Elias J. Corey Award For Outstanding Original Contribution In Organic Synthesis By A Young Investigator | Chemical & Engineering News
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> Elias J. Corey Award For Outstanding Original Contribution In Organic Synthesis By A Young Investigator
Volume 91 Issue 8 | pp. 38-39 | Awards
Issue Date: February 25, 2013
Elias J. Corey Award For Outstanding Original
Contribution In Organic Synthesis By A Young
Investigator
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2013 ACS National Award
Winners
National Fresenius Award
Elias J. Corey Award For
Outstanding Original Contribution
In Organic Synthesis By A Young
Investigator
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Keywords: awards, ACS, organic chemistry, Martin Burke
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Martin D. Burke, 37, has “introduced and commercialized
the most powerful set of synthetic reagents for organic
synthesis disclosed in the past five years,” according to
Dale L. Boger, the Richard & Alice Cramer Professor of
Chemistry at Skaggs Institute for Chemical Biology at
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Scripps Research Institute, in La Jolla, Calif. What’s more,
Burke’s discoveries haven’t sat on a dusty shelf but have
been rapidly used by research chemists in academia as
Arthur C. Cope Scholar Awards:
Martin D. Burke
Roger Adams Award In Organic
Chemistry
well as those in industry.
Amphotericin B Mystery Solved
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Nuclear Chemistry
In the work for which he is being honored, Burke exploited
Ahmed Zewail Award In Ultrafast
Science & Technology
Nakanishi Prize
Charles Lathrop Parsons Award
the unique stability and control of N-methyliminodiacetic
acid (MIDA)-stabilized boronic acids in complex organic
syntheses. His work behind the development of the
reagents is “impeccable,” Boger says.
Prefab Synthesis Moves Ahead
Burke
Credit: Leah Delcamp
All Awards
Burke, an associate professor of chemistry at the University of Illinois, Urbana-Champaign
(UIUC), has succeeded in applying his MIDA boronate reagents to generate complex
molecules. In recent applications, Burke has succeeded in synthesizing peridinin, parinaric acid, synechoxanthin, crocacin C, the
polyene core of vacidin A, and a glucagon receptor inhibitor. In related work, Burke has determined the mechanism of action for
amphotericin B, dissecting out key structural features required for the natural compound’s antifungal behavior, ion channel
formation activity, and ergosterol-binding capability.
This selection of synthetic targets also has impressed Boger. “Their choice, based on unresolved fundamental questions at the
chemistry-biology interface, represents the best I have seen among young chemists around the world,” he states.
Burke has discovered general methods for addressing the key challenges of storing and coupling unstable boronic acids as well as
preparing structurally complex boronating building blocks in a highly stereo​controlled fashion.
Next on his agenda is to develop an automated platform for small-molecule synthesis. John A. Katzenellenbogen, a chemistry
professor at UIUC, describes it as a small-molecule synthesizer machine that could ultimately bring the power of small-molecule
synthesis to the nonchemist and thereby have a pervasive enabling impact throughout many fields of science, medicine, and
engineering.
http://cen.acs.org/articles/91/i8/Elias-J-Corey-Award-Outstanding.html
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Elias J. Corey Award For Outstanding Original Contribution In Organic Synthesis By A Young Investigator | Chemical & Engineering News
3/26/13 3:10 PM
Burke has attracted more than 30 awards and honors since leaving John Hopkins University with a B.A. in chemistry in 1998. He
earned a Ph.D. in chemistry in 2003 and an M.D. in 2005, both at Harvard University. Burke originally intended to do medical
research but switched to chemistry because he became more interested in the idea of developing therapies for treating disease. He
joined the UIUC faculty in 2005 as an assistant professor of chemistry and was promoted to his current position in 2011.
The prospect of developing—or enabling the rapid development of—small molecules for treating a host of diseases in humans is a
task that excites Burke.
He concedes that he ruminates on chemistry problems before going to sleep and often finds himself picking up his BlackBerry and
e-mailing himself ideas and solutions during the night. Sometimes it works, but the e-mails “don’t always make sense,” he says.
Problems that Burke is interested in solving involve the development of “molecular prosthetics,” in which diseases, such as cystic
fibrosis, could be treated by replacing missing proteins with small-molecule surrogates.
Burke will present the award address before the ACS Division of Organic Chemistry.
Chemical & Engineering News
ISSN 0009-2347
Copyright © 2013 American Chemical Society
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http://cen.acs.org/articles/91/i8/Elias-J-Corey-Award-Outstanding.html
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Elias J. Corey Award For Outstanding Original Contribution In Organic Synthesis By A Young Investigator | Chemical & Engineering News
http://cen.acs.org/articles/91/i8/Elias-J-Corey-Award-Outstanding.html
3/26/13 3:10 PM
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