING ADVERSE EFFECTS IN A PATIENT [71] Proprietors(s): PERICOR THERAPEUTICS, INC. [US] [72] Inventor(s): DENNIS MANGANO[US] [73] Assignee(s): PERICOR THERAPEUTICS, INC. [US] [74] Attorney / Agent: SAPALO VELEZ BUNDANG & BULILAN LAW OFFICES [30] Priority Data: 60/666,071 28/03/2005 US [51] International Class 8: A 61K 31/70, 31/7056 Abstract: The present invention provides methods, compositions, formulations and kits related to acadesine, or a prodrug, analog, or salt thereof, and/or a blood clotting inhibitor for preventing or reducing adverse side effects in a patient. The type of patient that may benefit includes a patient with decreased left ventricular function, a patient with prior myocardial infraction, a patient undergoing non-vascular surgery, or a fetus during labor and delivery. [57] Representative Drawing(s): [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 14 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2008/500782 [22] Date Filed: 01/04/2008 [54] Title: CARRIER COMPOSITION FOR NUCLEIC ACID TRANSPORT [71] Proprietors(s): OTSUKA PHARMACETICAL CO., LTD. [JP] [72] Inventor(s): HIDEKAZU TOYOBUKU[JP]: HIDEO MIYAO[JP]: MASAKO SATO[JP]: KAZUO SEKIGUCHI[JP] [73] Assignee(s): OTSUKA PHARMACETICAL CO., LTD. [JP] [74] Attorney / Agent: FEDERIS AND ASSOCIATES LAW OFFICES [30] Priority Data: 2005-303497 18/10/2005 JP [51] International Class 8: A 61K 31/7105, 47/18, 47/28, 47/44, 48/00 Abstract: An object of the present invention is to provide a nucleic acid delivery carrier composition of low toxicity and high safety, the carrier composition, when used to administer a nucleic acid such as siRNA into an animal- derived cell or organism, being capable of delivering efficiently the nucleic acids into the cells while protecting it from being degraded; and a nucleic acid deliver composition containing the carrier and a nucleic acid. [57] 45] Issued Date: 17 August 2015 Document Code: B1 The carrier composition for delivery of a nucleic acid is prepared by mixing (A) a cationic lipid having a steroid skeleton with (B) a tertiary ammonium salt type cationic lipid. The nucleic acid delivery composition is prepared by mixing the nucleic acid delivery carrier with a nucleic acid. Representative Drawing(s): [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 17 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2008/501552 [22] Date Filed: 26/06/2008 [54] Title: A NOVEL SURFACE EXPOSED HAEMOPHILUS INFLUENZAE PROTEIN (PROTEIN E, pE) [71] Proprietors(s): ARNE FORSGREN [SE] [72] Inventor(s): KRISTIAN RIESBECK[SE] [73] Assignee(s): ARNE FORSGREN [SE] [74] Attorney / Agent: SIGUION REYNA MONTECILLO AND ONGSIAKO [30] Priority Data: 60/758,987 17/01/2006 US [51] International Class 8: A 61K 39/012, C 07K 14/285, 16/12 Abstract: The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in Haemophilus influenzae, having an amino acid sequence as described in SEQ ID NO 1, an immunogenic fragment of said surface exposed protein, and a recombinant immunogenic protein (pE (A) ) or truncated variants thereof based on said surface exposed protein. Nucleic acid sequences, vaccines, plasmids and phages, non human hosts, recombinant nucleic acid sequences, fusion proteins and fusion products are also described. A method of producing the said protein or truncated fragments thereof recombinantly is also disclosed. [57] Representative Drawing(s): 45] Issued Date: 17 August 2015 Document Code: NONE [56] Reference(s) Cited and/or Considered: WO 2005/111066 A2 No. of Claims: 11/24/2005 353 CHIRON SRL B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2008/502061 [22] Date Filed: 15/09/2008 [54] Title: SOLID ORAL COMPOSITIONS BASED ON S-ADENOSYL METHIONINE AND/OR NADH AND PROCESS FOR OBTAINING THEM [71] Proprietors(s): GIOVANNONE, DANIELE [IT] and GNOSIS SPA [IT] [72] Inventor(s): DE ANGELIS, CARLO[IT] [73] Assignee(s): GIOVANNONE, DANIELE [IT] and GNOSIS SPA [IT] [74] Attorney / Agent: BUCOY POBLADOR & ASSOCIATES [30] Priority Data: MI2006A000629 31/03/2006 IT [51] International Class 8: A 61K 31/52, 31/7084, 47/02, A 61P 25/24 Abstract: This invention relates to solid oral compositions based on SAMe and/or NADH or their salts in association with calcium oxide and/or calcium hydroxide and a process for obtaining them. This invention also relates to a method for stabilising a solid oral composition based on SAMe and/or NADH or their salts, making use of calcium oxide, calcium hydroxide optionally in association with malic acid, glutamic acid, xylitol, calcium sulphate hemihydrate, magnesium oxide and/or mixtures thereof. This invention also relates to the use of SAMe or its salts in association with calcium oxide and/or calcium hydroxide with the possible further addition of melatonin and/or l-the^anine and/or 1 -tryptophan and/or 5- hydroxytryptophan for the treatment of depressive states. [57] 45] Issued Date: 17 August 2015 Document Code: B1 Representative Drawing(s): [56] Reference(s) Cited and/or Considered: WO 01/93847 12/13/2001 PROCTER AND GAMBLE Birkmayer J G D, et. al. "Safety of Stabilized.." Drug under Experimental and Clinical research 2002, vol. 28, pages 185-192 US 2002/0132780 (HEISEY MATTHEW THOMAS; KERN KENNETH NORMAN; SPENCE KRIS EUGENE) 19 September 2002 US 4870059 (MITSUHASHI MASAKAZU; SAKAI SHUZO; MIYAKE TOSHIO) 26 September 1989 No. of Claims: 65 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2008/502606 [22] Date Filed: 26/11/2008 [54] Title: SUBSTITUTED PYRIDYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR [71] Proprietors(s): JANSSEN PHARMACEUTICA N.V. [BE] [72] Inventor(s): VILLANI, FRANK J.[US]: LY, KIEV S.[US]: MANI, NEELAKANDHA S.[US]: PANDIT, CHENNAGIRI R.[US]: ZHONG, HUA[US]: LETAVIC, MICHAEL A.[US]: KEITH, JOHN M.[US]: MILLS, JOHN E.[US] [73] Assignee(s): JANSSEN PHARMACEUTICA N.V. [BE] [74] Attorney / Agent: ROMULO MABANTA BUENAVENTURA SAYOC AND DELOS ANGELES [30] Priority Data: 60/803,407 30/05/2006 US and 60/823,108 22/08/2006 US [51] International Class 8: A 61K 31/44, A 61P 25/00, C 07D 213/81 [57] Abstract: Certain substituted pyridyl amide compounds as histamine H3 receptor modulators useful in the treatment of histamine H3 receptor- mediated diseases Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 260 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2009/500694 [22] Date Filed: 13/04/2009 [54] Title: CRYSTALLINE FORM OF 2-CHLORO-5-[3,6-DIHYDRO-3-METHYL-2,6-DIOXO4- (TRIFLUOROMETHYL)-1-(2H)-PYRIMIDINYL]-4-FLUORO-N-[[METHYL- (1METHYL-ETHYL)AMINO]SULPHONYL]BENZAMIDE [71] Proprietors(s): BASF SE, [DE] [72] Inventor(s): SANDRA LOHR[DE]: THOMAS SCHMIDT[DE]: ALFRED MICHEL[DE]: GERHARD COX[DE]: CYRILL ZAGAR[CN]: ROBERT REINHARD[DE]: GERHARD HAMPRECHT[DE]: BERND WOLF[DE]: PETER ERK[DE]: MICHAEL KEIL[DE]: GUIDO MATER[GE]: BERND SIEVERNICH[DE]: JOACHIM GEBHARDT[DE]: WERNER SEITZ[DE]: JAN HENCRIK WEVERS[GE]: HEIDI EMILIA SAXELL[DE] [73] Assignee(s): BASF SE, [DE] [74] Attorney / Agent: E.B. ASTUDILLO AND ASSOCIATES [30] Priority Data: 06122265.9 13/10/2006 EP [51] International Class 8: A 01N 43/48, C 07D 239/54 Abstract: The present invention relates to a crystalline form of 2-chloro-5-[3,6-dihydro3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulphonyl]benzamide. The invention also relates to a process for preparing this crystalline form and to plant protection formulations which comprise this crystalline form of the phenyluracil. [57] Representative Drawing(s): [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 15 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2009/500846 [22] Date Filed: 30/04/2009 [54] Title: USE OF TESTOSTERONE AND A 5-HT 1A AGONIST IN THE TREATMENT OF SEXUAL DYSFUNCTION [71] Proprietors(s): EB IP LYBRIDOS B.V. [NL] [72] Inventor(s): JAN JOHAN ADRIAAN TUITEN[NL]: JOHANNES MARTINUS MARIA BLOEMERS[NL]: ROBERTUS PETRUS JOHANNES DE LANGE[NL] [73] Assignee(s): EB IP LYBRIDOS B.V. [NL] [74] Attorney / Agent: SAPALO VELEZ BUNDANG & BULILAN LAW OFFICES [30] Priority Data: 06076976.7 03/11/2006 EP [51] International Class 8: A 61K 31/496, 31/519, 31/568, A 61P 15/00 [57] Abstract: The invention relates to the field of male and/or female sexual dysfunction. The invention specifically relates to the use of testosterone and 5-HT1A agonist. Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 15 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2009/501511 [22] Date Filed: 06/08/2009 [54] Title: PROGESTERONE FOR THE TREATMENT OR PREVENTION OF SPONTANEOUS PRETERM BIRTH [71] Proprietors(s): COLUMBIA LABORATORIES (BERMUDA) LIMITED, [BM] [72] Inventor(s): GEORGE CREASY[US] [73] Assignee(s): COLUMBIA LABORATORIES (BERMUDA) LIMITED, [BM] [74] Attorney / Agent: ORBOS CABUSORA TAGUIAM [30] Priority Data: 60/888,480 06/02/2007 US and 60/973,667 19/09/2007 US [51] International Class 8: A 61K 31/57, 45/06, A 61P 15/06 Abstract: A method for treating or preventing spontaneous preterm birth in pregnant women and improving neonatal morbidity and mortality. The method includes administering to a pregnant woman in need thereof an effective amount of progesterone sufficient to prolong gestation by minimizing the shortening or effacing of her cervix. Treatment and prophylaxis with progesterone in pregnant women having symptoms of short cervix has been clinically shown to increase neonatal health. [57] Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 59 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2010/500173 [22] Date Filed: 22/01/2010 [54] Title: IMPROVED PHARMACEUTICAL COMPOSITION CONTAINING DIHYDROPYRIDINE CALCIUM CHANNEL ANTAGONIST AND METHOD FOR THE PREPARATION THEREOF [71] Proprietors(s): PHARMATHEN SA, [GR] and RECORDATI IRELAND LIMITED, [IE] [72] Inventor(s): EVANGELOS KARAVAS[GR]: MAKIS KOUTRIS[GR]: VICKY SAMARA[GR]: CHRISTINA MATSINGOU[GR]: ATHINA ILIOPOULOU[GR] [73] Assignee(s): PHARMATHEN SA, [GR] and RECORDATI IRELAND LIMITED, [IE] [74] Attorney / Agent: ANGARA ABELLO CONCEPCION REGALA AND CRUZ [30] Priority Data: PCT/EP2007/006517 23/07/2007 EP [51] International Class 8: A 61K 31/4422, 9/20 Abstract: The present invention relates to the formulation of solid dosage forms comprising a therapeutically effective amount of a dihydropyridine calcium channel antagonist such as Lercanidipine or salt thereof, in combination with colloidal silicon dioxide such as Aerosil to enhance bioavailability and improve solubility, and a process for the preparation thereof by wet granulation. [57] Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 17 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2010/500462 [22] Date Filed: 26/02/2010 [54] Title: ANTI-EPHA2 ANTIBODY [71] Proprietors(s): DAIICHI SANKYO COMPANY, LIMITED, [JP] [72] Inventor(s): JUN HASEGAWA[JP]: TAKESHI TAKIZAWA[JP]: TOSHIAKI OHTSUKA[JP]: TOSHINORI AGATSUMA[JP]: ATSUSHI URANO[JP]: JUNKO YAMAGUCHI[JP]: KAORI NAKAHARA[JP] [73] Assignee(s): DAIICHI SANKYO COMPANY, LIMITED, [JP] [74] Attorney / Agent: ORTEGA DEL CASTILLO BACORRO ODULIO CALMA AND CARBONELL [30] Priority Data: 2007-224007 30/08/2007 JP [51] International Class 8: A 61K 39/395, A 61P 35/00, C 07K 16/28, 16/46, C 12N 15/02, C 12P 21/08 Abstract: The present invention provides an antibody which recognizes an epitope that can be recognized by an antibody produced by a hybridoma SH 348-1 (FERM BP-10836) or a hybridoma SH 357-1 (FERM BP-10837); an antibody produced by a hybridoma SH 348-1 or a hybridoma SH 357-1; an antibody which is produced by humanizing an antibody produced by a hybridoma SH 348-1 or a hybridoma SH 357-1; a pharmaceutical agent comprising any one of the aforementioned antibodies as an active ingredient, and others. [57] Representative Drawing(s): 45] Issued Date: 17 August 2015 Document Code: B1 NONE [56] Reference(s) Cited and/or Considered: KIEWLICH D. ET AL.: "Anti-EphA2 antibodies decrease EphA2 protein levels inmurine CT26 colorectal and human MDA-231 breast tumors but do not inhibit tumor growth", NEOPLASIA, 2006, vol. 8, no. 1, pp. 1830 CARLES-KINCH K. ET AL.: "Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior", CANCER ES., 2002, vol. 62, nol. 10, pp. 2840-2847 COFFMAN KT, ET AL.: "Differential EphA2 epitope display on normal versus malignant cells"CANCER RES., 2003, vol. 63, no. 22, pp. 7907-7912 WO 2007/030642 A2 (MEDIMMUNE INC.) March 15, 2007 WO 2006/084226 A2 (RAVEN BIOTECHNOLOGIES, INC.) August 10, 2008 No. of Claims: 238 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2010/502838 [22] Date Filed: 15/12/2010 [54] Title: DETERGENT COMPOSITION FOR CLOTHING [71] Proprietors(s): LION CORPORATION [JP] [72] Inventor(s): KANEDA, HIDEYUKI[JP]: HYODO, RYO[JP]: SASAKI, DAISUKE[JP] [73] Assignee(s): LION CORPORATION [JP] [74] Attorney / Agent: E.B. ASTUDILLO AND ASSOCIATES [30] Priority Data: 2008-157714 17/06/2008 JP [51] International Class 8: C 11D 3/20, 3/37 Abstract: A detergent composition is provided that is able to suppress color fading of clothing caused by the effects of sunlight. The detergent composition is comprised of (A) a surfactant and (B) a fatty acid ester of ascorbic acid, and preferably further contains at least one member (C) selected from the group consisting of cationized cellulose, carboxymethyl cellulose and hydroxypropylmethyl cellulose. In addition, the detergent composition preferably further contains cationized cellulose, and the degree of cationization of the cationized cellulose is preferably 0.4 to 1.2% by weight. [57] Representative Drawing(s): 45] Issued Date: 17 August 2015 Document Code: NONE [56] Reference(s) Cited and/or Considered: US 2003/0064042 A1 No. of Claims: 04/03/2003 6 BERGQUIST, ET. AL. B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2010/502860 [22] Date Filed: 17/12/2010 [54] Title: AXMI-115, AXMI-113, AXMI-005, AXMI-163 AND AXMI-184: INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE [71] Proprietors(s): ATHENIX CORPORATION [US] [72] Inventor(s): DUCK, NICHOLAS B.[US]: KOZIEL, MICHAEL G.[US]: AGARWAL, SHRUTI[US]: CAROZZI, NADINE[US]: CAMPBELL, CHRIS[US]: HARGISS, TRACY[US]: HEINRICHS, VOLKER[US]: MCNULTY, BRIAN[US]: SAMPSON, KIMBERLY S.[US]: TOMSO, DANIEL J.[US] [73] Assignee(s): ATHENIX CORPORATION [US] [74] Attorney / Agent: SANKAR, SABITA [30] Priority Data: 61/077,812 02/07/2008 US and 61/158,953 10/03/2009 US [51] International Class 8: C 07K 14/325, C 12N 15/82 Abstract: Compositions and methods for conferring insecticidal activity to host cells are provided. Compositions comprising a coding sequence for a deltaendotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in host cells. Compositions also comprise transformed host cells. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4, 5, 6, 13, or 14, or the nucleotide sequence set forth in SEQ ID NO: 1, 2, 3, 11, or 12, as well as variants and fragments thereof. [57] Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 19 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2011/500349 [22] Date Filed: 16/02/2011 [54] Title: COMPOSITION OF THROMBOLYTIC AGENT AND ANTI THROMBOSIS AND ALSO ITS PRODUCTION METHOD [71] Proprietors(s): PT. DEXA MEDICA [ID] [72] Inventor(s): TRISINA, JESSICA[ID]: TJANDRAWINATA, RAYMOND R.[ID] [73] Assignee(s): PT. DEXA MEDICA [ID] [74] Attorney / Agent: OFFICE OF BAGAY- VILLAMOR AND FABIOSA [30] Priority Data: P00200800610 10/09/2008 ID [51] International Class 8: A 61K 38/57, A 61P 7/02 Abstract: The present invention describes a composition of thrombolytic agent and anti-thrombosis that contains earthworm extracts having thrombolytic and anti-thrombosis activities. Its production method includes some steps: preparation of the earthworm raw materials by washing alive earthworms with alcohol and water, freezing the earthworms, extracting by water-based or thawing process, separating the extract from other earthworm body parts using filtration and or centrifugation, concentrating the extract liquid, solidifying the extract, and drying the earthworm extract. In addition, a pharmaceutical composition that directly using such extract as a single component or in a combination with suitable pharmaceutical excipient(s) to produce a pharmaceutical composition that is useful to prevent and treat diseases related to vascular blockage because of thrombus. Oral pharmaceutical dosage forms can be in the form of powder/granule, pellet, capsule, tablet, caplet, and preferably in an enteric-coated form. [57] Representative Drawing(s): 45] Issued Date: 17 August 2015 Document Code: NONE [56] Reference(s) Cited and/or Considered: US 2008/206352 A1 JP 2004292402 A JP 2006096673 A CN 1229852 A CN 1651079 A No. of Claims: 08/28/2008 10/21/2004 04/13/2006 09/29/1999 08/10/2005 9 Z. LI M. HISASHI, ET. AL. M. HISASHI, ET. AL. S. QILIANG, ET. AL. W. MEICHUN, ET. AL. B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2011/500454 [22] Date Filed: 03/03/2011 [54] Title: METHOD FOR PREPARING CATALYST [71] Proprietors(s): KAO CORPORATION [JP] [72] Inventor(s): SAKAMOTO, TORU[JP]: HASEGAWA, SHOJI[JP] [73] Assignee(s): KAO CORPORATION [JP] [74] Attorney / Agent: SALUDO FERNANDEZ AND AQUINO (SAFA LAW) [30] Priority Data: 2008-233586 11/09/2008 JP [51] International Class 8: B 01J 23/80, 37/18, C 07B 61/00, C 07C 29/149, 31/125 Abstract: The present invention provides a method of preparing the copper-containing hydrogenation catalyst having high activity by liquid phase reduction without decreasing purity of the solvent and a method for efficiently producing an alcohol. The present invention provides the method of preparing the coppercontaining hydrogenation catalyst, including reducing a molded precursor of the copper-containing hydrogenationcatalyst by supplying hydrogen gas or a mixture of hydrogen gas with an inert gas at a temperature of 50to 150°C in the presence of a solvent to obtain the copper-containing hydrogenation catalyst, wherein the reduction is conducted at an average reduction velocity of the copper-containing hydrogenation catalyst of not more than 3.0% by weight/hour. The present invention also provides the method of producing an alcohol, including preparing the copper-containing hydrogenation catalyst by the method of preparation, and subjecting a carboxylic acid or a carboxylic acid ester to catalytic reduction with hydrogen in the presence of the prepared copper-containing hydrogenation catalyst. [57] Representative Drawing(s): 45] Issued Date: 17 August 2015 Document Code: NONE [56] Reference(s) Cited and/or Considered: US 5481048 A US 2001/0016671 A1 No. of Claims: 01/02/1996 08/23/2001 9 TSUKADA, ET. AL. OKU, ET. AL. B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2011/500670 [22] Date Filed: 31/03/2011 [54] Title: FUNGICIDAL COMPOSITIONS [71] Proprietors(s): SYNGENTA PARTICIPATIONS AG [CH] [72] Inventor(s): HARALD WALTER[CH]: URS NEUENSHWANDER[CH]: RONALD ZEUN[CH]: HANS TOBLER[CH]: JOSEF EHRENFREUND[CH]: CLEMENS LAMBERTH[CH]: CAMILLA CORSI[CH] [73] Assignee(s): SYNGENTA PARTICIPATIONS AG [CH] [74] Attorney / Agent: E.B. ASTUDILLO AND ASSOCIATES [30] Priority Data: 0418047,7 12/08/2004 GB [51] International Class 8: A 01N 43/36, 43/54, 43/56 Abstract: he invention relates to fungicidal compositions comprising as active ingredient a combination of components A) and B) as defined in the patent claims, to a method of controlling phytopathogenic diseases on crop plants using such a compositions and to a method of protecting natural substances of vegetable and/or animal origin and/or their processed forms using such a composition. [57] Representative Drawing(s): 45] Issued Date: 17 August 2015 Document Code: NONE [56] Reference(s) Cited and/or Considered: WO03074491 A1 US2003036480 A1 No. of Claims: 09/12/2003 02/20/2003 7 EHRENFREUND JOSEF, ET. AL. SCHELBERGER KLAUS, ET. AL. B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2011/500826 [22] Date Filed: 28/04/2011 [54] Title: DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE [71] Proprietors(s): CENTOCOR ORTHO BIOTECH INC. [US] [72] Inventor(s): REZANIA, ALIREZA [US]: FRYER, BENJAMIN[US] [73] Assignee(s): CENTOCOR ORTHO BIOTECH INC. [US] [74] Attorney / Agent: ROMULO MABANTA BUENAVENTURA SAYOC AND DELOS ANGELES [30] Priority Data: 61/110,287 31/10/2008 US [51] International Class 8: NONE Abstract: The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependant kinase inhibitor to cause an increase in expression of MAFA. [57] Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 2 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2011/501280 [22] Date Filed: 21/06/2011 [54] Title: DIPEPTIDE LINKED MEDICINAL AGENTS [71] Proprietors(s): INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] [72] Inventor(s): RICHARD D. DIMARCHI[US] [73] Assignee(s): INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] [74] Attorney / Agent: HECHANOVA AND CO. INC. [30] Priority Data: 61/139,227 19/12/2008 US [51] International Class 8: A 61K 38/00, 38/28 Abstract: A non-enzymatically self cleaving dipeptide element is provided that can be linked to known medicinal agents via an amide bond. The dipeptide will spontaneously be cleaved from the medicinal agent under physiological conditions through a reaction driven by chemical instability. Accordingly, the dipeptide element provides a means of linking various compounds to known medicinal agents wherein the compounds are subsequently released from the medicinal agent after a predetermined time of exposure to physiological conditions. For example, the dipeptide can be linked to an active site of a drug to form a prodrug and/or the dipeptide may comprise a depot polymer to sequester an injectable composition comprising the complex at the point of administration. [57] Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 49 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2011/502240 [22] Date Filed: 28/10/2011 [54] Title: WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION [71] Proprietors(s): OTSUKA PHARMACEUTICAL CO., LTD. [JP] [72] Inventor(s): KOMATSU, MAKOTO[JP]: GOTO, FUMITAKA[JP]: MENJO, YASUHIRO[JP]: YAMADA, KEIGO[JP]: MATSUDA, TAKAKUNI[JP]: KATO, YUSUKE[JP] [73] Assignee(s): OTSUKA PHARMACEUTICAL CO., LTD. [JP] [74] Attorney / Agent: FEDERIS AND ASSOCIATES LAW OFFICES [30] Priority Data: 2005-375457 27/12/2005 JP [51] International Class 8: A 61K 31/661, 31/675, 47/02, 9/08, A 61P 7/02, 9/00, C 07F 9/553 45] Issued Date: 17 August 2015 Document Code: B1 The present invention provides a benzoazepine compound represented by following general formula (1): [57] Abstract: or a salt thereof, wherein R represents a hydrogen atom, a hydroxy group 1 optionally protected with a protecting group, etc., R represents a hydrogen atom or hydroxy-protecting group, and X represents an oxygen atom or a sulfur atom. The benzoazepine compound of the present invention and salts thereof have high solubility in water, and can be suitably used for injections. Representative Drawing(s): [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 14 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2011/502442 [22] Date Filed: 23/11/2011 [54] Title: COMPOSITION AND METHOD FOR CONTROLLING PLANT DISEASES [71] Proprietors(s): SUMITOMO CHEMICAL COMPANY, LIMITED [JP] [72] Inventor(s): KURAHASHI, MAKOTO[JP] [73] Assignee(s): SUMITOMO CHEMICAL COMPANY, LIMITED [JP] [74] Attorney / Agent: SYCIP SALAZAR HERNANDEZ & GATMAITAN [30] Priority Data: 2009-125900 25/05/2009 JP [51] International Class 8: [57] Abstract: Representative Drawing(s): Document Code: B1 A 01C 1/06, 1/08, A 01G 13/00, A 01N 37/30, 37/36, 37/50, 43/40, 43/54, 43/88, 47/24, A 01P 3/00 The present invention provides: a composition for controlling plant diseases comprising, as active ingredients, 4-oxo-4-[(2-phenylethyl)amino]-butyric acid and a quinone outside inhibitor; a method for controlling plant diseases which comprises applying effective amounts of 4-oxo-4-[(2-phenylethyl) amino]-butyric acid and a quinone outside inhibitor to a plant or soil for growing plant; and so on. NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 45] Issued Date: 17 August 2015 4 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2011/502577 [22] Date Filed: 13/12/2011 [54] Title: DETERGENT COMPOSITON COMPRISING ANIONIC DYE POLYMER [71] Proprietors(s): UNILEVER N.V. [NL] [72] Inventor(s): BATCHELOR, STEPHEN NORMAN[GB]: BIRD, JAYNE MICHELLE[GB]: CHEN, WEI[CN]: TAO, QINGSHENG[CN]: WANG, JINFANG[CN] [73] Assignee(s): UNILEVER N.V. [NL] [74] Attorney / Agent: OSCAR M. MANAHAN, ESQ. [30] Priority Data: 09162671.3 15/06/2009 EP [51] International Class 8: C 11D 3/37, 3/40, D 06L 3/12 [57] Abstract: The present invention provides a laundry treatment composition comprising an anionic dye-polymer. Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 22 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2012/500434 [22] Date Filed: 01/03/2012 [54] Title: FATTY ACID NIACIN CONJUGATES AND THEIR USES [71] Proprietors(s): CATABASIS PHARMACEUTICALS, INC. [US] [72] Inventor(s): BEMIS, JEAN E.[US]: JIROUSEK, MICHAEL R.[US]: VU, CHI B. [US]: MILNE, JILL C.[US] [73] Assignee(s): CATABASIS PHARMACEUTICALS, INC. [US] [74] Attorney / Agent: HECHANOVA AND CO. INC. [30] Priority Data: 61/238,903 01/09/2009 US; 61/308,524 26/02/2010 US and 61/310,952 05/03/2010 US [51] International Class 8: A 61K 31/44, 31/455, A 61P 1/16, 13/12, C 07D 213/82 Abstract: The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin conjugate. [57] Representative Drawing(s): [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 33 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2012/500469 [22] Date Filed: 07/03/2012 [54] Title: NOVEL ALDEHYDES AND NITRILES FROM ISOPHORONE, AND THE USE THEREOF IN PERFUMERY [71] Proprietors(s): V. MANE FILS [FR] [72] Inventor(s): AGNÈS MURATORE[FR]: JEAN-JACQUES CHANOT[FR] [73] Assignee(s): V. MANE FILS [FR] [74] Attorney / Agent: HECHANOVA AND CO. INC. [30] Priority Data: 0956422 18/09/2009 FR [51] International Class 8: A 61K 8/33, 8/40, C 07C 253/30, 255/03, 255/07, 47/11, 47/225, C 11B 9/00 [57] Abstract: The invention relates to novel aldehydes and nitriles from isophorone with general formula (I) having a specific fragrance (Formula I) (I), as well as to the use of said compounds in perfumery. Representative Drawing(s): 45] Issued Date: 17 August 2015 Document Code: NONE [56] Reference(s) Cited and/or Considered: US 5 073 538 A US 4 477 683 A No. of Claims: 12/17/1991 10/16/1984 10 HEULLMANN, ET. AL. VIRGILIO, ET. AL. B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2012/500487 [22] Date Filed: 08/03/2012 [54] Title: HERBICIDAL PYRIMIDONE DERIVATIVES [71] Proprietors(s): E.I. DU PONT DE NEMOURS AND COMPANY [US] [72] Inventor(s): PATRICK RYAN KOVACS[US]: KANU MAGANBHAI PATEL[US]: THOMAS PAUL SELBY[US]: BRENTON TODD SMITH[US]: ANDREW EDMUND TAGGI[US] [73] Assignee(s): E.I. DU PONT DE NEMOURS AND COMPANY [US] [74] Attorney / Agent: ORTEGA DEL CASTILLO BACORRO ODULIO CALMA AND CARBONELL [30] Priority Data: 61/240,792 09/09/2009 US [51] International Class 8: 45] Issued Date: 17 August 2015 B1 Document Code: C 07D 401/04, 401/14, 403/06, 403/12, 403/14, 405/04, 405/06, 405/12, 405/14, 409/04, 409/06, 409/14, 413/04, 413/06, 413/14 Disclosed are compounds of Formula (1), including all stereoisomers, Noxides, and salts thereof, X is CH or N; Y is C(O) or S(O)2; provided that when Y is S(O)2, then X is CH; A is a radical selected from the group consisting of [57] Abstract: 1 2 3 1 2 3 4 5 6 7 8 9 10 11 12 13 and B , B , B , T, R , R , R , R , R , R , R , R , R , R , R , R and R are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention. Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 22 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2012/500511 [22] Date Filed: 13/03/2012 [54] Title: SYNERGISTIC FUNGICIDAL COMBINATIONS CONTAINING A DITHIINOTETRACARBOXAMIDE FUNGICIDE [71] Proprietors(s): BAYER CROPSCIENCE AG [DE] [72] Inventor(s): THOMAS SEITZ[DE]: ULRIKE WACHENDORFF-NEUMANN[DE]: PETER DAHMEN[DE] [73] Assignee(s): BAYER CROPSCIENCE AG [DE] [74] Attorney / Agent: ORTEGA DEL CASTILLO BACORRO ODULIO CALMA AND CARBONELL [30] Priority Data: 09170209.2 14/09/2009 EP; 09176213.8 17/11/2009 EP and 61/242,076 14/09/2009 US [51] International Class 8: [57] Abstract: Representative Drawing(s): Document Code: No. of Claims: B1 A 01N 37/20, 37/24, 37/36, 37/50, 43/40, 43/50, 43/54, 43/56, 43/653, 43/88, 43/90, 45/02, 47/12, 47/24, 47/38 The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a dithiinotetracarboximide of formula (I) and a further fungicidally active Compound (B). Moreover, the invention relates to a method for curatively or preventively Controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed. NONE [56] Reference(s) Cited and/or Considered: XP0055151567 45] Issued Date: 17 August 2015 11/01/2005 24 ZENTZ, ET. AL. Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2012/500647 [22] Date Filed: 29/03/2012 [54] Title: POWDER INHALER [71] Proprietors(s): BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE] [72] Inventor(s): JOERN-ERIC SCHULZ[DE]: MARKUS KAEMPER[DE] [73] Assignee(s): BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE] [74] Attorney / Agent: CASTILLO LAMAN TAN PANTALEON & SAN JOSE LAW OFFICES [30] Priority Data: 09172107.6 02/10/2009 EP [51] International Class 8: A 61M 15/00 Abstract: Inhaler for inhaling powdered medicaments from capsules, comprising a lower part (6), a plate (3) accommodated in the lower part (6), and a holder (18) inserted in the lower part (6), a mouthpiece (2) that can be latched to the lower part (6) on the plate (3), a cover (1) that covers the mouthpiece (2) in a closed position and latches by means of a closure element (14), the lower part (6) and the cover (1) being rotatably (4) connected to one another by a spindle (4), and an actuating member (7, 10) that can be moved from a resting position and set in motion and at the same time co-operates with at least one pin (8, 11) that can be stuck into the holder (18) and is located in a pin holder in the inner actuating member (10). In the holder (18) an exchangeable tube (22) can be inserted, as expulsion channel, which comprises a capsule chamber (21) with the capsule. [57] Representative Drawing(s): [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 19 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2013/500265 [22] Date Filed: 08/02/2013 [54] Title: PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS [71] Proprietors(s): [72] Inventor(s): [73] Assignee(s): [74] Attorney / Agent: JIMENEZ GONZALES BELLO VALDEZ CALUYA AND FERNANDEZ (JGLAW) [30] Priority Data: 10075374.8 28/08/2010 EP and 61/344,959 29/11/2010 US [51] International Class 8: [57] Abstract: 45] Issued Date: 17 August 2015 Document Code: B1 LEAD DISCOVERY CENTER GMBH [DE] and MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE] SCHULTZ-FADEMRECHT, CARSTEN[DE]: KLEBL, BERT[DE]: CHOIDAS, AXEL[DE]: KOCH, UWE[DE]: EICKHOFF, JAN[DE]: WOLF, ALEXANDER[DE]: ULLRICH, AXEL[DE] LEAD DISCOVERY CENTER GMBH [DE] and MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE] A 61K 31/4709, A 61P 35/00, C 07D 401/12, 401/14, 413/12, 413/14, 417/12, 417/14 The present invention relates to 1-nitrogen-heterocyclic-2-carboxamides of general formula (I): and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the treatment and/or prevention of Axl receptor tyrosine kinase subfamily induced disorders, including cancer and primary tumor metastases, and pharmaceutical compositions containing at least one of said 1-nitrogen-heterocyclic-2carboxamide derivatives and/or pharmaceutically acceptable salts thereof. Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: WO2008035209 A1 EP0860433 A1 WO2007146824 A2 No. of Claims: 03/27/2008 08/26/1998 12/21/2007 120 METHYLGENE, INC. [CA] KIRIN BEER KABUSHIKI KAISHA [JP] ARRAY BIOPHARMA INC. [US] Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2013/500555 [22] Date Filed: 25/03/2013 [54] Title: A SECURITY DEVICE [71] Proprietors(s): RACER TECHNOLOGY PTE LTD [SG] [72] Inventor(s): KEE JOO WILLY KOH[SG]: CHEE KEAN LIM[SG]: KIA BOON CHEW[SG] [73] Assignee(s): RACER TECHNOLOGY PTE LTD [SG] [74] Attorney / Agent: FEDERIS AND ASSOCIATES LAW OFFICES [30] Priority Data: NONE [51] International Class 8: E 05B 39/00, 45/00 Abstract: A security device for securing an item, the security device comprising a housing configured to house a circuit board comprising electronics configured to send a telecommunication signal to a receiver when the electronics is activated; a cable configured to establish a conductive path with the circuit board when the housing is closed, thereby activating the electronics; a lock assembly configured to be activated when the housing is closed; and a cover configured to close the housing, the cover having a first pin configured to engage a first end of the cable to prevent removal of a first end of the cable from the housing when housing is closed, and the cover having a second pin configured to activate the lock assembly to prevent removal of a second end of the cable from the housing when the housing is closed. [57] Representative Drawing(s): [56] Reference(s) Cited and/or Considered: US7474209 No. of Claims: US5959532 15 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2013/500808 [22] Date Filed: 25/04/2013 [54] Title: PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF METABOLIC DISORDERS [71] Proprietors(s): BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE] [72] Inventor(s): HAMILTON, BRADFORD S.[CA]: RAUCH, THOMAS[DE]: TSUTSUMI, MANAMI[JP] [73] Assignee(s): BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE] [74] Attorney / Agent: CASTILLO LAMAN TAN PANTALEON & SAN JOSE [30] Priority Data: 61/409,241 02/11/2010 US [51] International Class 8: [57] Abstract: Representative Drawing(s): Document Code: B1 A 61K 31/155, 31/422, 31/427, 31/522, 31/55, 31/7048, 45/06, A 61P 13/12, 27/06, 3/00, 3/10, 9/10 The invention relates to a pharmaceutical composition comprising 1.a and/or 1.b according to claim 1 in combination with at least one second therapeutic agent 2 which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions. NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 45] Issued Date: 17 August 2015 17 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2013/501591 [22] Date Filed: 26/07/2013 [54] Title: IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION [71] Proprietors(s): 4SC DISCOVERY GMBH [DE] [72] Inventor(s): JOHANN LEBAN[AT]: STEFAN TASLER[AT]: WAEL SAEB[DE]: CARINE CHEVRIER[FR] [73] Assignee(s): 4SC DISCOVERY GMBH [DE] [74] Attorney / Agent: E.B. ASTUDILLO AND ASSOCIATES [30] Priority Data: 11152512.7 28/01/2011 EP and 61/437,080 28/01/2011 US [51] International Class 8: A 61K 31/4155, A 61P 19/00, 29/00, C 07D 413/04, 413/14, 417/14 [57] Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents. Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 69 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2013/502401 [22] Date Filed: 19/11/2013 [54] Title: NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS [71] Proprietors(s): GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED [GB] [72] Inventor(s): QIN, DONGHUI[US]: CHEUNG, MUI[US]: JOSHI, HEMANT[IN]: TANGIRALA, RAGHURAM[IN]: BETHI, SRIDHAR, REDDY[IN] [73] Assignee(s): GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED [GB] [74] Attorney / Agent: E.B. ASTUDILLO AND ASSOCIATES [30] Priority Data: 1452/DEL/2011 20/05/2011 IN and 61/503,728 01/07/2011 US [51] International Class 8: C 07D 498/04 Abstract: This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders. [57] Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 10 45] Issued Date: 17 August 2015 Document Code: B1 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2014/500887 [22] Date Filed: 23/04/2014 [54] Title: AMINOALKYL-SUBSTITUTED N-THIENYL BENZAMIDE DERIVATIVE [71] Proprietors(s): ASTELLAS PHARMA INC. [JP] [72] Inventor(s): MIURA, MASANORI[--]: KAGA, DAISUKE[--]: WATANUKI, SUSUMU[--]: HACHIYA, SHUNICHIRO[--]: OKUDA, TAKAO[--]: SATO, IPPEI[--]: ISOMURA, MAI[--]: TERAI, KAZUHIRO[--]: TERADA, YOH[--] [73] Assignee(s): ASTELLAS PHARMA INC. [JP] [74] Attorney / Agent: A.Q. ANCHETA AND PARTNERS [30] Priority Data: 2011-236533 27/10/2011 JP [51] International Class 8: [57] Abstract: Representative Drawing(s): Document Code: B1 A 61K 31/381, 31/439, 31/4436, 31/444, 31/4535, 31/496, 31/506, 31/5377, A 61P 13/12, 19/00, 43/00, 7/00, C 07D 333/68, 333/78, 333/80, 409/12, 409/14, 413/12, 417/12, 453/02, 495/04 To provide a compound that has an intestinal phosphate transporter (NPT-IIb) inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. [Means for Solution] The present inventors conducted thier studies on a compound that has an NPT-IIb inhibitory action and is useful as an active ingredient of an agent for treating and/or preventing hyperphosphatemia. As a result, they created an aminoalkyl-substituted N-thienylbenzamide derivative which has NPT-IIb inhibitory action, thereby completing the present invention. The aminoalkyl-substituted N-thienylbenzamide derivative of the present invention has an NPT-IIb inhibitory action and can be used as an agent for preventing and/or treating hyperphosphatemia. NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 45] Issued Date: 17 August 2015 22 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2014/500987 [22] Date Filed: 02/05/2014 [54] Title: NEPRILYSIN INHIBITORS [71] Proprietors(s): THERAVANCE, INC. [US] [72] Inventor(s): HUGHES, ADAM[GB]: FENSTER, ERIK[CA]: FLEURY, MELISSA[CA]: GENDRON, ROLAND[CA]: MORAN, EDMUND, J.[US] [73] Assignee(s): THERAVANCE, INC. [US] [74] Attorney / Agent: AGCAOILI & ASSOCIATES [30] Priority Data: 61/554,625 02/11/2011 US [51] International Class 8: [57] Abstract: 45] Issued Date: 17 August 2015 Document Code: B1 A 61K 31/165, 31/215, A 61P 5/00, 9/00, C 07C 231/02, 233/56, 241/04, 243/30, 271/22, C 07D 317/40 In one aspect, the invention relates to compounds having the formula: (I) 1 6 where R -R , a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds. Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 44 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2014/501162 [22] Date Filed: 23/05/2014 [54] Title: ARYL DIHYDROPYRIDINONE AND PIPERIDINONE AS MGAT2 INHIBITORS [71] Proprietors(s): BRISTOL-MYERS SQUIBB COMPANY [US] [72] Inventor(s): TURDI, HUJI[--]: HANGELAND, JON J[--]: LAWRENCE, R. MICHAEL[--]: CHENG, DONG[--]: AHMAD, SALEEM[--]: MENG, WEI[--]: BRIGANCE, ROBERT PAUL[--]: DEVASTHALE, PRATIK[--]: ZHAO, GUOHUA[--] [73] Assignee(s): BRISTOL-MYERS SQUIBB COMPANY [US] [74] Attorney / Agent: SIGUION REYNA, MONTECILLO AND ONGSIAKO LAW OFFICES [30] Priority Data: 13/688,584 29/11/2012 US and 61/566,039 02/12/2011 US [51] International Class 8: [57] Abstract: 45] Issued Date: 17 August 2015 Document Code: B1 A 61K 31/4418, 31/4427, A 61P 1/16, 3/00, C 07D 211/86, 211/90, 401/04, 401/10, 401/12, 401/14, 407/14, 413/04, 413/12, 417/04, 417/14, C 07F 9/40 The present invention provides compounds of Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments. Representative Drawing(s): NONE [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 41 Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [19] INTELLECTUAL PROPERTY PHILIPPINES [12] INVENTION GRANT [21] Registration Number: 1/2014/501992 [22] Date Filed: 05/09/2014 [54] Title: MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES [71] Proprietors(s): PFIZER INC. [US] [72] Inventor(s): SIMON BAILEY[US]: BENJAMIN JOSEPH BURKE[US]: MICHAEL RAYMOND COLLINS[US]: JINGRONG JEAN CUI[US]: JUDITH GAIL DEAL[US]: ROBERT LOUIS HOFFMAN[US]: QINHUA HUANG[US]: TED WILLIAM JOHNSON[US]: ROBERT STEVEN KANIA[US]: JOHN CHARLES KATH[US]: PHUONG THI QUY LE[US]: MICHELE ANN MCTIGUE[US]: CYNTHIA LOUISE PALMER[US]: PAUL FRANCIS RICHARDSON[US]: NEAL WILLIAM SACH[US] [73] Assignee(s): PFIZER INC. [US] [74] Attorney / Agent: E. B. ASTUDILLO & ASSOCIATES [30] Priority Data: 61/607,485 06/03/2012 US and 61/759,307 31/01/2013 US [51] International Class 8: [57] Abstract: 45] Issued Date: 17 August 2015 Document Code: B1 A 61K 31/4353, A 61P 35/00, C 07D 491/08, 491/18, 498/08, 498/18, 498/22, 513/18 The invention relates to compounds of formula (Φ Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer. Representative Drawing(s): Intellectual Property Center, 28 Upper McKinley Rd. McKinley Hill Town Center, Fort Bonifacio, Taguig City 1634 Philippines Tel. No. 238-6300 Website: http://www.ipophil.gov.ph e-mail: mail@ipophil.gov.ph Volume 18 Number 106 Date Released: October 07, 2015 [56] Reference(s) Cited and/or Considered: NONE No. of Claims: 18