November 2007, Volume 13 No 11 pp1265-1388 Editorial The long and short of it - p1265 News Researchers look for 'sweet' method to diagnose cancer - p1267 Cassandra Willyard Program targets undergrads to make an early start on science - p1268 Emma Marris New law gives FDA more influence to monitor drug safety - p1269 Meredith Wadman News in brief - pp1270 - 1271 News Feature Blue's clues - pp1272 - 1273 Cassandra Willyard Q&A Straight talk from... Victoria Hale - p1274 Erika Check Hayden Correspondence Reply to 'Must maternity medicine be reborn?' - p1275 Jennifer Block Reply to 'pH paper trumps expensive kits in measuring acidity' - p1275 Biji T Kurien Reply to 'Poor trial design leaves gene therapy death a mystery' - p1276 H Stewart Parker Microarrays: retracing steps - pp1276 - 1277 Kevin R Coombes, Jing Wang & Keith A Baggerly Reply to 'Microarrays: retracing steps' - pp1277 - 1278 Anil Potti & Joseph R Nevins Reply to 'Arsenic patent keeps drug for rare cancer out of reach for many' - p1278 Raymond P Warrell, Jr Book Review The history and ideology of allergies - p1279 Fernando Martinez reviews Breathing Space: How Allergies Shape Our Lives and Landscapes by Gregg Mitman News and Views A deer in the headlights: BAMBI meets liver fibrosis - pp1281 - 1282 Scott L Friedman Blocking HDACs boosts regulatory T cells - pp1282 - 1284 Pavan Reddy & Weiping Zou Preventing kidney cell suicide - pp1284 - 1285 Michael Brownlee APC and colon cancer: two hits for one - pp1286 - 1287 Craig J Ceol, David Pellman & Leonard I Zon Seeking the source of schizophrenia - p1287 Charlotte Schubert Worms tame mast cells - pp1288 - 1289 Edward J Pearce A MSC-ing link in metastasis? - pp1289 - 1291 Douglas R Hurst & Danny R Welch Platelets budding off the mothership - p1291 Charlotte Schubert Research Highlights - p1293 Brief Communication B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates - pp1295 - 1298 Chengyang Liu, Hooman Noorchashm, Jennifer A Sutter, Mina Naji, Eline Luning Prak, Jean Boyer, Taryn Green, Michael R Rickels, John E Tomaszewski, Brigitte Koeberlein, Zhonglin Wang, Michelle E Paessler, Ergun Velidedeoglu, Susan Y Rostami, Ming Yu, Clyde F Barker & Ali Naji Articles Deacetylase inhibition promotes the generation and function of regulatory T cells - pp1299 - 1307 Ran Tao, Edwin F de Zoeten, Engin Özkaynak, Chunxia Chen, Liqing Wang, Paige M Porrett, Bin Li, Laurence A Turka, Eric N Olson, Mark I Greene, Andrew D Wells & Wayne W Hancock Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease - pp1308 - 1315 Markus Weckmann, Adam Collison, Jodie L Simpson, Matthias V Kopp, Peter A B Wark, Mark J Smyth, Hideo Yagita, Klaus I Matthaei, Nicole Hansbro, Bruce Whitehead, Peter G Gibson, Paul S Foster & Joerg Mattes Extralymphatic virus sanctuaries as a consequence of potent T-cell activation - pp1316 - 1323 Mike Recher, Karl S Lang, Alexander Navarini, Lukas Hunziker, Philipp A Lang, Katja Fink, Stefan Freigang, Panco Georgiev, Lars Hangartner, Raphael Zellweger, Andreas Bergthaler, Ahmed N Hegazy, Bruno Eschli, Alexandre Theocharides, Lukas T Jeker, Doron Merkler, Bernhard Odermatt, Martin Hersberger, Hans Hengartner & Rolf M Zinkernagel TLR4 enhances TGF-beta signaling and hepatic fibrosis - pp1324 - 1332 Ekihiro Seki, Samuele De Minicis, Christoph H Österreicher, Johannes Kluwe, Yosuke Osawa, David A Brenner & Robert F Schwabe Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC1 - pp1333 - 1340 Heiko Johnen, Shu Lin, Tamara Kuffner, David A Brown, Vicky Wang-Wei Tsai, Asne R Bauskin, Liyun Wu, Greg Pankhurst, Lele Jiang, Simon Junankar, Mark Hunter, W Douglas Fairlie, Nicola J Lee, Ronaldo F Enriquez, Paul A Baldock, Eva Corey, Fred S Apple, MaryAnn M Murakami, En- Ju Lin, Chuansong Wang, Matthew J During, Amanda Sainsbury, Herbert Herzog & Samuel N Breit STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression - pp1341 - 1348 Qian Zhang, Hong Y Wang, Xiaobin Liu & Mariusz A Wasik Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis - pp1349 - 1358 Berend Isermann, Ilya A Vinnikov, Thati Madhusudhan, Stefanie Herzog, Muhammed Kashif, Janusch Blautzik, Marcus A F Corat, Martin Zeier, Erwin Blessing, Jun Oh, Bruce Gerlitz, David T Berg, Brian W Grinnell, Triantafyllos Chavakis, Charles T Esmon, Hartmut Weiler, Angelika Bierhaus & Peter P Nawroth Letters Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins pp1359 - 1362 Sandip Ray, Markus Britschgi, Charles Herbert, Yoshiko Takeda-Uchimura, Adam Boxer, Kaj Blennow, Leah F Friedman, Douglas R Galasko, Marek Jutel, Anna Karydas, Jeffrey A Kaye, Jerzy Leszek, Bruce L Miller, Lennart Minthon, Joseph F Quinn, Gil D Rabinovici, William H Robinson, Marwan N Sabbagh, Yuen T So, D Larry Sparks, Massimo Tabaton, Jared Tinklenberg, Jerome A Yesavage, Robert Tibshirani & Tony Wyss-Coray Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human - pp1363 - 1367 Shuichi Hiraoka, Tatsuya Furuichi, Gen Nishimura, Shunichi Shibata, Masaki Yanagishita, David L Rimoin, Andrea Superti-Furga, Peter G Nikkels, Minako Ogawa, Kayoko Katsuyama, Hidenao Toyoda, Akiko Kinoshita-Toyoda, Nobuhiro Ishida, Kyoichi Isono, Yutaka Sanai, Daniel H Cohn, Haruhiko Koseki & Shiro Ikegawa CD16 promotes Escherichia coli sepsis through an FcRbold gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation - pp1368 - 1374 Fabiano Pinheiro da Silva, Meryem Aloulou, David Skurnik, Marc Benhamou, Antoine Andremont, Irineu T Velasco, Murilo Chiamolera, J Sjef Verbeek, Pierre Launay & Renato C Monteiro Inhibition of FcepsilonRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes - pp1375 - 1381 Alirio J Melendez, Margaret M Harnett, Peter N Pushparaj, WS Fred Wong, Hwee Kee Tay, Charles P McSharry & William Harnett Technical Report Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy - pp1382 - 1387 Sam E Day, Mikko I Kettunen, Ferdia A Gallagher, De-En Hu, Mathilde Lerche, Jan Wolber, Klaes Golman, Jan Henrik Ardenkjaer-Larsen & Kevin M Brindle Corrigendum Corrigenda: Genomic signatures to guide the use of chemotherapeutics - p1388 Anil Potti, Holly K Dressman, Andrea Bild, Richard F Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, Hope Cottrill, Michael J Kelley, Rebecca Petersen, David Harpole, Jeffrey Marks, Andrew Berchuck, Geoffrey S Ginsburg, Phillip Febbo, Johnathan Lancaster & Joseph R Nevins