LMP
lmp news
INVESTIGATING DISEASE.
IMPACTING HEALTH.
VOL. 15 NO. 1 – 2013
Comments from the Chair
The continuing journey from
excellence to impact
LMP will be undergoing an academic five-year
cyclical review on September 16 and 17, 2013. A
team of external reviewers will be evaluating the
activity and performance of LMP, culminating in the
production of a report that contains recommendations
for future directions. In preparation for this major
event, LMP is undergoing an extensive self-study
done in broad consultation with our key stakeholders.
Among many notable successes, this self-study has clearly identified our
department’s sustained record of obtaining highly competitive awards in
research, education, service, social responsibility and professionalism. These
awards provide important validation that our diverse and talented faculty,
students, trainees and staff uphold LMP’s standard of excellence. We are
recognized for exhibiting the knowledge, skills, attitudes and behaviours of
engaged citizens living in a progressive society: an important feature of a
major national and international academic department is excellence in each
of these areas.
As the 2012-2013 academic year comes to a close, let us reflect on our
successes in a multitude of educational programs:
•
he second year course, Mechanisms, Manifestations, and
T
Management of Disease (affectionately known as “Triple M-D”), was
taught at the Mississauga Academy of Medicine for the first time this
year. Newly recruited local, community-based faculty participating
in problem-based learning marks a new era for LMP in integrated
medical education. Increased involvement of part-time faculty at
community-affiliated sites across the GTA presents exciting new
opportunities in LMP’s education mandate.
(Cont’d on next page)
INSIDE THIS ISSUE
3 | Feature Story
IT’S IN THE BLOOD
Professor Tsao inspires the next generation
of clinician-scientists.
4 | Inspirational Alumni
5 |Research
6 |Education
FOCUSED ON THE FUTURE
LMP students host the first
Undergraduate Conference on Cancer.
9
10
11
14
16
19
25
| Student Life
| Awards & Honours
|Appointments
|Announcements
| Funding & Events
|Publications
| Off the Clock at LMP
www.lmp.utoronto.ca
COMMENTS FROM THE CHAIR
LMP News
Vol. 15 No. 1 ­– 2013
•
he Royal College of Physicians and Surgeons of Canada carried out its
T
accreditation review of U of T residency programs, a process that occurs
every six years. LMP’s programs fared very well, thus setting the stage for a
leading role in shaping the future of the profession.
•
MP Graduate Studies carefully balances the demands of carrying out and
L
publishing high-calibre research, with particular attention paid to achieving
acceptable times to degree completion. Curricular revision is an important
ongoing endeavour to ensure our graduates are well prepared to pursue
diverse options for further career growth and development.
•
he outcomes of the undergraduate Pathobiology Specialist Program in
T
the Faculty of Arts and Science continue to speak for themselves. This
unique program attracts and develops exceptional students who go on to
pursue further studies in medicine and research.
•
he post-PhD training programs in Clinical Chemistry and Clinical
T
Microbiology are thriving, with ever-increasing numbers of strong
applicants and a solid job market.
•
linical and research fellowships are becoming increasingly robust. With
C
the advent of “AFCs” (Areas of Focused Competence), instituted by the
Royal College, LMP is working proactively in several areas and is “raising
the bar” for standards in fellowship training.
LMP News is a communication of the
Department of Laboratory Medicine and
Pathobiology, Faculty of Medicine,
University of Toronto.
Please send your submissions to:
Katie Babcock
Web and Communications Coordinator
1 King’s College Circle, Rm 6221
Toronto, ON M5S 1A8
Tel:416-946-7707
Email:katie.babcock@utoronto.ca
The road to high impact begins with a foundation of excellence. Through
our departmental lens (“Investigating Disease. Impacting Health.”), LMP is well
positioned to make contributions of a practical and wide-ranging impact. I ask that
you take time to reflect on what “Investigating Disease. Impacting Health.” means to
you in your own departmental context, and I invite you to share your thoughts for
us to increase our collective understanding of what we do, and why we do it.
In closing, I hope you enjoy the new format of “LMP News.” Feel free to
contact the LMP Web and Communications Coordinator, Ms. Katie Babcock (katie.
babcock@utoronto.ca) with your input.
Finally, I hope to see you at the Annual Banquet on June 6th. It promises to be a
fun and memorable evening!
Richard G. Hegele, MD, FRCPC, PhD
Professor and Chair
FEATURE
Professor Ming-Sound Tsao.
IT’S IN THE BLOOD
Professor Tsao inspires the next generation of clinician-scientists
BY KATIE BABCOCK
“Innovative research today demands
the intercommunication of a widespectrum of expertise, with the end goal
of translational science depending on
the contributions of scientists at every
imaginable level,” explains Desmond
She, fourth-year LMP undergraduate
Pathobiology Specialist student.
Inspired by his supervisor, LMP
Professor Ming-Sound Tsao (MD,
FRCPC), She clearly understands the
complexity of translating basic science
into a clinical setting. The passion and
dedication of pathologist and scientist
Prof. Tsao drive him to develop a
personalized approach for the diagnosis of
two of the most deadly cancers: lung and
pancreatic cancer.
“My passion for research is in the
blood. Research is often unpredictable so
you have to be persistent, imaginative and
innovative, and that takes a lot of time. It’s
commitment,” Prof. Tsao explains.
Prof. Tsao is researching genetic
aberrations in lung and pancreatic cancer
to discover what kinds of mutations cause
cancer cells to multiply and survive. Once
these mutations are defined, they may
serve as biomarkers allowing clinicians
to identify them for earlier and more
accurate diagnosis and thus providing
more selective treatment for patients.
Prof. Tsao states, “With molecular
testing, you can select patients for more
effective treatments. It’s equally important
not to give ineffective therapy to patients
who would not benefit.”
The statistics are sobering. If you
are diagnosed with lung cancer, your
expected survival rate in five years is 15
per cent and with pancreatic cancer, it is
less than five per cent.
Selective and more specific
treatments based on their biomarkers may
improve the survival rates and quality of
life of the patients.
As a clinician-scientist, Prof. Tsao
offers a unique perspective on translating
his basic research into clinical practice.
“Molecular biomarkers of treatment
were not a traditional part of pathology
but now they’re necessary for diagnosis.
I think it’s important that pathologists
are involved in the treatment decision of
patients so that patients can be offered
more specific and effective therapies. It’s
very rewarding.”
Fostering the next generation of
clinician-scientists, Prof. Tsao has been
involved in the innovative Terry Fox
Foundation Strategic Health Research
Training Program in Molecular
Oncologic Pathology at the Canadian
Institutes of Health Research. Created
approximately ten years ago, this program
was designed to train the next generation
of pathologists who are competent in
translational research methods and clinical
delivery or molecular pathology.
Emphasizing the importance of
mentoring, Prof. Tsao says, “When you
get to a certain stage of your career, you
owe the next generation and hopefully
you can pass on all you’ve learned. I’m
not necessarily referring to knowledge
because students can learn this from
textbooks. I think it’s important to teach
them how to become clinician-scientists
and how to have a successful academic
career. It’s all about inspiration.”
Over his impressive 25 year career,
Prof. Tsao has inspired many students
from undergraduates, graduates, trainees
and the next generation of clinicianscientists. With a promising future and a
passion for cancer research, She says, “Dr.
Tsao was the catalyst who evolved my
juvenile passion in cell signalling into a
portfolio of real, unanswered questions
about lung cancer – about how it begins,
how it grows, and how it changes – and
who helped me understand challenges
that I hope to overcome with my new
skills and abilities.” n
LMP News | Vol. 15 No. 1 – 2013
3
INSPIRATIONAL ALUMNI
Alumnus Runjun Kumar.
MAKING THE CONNECTION
LMP alumnus uses bioinformatics in the fight against cancer
BY KATIE BABCOCK
Every day, thousands of statisticians work to find patterns that
During his summers, Kumar broadened this understanding
could raise profits for corporations. What if the same resources
even more by conducting research at the University of Toronto,
were dedicated to finding patterns of disease? In the fight against Harvard Medical School and the European Molecular Biology
cancer, Runjun Kumar, LMP alumnus and MD/PhD candidate
Laboratories in Heildelberg, Germany.
at Washington University School of Medicine in St. Louis,
Heading into his third year of the MD/PhD program,
Missouri, is using the power of statistics to translate a massive 60
Kumar concedes that this intensive eight-year commitment isn’t
terabytes of data into meaningful information.
for everyone. “I tend to be a very process-oriented person and
“I’m aspiring to be like a corporate statistician, only
I enjoy the variety of the program. I like that every four years
I’m interested in patterns that say something about different
or so my job completely changes and I get to try something
cancers,” explains Kumar. “What mutations and genes drive
completely different. It’s not for everybody but it’s definitely
different cancers? What
for me.”
“I’M ASPIRING TO BE LIKE A CORPORATE
mutations can help with
While the program is
prognostication? What genes
intense, he still makes time
STATISTICIAN, ONLY I’M INTERESTED IN
are causing cancer and could
to enjoy St. Louis. He’s parPATTERNS THAT SAY SOMETHING ABOUT ticipated in the school musical
be immediately treatable?
And to tackle these questions, DIFFERENT CANCERS.”
three times, and recently earned
I’m trying to gain insights by
his first named role this year as
using some incredibly interesting whole genome and transcripthe “bellhop” in the musical farce Lucky Stiff. He’s also an avid
tome datasets.”
furniture builder and is looking forward to volunteer opportuni
There aren’t many people who can say they have a passion
ties and playing ultimate frisbee.
for statistics. “All of my friends will tell you that when I started
Making the most of his past and present experience, Kumar
statistics I clearly had found a topic that spoke to me,” says
concludes, “I’m a biologist first, and my pathobiology and
Kumar. “On a conceptual level, the practice of statistics is quite
medical training are well used.You can ask many questions of a
simple and elegant, and once you start to see the world through
big dataset—but you need to know the biology in order to ask
that lens a lot of things start to make more sense.”
good questions, and make sense of the answers.” n
As an alumnus of the LMP undergraduate Pathobiology
Specialist Program, and as past President of the Laboratory
Medicine and Pathobiology Student Union (LMPSU), Kumar
recognizes the importance of understanding the biology behind
the complex data. “In the Pathobiology Specialist Program,
you’re exposed to biochemistry, biology, genetics and so many
other things and you really end up gaining a uniquely broad
understanding of biology.”
4
Investigating Disease. Impacting Health.
RESEARCH
RESONATING RESEARCH
LMP hosts the first Cardiovascular Research Day
BY KATIE BABCOCK
What do University of Toronto faculty
members from the Departments of
LMP, Dentistry and Medicine, and
the Institute of Biomaterials and
Biomedical Engineering (IBBME) have
in common? Their interest in what
causes the thickening of artery walls,
known as atherosclerosis, and the way
this condition affects the function of the
cardiovascular system.
On March 25, 2013, eight of Toronto’s
top cardiovascular researchers presented
their cutting-edge research at LMP’s first
Cardiovascular Research Day. Held at the
University of Toronto’s intimate George
Ignatieff Theatre, approximately fifty
faculty members and students participated in active discussions about the most
pressing issues in the field.
Atherosclerosis was the focus of the
first part of the day and LMP Professor
Phil Marsden (MD) set the stage by
discussing how a toxin produced by
the bacteria E. coli damages blood and
artery cells. Next, LMP Prof. Heyu Ni
(MD, PhD) described his search for
new molecules that create blood clots.
LMP Prof. Clinton Robbins (BSc, PhD)
explained a new mechanism for how
inflammatory cells, called macrophages,
accumulate in diseased arteries.
Concluding this session was a
fascinating presentation on the precise
mapping of patterns of blood flow in the
carotid artery by Prof. David Steinman
(PhD) from IBBME.
Second-year MSc candidate Allan Siu
commented, “I thought the first session
was very diverse. One presentation was
on platelets, one was on macrophages and
one on hemodynamics; all of these are
major contributors to the disease.”
The second part of the day delved
into the importance of the matrix, a
complex network of extracellular proteins
that surrounds the cells providing a
structural scaffold and signaling changes
in cell behaviour in disease. Department
of Medicine Prof. Ren-Ke Li (MD,
PhD) has found that a novel miRNA is
important in stimulating the production
of enzymes which degrade the matrix
and compromise heart function. LMP
Prof. Fred Keeley (PhD) discussed the
role of elastin proteins in building arteries,
and explained how mutations in elastin
genes may lead to vascular disease. Faculty
of Dentistry Prof. Borris Hinz (PhD)
described his research on mechanisms
leading to tissue fibrosis, which refers
to the accumulation of collagen, and
contributes to heart, blood vessel and
heart valve disease. Finally, translational
research on matrix-degrading enzymes
injected to soften previously untreatable
artery blockages was presented by LMP
Prof. Bradley Strauss (MD, PhD).
“I really enjoyed learning about
the wide range of research that’s being
conducted within the department,” said
Bunty Singh, third-year PhD candidate.
He continued, “Inviting speakers from the
Faculty of Dentistry as well as IBBME
also gave us exposure to very exciting
work being done by other departments,
which we may not have a chance to see
on a daily basis.”
Asked why this type of day is
important, LMP Prof. and Research Day
organizer Michelle Bendeck said, “The
reason why I wanted to host this research
day was to provide an opportunity for
cardiovascular researchers within the city
to come together to speak about their
latest and most exciting research.” She
elaborated, “We want to foster collaborations within our department and,
at the same time, we want to reach out
to the larger cardiovascular community
and work with researchers in other
departments and Faculties who are doing
very relevant work.”
This inspiring day is only the
beginning. Prof. Bendeck explained, “I see
this as the first of many research days. Our
department has identified nine research
areas and we look forward to hosting
other days to get people interacting with
one another.” n
Organizer, Professor Michelle Bendeck, with speakers.
LMP News | Vol. 15 No. 1 – 2013
5
UNDERGRADUATE
Keynote speaker
Dr. David Malkin.
Conference co-organizer Jasmine Song.
LMPSU – undergraduate student union.
FOCUSED ON THE FUTURE
LMP students host the first Undergraduate Conference on Cancer
BY KATIE BABCOCK
6
Investigating Disease. Impacting Health.
Bean (JD, MA) and David Uehling (PhD), and a presentation led by cancer survivors from Ovarian Cancer Canada:
Survivors Teaching Students. Over lunch, students networked
with researchers, clinicians, graduate students and non-profit
organizations including the Canadian Breast Cancer Foundation,
Colorectal Cancer Association of Canada, Lymphoma Canada
and Myeloma Canada.
At the end of this successful day, final keynote speaker David
Malkin (MD, FRCPC, FAAP), Senior Staff Oncologist at the
Hospital for Sick Children, explained how clinicians can leverage
innovative research to create more personalized treatment for
patients. He discussed the explosion of new technologies that
have accelerated the translation of discoveries in the lab into
diagnostic and treatment applications in the clinic.
He also explained the importance of monitoring patients
with an increased risk of developing certain types of cancer.
“If you institute surveillance you can prevent cancers from
becoming so large and you can treat them while they’re still
small and curable.” He continued, “This cannot be done if
you’re working in the lab on your own or if you’re working in
the clinic on your own. It can only be done when you bring
teams together. Ultimately, you can end up with survival rates
that every oncologist would like to see.”
Recognizing the accomplishments of the conference
organizers, LMP Prof. Douglas Templeton (PhD, MD), stated,
“The resounding success of this one-day event, conceived of
by the students, then managed and staged with minimal input
from faculty, speaks volumes towards their potential for future
leadership roles in the medical scientific community.” n
PHOTOS: THOMAS LU
On Saturday, January 12, 2013, enthusiastic students from across
the University of Toronto gathered at the Medical Sciences
Building for the first Undergraduate Conference on Cancer.
From engaging seminars and panel discussions to non-profit
networking opportunities and exciting keynote presentations,
attendees were inspired by leading-edge cancer researchers,
clinicians and non-profit organizations.
This ambitious event was organized by fourth-year LMP
undergraduate students Jasmine Song and Desmond She,
and fellow members of the LMP Undergraduate Student
Union (LMPSU). The inspiration for the conference came
from an LMP course on neoplasia: the pathophysiological
process that results in the formation and growth of a tumour.
Song explained, “All of our life science courses touch upon
cancer, but this is the only course that offers a comprehensive
perspective on this complex disease. It was really inspiring.”
Beyond an academic interest, Song also recognized the
impact that cancer has on society. “Cancer has touched almost
everyone. One in four Canadians will have cancer in their
lifetime and, as the next generation, we really need to address
this serious disease and provide a platform for discussion.”
Opening keynote speaker Gurmit Singh (PhD), Professor
of Pathology and Molecular Medicine at McMaster University
and Senior Scientist at Hamilton Health Sciences, discussed the
mechanisms associated with cancer-induced pain and depression.
Singh also acknowledged the value of involving young people
in the fight against cancer.“We are always trying to advance
research by increments and focus on the knowledge that is
already out there. But sometimes we need to step outside and
ask what is really going on. And this is where young minds like
yourselves are much more capable of doing this.”
There were many highlights during the day, including
seminars, a panel discussion with Sylvia Asa (MD, PhD), Sally
GRADUATE
MSc candidates Samantha Wala
and Emily Mathieu.
Organizers Eric Shikitani
and Stephen McCarthy.
MSc candidate Carl Figueiredo.
BREADTH AND DEPTH
Successful 16th Annual LMP Graduate Student Research Day
PHOTOS: PAUL HAMEL
BY KATIE BABCOCK
With 190 attendees and a record 105
poster presenters, the 16th Annual LMP
Graduate Student Research Day was a
resounding success. On Tuesday, March
12, 2013, excited LMP students gathered
at the University of Toronto’s Chestnut
Residence Conference Centre to present
their work and exchange ideas. In his
opening address, Department Chair
Professor Richard Hegele emphasized
LMP’s unique breadth and depth, which
acts as a catalyst for innovation. Diversity
and innovation were clearly present
during the day with cutting-edge poster
presentations, engaging seminars and a
memorable keynote speech.
This inspiring event was organized
by LMP’s student association the
Confederation of Laboratory Medicine
and Pathobiology Students (CLAMPS).
It was spearheaded by fourth-year
PhD candidate Stephen McCarthy, the
President of CLAMPS, and third-year
PhD candidate Eric Shikitani,Vice
President Academic.
Asked why the day was so important,
McCarthy said, “Students work tirelessly
and I feel that they really put great ideas
into action. I think it’s important to
highlight their research, engage students
from all levels and provide them with a
sense of accomplishment.”
Participants presented their research
to a small group of judges—each
consisting of a faculty member,
postdoctoral fellow, and senior PhD
student—allowing for immediate
feedback and one-on-one interaction.
They attended focused seminars
divided into themes such as Cancer
and Neoplasia, Developmental and
Cell Biology, and Hematology and
Immunology. First-year graduate students
also participated in a workshop on how
to make an effective poster.
2013 Poster Presentation Winners.
See page 10 for the list of award winners.
Bunty Singh, third-year PhD candidate
explained the value of the event,
“This day offers all LMP students an
opportunity to present their work.
Personally, it gives me a chance to see
if I can network with someone or if
there’s an assay that will work for my
research.” He continued, “I’ll give you an
example. My poster is beside someone
who is doing research in the same area.
I’m excited because this gives me the
opportunity to network with her and
expand my knowledge.”
Graduate Coordinator Prof. Harry
Elsholtz described the role of the
Research Day for career development.
“Most of our students expect to develop
a career in science and it’s important
for them to learn how to communicate
effectively and to field a range of
questions. It’s important to prepare them
for future positions in research, medicine,
education and other areas.”
As a new addition to the event,
students also enjoyed a keynote presentation by Dr. Freda Miller, Senior Scientist,
Developmental and Stem Cell Biology at
the Hospital for Sick Children Institute
and Professor, Department of Molecular
Genetics, University of Toronto. Dr. Miller
spoke about stem cells and their role
in building and rebuilding the nervous
system. She discussed the identification
of drugs, in particular metformin, that
stimulate stem cells leading to improved
cognition. She also described a population
of stem cells from the skin that gives rise
to peripheral nerve cells with therapeutic
potential for spinal cord injury. Dr.
Miller provided inspiring advice to the
young scientists: “Don’t be afraid. And
I’m not just talking about in your career;
I’m talking about in your science.” She
continued, “The important thing is to
ask the question, ‘What is your science
contributing to the human race?’” n
LMP News | Vol. 15 No. 1 – 2013
7
POSTGRADUATE
PGY 2 Anatomical Pathology resident Lorna Mirham.
Keynote speaker Dr. John Eble.
IMPRESSIVE INTERACTIONS
LMP hosts successful 2013 Postgraduate Research Day
BY KATIE BABCOCK
“It is our belief, in the Department of Laboratory Medicine and
Pathobiology, that research should not be a single-day event per
year but rather an integral component of our training program,”
says Professor George Yousef (MD, MSc, PhD FRCPC), Director
of Postgraduate Research for LMP.
This year’s Research Day featured dynamic interactions
between residents, fellows and faculty judges allowing participants to exchange ideas and develop research collaborations.
It was also an opportunity for residents and fellows not only
to present their research activity, but also to learn how to
efficiently communicate their ideas and respond to criticism.
The breadth and depth of research were impressive with 30
poster and six oral presentations. Each presentation encouraged
a lively discussion.
The highlight of the event was a remarkable presentation by
keynote speaker Dr. John Eble (MD) on “The Art and Science
of Pathology Publication: Lessons Learned from Fifteen Years
in the Editorial Office.” This journey through the mind of the
editor-in-chief of Modern Pathology, one of the most prestigious
pathology journals, provided key insights into the review process
and the criteria for accepting a manuscript for publication.
“In my opinion, the single most important factor for getting
published is to inspire confidence in the reviewers and editors,”
said Dr. Eble. “Because, when you think about it, you distill all
of your detailed research into a manuscript and a lot of that
research is not directly included. Reviewers and editors have to
rely on faith. If you don’t inspire confidence then they are not
going to take things on faith.”
How do researchers inspire confidence in reviewers and
editors? Dr. Eble described several key factors such as targeting
specific journals and then following their specifications with
data presented in an understandable format. He also emphasized
the role of integrity in obtaining and publishing data, avoiding
grammatical and linguistic mistakes, accurately citing references
8
Investigating Disease. Impacting Health.
and properly organizing tables and figures.
Prof.Yousef said, “The elaborate discussion after the keynote
speaker’s presentation showed the immense enthusiasm of our
residents and fellows for research and academic activities, and is
an incentive for the department to strive to make the Research
Day better every year.”
Anatomical Pathology resident Eric Morgen found the day
very useful. “For me, the highlights of the day were getting to
present my research to colleagues and friends and hearing from
the guest speaker Dr. Eble, who gave some extremely candid and
helpful advice about the peer review and editorial process of
academic journals.”
Postgraduate research opportunities are expanding beyond
this one-day event, as LMP has established dedicated and
longitudinal research electives for residents and fellows. n
The winners of this year’s research day are:
Oral Presentation:
Nicole White
Poster Presentation:
First place – Hala Faragalla
First place – Phedias Diamandis
Second place – Brett Danielson
Third place – Tao Wang
STUDENT LIFE
RAISING MONEY,
DODGING BALLS
BY DESMOND SHE
For the second year in a row, the undergraduate Laboratory
Medicine and Pathobiology Student Union (LMPSU), led
by executive Anastasia Bosc, hosted the Annual University of
Toronto Life Sciences Charity Dodgeball Tournament on
February 14, 2013. Featuring 11 teams from across campus, both
undergraduate and graduate students competed to win the $165
prize for their team’s sponsored organization. The championed
causes ranged from well-known groups, like the Heart and
Stroke Foundation, to the more diverse, like Let’s Talk Science
and Meagan’s Walk.
Three hours into the intense competition, the HOX played
against the Ram-Rods in the tournament finals for the night. With all eyes on the HOX team, undefeated throughout the
entire evening, participants Alex Protomanni, Anthony Rizzo,
Francis Ayling, Matt Zanardo, and Michael Naccarato stayed
true to their impressive performance and arose as the grand
champions, winning the prize for Prostate Cancer Canada. The LMPSU would like to congratulate all participants for
coming to our second tournament; it is always a great pleasure to
collaborate with many other student groups across campus that
lend us their support and turn the evening into the fantastic event
that it has become. We hope to see you all again next year, and
congratulations to the HOX and to Prostate Cancer Canada! n
The Artful Dodgers (orange) battle PULSE (blue).
SMASHING SUCCESS
PHOTO: TOP, THOMAS LU
BY STEPHEN MCCARTHY
CLAMPS volleyball champs (left to right): Jason Do, Sally Hu,
Alex Falkenhagen, Olga Broshevitskaya, Raymond Wong, Stephen
McCarthy, Pedram Akbari, Sarah Higgins and Rachel Lo.
The LMP Graduate Student Union (CLAMPS) is happy to
announce that our co-ed intramural volleyball team has won the
first team event for our graduate department!
With regular practice on Tuesday and Thursday nights, it
was the dedication of the team that led to our success. Although
we began as underdogs in the fall season, by the winter we had
qualified for the semi-finals and finals. We managed to beat such
high-ranking teams as the School of Graduate Studies, which has
players from all graduate departments! Our championship match
was against the Engineering team Skule C, and we defeated them
in two of the three sets.
Our highly competitive volleyball league is composed of
undergraduate and graduate student teams at the St. George
campus. In our division, eight competitive teams represented
departments and undergraduate colleges.
This success for LMP and CLAMPS was particularly
gratifying because, last fall, we acquired a sponsorship from the
local student bar O’Grady’s on College St. They provided free
CLAMPS T-shirts for all of our sports. It was satisfying to live up
to our team slogan on our bright green shirts: CLAMPS, an “H”
away from CHAMPS.
CLAMPS is now planning to have two volleyball teams
next year. We’re also looking forward to having similar success
with softball this summer. Email Stephen McCarthy at
s.mccarthy@mail.utoronto.ca if you are interested in participating. All LMP students are invited! n
LMP News | Vol. 15 No. 1 – 2013
9
AWARDS & HONOURS
AWARDS & HONOURS
FACULTY
Blaise Clarke has won the Robert E. Scully Young Investigator Award for his paper “Prevalence of Loss of Expression of
DNA Mismatch Repair Proteins in Primary Epithelial Ovarian
Tumors.” (Int J Gynecol Pathol 2012;31;524-531). The award
was presented at the International Society of Gynecological
Pathologists (ISGyP) symposium during USCAP.
Eleftherios Diamandis has received the Faculty of Medicine’s
Senior Sustained Excellence in Graduate Teaching Award. This
award recognizes Prof. Diamandis’s exceptional contributions
to graduate teaching over the past 25 years, contributions
which include outstanding student supervision, mentoring and
curriculum development.
Avrum Gotlieb has won the highly prestigious Distinguished
Service Award from the Association of Pathology Chairs. As the
North American group’s highest honour, this award has been
presented annually since 1986 to an individual who has made
substantial contributions to academic pathology in research, in
education or in advancing the discipline of pathology in the
medical community and to the public.
Eleanor Latta has received the 2013 W. T. Aikins Award in
Course/Program Development and Coordination. The W. T.
Aikins Award is the Faculty of Medicine’s most prestigious
award for sustained commitment to and excellence in
undergraduate teaching. As LMP’s Director of Undergraduate
Medical Education, she has been a leader in developing LMP’s
Mechanisms, Manifestation and Management of Disease.
Beginning in 2004, Prof. Latta has been an integral force in
coordinating and designing courses that relate the causes and
mechanisms of disease with approaches to management.
Don Low received the 2013 John G. Fitzgerald Award from
the Canadian Association for Clinical Microbiology and
Infectious Diseases. This award recognizes Canadian microbiologists who have significantly advanced the field of medical
microbiology through their contributions to clinical, academic
and/or educational pillars.
Heyu Ni has been awarded the Graduate Student Mentorship
Award. Prof. Ni was recognized for making a major contribution to graduate student learning during his 11 years of
working at LMP. His intense interest in seeing his students
succeed and his enthusiasm for his research make him an
exceptional mentor.
Simon Raphael has been awarded the Faculty of Medicine’s
2013 Sarita Verma Award for Advocacy and Mentorship in
Postgraduate Medicine. This award celebrates Prof. Raphael’s
commitment to mentorship, social responsibility and resident
advocacy. A faculty member of LMP since 2007, and LMP
Program Director of Anatomic Pathology since 2008, Prof.
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Investigating Disease. Impacting Health.
Raphael has made a profound impact on the Anatomic
Pathology Program and its residents.
Kathryn Tinckam received the 2013 American Society of
Transplantation Clinical Science Career Development Award.
STUDENTS & TRAINEES
UNDERGRADUATE
Jasmine Song, fourth-year Pathobiology Specialist Program
student, has won the 2013 Gordon Cressy Student Leadership
Award. Presented by the University of Toronto Alumni
Association and the Division of University Advancement, this
award recognizes students who have made an outstanding
extracurricular contribution to their college, Faculty or school
or to the University as a whole.
GRADUATE
Stephen McCarthy (Prof. Don Branch) has been awarded
the University of Toronto Alumni Association’s 2013 Graduate
Scholar Award. This award is presented to three students who
demonstrate outstanding academic and extracurricular leadership.
Alzheimer Society of Canada Doctoral Award
Keran Ma (Prof. JoAnne McLaurin)
Bank of Montreal Fellowships in Medical Research
Felix Leung (Prof. Eleftherios Diamandis)
Department of Medicine Graduate Student Award
Jenny Wang (Prof. Phil Marsden)
Kristi Piia Callum Memorial Fellowship in Ovarian
Cancer Research
Felix Leung (Prof. Eleftherios Diamandis)
LMP Graduate Student Research Day
Poster Presentation Prizes
MSc
Mark Barszczyk (Prof. Cynthia Hawkins)
Grace Choong (Prof. Doug Templeton)
June Li (Prof. Heyu Ni)
Reuben Thomas (Prof. Bradley Strauss)
Lily Yip (Prof. Nades Palaniyar)
PhD
Halil Aydin (Prof. Jeffrey Lee)
Roberto Diaz (Prof. James Rutka)
Sonam Dolma (Prof. Peter Dirks)
Justin Parreno (Prof. Rita Kandel)
Punit Saraon (Prof. Eleftherios Diamandis)
Eric Shikatani (Prof. Mansoor Husain)
Lynsie Thomason (Prof. JoAnne McLaurin)
Jonathan Torchia (Prof. Annie Huang)
APPOINTMENTS
Lap-Chee Tsui Publication Award Finalist
Paul Northcott* and David Shih (Prof. Michael Taylor)
*LMP Alumnus
APPOINTMENTS
NSERC CGS Master’s
Daniel Ka-Chun Chung (Prof. Karim Mekhail)
Co-Presidents: Darren Benedict and Anastasia Bosc
Vice President of Financial Affairs: Alena Zelinka
Vice President of Academic Affairs: Ariel Gershon
Vice President of Social Affairs: Robert Jie Guo
Events Committee Member: Qingda Hu
External Communications Director: Maya Deeb
Internal Communications Director: Thomas Lu
Mildred Scheel Cancer Foundation Fellowship
Marc Remke (Prof. Michael Taylor)
Queen Elizabeth II Graduate Scholarship in Science and
Technology – Heart and Stroke Foundation of Ontario
Henry Cheng (Prof. Jason Fish)
Paul Turgeon (Prof. Phil Marsden)
University of Toronto Fellowship
• Pedram Akbari (Prof. Herman Yeger)
• Ilijana Begcevic (Prof. Eleftherios Diamandis)
• Victoria Bevilacqua (Prof. Khosrow Adeli)
• Hisham Ibrahim (Prof. Myron Cybulsky)
• Tarek Ibrahim (Prof. Joanne McLaurin)
• Mona Sobhani (Prof. Hong Chang)
• Kirk Szafranski (Prof. Karim Mekhail)
• Lampros Dimitrakapoulos (Prof. Eleftherios Diamandis)
• Sofia Farkona (Prof. Eleftherios Diamandis)
• Andrew Fleet (Prof. Paul Hamel)
• Christina Schiza (Prof. Eleftherios Diamandis)
Vision Science Research Program OSOTF
Rachel Exler (Prof. Jeremy Sivak)
Yow-Kam-Yuen Graduate Scholarship in Diabetes
Research
Jennifer Sacco (Prof. Khosrow Adeli)
POSTGRADUATE
Clarissa Cassol (MD) has received the Stowel-Orbison Award
at the 102nd United States and Canadian Academy of Pathology
Annual Meeting. Out of 422 trainees, this prestigious award was
given to four trainees who presented outstanding pathology
research.
LMP Postgraduate Research Day Presentation Prizes
Oral Presentation:
Nicole White
Poster Presentation:
First place – Hala Faragalla
First place – Phedias Diamandis
Second place – Brett Danielson
Third place – Tao Wang
LMPSU EXECUTIVE COUNCIL 2013-2014
NEW LMP STAFF APPOINTMENTS
Faisal Al-Mohammedi, Sunnybrook Health Sciences Centre
Rank: Lecturer | Effective: December 1, 2012
Michael D’Agostino, Sault Area Hospitals
Rank: Lecturer | Effective: February 1, 2013
William Dubinski, Humber River Regional Hospital
Rank: Lecturer | Effective: March 15, 2013
Sandra Farrell, Credit Valley Hospital
Rank: Assistant Professor | Effective: November 1, 2012
Nahuel Fittipaldi, Public Health Ontario Laboratories
Rank: Assistant Professor | Effective: November 1, 2012
Cynthia Forster-Gibson, Credit Valley Hospital
Rank: Assistant Professor | Effective: November 1, 2012
Elaine Goh, Credit Valley Hospital
Rank: Lecturer | Effective: December 1, 2012
Jayantha Herath, Ontario Forensic Pathology Service
Rank: Assistant Professor | Effective: January 1, 2013
Elizabeth Hyjek, University Health Network
Rank: Associate Professor | Effective: November 23, 2012
Navid Liaghati, Credit Valley Hospital
Rank: Lecturer | Effective: December 1, 2012
Rumina Musani, University Health Network
Rank: Lecturer | Effective: March 15, 2013
Maria Pasic, St. Joseph’s Health Centre Toronto
Rank: Assistant Professor | Effective: March 1, 2013
Dragana Pilavdzic, University Health Network
Rank: Assistant Professor | Effective: December 31, 2012
Clinton Robbins, University Health Network
Rank: Assistant Professor | Effective: March 1, 2013
LMP News | Vol. 15 No. 1 – 2013
11
APPOINTMENTS
NEW LMP STAFF APPOINTMENTS CONT’D
Joyce So, Credit Valley Hospital
Rank: Lecturer | Effective: November 1, 2012
Deborah Terspolsky, Credit Valley Hospital
Rank: Lecturer | Effective: December 1, 2012
Julia Wang, University Health Network
Rank: Associate Professor | Effective: December 1, 2012
SENIOR ACADEMIC PROMOTIONS 2013
Richard G. Hegele, MD, FRCPC, PhD
It is with great pride that we congratulate the nine individuals
(four Professors and five Associate Professors) who received
approval from the Provost for promotion effective July 1, 2013.
These esteemed colleagues have demonstrated excellence in
scholarship, teaching and service that has been recognized by
peers within the University, nationally and internationally.
This year’s group of promoted faculty is an excellent representation of the wide range of expertise in our department.
It is also noteworthy that seven of the promoted faculty were
recognized for excellence in Creative Professional Activity, the
highest number promoted under this platform in a given year
for LMP.
My gratitude goes to the LMP Promotions Committee
chaired by Ingrid Zbieranowski and to Patricia Cayetano, LMP
Human Resources Coordinator. They have worked tirelessly
in ensuring that we provide valuable feedback and guidance
to our colleagues. Members of the committee include: Harry
Elsholtz, Fran Jamieson, Sarah Keating, Michael Pollanen,
Margaret Rand, Alex Romaschin, Theo van der Kwast, Herman
Yeger and Li Zhang.
On behalf of Dean Catharine Whiteside and myself, please
join me in congratulating the following LMP faculty members
on their promotions:
Faculty promoted to the rank of Professor
Hala El-Zimaity, University Health Network
An internationally acclaimed leader in gastrointestinal pathology, Prof. El-Zimaity has made original
and important contributions to our understanding
of gastritis and the development of gastric cancer.
She has developed an international reputation
through faculty development efforts aimed at the education
of pathologists in gastrointestinal pathology with a focus on
esophageal and gastric disorders. In addition, Prof. El-Zimaity
has had international impact in pathology education through
her contributions to key textbooks in the field.
Cynthia Hawkins, The Hospital for Sick Children
Prof. Hawkins has made groundbreaking
discoveries in unravelling the pathogenesis of
certain types of paediatric brain tumours, and
these have stimulated the development of new
therapeutic strategies. In particular, Prof. Hawkins’s
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Investigating Disease. Impacting Health.
paradigm-shifting work on the genomic analysis of paediatric
diffuse intrinsic pontine glioma, an aggressive brainstem astrocytic
tumour that arises in children, has gained international acclaim.
Heyu Ni, St. Michael’s Hospital
Prof. Ni is internationally renowned for his
research on platelet biology and immunology
and related human diseases. He has advanced our
understanding of both platelet physiology and
the pathophysiology of thrombosis and immunemediated thrombocytopenias, in which his research accomplishments have significant scientific and clinical implications.
Susan Richardson, The Hospital for Sick Children
Prof. Richardson is internationally recognized
for her work in the areas of fungal and viral
molecular diagnostics, respiratory pathogens
and paediatric microbiology. Her work has
resulted in pivotal advances in the early diagnosis
and management of infectious diseases with subsequent
improvement in patient care.
Faculty promoted to the rank of Associate Professor
Bhushan Kapur, Sunnybrook Health Sciences Centre
Prof. Kapur has attained national and international
recognition as an expert in clinical chemistry and
toxicology. His numerous contributions in the
field have been recognized by several societies
including Fellowships from the Royal Society
of Chemistry, National Academy of Clinical Biochemistry and
Canadian Academy of Clinical Biochemistry. He was named
an Honorary Member of the Canadian Society of Addiction
Medicine. Prof. Kapur has represented these academies with
distinction, and his research studies have advanced clinical
diagnosis and practice.
Anna Marie Mulligan, University Health Network
Prof. Mulligan has established herself as a
prominent national expert and leading educator
in breast pathology. She has accomplished this
through her education, research and administrative
endeavours which have advanced our understanding of breast cancer and resulted in changes in clinical practice
and patient management.
Sharon Nofech-Mozes,
Sunnybrook Health Sciences Centre
Prof. Nofech-Mozes has developed important
evidence-based guidelines that have had
significant impact in the diagnosis and
management of breast and endometrial cancers.
She is a recognized national expert in the area of predictive
marker testing in breast cancer.
APPOINTMENTS
Susan Poutanen, Mount Sinai Hospital
Prof. Poutanen is a national expert in emerging
infectious diseases, including respiratory viruses
(SARS, pandemic influenza), carbapenemaseproducing Enterobacteriaceae and Clostridium
difficile. She has made significant contributions to
our understanding of the epidemiology, diagnosis and clinical
management of these infectious diseases.
Catherine Streutker, St. Michael’s Hospital
Prof. Streutker is recognized for her contributions
to the diagnosis, treatment and management
of patients with gastrointestinal disease, with
an emphasis on upper gastrointestinal tract
malignancies. Her creative professional activities
in this area are complemented by translational research, most
significantly work with gastric carcinoma, as well as an interest
in the histology of animal models of gastrointestinal disease. Her
contributions to teaching and mentoring undergraduate and
postgraduate medical trainees are laudatory.
LMP RETIREMENTS
Denis Bailey, University Health Network
Retirement: March 31, 2013
Prof. Denis Bailey joined LMP in 1981 as part of
the Department of Pathology. Over his 32 years
of dedicated service he was involved in Undergraduate, Postgraduate and Continuing Medical
Education, as well as in research and clinical practice.
In Undergraduate Medical Education, he was a member
of the Pathobiology of Disease Curriculum Planning
Committee and was the course coordinator for a two-week
section on Neoplasia. At the Postgraduate level, he presented
lectures for Recent Advances in Pathology and conducted
teaching rounds with residents in Anatomical Pathology and
Hematology-Oncology for the interpretation of histological
and immunohistological slides and flow cytometric data. He
also presented multiple lectures for the Continuing Medical
Education program.
In recognition of his outstanding contributions to
education, he won the LMP Teaching Award for Undergraduate
Education in 2001 and the LMP Resident Award for Best
Teacher 2002-2003.
“Dr. Bailey had an immense impact on the department and
was a mainstay in the pathology department,” says former colleague
LMP Prof. David Hwang. “He was someone that valued highquality work and trained a huge number of pathologists. He was
also an excellent colleague and he was constantly fielding questions
from other pathologists. He’ll leave some big shoes to fill!”
Clinical Biochemistry, Medical Microbiology and Pathology—
forming our current department, LMP.
“The merger greatly expanded the department and created
a diverse and multidisciplinary environment,” says Boggs.
Beyond shaping the future of the department, she also found
her role as Graduate Coordinator of the Department of Clinical
Biochemistry from 1988 to 1991 extremely fulfilling. She
enjoyed interviewing and admitting students to the department
and fostering the next generation of clinical biochemists.
Her research focused on understanding the roles of the
lipids and proteins in the myelin layer surrounding nerve axons
and their role in diseases such as multiple sclerosis. This research
will aid in developing treatments and drugs for these diseases.
Asked what advice she would give to LMP students, Boggs
says, “You should follow your interests, work really hard and
pursue any opportunities that present themselves.”
Harriette Kahn, Sunnybrook Health Sciences Centre
Retirement: March 31, 2013
Involved in research, teaching and clinical practice,
Prof. Harriette Kahn joined LMP in 1981 as part
of the Department of Pathology. While working
at Women’s College Hospital, she also conducted
research at The Hospital for Sick Children and became
interested in immunohistochemistry: the study of biological
tissues and pathological diseases using antibodies.
Working closely with other researchers, Prof. Kahn
discovered that the antibody S100 protein identified melanomas.
Her research on keratins resulted in many publications,
numerous presentations and resulted in the utilization of these
antibodies in diagnostic services. She later discovered that the
D2-40 antibody, produced by Dr. A. Marks from the Banting
and Best Institute of Medical Research, identified lymphatic
vessels; this insight has resulted in over 900 citations.
Along with research, Prof. Kahn was the Coordinator of
Continuing Medical Education at the Faculty of Medicine from
1990 to 1993, and in this capacity, she initiated a project that was
presented through Telemedicine Canada. This endeavour involved
mailing out slides to pathologists across North America and
organizing conference calls with guest speakers. In recognition of
her contributions to Continuing Medical Education, she received
the Colin R. Woolf Award from the Faculty of Medicine in 1993.
Prof. Kahn enjoyed her diverse experience during her 32
years with the department. “My interactions with the University
have been excellent from a research, teaching and a clinical
service point of view. It’s been a wonderful experience and I
can’t believe how the years have flown by,” she says.
Still passionate about her research, she plans to be involved
in ongoing projects and to continue her service on the editorial
board of Modern Pathology.
Joan Boggs, The Hospital for Sick Children
Retirement: April 30, 2013
A biochemist, cell biologist and biophysicist, Prof.
Joan Boggs joined the Department of Clinical
Biochemistry in 1980 and was also a member
of the merger committee of the Departments of
LMP News | Vol. 15 No. 1 – 2013
13
ANNOUNCEMENTS
ANNOUNCEMENTS
UNDERGRADUATE
LMP would like to welcome our incoming undergraduate
students to the LMP Summer Student Research Program!
GRADUATE
THESIS DEFENSES – MSc
Ghassan Allo (Prof. Ming-Sound Tsao), Genomic characterization of pleural solitary fibrous tumours.
Steve Balgobin (Prof. Maria Rozakis), Investigating the role of
PHIP1 in hepatic gluconeogenesis.
Cassandra Belo (Prof. Joan Boggs), The effect of 17β- and 17αestradiol on myelination and remyelination in cerebellar slices.
CHIEF ANATOMICAL PATHOLOGY RESIDENT
On behalf of Prof. Simon Raphael, the Anatomical Pathology
Residency Program would like to congratulate and welcome
Ghassan Allo as the new Anatomical Pathology Chief Resident.
We would like to thank Will Chen for his hard work over the
past year and wish him the best in his future endeavours.
NEW TRAINEES
LMP would like to extend a warm welcome to our new
trainees starting on July 1, 2013:
Anatomical Pathology: Elena Diana Diaconescu, Konstaninos
(Gus) Sidiropoulos, Catherine Forse, Howard Yang, Tiffany Shao
Medical Microbiology: Nancy Matic
Hematopathology: Mohamed Bahmanyar
Forensic Pathology: Magdeleni (Maggie) Bellis
John Martirosyan (Prof. Norm Rosenblum), Active hedgehog
signaling regulates renal capsule morphogenesis.
Tyler Robinson (Prof. Eldad Zackenhaus), Identification of
disulfiram as a potential therapeutic for RB-1 proficient and
deficient triple negative breast cancer.
Clinical Chemistry: Dylan Thomas, Dan Lin,
Mohamed El-Hassan
Clinical Microbiology: Ramzi Fattouh
Compiled by Ferzeen Sammy
Clinical Fellows: Nadya Al-Faraidy, Sana Alsolami, Michelle
Downes, Rene Gerhard, Shirin Karimi, Mona Kassim, Megan
Kennedy, Seema Kudsia, Adriana Krizova, Jonathan LaChapelle,
Belinda Lategan, Karen Naert, Farshid Siadat, Raheela Siddiqui,
Kathryn Whelan, Welhena Rajapaksha
POSTGRADUATE
Research Fellow: Carolina Lopez-Uran
ACCREDITATION
LMP is proud to announce that all of our residency programs have
been accredited by the Royal College of Physicians and Surgeons
of Canada.The process of accreditation ensures the highest-quality
medical education. Accredited programs include: Anatomical
Pathology, Hematological Pathology, Medical Microbiology,
Neuropatholgy, Forensic Pathology and General Pathology.
GRADUATING TRAINEES
We would also like to extend our congratulations to our
graduating trainees:
Mark Wan (Prof. Michelle Bendeck), The mechanism of
discordin domain receptor 1 - mediated vascular calcification.
USCAP
LMP would like to congratulate those who presented at the
United States and Canadian Academy of Pathology (USCAP)
2013 Annual Meeting.
Posters:
Joerg Schwock
Clarissa Cassol
Ghassan Allo
Tao Wang
Dominque Trudel (fellow)
Ann Treacy (fellow)
Anatomical Pathology: Magdaleni (Maggie) Bellis, Will
Chen, Kiran Jakate, Wondu Kidanewold, Adriana Krizova, Seema
Kudsia, Jonathan Lai, Janet Malowany, Raheela Siddiqui
General Pathology: Jordan Radigan
Transfusion Medicine: Lani Lieberman
Forensic Pathology: Angela Guenther, Ashwyn Rajagopalan
Medical Microbiology: Chris Lowe, Manal Tadros
Clinical Chemistry: Mathew Estey, Jennifer Shea, Dana Nyholt
Clinical Microbiology: Julianne Kus
Proffered Paper:Gillian Bethune (fellow)
Ghassan Allo
Hector Li Chang (fellow)
Carlos Parra-Herran (fellow)
Herman Chui
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Investigating Disease. Impacting Health.
Compiled by Paula Nixon
ANNOUNCEMENTS
FACULTY
Blaise Clarke has been invited to participate in the College of
American Pathologists Gynecological Cancer Protocol Review
Panel.
Department of Anatomic Pathology at Sunnybrook
Health Sciences Centre has received a Canada Health
Infoway Momentum Award related to the early adoption and
increasing use of clinical synoptic reporting. The award was
presented to Dr. Mahmoud Khalifa by John Carmichael, MP for
Don Valley West.
The American Association for Cancer Research (AACR)
has named Prof. Emmanuel Farber a Fellow of the AACR
Academy. The AACR Academy recognizes scientists whose
major scientific contributions have propelled significant
innovation and progress against cancer. Fellows are selected
through a rigorous peer-reviewed process that evaluates
individuals for their scientific achievements in cancer research.
Zeina Ghorab is now a member of the Population Health
Advocacy Group of the Canadian Partnership Against Cancer
and a member of the QMP-LS Cytopathology Committee.
Glenn Taylor was appointed President of the Society for
Pediatric Pathology 2013-2014 at the Annual Meeting of the
Society in Baltimore on March 2, 2013.
Kathyrn Tinckam was elected to the executive Board at the
Canadian Society of Transplantation.
LMP News | Vol. 15 No. 1 – 2013
15
FUNDING & EVENTS
FUNDING
GRANTS AWARDED
NSERC 2013 DISCOVERY GRANT RESULTS
Aubert I. MRI-guided focused ultrasound IVIg immunotherapy for Alzheimer’s disease. The W. Garfield Weston Foundation.
($150,000)
Adeli K. Discovery Grant Natural Sciences and Engineering
Research Council of Canada (NSERC). ($200,000)
Fish JE. Control of vascular inflammation by microRNA.
Operating Grant - PA: ICRH New investigators - Bridge
Funding. ($100,000)
Keith J. The National Neuropathology Lecture Series: collaborative interprofessional E-learning for a very small specialty.
($8,448)
Somers G. Institution of a Molecular Translational Laboratory
for Paediatric Oncology. Garron Family Cancer Centre Fund,
Hospital for Sick Children. ($123,270)
Zhang L. (PI). Dick J. Schuh A. (Co-PI’s). Preventing AML
relapse by targeting stem cells with double-negative T cells.
Leukemia & Lymphoma Society. (US$600,000)
CANADIAN CANCER SOCIETY
Lee J. Characterization of a glycoprotein entry complex from a
novel orthomyxovirus. ($63,000)
Palaniyar N. Generating Innate Immune Diversity to
Recognize Newly Emerging Pathogens. ($30,000)
EVENTS
FORENSIC PATHOLOGY
Advancements in the Modern Autopsy
Thursday, May 23, 2013
Medical Sciences Building, MacLeod Auditorium
University of Toronto
1 King’s College Circle, Toronto
Information and registration:
www.cepd.utoronto.ca/forensics
IMPACT, QUALITY OF LIFE RESEARCH AND
INNOVATION GRANTS
Compiled by Sue Sarju Balaga
Ohh M. Role of VHL in DNA damage response. ($200,000)
RESERVE THE DATE
McPherson JD. (Co-PI). Accelerated identification and
validation of novel molecular signatures to improve treatment
and survival in early stage non-small cell lung cancer patients.
($1,248,401)
48th Annual Pritzker Day
Professor J. Coindre: Use of Immunohistochemistry in Sarcomas
Monday, June 3, 2013 Ben Sadowski Auditorium, 18th floor
Mount Sinai Hospital
600 University Avenue, Toronto
Tsao MS. Accelerated identification and validation of novel
molecular signatures to improve treatment and survival in early
stage non-small cell lung cancer patients. ($1,248,401)
Tsao MS. Epigenetic mechanism of resistance to epidermal
growth factor receptor (EGFR) inhibitor therapy in lung
adenocarcinoma. ($193,000)
CIHR RESULTS
Laurence Becker Symposium
17th Annual DPLM Symposium and 11th Laurence Becker
Symposium: Molecular Approaches to Diagnosis and
Targeted Therapy of Cancer
Wednesday, June 5, 2013
Registration: 1st Floor, Black Wing
Presentations: Daniels Hollywood Theatre, 1246 Elm Wing
The Hospital for Sick Children
555 University Avenue, Toronto
Ezzat S., Asa SL. (co-PI): Fibroblast Growth Factor Receptor 4
in Endocrine Homeostasis. ($714,515)
Visit www.lmp.utoronto.ca to see a full list of departmental publications.
Bendeck MP. Defining the Role of Type VIII Collagen in
Atherosclerotic Plaque Stabilization. ($522,179)
Diamandis EP. Integrated Approach to Discover Prostate
Cancer Biomarkers in Seminal Plasma. ($417,240)
Kandel R. Regulation of articular cartilage homeostasis.
($790,786)
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Investigating Disease. Impacting Health.
LMP
INVESTIGATING
DISEASE.
IMPACTING
HEALTH.
LMP ANNUAL REUNION
& BANQUET
What a year! Connect, reconnect and celebrate
at LMP’s Annual Reunion & Banquet.
Thursday, June 6, 2013
The Metropolitan Hotel
108 Chestnut Street
5:30 p.m. – Reception
Mezzanine Café
6:30 p.m. – Awards Presentation & Dinner
Toronto Ballroom, 2nd Floor
LMP Faculty, Administrative Staff, Students, Residents, Research Associates,
Clinical and Postdoctoral Fellows and thier Guests are welcome.
Register at events at www.lmp.utoronto.ca
Interested in participating?
Registration required.
Students contact: Stephen McCarthy at s.mccarthy@mail.utoronto.ca | Faculty contact: Dr. Vathany Kulasingam at vathany.kulasingam@uhn.ca
Spectators contact: Katie Babcock at katie.babcock@utoronto.ca (limited passes available).
18
Investigating Disease. Impacting Health.
PUBLICATIONS
PUBLICATIONS
Abla O, Halliday W, Laughlin S and Weitzman S. Central nervous
system juvenile xanthogranuloma after langerhans cell histiocytosis. Pediatr Blood Cancer. 2013 Feb;60(2):342-3. doi: 10.1002/
pbc.24379. Epub 2012 Oct 25.
Agnihotri S, Burrell KE, Wolf A, Jalali S, Hawkins C, Rutka JT
and Zadeh G. Glioblastoma, a brief review of history, molecular
genetics, animal models and novel therapeutic strategies. Arch
Immunol Ther Exp (Warsz). 2013 Feb;61(1):25-41. doi:
10.1007/s00005-012-0203-0. Epub 2012 Dec 7.
Annamalai AK, Dean AF, Kandasamy N, Kovacs K, Burton
H, Halsall DJ, Shaw AS, Antoun NM, Cheow HK, Kirollos
RW, Pickard JD, Simpson HL, Jefferies SJ, Burnet NG, Gurnell
M. Temozolomide responsiveness in aggressive corticotroph
tumours: a case report and review of the literature. Pituitary.
2012; 15:276-287.
Au K, Black S, Bilbao J, Masellis M, Keith J. Frontotemporal
lobar degeneration (FTLD): Updated pathology and co-existing
neurodegenerative phenomena in a cohort of 52 patients. Mod
Pathol. 26:414A (Suppl 2, abstr 1724).
Babwah J, Raphael S, Rowsell C. Intraoperative consultation
rounds: a pathologist educational and quality assurance initiative.
Mod Pathol. 26:125A (Suppl 2, abstr 516).
Balakier, H., R. Xiao, J. Zhao, S. Zaver, E. Dziak, K. Szczepanska,
M. Opas, S.Yie and C. Librach. 2013: Expression of survivin, a
key regulator of cell division and apoptosis, in human oocytes
and preimplantation embryos. Fertil Steril. 99, 518-525.
Bayani J, Kuzmanov U, Saraon P, Fung WA, Soosaipillai A, Squire
JA, Diamandis EP. Copy-number and expression alterations of
miRNAs in the ovarian cancer cell line OVCAR-3: Impact on
kallikrien 6 protein expression. Clin Chem 2013;59:296-305.
Berczi I, Quintanar EC,Villalobos-Hernandez R, Campos
R, Kovacs K. The healing power vasopressin. Advances in
neuroimmune biology. 2012; 3:217-224.
beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause
Walker-Warburg syndrome. Hum Mol Genet. 2013 Feb 18.
Carbone DP, Ding K, Roder H, Grigorieva J, Roder J, Tsao
MS, Seymour L, Shepherd FA. Prognostic and Predictive Role
of the VeriStrat Plasma Test in Patients with Advanced NonSmall-Cell Lung Cancer Treated with Erlotinib or Placebo in
the NCIC Clinical Trials Group BR.21 Trial. J Thorac Oncol.
2012;Nov;7(11):1653-60.
Chang WY, Lavoie JR, Kwon SY, Chen Z, Manias JL, Behbahani
J, Ling V, Kandel RA, Stewart DJ, Stanford WL. Feederindependent derivation of induced-pluripotent stem cells from
peripheral blood endothelial progenitor cells. Stem Cell Cancer
Res. 10(2):195-202, 2013.
Chen Y, Kinney L, Bozovic A, Smith H, Tarr H, Diamandis EP,
LeBlanc A. Performance evaluation of Siemens ADVIA Centaur
and Roche MODULAR Analytics E170. Total 25-OH Vitamin
D assays. Clin Biochem 2012;45:1485-1490.
Chetty R, Gill P, Bateman AC, Driman DK, Govender D,
Bateman AR, Chua YJ, Greywoode G, Hemmings C, Imat
I, Jaynes E, Lee CS, Locketz M, Rowsell C, Rullier A, Serra S,
Szentgyorgyi E,Vajpeyi R, Delaney D, Wang LM. Pathological
grading of regression: an International Study Group perspective.
J Clin Pathol 2012. 65(10):865-6.
Chrystoja C, Diamandis EP, Brand R, Ruckert F, Haun R,
Molina R. Pancreatic Cancer. Clin Chem 2013;59:41-46.
Chui MH, Streutker CJ, Mulligan AM, Lakovlev VV. Histological and immunohistochemical features to distinguish between
adipocyte hyperplasia, atrophy and neoplasia: differential
diagnosis of small round adipocytes in Crohn’s disease. Histopathology. 2012; 61:984-985.
Cusimano M, Kan P, Nassiri F, Anderson J, Goguen J,Vanek
I, Smyth HS, Fenton R, Muller PJ, Kovacs K. Outcomes of
surgically treated giant pituitary tumours. Can J Neurol Sci.
2012; 39:446-457.
Biankin AV, Waddell N, Tsao MS, et al. Pancreatic cancer
genomes reveal aberrations in axon guidance pathway genes.
Nature. 2012;Nov;15;491(7424):399-405.
Darling ME, Hashem NN, Zhang I, Mohamed AB, Fung K,
Kwan K, Mara TW, Daley TD, Diamandis EP. Kallikrein-related
peptidase 10 expression in salivary gland tissues and tumours. Int
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Eser Adiguzel, Guangpei Hou, Peter JB Sabatini, Michelle
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Joshua Lopes, Eser Adiguzel, Steven Gu, Shu-Lin Lui, Guangpei
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Lad EM, Karamchandani JR, Alcorn DM, Moshfeghi DM,
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age and renal failure. Clin Chem Lab Med 2012;50:931-934.
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Tsao MS, Goparaju C. Fibulin-3 as a blood and effusion
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Ramachandran R, Eissa A, Mihara K, Oikonomopoulou
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Sav A, Rotondo F, Syro LV, Scheithauer BW, Kovacs K.
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OFF THE CLOCK AT LMP
THE ART OF SCIENCE
Professor Tim-Rasmus Kiehl (MD)
Staff Pathologist, University Health Network
Prof. Tim-Rasmus Kiehl joined LMP in 2006, and in the same year, he developed a
personal interest in pathology-based art. This interest was sparked by a departmentwide initiative to feature artwork at Toronto General Hospital’s Laboratory
Medicine Program.
The main purpose of his art is to communicate science in an interesting way. He explains, “We really
need to engage people and get them interested in science and pathology. What good is science if it goes
unnoticed by the public? We have reached dangerous levels of public non-understanding of science.
Sooner or later, this will start to cripple science.”
Favourite Quote:
“Any sufficiently advanced technology is indistinguishable from magic.”
- Arthur C. Clarke
Favourite Artist:
Johannes Vermeer
The Great Wave of Wet Keratin (2008)
Among the diagnostic features of the adamantinomatous subtype of craniopharyngioma, a type of brain tumour that occurs in the sellar region of the pituitary gland,
are: 1) “wet” keratin, 2) basaloid palisading epithelium and a 3) “stellate reticulum”
matrix. Pathology residents should know these for the Royal College examinations.
This work was modelled after “The Great Wave off Kanagawa” by Katsushika
Hokusai, Japan (1760-1849), created around 1831.
Polarized Bear (2011)
The polar bear is an iconic inhabitant of Canada’s North. It is also an important icon
of climate change, which unfortunately has become a highly politically polarized
issue. This kind of polarization, also present in other topics such as evolution, is
terrible for science and for informed policy.
In pathology, however, polarization is a very useful thing. When a Congo red stain
is viewed under polarized light, it can help us detect the presence of amyloid: A
hard waxy deposit consisting of protein and polysaccharides that results from the
degeneration of tissue. The source images for this picture were taken from a patient
with cerebral amyloid angiopathy (CAA) in which amyloid accumulates in blood
vessels, making them brittle and prone to catastrophic events.
Immuna Lisa (2007)
LMP News | Vol. 15 No. 1 – 2013
25
INVESTIGATING
DISEASE.
IMPACTING
HEALTH.
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