2013 Annual Meeting Report The 61st Meeting of MACTLAC Frontiers In Chemistry Westminster College, Fulton, MO October 4-5, 2013 General Session 1, Friday Afternoon, 1:10 PM Bernhard Hansert opened the 2013 meeting by welcoming everyone to Westminster College. Bernhard then made several meeting announcements and then introduced the Plenary Session speaker. Plenary Address Combining Nanoscience and Neutrons to Treat Cancer Dr. Mark Lee, Jr., Assistant Professor of Radiology and Chemistry, University of Missouri-Columbia Dr. Lee begin his presentation by summarizing the current state of cancer treatment: how surgery, chemotherapy, immunotherapy, and radiation therapy are used in various combinations. Dr. Lee then summarized common radiation therapies: photon beam, boron neutron capture, beta/gamma, and fast neutrons or protons. Dr. Lee's work focuses on boron neutron capture therapy (BNCT), which is a newer form of radiation therapy. This therapy creates the radiation inside the tumor, which means that the exposure of healthy tissue is minimized. Also, the entire dose of radiation can be delivered in one thirty minute session as opposed a six or eight week regimen. BNCT was proposed in 1936 by G.L. Locher, just four years after Chadwick proved the existence of neutrons. BNCT works by delivering boron directly to the tumor, which is then irradiated with neutrons. When the neutrons are captured by the boron atoms, radiation is released, which kills the cancer cells. The radiation released only lasts for a very short period of time, so it never leaves the cancer cell to expose healthy cells. The boron and the neutrons are not toxic to healthy cells by themselves, but together, they release lots of kinetic energy and gamma radiation: 10 B + 1n -----> 7Li+ + α + γ + 2.4MeV The damage to the cancer cells comes mostly from the 2.4MeV of kinetic energy, which dissipates in less than 10 micrometers (less than the size of most human cells). To kill cancer cells, about 10 boron atoms need to be delivered to each cell. The neutrons will come from a heavy water reactor. These are the main issues with developing this therapy. Today, BNCT is mostly used in Europe and Japan. Support for most BNCT research has stopped in the US due to lack of progress in the boron and neutron delivery systems and a badly designed clinical trial in which many of the patients died of the therapy (the trial was conducted in the 1950's). Dr. Lee's research is focused on finding better boron agents for the delivery of the element to tumors. His early research showed that current cell-selective molecular delivery systems can't get enough boron to the tumor cells (which is what has led, in part, to the cessation of BNCT funding in the US) because the amount of boron required (>>30 ppm) quickly saturates cell receptors. So, in 2007, Dr. Lee began to look at other ways to get boron into cancer cells at the required level, which has lead to using nano-scale delivery agents. Using nano-scale particles to deliver boron shows promise as each nano-scale particle can hold up to millions of boron atoms. If the targeting system can be attached to the nano-particle, then the receptors used by the targeting system will not become saturated. His nano-particles range in size from 100 to 200 nanometers, and are generated using a 1920 method for making synthetic rubber. His initial data shows that his smallest particles will contain 40% boron by weight, which is the range needed to get enough boron into the tumor cells for BNCT to work. This initial data is for nontargeted tumor cells in the presence of healthy cells, which shows that the nano-particles will get into tumor cells without affecting healthy tissue. Once the target vectors are attached to the nanoparticles, very specific and targeted amounts for boron can be delivered. Targeting will also allow for custom therapies for individual patients. Dr. Lee closed his presentation by describing how BNCT can be used to treat other diseases such as collagen-induced arthritis (synovial arthritis). This type of arthritis behaves like cancer as far as BNCT treatment is concerned. General Session 2, Friday Evening, 7:30 PM Plenary Address Sherlock Homes as Scientist Dr. James O'Brien, Distinguished Professor of Chemistry Emeritus, Missouri State University Dr. O'Brien began his presentation describing his interest in Sherlock Holmes, which began as a young boy when he read his first Sherlock Homes story. He started giving talks about Sherlock Homes as a way to recruit chemistry majors. Since then, he has giving his Sherlock Homes talks at ACS meetings and other places. To date, he has given about 130 such talks, and plans to give another set of talks later this year. In January 2013, Dr. O'Brien published his book The Scientific Sherlock Holmes: Cracking the Case with Science & Forensics by Oxford University Press, which describes his assessment of Sherlock Homes' knowledge of science and math. He received an Edgar Award for his work in the later part of 2013. Dr. O'Brien then used story excerpts to illustrate the understanding that Sherlock Homes had in various fields of science. Sherlock Homes had a very good working knowledge of math. Sherlock Homes had an excellent understanding of astronomy in later stories. Sherlock Homes had an excellent knowledge of physics. Sherlock Homes had a practical, but limited, knowledge of biology. Sherlock Homes had only a mediocre understanding of geology. Sherlock Homes had only a poor understanding of meteorology. Sherlock Homes had an eccentric knowledge of chemistry. Sherlock Homes had an outstanding understanding of forensic science. Dr. O'Brien closed his talk by describing some of the forensic science techniques used by Sherlock Homes, most of which were ahead of their real world adoption by Scotland Yard and other police agencies. General Session 3, Saturday Morning, 9:45 AM Plenary Address When Electrons Aren't Enough: Applications of Radiochemistry Dr. David Robertson, Professor of Chemistry, University of Missouri-Columbia Dr. Robertson began his presentation by defining the term nuclear chemistry, which is using chemistry to understand the nature and structure of the nucleus. Radiochemistry, in contrast, is using the properties of the nucleus to study chemical reactions and substances. Dr. Robertson then briefly described the University of Missouri Research Reactor (MURR) at UMColumbia. Their reactor runs 6.5 days a week, 24 hours a day, 52 weeks of the year, and has a power of 10 MW. The center supplies radioisotopes for various FDA health studies and hospitals throughout the country. Dr. Robertson next turned his presentation to Neutron Activation Analysis, which uses neutrons as an excitation source that is matrix independent, nondestructive, and free of reagent and other laboratory contamination. This technology is a fluorescence technique that Dr. Robertson uses to study the structure of gold nano-particles. An example is the bio-distribution of gold nano-particles by the following reaction: 197 Au + 1n ----> 198Au (t1/2 = 2.70 days) -----> 412 keV γ. Their research shows that the bio-distribution of gold nano-particles in rats with ovarian cancer is influenced not only by the size of the nano-particle, but also by their surface charge. The nanoparticles could also be targeted to ovarian cancer tumors using receptors attached the the particles that are specific for the cancer cells. Dr. Robertson then described Targeted Alpha Radiotherapy, which uses alpha emitters to target cancer tumors. The benefits are that alpha emitters release high energy particles that cause lots of cell damage, but that don't travel very far (2 to 3 cell widths), and that alpha emitters aren't affected by the internal environment of the cell. Dr. Robertson's research here focuses on Ac-225, which releases 4 alpha particles from itself and its decay daughters. The challenge with Ac-225 is that its decay daughters tend not to stay within the tumor, so local healthy tissues are affected. Dr. Robertson's solution to this problem was to use a Ac-225, LaGdPO 4, and gold coated nano-particle (the core of the particle is composed of La0.5Gd0.5Ac-225PO4), which keeps the decay daughters within the tumor cells. The decay daughters stay put because the nano-particle buffers their movement so that they stay in one place. To get the nano-particles into the tumor, Dr. Robertson attached a receptor to the particles which was specific for the tumor cells, and showed that they were indeed delivered to the cancer cells. Time course experiments showed that over 90% of the Ac-225 and its decay daughters were retained at the targeted tumors. Mice experiments show that the coated nanoparticles do indeed have a therapeutic affect on tumors compared to controls. Dr. Robertson next described Micro Electro Mechanical Systems, which can be used to power microsensors and micro-machines. Dr. Robertson is currently researching how nuclear based batteries can be used to power such devices. Nuclear batteries have plenty of energy to power micro-devices: 6 orders of magnitude more power compared to common battery chemistries. The trick is to capture the nuclear decay energy and convert it into electricity and or mechanical energy. Dr. Robertson focuses this conversion research on decay voltaics, which have been used in pacemaker devices since the 1960's. The problem has always been finding a radioisotope that produced a non-lethal decay with enough energy to get the right amount of conversion over a long period time. What his research lead to was the realization that beta decay voltaics probably would not work (too much radioisotope is required to get the right conversion energy), so he began to look at alpha decay voltaics. By using a liquid semiconductor, he could eliminate all these problems. He is now working on refining this liquid semiconductor system using Po-210 as the alpha source. Dr. Robertson closed his presentation by thanking all of his collaborators and financial supporters. He then thanked MACTLAC for the invitation to present at this year's meeting. MACTLAC Business Meeting 1. President-Elect Jaime Mueller called the meeting to order at 8:52 AM. (President Christine DeVries was unable to attend this year's Annual Meeting. As per the Association's Constitution, when the President is unable to preside, the President-Elect does so.) Jaime thanked Bernie Hansert, the rest of the Chemistry Department, the vendors, and the College for hosting this year's meeting. 2. Mark Sinton presented the Treasurer’s report. The Association’s finances have continued to rebound, this time due to an influx of dues. Mark pointed out that the increase in dues received during the year were directly related to the issuance of paper dues statements by the Albion meeting organizers. Mark suggested that regardless of where the Annual meeting is held, paper dues statements should be considered a required activity for the host institution, as was again done this year at Westminster. A motion to accept the Treasurer’s report was made and seconded. The motion passed. Year 2009 2010 2011 2012 2013 $4,453.08 $5,041.70 $5,631.52 $7,373.13 $8,100.58 $0.00 $0.00 $0.00 $0.00 $0.00 $4,453.08 $5,041.70 $5,631.52 $7,373.13 $8,100.58 Dues $673.00 $445.00 $420.00 $1,320.00 $120.00 Annual Meeting $464.27 $4,155.00 $4,280.11 $2,295.00 $10.81 $12.49 $14.34 $11.26 $0.00 $101.00 $598.52 $60.00 $1,148.08 $4,713.49 $5,312.97 $3,686.26 Beginning Assets Checking Savings Total Beginning Assets Income Interest Other Total Income $8.01 $128.01 Year 2009 2010 2011 2012 2013 Expenses Postage, copying, website $163.10 $363.98 $246.06 $147.16 Annual Meeting $376.96 $3,759.69 $3,325.30 $2,811.65 $19.40 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $0.00 $559.46 $4,123.67 $3,571.36 $2,958.81 $111.02 $5,041.70 $5,631.52 $7,373.13 $8,100.58 $8,117.57 $588.62 $589.82 $1,741.61 $727.45 $16.99 Placement, Archives Other Total Expenses Ending Assets Asset Change 3 $111.02 Mark Sinton next presented the Secretary's report. Mark noted the same general trends that have been pointed out in pervious Secretary's reports: 16% of the membership has Emeritus and/or Honorary status, and thus do not pay dues, and that 61% of the Association’s membership is now in one or more years in arrears for dues. Mark noted that should the membership stand at the end of the year as reported in the Secretary's report, 49 members will be removed from the membership database. Several members asked about how the membership database is maintained, wondering if an on-line electronic form of it could be accessed by members via the Internet. A brief discussion ensured, but no consensus was achieved. A motion to accept the Secretary's report was made and seconded. The motion passed. Year 2011 2012 2013 Beginning Membership 384 297 287 New Members 3 25 35 Members Removed 90 35 29 Ending Membership 297 287 293 Emeritus and Honorary members 43 47 47 Paid up members 86 65 67 In arrears members 168 175 179 297 287 293 Member Dues Breakdown Total Dues Paying Units Year 2011 2012 2013 Member Dues by Year Paid up 86 65 67 One year behind 57 74 83 Two years behind 64 43 47 Three years behind 47 58 49 4. John Zimmerman presented the Archivist’s report. John announced that he will be stepping down from the Archivist position once he has finished bringing the archives up to date through this year's meeting. A motion to accept the Archivist’s report was made and seconded. The motion passed. 1. A multi-image poster and a computer driven slide-show created from my photos taken at the Beloit meeting were on display at the Albion meeting. The display also included a few historical items. Several hundred images were taken to document the Albion event. 2. The sorting of items to be archival copied is complete. Archival copying should be 99% complete by the 2013 meeting time. There is one glitch. On return from a vacation when my office was cleared for floor work, I discovered a major segment of the sorted “to be copied” material to be missing. I was able to back up most of the loss, but at this time the folders for the 1987 through 1998 meetings have vanished. 3. As I near the end of my duties as MACTLAC Archivist, we need to decide on the future of the Archives. a. Do we want to continue the Archivist position, and if so, in what form? b. What do we archive considering that the Annual Report is posted on the MACTLAC web site? c. Where will the archives be located and how will they be updated? d. Do we want to continue photo-documenting our meetings? e. My archive work has been of minimal cost to date, and will likely create no added expense. f. I suggest that I bring the archives up to date though the 2013 meeting, before they are passed on to the new Archivist should we continue to have that position. I continue to struggle with the eclectic collection of prints and slides and digitally stored images. At this point, I suggest that I do a hard sort as to lack of quality, lack of information, and lack of ID, after which I would digitize the remainder. Given how long I have been with MACTLAC (since 1963), I have a good chance of identifying those who are an important part of the MACTLAC story. I also have access to the relevant scanners. 5. Larry Ferren presented the Placement Officer’s report. Larry announced that he'd be willing to pass the position to another person if someone wanted to do placement work. A motion to accept the Placement Officer’s report was made and seconded. The motion passed. In 2013, 21 applicants used the Placement Service, and 24 positions were listed with the Placement Service. Of all the positions advertised, all 24 were MACTLAC Colleges. All the positions advertised were either located by way of advertisements placed with the Placement Service, C & E News, the Internet, or electronic notices forwarded to me by various sources. The 24 MACTLAC positions were advertised only to those candidates who had e-mail capabilities. Of the 24 MACTLAC positions listed, 6.2 % were Inorganic Chemistry, 18.8 % were Organic Chemistry, 25.0 % were Analytical Chemistry, 15.6 % were Physical Chemistry, 21.9 % were Biochemistry, and 12.5 % were other areas of chemistry (Introductory level or Open). All MACTLAC schools with positions open had their advertisements forwarded to Craig Bieler who placed them on the MACTLAC web page. Applicants to the Placement service were of several groups -- graduate students, Ph.D.'s as post doctorates, and some professors at MACTLAC schools looking for positions. This past year two new candidates came into the Placement Service, and six candidates had their names removed from the service after securing a position. Presently (September, 2013), 21 candidates are in the Placement Service looking for employment. This past year no schools requested resumes or specific information related to qualified candidates from the Placement Service. Electronic mail was sent to the e-mail candidates as positions were sent to me. The MACTLAC schools are very good at sending me notices of open positions. I appreciate the notices and try to respond promptly when a notice comes in to get it out to everyone on the electronic list and to get it to Craig for posting on the web page. The Placement service has a bulletin board at this meeting to advertise positions currently available. I remain willing to do the Placement service work; however, I feel that there are many better qualified individuals in MACTLAC who should have their chance. I am willing to step aside as soon as anyone would volunteer to take on this position and run with it to implement a new plan of attack to make this office work better for the organization. Perhaps we should check to see if any interest in the job exists among the membership. 6. Larry Ferren announced that 15 copies of the book Publish and Flourish by Stephen Taylor at Hope College were available for free for junior faculty members. 7. Jaime Mueller announced that William Bordeaux (Hunting University), Fred Hadley (Rockford College), Kenneth Kraus (Loras College), and Brock Spencer (Beloit College) have been awarded Emeritus membership status. She directed Mark Sinton to send each a certificate designating their new membership status. 8. Jaime Mueller then introduced the new State Representatives elected at the end of Friday’s Plenary Session. Dr. Joshua Stratton, from St. Ambrose University is the new Iowa representative; Dr. Christopher Halsey from Westminster College is the new Missouri representative; and Dr. Kim Ha from St. Catherine University is the new Minnesota representative. 9. Jaime Mueller next opened the floor for nominations for President-Elect. James Wollack from St. Catherine University was nominated. James was elected by acclamation. 10. A motion to have the Secretary-Treasurer send letters of thanks to the following individuals was made. The motion was seconded and passed. Outgoing officers: Christine DeVries (Past-President) Outgoing state representatives: Adam Hoffman (Iowa Representative) Bernhard Hansert (Missouri Representative) Jaime Mueller (Minnesota Representative) Host institution: Westminster College Host organizer: Bernhard Hansert 12. Heather Mernitz invited the Association to Alverno College for the 2014 meeting. The meeting will be held on October 24 and 25. Theme of the meeting will be Chemistry in Our Community. 13. Jaime Mueller reviewed for the membership our future meetings sites. She asked those in attendance from Missouri, Iowa, and Minnesota to consider hosting the 2016 meeting since we do not as yet have a meeting site for that year. 2014: 2015: 2016: 2017: Alverno (Central) Millikin University (East) ? (West) Monmouth College (Central) 14. Jamie Mueller asked if there was any other business. As there was none, Jamie asked for a motion to adjourn, which was made and seconded. The motion passed. The meeting adjourned at 9:23 AM. Respectfully submitted, Mark Sinton MACTLAC Secretary-Treasurer Discussion Groups Biochemistry Friday, October 5th, 2013 3:00-4:00 PM There was the introduction of members including college taught at and courses taught. We spent some time talking about the types of biochemistry courses that each of us teach. Most teach a one semester course in the Spring. What are we going to do about the new MCAT? When is it best to offer the biochemistry course for the premed students? If you Google "MCAT 2015" you can see what will be covered in the biochemistry section of the new MCAT exam. The group also asked if anything needed to be done differently in the lab for the new MCAT exam. One member of the discussion group who had looked over the MCAT sample questions, remarked that it was interesting how Biochemistry had been worked into the problems of the new exam. The group discussed prerequisites for biochemistry courses. Most schools required both Organic I and Organic II as prerequisites. The question was whether Biology I should also be required. It was felt that it would be helpful but that it would be too prohibitive time-wise for students to require it. One school required only Organic I as a prerequisite. One school also had several quizzes that they must pass to go ahead in the course within the first two weeks. There was a discussion of what was generally covered in a one-semester biochemistry course. Most one-semester courses covered biomolecules, enzymes, and intermediary metabolism. Lab content was discussed. Labs seemed to include enzyme kinetics, amino acid titrations, buffer preparations, Beer's Law experiments, gel filtration experiments, and protein preparation experiments. Christopher from Westminster described their lab program in which each student tries to purify a unique enzyme and assay it in a guided project format. The question was asked if anyone has a good carbohydrate lab. It was mentioned that Vernier has a new probe for CO 2 that can be used to measure fermentation of sugars. When the lipid labs were discussed, there was some talk about extracting lipids from nuts working successfully. Janice from Carthage has designed a lab program with her students centered around her RNA research. The question was asked if anyone has tried "Flipping the Classroom"? Heather from Alverno reported that they try to do this. They use a lot of molecular modeling (borrow models from MSOE) in class to try to achieve this. Their students are also engaged in a project to generate a Joule tutorial to tell a story on a protein topic rather than lecturing on protein structure. It was mentioned that "Flipping the Classroom" is not the answer but that it is just another way of teaching. Someone mentioned that to do it, one needs to have a pre-quiz to get an idea of what the students know, and then you go from there. It does not necessarily allow you to get through more content, but is good for helping elucidate misconceptions held by the students. It also puts much of the onus of learning on the students. Success with this model largely comes down to execution. The group discussed incorporating primary literature into the course. Most faculty use primary literature in some format. Heather from Alverno uses the CREATE method of walking students through the article (Student create a concept map of the intro; cartoon key experimental methods; annotate key specific figures; write their own discussion and compare it to the paper's; and propose the next experiment.) The group agreed that it is nice to have a list of articles that work well in class. Kim from St. Catherine's uses the 1961 PNAS Anfinsen paper with success. The group discussed textbooks (most use Voet, Voet, and Pratt) and the balance between using a one-semester text vs. a more complete one. We also discussed the rising costs of textbooks--most faculty let students use older or international versions of the text. It was noted that McKee has free online student resources (like tutorials) that anyone can use. Most agreed that the end-of-thechapter questions in the textbooks don't mirror our own questions well. The overall grade breakdown of courses was discussed--the majority of schools weighed exams ~50% and labs ~25-30%, with the remainder for writing, homework, and in-class activities. General Chemistry Friday, October 4th, 2013 3:00-4:00 PM The file containing the report for this discussion session was corrupted and unrecoverable. Thus, there is no report for this session. No reports were submitted for the following sessions: Analytical Chemistry Environmental Chemistry Inorganic Chemistry Organic Chemistry Physical Chemistry Ask Dr. Safety Meet the Speaker Liberal Arts Chemistry: Using “Chemistry in Context” Finding a Job at a Primarily Undergraduate Institution Flipping the Classroom Undergraduate Research Vendors and Sponsors The organizers of this year’s meeting wish to express their thanks to the following vendors and sponsors: MicroLab Midwest Chemical Safety picoSpin ThermoFisher Scientific MACTLAC Officers and Representatives for 2014 Past President: President: President Elect: Secretary/Treasurer: Placement Officer: Archivist: State Representatives: Illinois: Indiana: Iowa: Michigan: Minnesota: Missouri: Wisconsin: Christine DeVries Jamie Mueller James Wollack Mark Sinton Larry Ferren John Zimmerman Wartburg College St. Mary’s University of Minn. St. Catherine University University of Dubuque Olivet Nazarene University Wabash College Paris Barnes Todsapon Thananatthananchon Joshua Stratton Michael Seymour Kim Ha Christopher Halsey Janice Pellino Millikin University University of Evansville St. Ambrose University Hope College St. Catherine University Westminster College Carthage College MACTLAC Weather Report It has become somewhat of a tradition to mention something about the weather surrounding the MACTLAC meeting. Friday’s Weather Friday saw a sunny day with light wind and only a trace of precipitation in Fulton, Missouri. The temperature ranged from a low of 68 oF (20 oC) to a high of 87 oF (30 oC). The day had a light wind (12 mph or 19 kph) out of the south southeast. The barometric pressure held steady all day at 29.89 inHg (759.2 mmHg). Saturday’s Weather Saturday saw an overcast day with light wind and rain. The temperature ranged from a low of 45 oF (7.2 oC) to a high of 74 oF (23 oC). The wind came out of the west southwest at 9 mph (14 kph). The barometric pressure again remained stead all day at 29.93 inHg (760.2 mmHg). The day saw 0.52 inches (1.3 cm) of rain. MACTLAC News Placement MACTLAC's Placement Officer maintains two lists: 1) a list of faculty positions available within the MACTLAC member colleges, and 2) a list of candidates seeking positions with member colleges. Our goal is to ensure that candidates are in contact with the colleges having positions available. If you are currently recruiting new faculty, are looking for a teaching position at a Liberal Arts college, or have any other questions, please contact the Placement Officer. A copy of the list of available positions can also be found at www.mactlac.org. Website The address for the Association’s website is www.mactlac.org. Feel free to visit this site to get information on our organization and the services that it offers. Be sure to check out the links page as there are some things on that page that may be of interest to you. Honorary and Emeritus Membership Honorary membership is granted only by a unanimous vote of the Executive Council, and shall be reserved for those persons who have rendered extraordinary service to the Association or who have made noteworthy contributions to the improvement of chemistry teaching in member colleges. To be considered for honorary status, the candidate must be nominated by a colleague in a letter submitted to the Secretary-Treasurer at least one month prior to the Annual Meeting at which the letter is to be considered by the Executive Council. A second letter of support from another colleague should also be submitted at least two weeks before the Annual Meeting to the Secretary-Treasurer. These letters should attest to the criteria needed for honorary membership status. An Honorary member will be excused from further payment of dues and will be listed as an Honorary member. Emeritus membership is reserved for any person who has been an active member of MACTLAC for 10 years and who has retired from teaching. An Emeritus member will be excused from further payment of dues and will be listed as an Emeritus member. Anyone seeking emeritus membership should request it, preferably by sending a letter to the Secretary-Treasurer of MACTLAC. 2014 Meeting Our 2014 meeting will be held at Alverno College in Milwaukee, Wisconsin, on October 24 th and 25th. The meeting theme will be Chemistry in Our Community. The featured speakers will be Dr. Stacey Bretz from the Department of Chemistry and Biochemistry, Miami University, and Dr. Tim Grundl from the School of Freshwater Science and the Department of Geosciences, UW-Milwaukee. Dr. Bretz will present Measuring Student Understanding of Multiple Representations, while Dr. Grundl will present The Use of Chemical Signatures to Deduce the Health, Provenance and History of Groundwater in Eastern Wisconsin. We hope to see as many of you as possible in Milwaukee next fall for another excellent meeting!