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Rabbit polyclonal to FAM134C. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases
encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.
Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair
versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.
Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset
breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also
linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell
growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. The
FAM134C gene product has been provisionally designated FAM134C pending further characterization.
Category
Primary antibodies
Product name
FAM134C antibody
Catalog Number
orb2448
Host
Rabbit
Clonality
Polyclonal
Tested applications
WB, IHC-P, P-ELISA
Dilution range
WB:1:100-500, IHC-P:1:50-250 (based on 0.5 mg/ml)
Concentration
- 100 μg (in 200 μl): 0.5 mg/ml
- 200 μg (in 400 μl): 0.5 mg/ml
Reacts with
Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Pig
Conjugation
Unconjugated
Immunogen
Synthetic peptide (please contact us for details)
Purity
Protein A purified
Isotype
IgG
Form
Liquid: 10 mM PBS, pH 7.4 with 10 mg/ml BSA and 0.1% sodium azide
Storage
Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
Note
For research use only.
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