Curriculum Vitae Nozomu Inoue M.D., Ph.D. Work Address: Department of Orthopedic Surgery, RUSH UniversityMedical Center 1611West Harrison Street, Orthopedic Building 205 J, Chicago, Illinois 60612-3833 Work Telephone: Office: 312-942-8151 E-mail: nozomu_inoue@rush.edu Education: Fax: 312-942-2101 Kyoto Prefectural University of Medicine, Kyoto, Japan M.D. 1981 Internship, Orthopaedic Surgery, Kyoto Prefect. Univ. of Med., Kyoto, Japan 1981-83 Kyoto Prefect. Univ. of Med.,Graduate School, Kyoto, Japan 1983-87 Ph.D. 1987 Current Position: Propessor, Department of Orthopedic Surgery, RUSH University Medical Center Professor, Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University Research and Professional Experience: Apr. 1983-Mar. 1987 Assistant and Research Fellow, Mechanical Engineering, Doshisha University, Kyoto, Japan Apr. 1987- Sept. 1992 Instructor of Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan Apr. 1989-Sept. 1992 Chief of Fracture Clinic, Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan Apr. 1991-Mar. 1995 Part-time Lecture (Biomechanics), Mechanical Engineering, Doshisha University, Kyoto, Japan Oct. 1992-Sept. 1994 Visiting Instructor of Orthopaedic Surgery, Johns Hopkins University (JHU), Baltimore Oct. 1994-Aug. 1996 Instructor of Orthopaedic Surgery, JHU, Baltimore Sept. 1996-Apr. 2000 Assistant Professor of Orthopaedic Surgery, JHU, Baltimore May 2000-Apr. 2003 Associate Professor of Orthopaedic Surgery, JHU, Baltimore Jul. 1995-Apr. 2003 Assistant Director of Orthopaedic Biomechanics Laboratory, JHU, Baltimore Apr. 2003-Nov.2007 Associate Professor of Orthopedic Surgery, Director of Orthopedic Biomechanics Laboratory, RUSH University Medical Center, Chicago Nov.2007-present Professor of Orthopedic Surgery, RUSH University Medical Center, Chicago 1 Apr. 1996-Apr.2007 Visiting Lecture, Kyoto Prefectural University of Medicine, Kyoto, Japan Apr. 2004-present Chairman, Committee on Biomedical Materials, Japan Society of Material Sciences, Japan Apr. 2004-present Visiting Professor, Faculty of Engineering, Graduate School of Niigata University, Niigata, Japan Apr. 2006-present Program Director, Biomedical Engineering Research Center, Doshisha University, Kyoto, Japan Apr. 2007-present Visiting Professor, Kyoto Prefectural University of Medicine, Kyoto, Japan List of Publications DOCTORAL DISSERTATION N.Inoue: Mechanical properties of cancellous bone -Dependence of strength and elastic modulus on trabecular orientation-, J. Kyoto Pref. Univ. Med., 96(10), 847-865, 1987. (in Japanese with English abstract ) BOOK CHAPTER 1) N.Inoue, K.Sakakida, F.Yamashita, T.Hirai, T.Katayama: Quantitative analysis of trabecular orientation of cancellous bone by Fourier analysis, IN: Bone Morphometry 5,(Ed. K.Yamamoto), 112-120, Nishimura Co. Ltd., Niigata, 1985. (Japanese) 2) N.Inoue, K.Sakakida, F.Yamashita, T.Hirai, T.Katayama : The elastic modulus of cancellous bone : Dependence on trabecular orientation, Biomechanics: Basic and Applied Research (Ed. G.Bergmann, R.Kolbel, A.Rohlmann), 207-212, Martinus Nijihoff Publishers, Dordrecht, 1987. 3) T.Hirai, T.Katayama, N.Inoue, Y.Kida: Optimum design for knee prosthesis using laminated composite materials - Stress transmission pattern and its estimation, Composite Structures 5 (Ed. I.H. Marshall), 849-861, Elsevier Applied Science Publishers Ltd., London, 1989. 4) N.Inoue, Y.Hirasawa, F.Yamashita, Y.Watanabe, T.Hirai, T.Katayama, T.Kida : Isoelastic knee prosthesis using laminated composite materials, Clinical Implant Materials (Ed. G.Heimke, U.Soltesz , A.J.C.Lee), 425-430, Elsevier Science Publishers B.V., Amsterdam, 1990. 5) T.Hirai, T.Katayama, N.Inoue, H.Yamamoto, J.Fukuzawa: Optimum structure of knee prosthesis using laminated composite considering the stress dispersion at prosthesis/bone interface, Composite Structures 6, (Ed. I.H. Marshall), 351-361, Elsevier Applied Science Publishers Ltd., London, 1991. 6) N.Yoshino, N.Inoue, Y.Watanabe, F.Yamashita, Y.Hirasawa, T.Hirai, T.Katayama: Stress analysis of the proximal tibia after total knee arthroplasty with the finite element method, Biomechanics in Orthopedics (Ed. Niwa, Perren, Hattori), 253-262, Springer-Verlag, Tokyo, 1992. 7) Y.Hirasawa, N.Inoue: External fixation with non-invasive method for estimating callus strength, Seikeigeka Mook Suppl.2-D, (Ed. Y.Itami, A.Nishio), 184-189, Kanahara Co. Ltd. Tokyo, 1993. (Japanese) 2 8) N.Inoue, F.Yamashita : Complication in treatment of intra-arthecular fracture of knee, IN: OS NOW 9, (Ed. K.Kanada), 122-133, Medical View, Tokyo, 1993. (Japanese) 9) N.Inoue, Y.Hirasawa, S.Kubo: Femoral head fracture, IN: OS NOW 10 (Ed. Y.Hirasawa), 158-163, Medical View, Tokyo, 1993. (Japanese) 10) M.Yoshida, W.Kim, N.Inoue, Y.Arai, Y.Watanabe: The effect of maturation on dynamic viscoelastic properties of epiphyseal plate in the rabbit, Clinical Biomechanics and Related Research (Ed. Y.Hirasawa, C.B.Sledge, S.L.Woo),155-160, Springer-Verlag, Tokyo, 1994. 11) E.Y.S.Chao, H.T.Aro, N.Inoue: Engineering principles for bone fracture fixation and repair, Biomedical Application of Synthetic Biodegradable Polymers (Ed. J.O.Hollinger), 145-171, CRC PRESS, Boca Raton, 1995. 12) A.D.C.Valdevit, N.Inoue, B.A.MacWilliams, L.L.Anderson: Methods for mechanical testing of spinal constructs, IN: SPINE: State of the Art Reviews. (Ed. Haher, T.R., Merola, A.A.), 231-248, HALEY & BELFUS, Philadelphia, 1996. 13) N.Inoue: Intra-articular fracture of knee. IN: Orthopaedic Surgery: Knee and Thigh Pain. (Ed. T.Toris), 87-104, Nankodo, Tokyo, 1996. (Japanese) 14) N.Inoue, E.Y.S.Chao: Biomechanics of external fixation, IN: OS NOW 21 (Ed. Y.Hirasawa), 1-7, Medical View, Tokyo, 1997. (Japanese) 15) E.Y.S.Chao, N.Inoue, J.J.Elias, F.J.Frassica: Computational biomechanics using image-based models, IN: Handbook of Medical Image Processing (Ed. Frank J., Brody W., Zerhouni E.), 2929, Academic Press, San Diego, 2000. 16) E.Y.S.Chao, N.Inoue, F.J.Frassica, F.H.Sim: Segmental Bone/Joint Replacement Using Guided Tissue Regeneration, IN: Tissue Engineering and Biodegradable Equivalents. (Ed. Lewandrowski, Wise, Trantolo, Gresser, Yaszemski, Altobelli), 355-384, Marcel Dekker Inc. New York, 2002. 17) N.Inoue, E.Y.S.Chao: Biomechanics of osteoporotic bone and fractures, IN: Internal Fixation in Osteoporotic Bone (Ed. An Y.Y.), 9-21, Thieme Medical, New York, 2002. 18) K.Aflatoon, D.A.Frassica, N.Inoue, F.J.Frassica: Bone fixation in patients with bone tumors, IN: Internal Fixation in Osteoporotic Bone (Ed. An Y.Y.), 178-185, Thieme Medical, New York, 2002. 19) N.Inoue, Y.H.Kim, T.Mihata, E.Y.S.Chao: Biomechanics of callus formation, IN: Basic and Clinic of External Fixation -Current Topics-, Seikei-SaigaiGeka 45. (Ed. Y.Hirasawa), 271-279, Kanahara Co.Ltd. Tokyo, 2002. (Japanese) 20) E.Y.S.Chao, N.Inoue: Pysical stimuli in bone fracture repair and remodeling, IN: Biokompatible Operationstechniken in der Unfall-und Handchirurgie (Ed. Meffert R.H., Munster M.L.), 15-33, Hans Marseille Verlag GmbH, Munchen, 2003. 21) N.Inoue, E.Y.S.Chao: Enhancement of fracture healing by ultrasound and electromagnetic fields stimulation, IN: Advanced Medicine in Orthopaedic Surgery (Ed. Y.Hirasawa, H.Inoue, K.Takaoka), Institute of Advanced Medical Technology, Tokyo, 2003. (Japanese) 22) E.Y.S.Chao, I.Ohnishi, B.Rafiee, R.Meffert, T.Wu, D.Cullinane, B.Simon, N.Inoue: Pulsed electromagnetic fields on osteotomy healing and normal bone turnover, IN: Physical Regulation of Skeletal Repair (Ed. R.K.Aaron, M.E.Bolander), 97-110, American Academy of Orthopaedic Surgeons, Chicago, 2005. 3 (Japanese translation based on English original) 1) N.Inoue: Planning and Reduction Technique in Fracture Surgery, (Ed. J.Mast, R.Jakob, R.Ganz), Springer-Verlag, Tokyo, 1991. 2) N.Inoue: Peripheral Nerve Surgery, (Ed. Makinnon, Dellon), Kimpodo, Tokyo, 1992. PEER-REVIEWED PAPER 1) N.Inoue, R.Imai, T.Kusakabe: Fatigue fracture of the pubic ramus with rapidly destructive coxopathy: Report of a case. Cent Jpn J Orthop Traumat 25:1667-1670, 1982. (Japanese) 2) N.Inoue, Y.Katumi, Y.Hirasawa, K.Sakakida, K.Tamai: Spontaneous rupture of the extensor pollicis longus after fracture of the lower end of the radius. Cent Jpn J Orthop Traumat 26:783785, 1983. (Japanese) 3) A.Ishino, K.Sakakida, F.Yamashita, T.Kusakabe, N.Inoue, E.Matsui, K.Hara: Study on biomechanical characteristics of epiphyseal plate (Part 1) Compressive strength. Cent Jpn J Orthop Traumat 27:250-251, 1984. (Japanese) 4) Y.Imamura, K.Sakakida, F.Yamashita, F.Suzu, N.Inoue, H.Fujii, K.Tachiiri, K.Hara: Two cases of lateral dislocation of patella after total condylar knee joint replacement. Orthop Surg 35:669-675, 1984. (Japanese) 5) N.Inoue: Estimation method of mechanical properties of cancellous bone by image analysis. Orthop Surg. 36:1596, 1985. (Japanese) 6) N.Inoue, K.Sakakida, F.Yamashita, S.Ban, H.Takeshita: Observation on bone-ceramics interface of an almina ceramic knee prosthesis. Orthopaedic Ceramic Implants 3:133-138, 1985. (Japanese) 7) N.Inoue, K.Sakakida, F.Yamashita, T.Hirai, T.Katayama: The mechanical properties of cancellous bone (Part 1) Tensile characteristics, torsional characteristics. Jpn J Clinical Biomechanics 6:107-113, 1985. (Japanese) 8) N.Inoue, K.Sakakida, F.Yamashita, T.Hirai, T.Katayama: Quantitative analysis of trabecular orientation of cancellous bone by Fourier analysis of soft X-ray image. Cent Jpn J Orthop Traumat 28: 277-279, 1985. (Japanese) 9) N.Inoue, K.Sakakida, F.Yamashita, T.Hirai, T.Katayama: Acoustic emission characteristics of the cancellous bone under tensile loading. Progress in Acoustic Emission III: 270-275, 1986. 10) S.Inoue, K.Sakakida, F.Yamashita, T.Kusakabe, N.Inoue, T.Hirai, T.Katayama: Acoustic emission characteristics of the cortical bone under tensile loading. Progress in Acoustic Emission III:244-249, 1986. 11) M.Suzuki, K.Sakakida, F.Yamashita, T.Kusakabe, N.Inoue, T.Hirai, T.Katayama: Acoustic emission characteristics of the epiphyseal plate under tensile loading. Progress in Acoustic Emission III:257-262, 1986. 12) W.Kim, N.Ishino, K.Sakakida, F.Yamashita, T.Kusakabe, N.Inoue, Y.Hamada: Specific configuration of epiphyseal plate and its mechanical strength. Cent Jpn J Orthop Traumat 29:512-514, 1986. (Japanese) 13) S.Okada, K.Sakakida, F.Suzu, N.Inoue: Observation on cartilage and subchondral bone of experimental unstable knee. Cent Jpn J Orthop Traumat 29:1698-1699, 1986. (Japanese) 4 14) T.Kusakabe, K.Sakakida, F.Yamashita, T.Kubo, E.Matsui, Y.Kusaka, N.Inoue, S.Inoue, R.Imai, A.Noguchi: Effectiveness of bone grafting for Lard type artificial joint. J Joint Surg 6:777-785, 1987. (Japanese) 15) N.Inoue, K.Sakakida, F.Yamashita, T.Hirai, T.Katayama: The mechanical properties of cancellous bone (Part 4) Young's modulus in off-axis direction. Jpn J Clinical Biomechanics 7:167-172, 1987. (Japanese) 16) N.Inoue, K.Sakakida, F.Yamashita, T.Hirai, T.Katayama: The mechanical properties of cancellous bone (Part 5) Anisotropy of strength depending on trabecular orientation. Jpn J Clinical Biomechanics 8:167-172, 1987. (Japanese) 17) N.Inoue, K.Sakakida, F.Yamashita, S.Inoue, T.Hirai, T.Katayama, M.Hayashibara: Acoustic source location during tensile test of cortical bone. Progress in Acoustic Emission IV:177-184, 1988. 18) N.Inoue, K.Sakakida, F.Yamashita, S.Kohno, T.Hirai, T.Katayama, Y.Kida: Evaluation of bone-artificial knee joint interface by acoustic emission technique. Progress in Acoustic Emission IV:222-229, 1988. 19) W.Kim, K.Sakakida, F.Yamashita, T.Kusakabe, A.Ishino, N.Inoue, N.Motoki, K.Ishikawa: The influence of the three-dimensional contour and the perichondrium in epiphyseal plate failure. Jpn J Clinical Biomechanics 8:83-88, 1988. (Japanese) 20) S.Inoue, N.Inoue, T.Kusakabe, F.Yamashita, K.Sakakida, T.Hirai, T.Katayama: Microcracking behavior of cortical bone -Acoustic emission characteristics under tensile loading-. Jpn J Clinical Biomechanics 8:59-63, 1988. (Japanese) 21) M.Suzuki, N.Inoue, T.Kusakabe, F.Yamashita, K.Sakakida, T.Hirai, T.Katayama: The experimental study on the characteristics of the epiphyseal plate under tensile loading. Jpn J Clinical Biomechanics 8:95-99, 1988. (Japanese) 22) K.Matano, H.Shimono, T.Fujita, K.Sakakida, S.Watanabe, Y.Okada, A.Mizutani, N.Inoue: Experimental study on strength of allograft of cortical bone. Cent Jpn J Orthop Traumat 31:777-779, 1988. (Japanese) 23) Y.Watanabe, N.Inoue, F.Yamashita, Y.Hirasawa, T.Hirai, T.Katayama, H.Yamamoto: Microfracture in fresh bovine tibial cortex analyzed with torsion test. Jpn J Clinical Biomechanics 9:103-107, 1989. 24) H.Tsuneoka, K.Sakakida, T.Fujita, A.Mizutani, Y.Okada, N.Inoue: Fracture mechanism of calcaneus. Fracture 11:333-338, 1989. (Japanese) 25) M.Suzuki, N.Inoue, Y.Watanabe, F.Yamashita, Y.Hirasawa, T.Kusakabe, T.Hirai, T.Katayama: Evaluation of callus strength using acoustic emission technique during lengthening of human long bone. Progress in Acoustic Emission V:297-302, 1990. 26) Y.Watanabe, N.Inoue, Y.Hirasawa, Y.Arai, T.Hirai, T.Katayama: Acoustic emission properties of fracture callus under tensile loading. Progress in Acoustic Emission V:303-310, 1990. 27) N.Inoue, T.Fujita, Y.Watanabe, A.Mizutani, Y.Okada, H.Tsuneoka, F.Yamashita, Y.Hirasawa, K.Sakakida: Biomechanical advantages of bone grafting in the treatment of calcaneal fracture. Fracture 12:173-177, 1990. (Japanese) 28) N.Inoue, F.Suzu, F.Yamashita, Y.Watanabe, Y.Hirasawa, T.Fujita, K.Sakakida: Fractures of the tibial plateau -Obstinate cases-. Jpn J Traumt Occup Med 38:371-377, 1990. (Japanese) 5 29) Y.Arai, N.Inoue, Y.Watanabe, T.Fujii, Y.Hirasawa: Biomechanical study of internal fixation for the fracture of distal femur. Jpn J Clinical Biomechanics 12:335-340, 1991. 30) N.Yoshino, N. Inoue, Y.Watanabe, F.Suzu, F.Yamashita, Y.Hirasawa, T.Hirai, T.Katayama, H.Yamamoto: Stress analysis of the proximal tibia after total knee arthroplasty with finite element analysis considering heterogeneous and anisotropic properties of cancellous bone. Jpn J Clinical Biomechanics 12:1265-1269, 1991. (Japanese) 31) Y.Okada, S.Asou, T.Fujita, Y.Hiwasawa, K.Sakakida, N.Inoue: Compression fracture of the bilateral talar domes; A case report. Orthop Surg Traumatol 34:439-443, 1991. (Japanese) 32) N.Inoue, F.Suzu: Tibial plateau fracture, M B Orthop 37, 43-53, 1991. (Japanese) 33) Y.Arai, N.Inoue, Y.Watanabe, T.Fujii, Y.Hirasawa: Biomechanical study of dynamic condylar screw for the fracture of distal femur. Cent Jpn J Orthop Traumat 33:2314-2316, 1991. (Japanese) 34) T.Kitaura, N.Inoue, Y.Watanabe, Y.Hirasawa, T.Fujita: Tibiofibular instability caused by injury of distal tibiofibular ligament. Cent Jpn J Orthop Traumat 34:893-894, 1991. (Japanese) 35) K.Fujita, Y.Kizaki, N.Koudou, F.Inoue, N.Furukawa, A.Kinugasa, N.Inoue: A case of osteogenesis imparfecta who increased incidence of bone fracture. Hormone and Clinic 39:501505, 1991. (Japanese) 36) N.Inoue, Y.Hirasawa, Y.Watanabe, M.Suzuki, N.Yoshino: Non-destructive inspection of callus strength by acoustic emission technique. Cent Jpn J Orthop Traumat 34:1577-1578, 1991. (Japanese) 37) H.Tsuneoka, N.Inoue, T.Shimono, T.Fujita: Ankle fracture dislocation of athletes. Clinical Sports Med 8:1125-1129, 1991. (Japanese) 38) T.Hirai, T.Katayama, H.Yamamoto, M.Inada, N.Inoue, Y.Watanabe, Y.Arai: Nonlinear behavior with AE of cortical bone treated with acid under tensile loading. Progress in Acoustic Emission VI:317-324, 1992. 39) N.Inoue, Y.Hirasawa, Y.Watanabe, Y.Arai, H.Tsuneoka, Y.Hatanaka: Non-destructive evaluation of yielding stress of bone during fracture treatment using acoustic emission technique. Progress in Acoustic Emission VI:311-316, 1992. 40) T.Kitaura, N.Inoue, Y.Watanabe, Y.Hirasawa, T.Fujita: Fracture mechanism of talus considering of trabecular structure of talus. Cent Jpn J Orthop Traumat 35:461-462, 1992. (Japanese) 41) Y.Arai, N.Inoue, Y.Watanabe, Y.Hirasawa, T.Hirai, T.Katayama: Piezoelectric potential of cancellous bone. J Jpn Bio-Electrical Res Soc 6:9-13, 1992. (Japanese) 42) Y.Watanabe, Y.Arai, Y.Hirasawa, N.Inoue, T.Hirai, T.Katayama: The relationship between piezoelectric and mechanical properties of decalcified and undecalcified cortical bone. J Jpn Bio-Electrical Res Soc 6:15-18, 1992. (Japanese) 43) Y.Arai, N.Inoue, W.Kim, Y.Watanabe, Y.Hirasawa: Dynamic viscoelastic properties of callus under the electrical stimulation. J Jpn Bio-Electrical Res Soc 7:37-43, 1992. (Japanese) 44) Y.Watanabe, N.Inoue, Y.Hirasawa, T.Hirai, T.Katayama, H.Yamamoto, T.Nakagawa: Two dimensional finite element analysis on the stress distribution of callus. Jpn J Clinical Biomechanics 13:317-320, 1992. (Japanese) 6 45) Y.Watanabe, Y.Kusaka, S.Takai, N.Inoue, Y.Hirasawa, T.Hirai, T.Katayama: Tensile and torsional characteristics of rabbit cortical bone during maturation. Jpn J Clinical Biomechanics 13:269-273, 1992. 46) T.Morito, S.Takai, M.Yasuhara, H.Dohno, Y.Okuda, K.Tamai, N.Inoue, Y.Hirasawa: Mechanical properties of digital deep flexor tendon attachment in rabbit. Jpn J Clinical Biomechanics 13:233-238, 1992. (Japanese) 47) Y.Arai, Y.Watanabe, N.Inoue, Y.Hirasawa, T.Hirai, T.Katayama, H.Yamamoto: Quantitative analysis of trabecular structure of distal femur using image analysis. Jpn J Clinical Biomechanics 13:275-279, 1992. (Japanese) 48) Y.Arai, N.Inoue, Y.Watanabe, Y.Hirasawa, T.Hirai, T.Katayama: Piezoelectric potential of cancellous bone. J Jpn Bio-Electrical Res Soc 6:9-13, 1992. (Japanese) 49) Y.Watanabe, Y.Arai, N.Inoue, Y.Hirasawa, T.Hirai, T.Katayama: Relationship between piezoelectricity and mechanical properties of decalcified and undecalcified cortical bone. J Jpn Bio-Electrical Res Soc 6:15-18, 1992. (Japanese) 50) S.Nakamura, F.Yamashita, K.Kususaki, N.Inoue, T.Yamagiwa, Y.Hirasawa: Long term follow up of the artificial knee replacement for osteosarcoma. Orthopaedic Ceramic Implants 10:125130, 1992. (Japanese) 51) M.Yoshida, N.Inoue, W.Kim, Y.Hirasawa, M.Suzuki: Epiphyseal separation of proximal tibia. Cent Jpn J Orthop Traumat 36:101-102, 1993. (Japanese) 52) N.Inoue, Y.Hirasawa, S.Kubo: Progress in external fixation system. Surgical Therapy 68:495500, 1993. (Japanese) 53) T.Morito, N.Inoue, Y.Hirasawa, A.Mizutani, K.Sakakida: Relationship between tibio-fibular separation and fracture pattern -fracture dislocation P-E type-. Fracture 15:80-85, 1993. (Japanese) 54) A.Mizutani, K.Sakakida, H.Shinjo, N.Inoue, Y.Hirasawa, T.Fujita: Fracture type and replacement of intra-articular fracture of distal radius. Fracture 15:166-170, 1993. (Japanese) 55) M.Yoshida, N.Inoue, H.Nishiura, Y.Watanabe, Y.Arai, Y.Hirasawa, Y.Shirai, A.Mizutani, Y.Mori, T.Fujita: Epiphyseal separation of proximal tibia. Fracture 15:246-250, 1993. (Japanese) 56) T.Shiga, N.Inoue, Y.Hirasawa: Epiphyseal separation of calcaneus -a case report-. Fracture 15, 251-254, 1993. (Japanese) 57) H.Shikata, K.Kusuzaki, N.Inoue, Y.Hirasawa: Hip arthroplasty using "pseudo arthlosis" for malignant fibro histiocytosis of pubic bone. Orthop Surg 44:1781-1784, 1993. (Japanese) 58) M.Yoshida, N.Inoue, Y.Watanabe, Y.Arai, W.Kim, S.Takai, Y.Hirasawa: Ultimate strain of epiphyseal plate under tensile loading in rabbit. Jpn J Clinical Biomechanics 14:159-162, 1993. (Japanese) 59) N.Yoshino, S.Takai, N.Inoue, Y.Watanabe, F.Yamashita, Y.Hirasawa, T.Hirai, T.Katayama, H.Yamamoto: Finite element analysis of proximal tibia after unicompartmental knee arthroplasty. Jpn J Clinical Biomechanics 14:361-365, 1993. (Japanese) 60) Y.Watanabe, Y.Hirasawa, N.Inoue, Y.Arai, T.Hirai, T.Katayama: Acoustic emission properties of tensile and torsional loading. Jpn J Clinical Biomechanics 14:205-210, 1993. (Japanese) 7 61) Y.Arai, N.Inoue, W.Kim, Y.Watanabe, Y.Hirasawa: Dynamic viscoelastic properties of callus under electrical stimulation. J Jpn Bio-Electrical Res Soc 7:37-43, 1993. (Japanese) 62) N.Inoue, Y.Hirasawa, T.Hirai, T.Katayama: Composite materials in bio-medical engineering. Materiaux & Techniques 92:23-26, 1994. 63) Y.Hirasawa, Y.Arai, Y.Watanabe, N.Inoue: Evaluation of strength during fracture healing using an acoustic emission technique. The Bone 8:109-115, 1994. (Japanese) 64) M.Yoshida, N.Inoue, W.Kim, Y.Watanabe, Y.Arai, S.Takai, Y.Hirasawa, T.Fujita: Clinical study of the tibial condylar fractures. Fracture 16:482-486, 1994. (Japanese) 65) M.Yoshida, W.Kim, Y.Arai, N.Inoue, Y.Watanabe, S.Takai, Y.Kusaka, Y.Hirasawa: The effect of maturation on dynamic visco-elastic properties of epiphyseal plate in rabbit. Jpn J Clinical Biomechanics 15:147-150, 1994. (Japanese) 66) N.Yoshino, S.Takai, N.Inoue, Y.Watanabe, Y.Hirasawa, T.Katayama: Finite element analysis of proximal tibia after unilateral knee artholoplasty. Joint Surgery 14:21-30, 1995. (Japanese) 67) M.Yoshida, N.Inoue, F.Suzu, W.Kim, Y.Watanabe, S.Takai, Y.Hirasawa: The clinical study of the approach in the surgical treatment of tibial condylar fractures. J Tokyo Knee Joint Soc 14:34-39, 1995. (Japanese) 68) T.Katayama, H.Yamamoto, N.Inoue: Optimum design of artificial joints considering initial fixation of prosthesis. Composite Structure 32:427-433, 1995. 69) K.Ikeda, R.L.Waltrip, N.Inoue, F.J.Frassica, E.Y.S.Chao: Development of canine multidrug chemotherapeutic model using doxorubicin, cisplatin, and ifosfamide. J Exp Clin Cancer Res 15(3):277-281, 1996. 70) K.Ikeda, N.Inoue, F.J.Frassica, R.C.Donehower, K.Tomita, E.Y.S.Chao: Development of canine chemotherapeutic model using ifosfamide. Laboratry Animal Science 46(5):503-506, 1996. 71) F.J.Frassica, N.Inoue, P.Virolainen, E.Y.S.Chao: Skeletal system: biomechanical concepts and relationship to normal and abnormal conditions. Semin Nucl Med 27(4):321-327, 1997. 72) D.R.Young, P.H. Virolainen, N. Inoue, F.J. Frassica, E.Y.S. Chao: The short-term effects of cisplatine chemotherapy on bone turnover. J Bone Miner Res 12:1874-1882, 1997. 73) J.Lin, N.Inoue, A.Valdevit, Y.S.Hang, S.M.Hou, E.Y.S.Chao: Biomechanical comparison of antegrade and retrograde nailing of humeral shaft fracture. Clin Orthop 351:203-213, 1998. 74) M.A.Shermak, L.Wong, N.Inoue, E.Y.S.Chao, P.N.Manson: Butyl-2-cyanoacrylate fixation of madibular osteotomies. Plast Reconstr Surg 102(2):319-324, 1998. 75) M.A.Shermak, L.Wong L, N.Inoue, B.J.Crin, M.J.Im, E.Y.S.Chao, P.N.Manson: Fixaton of the craniofacial skeleton with Butyl-2-cyanoacrylate and its effects on histotoxicity ad healing. Plast Reconstr Surg 102(2):309-318. 1998. 76) E.Y.S.Chao, N.Inoue, J.J.Elias, H.T.Aro: Enhancement of fracture healing by mechanical and surgical intervention. Clin Orthop 355:S163-178, 1999. 77) J.B.Nelson, S.H.Nguyen, J.R.Wu-Wong, T.J.Opgenorth, D.B.Dixon, L.W. Chung, N.Inoue: New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade. Urology 53(5):1063-1069, 1999. 8 78) P.H.Virolainen, N.Inoue, M.Nagao, I.Ohnishi, F.J.Frassica, E.Y.S.Chao: Autogenous onlay grafting for enhancement of extracortical tissue formation over porous-coated segmental replacement prostheses. J Bone Joint Surg (Am) 81(4):493-499, 1999. 79) S.A.Lietman, N.Inoue, E.Y.S.Chao, F.J.Frassica: Distal femoral osteoarticular allograft in limb salvage surgery. Ann Chir Gynaecol 88(3):221-225, 1999. 80) J.Lin, S.M.Hou, N.Inoue, E.Y.S.Chao, Y.S.Hang: Anatomic consideration of locked humeral nailing. Clin Orthop 368:247-254, 1999. 81) R.H.Meffert, J.E.Tis, S.Lounici, J.S.Rogers, N.Inoue, E.Y.S.Chao: Comparison of two systems for tibial external fixation in rabbits. Laboratry Animal Science 49(6):650-654, 1999. 82) R.H.Meffert, N.Inoue, J.E.Tis, E.Brug, E.Y.S.Chao: Limb reconstruction after primary shortening in tibial bone defect. J Bone Joint Surg (Am) 82(6):799-808, 2000. 83) R.H.Meffert, J.E.Tis, N.Inoue, E.F.McCarthy, E.Brug, E.Y.S.Chao: Primary resective shortening followed by distraction osteogenesis for limb reconstruction: A comparison to simple lengthening. J Orthop Res 18(4):629-636, 2000. 84) P.Virolainen, N.Inoue, D.R.Young, F.J.Frassica, E.Y.Chao: Method to remove intramedullary cement prior to mechanical testing in canine segmental replacement model. Biomed Mater Eng 10(2):51-56, 2000. 85) M.C.Pierce, A.Valdevit, L.Anderson, N.Inoue, D.L.Hauser: Biomechanical evaluation of dualenergy X-ray absorptiometry for predicting fracture loads of the infant femur for injury investigation: an in vitro porcine model. J Orthop Trauma 14(8):571-576, 2000. 86) M.A.Shermak, L.Wong, N.Inoue, T.Nicol: Reconstruction of complex cranial wounds with demineralized bone matrix and bilayer artificial skin. J Craniofac Surg 11(3):224-231, 2001. 87) S.Larsson, W.Kim, V.L.Caja, E.L.Egger, N.Inoue, E.Y.S.Chao: Effect of early dynamization on experimental tibial healing -A time-sequenced study in dogs. Clin Orthop 388:240-251, 2001. 88) M.A.Mont, L.C.Jones, J.J.Elias, N.Inoue, T.R.Yoon, E.Y.S.Chao, D.S.Hungerford: Strut autografting with and without osteogenic protain-1: evaluation using a canine femoral head defect model. J Bone Joint Surg (Am) 83(7):1013-1022, 2001. 89) M.S.Machen, J.E.Tis, R.H.Meffert, N.Inoue, K.A.McHale, E.Y.S.Chao: The effect of low intensity pulsed ultrasound on regenerate bone in a less-than-rigid biomechanical environment. Biomed Mater Eng 12(3):239-47, 2002. 90) S.A.Lietman, S.Miyamoto, P.R.Brown, N.Inoue, A.H.Reddi. Temporal sequence of spontaneous repair of osteochondral defects in the knee joint of rabbit is dependent on geometry of the defect. J Bone Joint Surg (Br) 84(4):600-606, 2002. 91) M.M.Mofid, N.Inoue, A.Atabey, G.Marti, E.Y.S.Chao, P.N.Manson, C.A.Vander Kolk: Callus stimulation in distraction osteogenesis. Plast Reconstr Surg 109(5):1621-1629, 2002. 92) J.E.Tis, R.H.Meffert, N.Inoue, E.F.McCarthy, M.S.Machen, K.A.McHale, E.Y.S.Chao. The effect of low intensity pulsed ultrasound applied to rabbit tibiae during the consolidation phase of distraction osteogenesis. J Orthop Res 20(4):793-800, 2002. 93) N.Inoue, I.Ohnishi, D.A.Chen, L.W.Deitz, J.D.Schwardt, E.Y.S.Chao: Effect of pulsed electromagnetic fields on osteotomy gap healing in a canine tibial model. J Orthop Res 20(5):957-966, 2002. 9 94) N.Inoue, K.Ikeda, H.T.Aro, F.J.Frassica, F.H.Sim, E.Y.S.Chao: Biologic tendon fixation to metallic implant augmented with autogenous cancellous bone graft and bone marrow in a canine model. J Orthop Res 20(5):1106-1114, 2002. 95) R.I.Gafni, E.F.McCarthy, T.Hatcher, J.L.Meyers, N.Inoue, C.Reddy, M.Weise, K.M.Barnes, V.Abad, J.Baron: Recovery from osteoporosis through skeletal growth: Early bone mass acquisition has little effect on adult bone density. FASEB Journal 16(7):736-738. 2002. 96) P.H.Virolainen, N.Inoue, M.Nagao, F.J.Frassica, E.Y.S.Chao: The effect of doxorubicin, cisplatin, and ifosfamide combination chemotherapy on bone turnover. Anticancer Res 22(5):1971-1975, 2002. 97) Y.H.Kim, N.Inoue, E.Y.S.Chao: Kinematic simulation of fracture reduction and bone deformity correction under unilateral external fixation. J Biomech 35(8):1047-1058, 2002. 98) D.M.Cullinane, S.A.Lietman, N.Inoue, L.W.Deitz, E.Y.S.Chao: The effect of recombinant human osteogenic protein-1 (bone morphogenetic protein-7) impregnation on allografts in a canine intercalary bone defect. J Orthop Res 20(6):1240-5, 2002. 99) M.Matsuura, S.Lounici, N.Inoue, E.Y.S.Chao: Can accelerated fatigue provide accurate prediction of external fixator reusability? Clin Orthop 406:275-81, 2003. 100) M.M.Mofid, N.Inoue, A.P.Tufaro, B.C.Robertson, C.A.VanderKolk, P.N.Manson: Springmediated mandibular distraction osteogenesis. J Craniofac Surg 14(5):756-62, 2003. 101) S.A.Lietman, W.Hobbs, N.Inoue, A.H.Reddi: Effects of selected growth factors on porcine meniscus in chemically defined medium. Orthopedics 26(8):799-803, 2003. 102) E.Y.Chao, N.Inoue: Biophysical stimulation of bone fracture repair, regeneration and remodelling. Eur Cell Mater 31(6):72-84; discussion 84-5, 2003. 103) J.P.Rue, N.Inoue, M.A.Mont: Current overview of neurovascular structures in hip arthroplasty: anatomy, preoperative evaluation, approaches, and operative techniques to avoid complications. Orthopedics 27(1):73-81; quiz 82-3, 2004. 104) A.Elshahat, M.A.Shermak, N.Inoue, E.Y.S.Chao, P.Manson: The use of Novabone and Norien in cranioplasty: a comparative study. J Craniofacial Surgery 15(3):483-9, 2004. 105) A.Elshahat, M.A.Shermak, N.Inoue, E.Y.S.Chao, P.Manson: Role of guided bone regeneration principle in preventing fibrous healing in distraction osteogenesis at high speed; an experimental study in rabbit mandibles. J Craniofacial Surgery 15(6):916-21, 2004. 106) E.Y.S.Chao, N.Inoue, T.K.K.Koo, Y.H.Kim: Biomechanical considerations of fracture treatment and bone quality maintenance in elderly and osteoporotic patients. Clin Orthop 425:12-25, 2004. 107) R.W.Liu, Y.H.Kim, D.C.Lee, N.Inoue, E.Y.S.Chao: Computational simulation of axial dynamization on long bone fractures. Clin Biomech 20(1):83-90, 2005. 108) K.F.Taylar, B.Rafiee, N.Inoue, K.A.McHale, R.S.Howard, E.Y.S.Chao: Linear increase in axial stiffness of regenerate callus during limb lengthening, Clin Orthop 435:239-244, 2005. 109) P.Virolainen, N.Inoue, M.Nagao, F.J.Frassica, E.Y.S.Chao: The effect of multidrug chemotherapy on bone graft augmented prosthesis fixation. J Orthop Res 23(4):795-801, 2005. 110) K.B.Jones, N.Inoue, J.E.Tis, E.F.McCarthy, K.A.McHale, E.Y.Chao: Quantification of the microstructural anisotropy of distraction osteogenesis in the rabbit tibia. Iowa Orthop J 25:11822, 2005. 10 111) S.A.Lietman, N.Inoue, B.Rafiee, L.W. Deitz, E.Y.S.Chao: Recombinant human osteogenic protein-1 (bone morphogenetic protein-7) impregnation in the presence of a type I collagen carrier increases allograft healing in a canine intercalary bone defect. J Bone Joint Surg (Br) 87(9):1292-7, 2005. 112) C.A.Higuera, N.Inoue, J.S.Lim, R.Zhang, N.Dimaano, F.J.Frassica, E.Y.S.Chao: Tendon reattachment to a metallic implant using an allogenic bone plate augmented with rhOP-1 vs. autogenous cancellous bone and marrow in a canine model. J Orthop Res 23(5):1091-9, 2005. 113) A.Elshahat, N.Inoue, G.Marti, I.Safe, P.Manson, C.Vaderkolk: Guided bone regeneration at the donor site of iliac bone grafts for future use as autogenous grafts. Plast Reconstr Surg 116(4):1068-75; discussion 1076, 2005. 114) K.F.Taylor, N.Inoue, B.Rafiee, J.E.Tis, K.A.McHale, E.Y.S.Chao: The effect of pulsed electromagnetic fields on maturation of regenerate bone in a rabbit limb lengthening model. J Orthop Res 24(1): 2-10, 2006. 115) K.Miyamoto, K.Masuda, N.Inoue, M.Okuma, C.Muehleman, H.S.An: Anti-adhesion properties of a thrombin-based hemostatic gelatin in a canine laminectomy model. Spine 31(4):E91-7, 2006. 116) D.R.Sumner, T.M.Turner, R.M.Urban, N.Inoue: Additive enhancement of implant fixation following combined treatment with rhTGF-β2 and rhBMP-2 in a canine model. J Bone Joint Surg (Am) 88(4):806-817, 2006. 117) R.Ochia, N.Inoue, S.Renner, E.Lorenz, T.Lim, G.Andersson, H. An: Three-dimensional in vivo measurement of lumbar segmental motion. Spine 31(17):2073-2078, 2006. 118) H.S.An, K.Masuda, N.Inoue: Intervertebral disc degeneration: biological and biomechanical factors. J Orthop Sci 11:541-552, 2006. 119) K.Miyamoto, K.Masuda, J.G.Kim, N.Inoue, K.Akeda, G.B.Andersson, H.S.An: Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs. Spine J 6(6):692-703, 2006. 120) R.S.Ochia, N.Inoue, R.Takatori, G.B.Andersson, H.S.An: In vivo 3D segmental motion measurement in the lumbar spine during axial rotation in asymptomatic and chronic low back pain subjects. Spine 32(13):1394-9, 2007. 121) J.Fukuroku, N.Inoue, B.Rafiee, F.H.Sim, F.J.Frassica, E.Y.S.Chao: Effect of cortical allograft with recombinant human osteogenic protein-1 on extracortical bone-bridging fixation of porous-coated segmental prosthesis. J Bone Joint Surg (Am) 89(7):1486-96, 2007. 122) R.M.Urban, T.M.Turner, D.J.Hall, N.Inoue, S.Gitelis: Increased bone formation using calcium sulfate-calcium phosphate composite graft. Clin Orthop 459:110-7, 2007. 123) K.F.Taylor, N.Inoue, B.Rafiee, J.E.Tis: Low intensity pulsed ultrasound does not enhance distraction callous in a rabbit model. Clin Orthop 459: 237-45, 2007. 124) A.Schiff, J.Li, N.Inoue, K.Masuda, R.Lidtke, C.Muehleman Trabecular angle of the human talus is associated with the level of cartilage degeneration. J Musculoskelet Neuronal Interact 7(3):224-30, 2007. 125) R.Takatori, D.Tokunaga, N.Inoue, H.Hase, T.Harada, H.Suzuki, H.Ito, T.Nishimura, H.S.An, T.Kubo: In vivo segmental motion of the cervical spine in rheumatoid arthritis patients with atlantoaxial subluxation, Clin Exp Rheumatol 26(3):442-8, 2008. 11 126) N.Inoue, A.A.Espinoza Orias: Bone as a composite material. Polyfile 45(11):30-2, 2008. (Japanese) 127) K.Imai, D.Tokunaga, R.Takatori, K.Ikoma, M.Maki, H.Ohkawa, A.Ogura, Y.Tsuji, N.Inoue, T.Kubo:In vivo three-dimensional analysis of hindfoot kinematics. Foot & Ankle International 30(11), 1094-100, 2009. 128) K.Sugisaki, H.S.An, A.A.Espinoza Orias, R.Rhim, G.B.J.Andersson, N.Inoue: In-vivo threedimensional morphometric analysis of the lumbar pedicle isthmus. Spine 15:34(24):2599-604, 2009. 129) Y.Otsuka, H.S.An, R.S.Ochia, G.B.J.Andersson, A.A.Espinoza Orias, N.Inoue: In vivo measurement of lumbar facet joint area in asymptomatic and chronic low back pain subjects. Spine 15:35(8):924-8, 2010. 130) M.Nakajima, M.Inoue, T.Hojo, N.Inoue, K.Tanaka, R.Takatori, M.Itoi: Effect of electroacupuncture on the healing process of tibia fracture in a rat model: a randomized controlled trial. Acupunct Med 28(3):140-3, 2010. 131) A.Hioki, K.Miyamoto, K.Shimizu, N.Inoue: Test-retest repeatability of lumbar sagittal alignment and disc height measurements with or without axial loading: a computed tomography study. J Spinal Disord Tech (in press) 132) R.Takatori, D.Tokunaga, H.Hase, Y.Mikami, T.Ikeda, T.Harada, K.Imai, H.Ito, T.Nishimura, H.S.An, N.Inoue, T.Kubo: Three-dimensional morphology and kinematics of the craniovertebral junction in rheumatoid arthritis. Spine (in press). 133) L.E.Ritacco, A.A. Espinoza Orías, L.Aponte-Tinao, D.L.Muscolo, F.González Bernaldo de Quirós, N.Inoue: Three-dimensional morphometric analysis of the distal femur: a validity method for allograft selection using a virtual bone bank. Stud Health Technol Inform 160:1287-90, 2010. 134) J.T.Hong, T.Takigawa, R.Udayakumar, A.A.Espinoza Orías, N.Inoue, H.S.An: Biomechanical comparison of three different types of C7 Fixation techniques: lateral mass screw, transpedicular screw and intralaminar screw. Spine (in press) 135) T.Takigawa, A.A.Espinoza Orías, H.S.An, S.Gohgi, R.Udayakumar, K.Sugisaki, R.N.Natarajan, M.A.Wimmer, N.Inoue: Spinal kinematics and facet load transmission after total disc replacement. Spine, (in press) 136) C.Y.Duan, H.S.An, A.A.Espinoza Orías, G.B.J.Andersson, S.Shott. J.Z.Hu, H.B. Lu, N.Inoue: In vivo measurement of the subchondral bone thickness of lumbar facet joint using MR imaging. (Osteoarthritis and Cartilage, in review) 12