CURRICULUM VITAE
01/12/09
BIOGRAPHICAL
Name:
Muhammad Shahab
Birth Date:
August 4, 1962
Home Address:
483, St. # 127, G-9/3
Islamabad
Birth Place:
Rawalpindi, Pakistan
Citizenship:
Pakistan
Home Phone:
92-51-2520829
E-Mail Address: shah_qau@yahoo.com
shahab@qau.edu.pk
Business Address: Department of Animal
Sciences
Quaid-i-Azam University
Islamabad 45320, Pakistan
Business Phone:
Business Fax:
92-51-2601176
92-51-90643014
-----------------------------------------------------------------------------------------------------------------------------EDUCATION AND TRAINING
1984
College of Veterinary Science
Lahore, Pakistan
Veterinary Medicine
D.V.M.
1988
Quaid-i-Azam University
Islamabad, Pakistan
Reproductive Physiology
M. Phil.
1994
Pennsylvania State University
Ph.D.
Dr. D.R. Deaver
University Park, PA, USA
Animal Science (Reproductive Physiology/Neuroendocrinology)
Dr. M. Arslan
------------------------------------------------------------------------------------------------------------------------APPOINTMENTS AND POSITIONS
ACADEMIC:
1985-1988
Pakistan Agricultural Research Council
World Bank Research Project (1158-PAK)
Department of Biological Sciences,
Quaid-I-Azam University
Islamabad, Pakistan
Research Officer
1988-1995
Quaid-I-Azam University
Department of Biological Sciences,
Primate Facility,
Veterinarian
CV: Shahab M
Page 2
Islamabad, Pakistan
1995-2004
2004-2007
2007- todate
Quaid-I-Azam University
Department of Biological Sciences
Islamabad, Pakistan
Assistant Professor
Associate Professor
Professor
1999-2001
Nagoya University
Laboratory of Animal Reproduction
Graduate School of Bioagricultural Science
Nagoya, Japan
JSPS Postdoctoral
Fellow
2001-2004
University of Pittsburgh School of Medicine
Department of Cell Biology and Physiology
Pittsburgh, PA, USA
Research Associate
------------------------------------------------------------------------------------------------------------------------ADMINISTRATIVE EXPERIENCE
2006- todate
Chairman, Department of Animal Sciences, Quaid-i-Azam University
------------------------------------------------------------------------------------------------------------------------MEMBERSHIPS IN PROFESSIONAL AND SCIENTIFIC SOCIETIES
Pakistan Physiological Society
International Neuroendocrine Federation
Society for the Study of Reproduction (1992-94)
Japan Society for Comparative Endocrinology (1999-2000)
Associate of the Endocrine Society 2004
Regular member of the Endocrine Society 2007- todate
Zoological Society of Pakistan (2009-todate)
------------------------------------------------------------------------------------------------------------------------ACADEMIC DISTINCTIONS/ HONORS
First class first position in DVM (Roll of Honors; 1984)
John O. Almquist Graduate Student Competitive Research Award from the Dept of Dairy and Anim Sci,
Penn State University, University Park, PA, USA (1992)
Fellowship awarded by International Union of Physiological Sciences (IUPS) to attend the XXXIII IUPS
Congress in St. Petersburg, Russia (July 1997)
German Academic Exchange Service (DAAD) fellowship for collaborative research in the laboratory of
Dr. W. Wuttke, Frauenklinik, Georg-August University, Gottingen, Germany (May - July 1997)
Young Biologist award (shared) from the Third World Academy of Science (1998)
Travel grant awarded by the Federation of Asian and Oceanian Physiological Societies (FAOPS) to
attend the 4th FAOPS Congress in Brisbane, Australia (Sept 1998)
Endeavour Research Fellowship (2008)
CV: Shahab M
Page 3
Reviewer for American Journal of Physiology (Endocrinology and Metabolism), Neuroendocrinology,
Journal of Neuroendocrinology (2006- todate)
Member Advisory Board, Pakistan Journal of Zoology (2009-10)
-------------------------------------------------------------------------------------------------------------------------
THESES SUPERVISED
1.
Study of morphology and membrane integrity of bull spermatozoa (M. Phil., Sadia Naheed,
1997)
2.
Use of milk progesterone concentrations in assessing the efficiency of artificial insemination in
cattle and buffalo (M. Phil., Umer Farooq, 1998)
3.
Some aspects of neuroendocrine regulation of growth hormone secretion in an infra-human
primate (Ph.D., S. Shakeel Raza, 1998; co-supervision with Prof M Arslan)
4.
Studies on the filtration of buffalo semen (M. Phil., Zulfiqar Ahmed, 1998)
5.
Hormonal profiles in pre- and post-menopausal Pakistani women (M. Phil., Tahira Saleem,
1999; co-supervision)
6.
The study of the role of hypothalamic kisspeptin-GPR54 signaling in causing fasting-induced
suppression of pituitary-testicular axis in the adult male rhesus monkey (M.Phil., Farzana Aziz,
2006)
7.
Studies of the role of GPR54-kisspeptin signaling in endocrine function of the primate testis
(M.Phil., Shazad Irfan, 2006)
8.
Effects of antibiotics on motility, sperm morphology, membrane integrity, fertility and
bacteriological quality of buffalo spermatozoa (Ph.D., S. M. H. Andrabi, 2007)
9.
A study of GPR54 receptor expression in the non-human primate testis (M. Phil., Mariam Anees,
2007)
10.
Study of affect of peripheral kisspeptin administration on plasma level of oxytocin in the adult
male rhesus monkey ( Macaca mulatta) (M. Phil., Amara Javaid, 2008)
11.
Role of RF-amides in regulation of prolactin secretion in the adult male rhesus monkey (M. Phil.,
Hina Salahuddin, 2008)
12.
Study of the role of RF-amide neuropeptides in affecting GH secretion in a non-human primate
model (M. Phil., Fatima Qaiser, 2008)
13.
A study of determination of plasma metastin levels during pubertal development in human males
(M. Phil., Riffat Bano, 2008)
14.
A study of the effect of peripheral administration of kisspeptin on plasma levels of testosterone in
male fish (M. Phil., Tanzeela Riaz, 2008)
------------------------------------------------------------------------------------------------------------------------TECHNIQUES
Extensive in vivo experimentation relating to reproductive endocrinology and testicular function in a
variety of models
RIA, EIA, Chemiluminescence assays, Radioiodinations
HPLC analyses for amino acids
Immunocytochemistry and confocal microscopy
Experimental surgeries (castration, jugular catheterization, vagotomy, stereotaxic brain surgery)
CV: Shahab M
Page 4
------------------------------------------------------------------------------------------------------------------------PUBLICATIONS
1. Refereed Articles:
1.
Ahmad N, M Shahab, S Khurshid and M Arslan 1989 Pubertal development in the male buffalo:
Longitudinal analysis of body growth, testicular size and serum profiles of testosterone and
oestradiol. Anim Reprod Sci 19:161-170.
2.
Arif M, N Ahmad, M Shahab and M Arslan 1991 Effect of pregnant mare's serum gonadotropin
(PMSG) on testicular function in the immature buffalo bull (Bubalus bubalis). Asian-Australasian J
Anim Sci 4:1-5.
3.
Ahmad N, M Shahab, M Anzar and M Arslan 1991 Changes in behaviour and androgen levels
during pubertal development of the buffalo bull. Appl Anim Behav Sci 32:101-105.
4.
Arslan M, SSR Rizvi, S Jahan, P Zaidi and M Shahab 1991 Possible modulation of N-methyl-D,Laspartic acid induced prolactin release by testicular steroids in the adult male rhesus monkey. Life
Sci 49:1073-1077.
5.
Ahmad MM, MR Mughal, A Bari, MI Khan and M Shahab 1992 Age related profiles of serum
thyroxine, tri-iodothyronine and testosterone in Kaghani, Rambouillet and Kaghani X Rambouillet
sheep. Asian-Australasian J Anim Sci 5:101-106.
6.
Rahil T, RA Chaudhry and M Shahab 1993 Serum progesterone concentrations in buffaloes
receiving superovulatory treatment at two different stages of oestrus cycle. Pakistan Vet J 13:63-65.
7.
Arslan M, GF Weinbauer, S Schlatt, M Shahab and E Nieschlag 1993 FSH and testosterone, alone
or in combination, initiate testicular growth and increase the number of spermatogonia and Sertoli
cells in a juvenile non-human primate (Macaca mulatta). J Endocrinol 136:235-243.
8.
Shahab M, KD Nusser, LC Griel and DR Deaver 1993 Effect of a single intravenous injection of
N-Methyl-D,L-aspartic acid on secretion of luteinizing hormone and growth hormone in Holstein
bull calves. J Neuroendocrinol 5:469-473.
9.
Shahab M, S Khurshid, M Arslan and N Ahmad 1993 Ontogeny of estradiol secretion in Nili-Ravi
buffalo bulls. Theriogenology 39:1235-1243.
10. Shahab M, KD Nusser, JL Peters and DR Deaver 1995 Involvement of N-methyl-D-aspartate
receptor utilizing excitatory amino acid neurotransmitters in control of pulsatile secretion of LH
during sexual development in Holstein bull calves. J Reprod Fertil 105:77-83.
11. Akhtar SA, Kayani, MM Ahmad and M Shahab 1996 Insecticide-induced changes in secretory
activity of the thyroid gland in rats. J Appl Toxicol 16, 397-400.
12. Shahab M, Waheed-uz-Zaman, K Bashir and M Arslan 1997 Fasting-induced suppression of
hypothalamic-pituitary-gonadal axis in the adult rhesus monkey: Evidence for involvement of
excitatory amino acid neurotransmitters. Life Sci 61:1293-1300.
CV: Shahab M
Page 5
13. Tariq S, U Ahmad, M Shahab, M Arslan and MA Hafeez 1997 Study of ultrastructure of adrenal
gland of the lizard, Uromastix hardwicki. Proc Pak Acad Sci 34:111-120
14. Ahmad U, S Tariq, M Shahab and M Arslan 1998 Annual histological changes in the adrenal
gland of spiny-tailed lizard, Uromastix hardwicki. Pak J Zool 30:7-11
15. Subhan F, F Tahir, AS Dil, M Shahab, W Alam and I Fayyaz 1998 Therapeutic potential of
vitamins in asthenospermia. Hamdard Medicus 41:53-55
16. Andrabi SMH, MM Ahmad and M Shahab 1998 Furazolidone treatment suppresses pubertal
testosterone secretion in male broiler breeder birds (Gallus domesticus). Vet Human Toxicol
40:321-325
17. Tahir F, F Subhan, R Faryal, M Asif, A Bari, AA Qazilbash, W Alam, AS Dil and M Shahab 1998
Chemical pathology of infertile Pakistani men. Hamdard Medicus 41:91-92
18. Subhan F, F Tahir, W Alam, S Sultan, AS Dil and M Shahab 1998 Interpreting immunoassays.
Hamdard Medicus 41:69-70
19. Leonhardt S, M Shahab H Luft, W Wuttke and H Jarry 1999 Reduction of luteinizing hormone
secretion induced by long-term feed restriction in male rats is associated with increased expression
of GABA-synthesizing enzymes without alterations of GnRH gene expression. J Neuroendocrinol
11:613-619
20. Plant TM and M Shahab 2002 Neuroendocrine mechanisms that delay and initiate puberty in
higher primates. Pysiol Behav 77:717-722
21. Ahmad Z, M Anzar, M Shahab, N Ahmad and SM Andrabi 2003 Sephadex and sephadex ionexchange filtration improves the quality and freezability of low-grade buffalo semen ejaculates.
Theriogenology 59:1189-1202
22. Shahab M, A Balasubramaniam, A Sahu and TM Plant 2003 Central nervous system receptors
involved in mediating the inhibitory action of neuropeptide Y on luteinizing hormone secretion in
the male rhesus monkey (Macaca mulatta). J Neuroendocrinol 15:965-970
23. Anzar M, U Farooq, MA Mirza, M Shahab and N Ahmad 2003 Factors affecting the efficiency of
artificial insemination in cattle and buffalo in Punjab, Pakistan. Pakistan Vet J 23:106-113
24. Cunningham MJ, M Shahab, KL Grove, JM Scarlett, TM Plant, JL Cameron, MS Smith, DK
Clifton and RA Steiner 2004 Galanin-like peptide as a possible link between metabolism and
reproduction in the macaque. J Clin Endocrinol Metab 89:1760-1766
25. Shabab M, C Mastronardi, SB. Seminara, WF Crowley, SR Ojeda and TM Plant 2005 Increased
hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc
Natl Acad Sci, USA 102:2129-2134
26. Shahab M, MJ Cunningham, RA. Steiner and TM Plant 2005 Galanin-like peptide elicits a robust
discharge of growth hormone in the rhesus monkey (Macaca mulatta). Neuroendocrinology
81:254-258
CV: Shahab M
Page 6
27. Shahab M, S Sajapitak, H Tsukamura, M Kinoshita, S Matsuyama, S Ohkura, S Yamada, Y
Uenoyama, H I Anson and K-I Maeda 2006 Acute lipoprivation suppresses pulsatile luteinizing
hormone secretion without affecting food intake in female rats. J Reprod Dev 52:763-772
28. Sajapitak S, K Iwata, M Shahab, Y Uenoyama, S Yamada, M Kinoshita, FY Bari, H I’anson, H
Tsukamura and K-I Maeda 2008 Central lipoprivation-induced suppression of LH pulses is
mediated by paraventricular catecholaminergic inputs in female rats. Endocrinology 149:3016-24
29. Wahab F, F Aziz, S Irfan, WU Zaman and M Shahab 2008 Short-term fasting attenuates the
response of the HPG axis to kisspeptin challenge in the adult male rhesus monkey (Macaca
mulatta). Life Sci 83:633-37
30. Ahmad N, S Umair, M Shahab and M Arslan 2009 Testicular development and establishment of
spermatogenesis in Nili-Ravi buffalo bulls. Theriogenology 73:20-25
31. Wahab F, R Bano, S Jabeen, S Irfan and M Shahab 2010 Effect of peripheral kisspeptin
administration on adiponectin, leptin, and resistin secretion under fed and fasting condition in the
adult male rhesus monkey (Macaca mulatta). Horm Metab Res 42:570-574
32. Smith JT, M Shahab, K-Y Francis Pau and IJ Clarke 2010 Hypothalamic expression of Kiss1 and
gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate. Biol
Reprod 83:568-577
33. Wahab F, T Riaz and M Shahab 2010. Study of the effect of peripheral kisspeptin administration
on basal and glucose-induced insulin secretion under fed and fasting conditions in the adult male
rhesus monkey (Macaca mulatta). Horm Metab Res (epub 6 Dec ahead of print)
34. Wahab F, F Ullah F, YM Chan, SB Seminara and M Shahab 2010. Decrease in hypothalamic
Kiss1 and Kiss1r expression: a potential mechanism for fasting-induced suppression of the HPG
axis in the adult male rhesus monkey (Macaca mulatta). Horm Metab Res (in press)
2. Published Abstracts:
1.
Aliya S, N Ahmad, M Shahab and M Arslan 1986 Invitro testicular androgens in Nili-Ravi buffalo
bulls: effect of LHRH exposure. Buffalo Bulletin 5:92.
2.
Ahmad N, M Ahmad, S Anjum, M Shahab, S Jalali and M Arslan 1987 Testicular development
and establishment of spermatogenesis in Nili-Ravi buffalo bulls. Proc Int Symp Milk Buffalo
Reprod (W Richter, C Heuer and M Anwar [eds]), Islamabad, Pakistan, p 351-352.
3.
Arslan M, M Shahab, GF Weinbauer and E Nieschlag 1990 Endocrine regulation of testicular
function during puberty in primates; role of FSH and testosterone. Proc Int Conf Perspectives in
Primate Reprod Biol, Bangalore, India, p 23.
4.
Shahab M, KD Nusser, JL Peters, RA Taft, MA Bhatti and DR Deaver 1994 Differential
regulation of secretion of prolactin and growth hormone by excitatory amino acid
neurotransmission in cattle. Program of the 76th Annual Meeting of The Endocrine Society,
Anaheim, CA, USA, p 541.
CV: Shahab M
Page 7
5.
Shahab M, KD Nusser, JL Peters, MA Bhatti, RA Taft and DR Deaver 1994 Role of endogenous
excitatory amino acid neurotransmitters in regulation of pulsatile secretion of luteinizing hormone
in bull calves. Biol Reprod 50 (Suppl 1):156 (abstract no. 407).
6.
Shahab M, JL Peters, LC Griel and DR Deaver 1995 Development of stimulatory actions Nmethyl-D-aspartate receptor utilizing excitatory amino acids on secretion of luteinizing hormone is
steroid dependent in bull calves. Biol Reprod 52 (Suppl 1): abstract no. 581.
7.
Aslam H, M Shahab and M Arslan 1995 Similar effects of dopamine and dopamine antagonist on
growth hormone secretion in a non-human primate. J Endocrinol 147 (suppl): P37.
8.
Arslan, M. and M Shahab 1996 Neuroendocrine control of Puberty. 3rd Annual National
Symposium of the Aga Khan University ‘’Impact of Research on Health, Education and
Community Development’’ at Karachi, Pakistan, September 1996. p 7.
9.
Shahab M, Waheed-uz-Zaman, K Bashir and M Arslan 1997 Are excitatory amino acids involved
in fasting-induced suppression of the hypothalamic-pituitary-testicular axis in primates? XXXIII
International Congress of Physiological Sciences at St.Petersburg, Russia, July 1997. abstract no.
P041.22.
10. Shahab M, Waheed-uz-Zaman, K Bashir and M Arslan 1997 Short-term fasting suppresses the
hypothalamic-pituitary-testicular axis response to excitatory amino acid neurotransmitters in the
adult male rhesus monkey. Int J Androl 20 (suppl 1 for the VI International Congress of Andrology
at Salzburg, Austria, May 1997): abstract no. 429.
11. Sajjad S, M Shahab, S Huma and M Arslan 1997 N-Methyl-D,L-Aspartate induced growth
hormone secretion in response to season. 17th Pakistan Congress of Zoology at Karachi, Pakistan,
April 1997. abstract no. CBGP-14
12. Anis RA, M Arslan, S Abbas and M Shahab 1997 Endocrine and clinical assessment of thyroidal
function in pregnant mothers and neonates from iodine deficient regions of Pakistan. 17th Pakistan
Congress of Zoology at Karachi, Pakistan, April 1997. abstract no. CBGP-3
13. Huma S, M Shahab, S Sajjad and M Arslan 1997 Season-related changes in prolactin secretion in
the rhesus monkey. 17th Pakistan Congress of Zoology at Karachi, Pakistan, April 1997. abstract
no. CBGP-15
14. Waheed-uz-Zaman, M Shahab and M Arslan 1997 Season-related changes in plasma levels of
TSH in adult male rhesus monkeys. 17th Pakistan Congress of Zoology at Karachi, Pakistan, April
1997. abstract no. CBGP-16
15. Alam W, M Arslan, M Shahab, F Tahir and Waheed-uz-Zaman 1997 Sex steroids influence
neuronal responses during development in non-human primates. 1st National Symp Current Trends
Develop Reprod Biol, Islamabad, Pakistan, November 1997. p 25-26.
16. Andrabi SMH, MM Ahmad and M Shahab 1997 Toxic effect of furazolidone on pubertal
development in male broiler breeder birds. 1st National Symp Current Trends Develop Reprod Biol,
Islamabad, Pakistan, November 1997. p 25.
CV: Shahab M
Page 8
17. Subhan F, F Tahir, W Alam, AS Dil and M Shahab 1997 Follicle stimulating hormone is the
principal male fertility affecting hormone. 1st National Symp Current Trends Develop Reprod Biol,
Islamabad, Pakistan, November 1997. p 18.
18. Saleem T, S Rana, M Shahab and S Aliya 1997 Hormone profiles in postmenopausal women from
Islamabad and Rawalpindi: a pilot study. 1st National Symp Current Trends Develop Reprod Biol,
Islamabad, Pakistan, November 1997. p 17.
19. Tahir F, F Subhan, W Alam, AS Dil and M Shahab 1997 Recognition of ignored seminal
attributes of male infertility. 1st National Symp Current Trends Develop Reprod Biol, Islamabad,
Pakistan, November 1997. p 16.
20. Waheed-uz-Zaman, S Huma, S Jahan, M Shahab and M Arslan 1998 Hypothalamic-pituitarytesticular axis response to NMDA receptor activation is strengthened during early reproductive
aging in the rhesus monkey. The Aging Male 1 (suppl 1 for the First World Congr on the Aging
Male at Geneva, Switzerland, February 1998. abstract no. 052): 27.
21. Rizvi SSR, M Arslan and M Shahab 1998 Age-related shifts in secretion of growth hormone in
non-human primates: are excitatory amino acid neurotransmitters involved? Proc Austral Physiol
Pharmacol Soc 29:358P.
22. Ahmad MM, J Kamran, S. Tariq and M Shahab 1998 Glutamate stimulates pituitary hormone
secretion in adult healthy individuals. Proc Austral Physiol Pharmacol Soc 29:357P.
23. Leonhardt S, M Shahab, W Wuttke and H Jarry 1998 Effect of food restriction on expression of
GnRH and compounds of the GABAergic neurotransmitter system in the hypothalamus of male
rats. Exp Clin Endocrinol Diab 106 (Suppl 1):v186.
24. Leonhardt S, M Shahab, W Wuttke and H Jarry 1998 Feed restriction affects the expression of
hypothalamic neurotransmitters in male rats. Program of the 80th Annual Meeting of The
Endocrine Society, New Orleans, LA, USA, P3-664.
25. Ahmad N, Z Ahmad, M Anzar and M Shahab 1999 Sephadex and sephadex ion-exchange
filtration improves the quality and freezability of lower grade buffalo semen. Proc 32nd Soc Study
Reprod Meet, Pullman, WA, USA, abst # 133
26. Shahab M, H Tsukamura, F Maekawa, B Reyes, R Moriyama, K-I Maeda 1999 Pharmacological
blockade of fatty acid oxidation suppresses LH secretion in adult female rats. Proc Japan Soc Comp
Endocrinol 14:77 (abst # P-62)
27. Shahab M, A Balasubramaniam, A Sahu and TM Plant 2002 Further studies of the
pharmacological basis of the neuropeptide Y (NPY) brake on hypothalamic gonadotropin-releasing
hormone (GnRH) release during prepubertal development in the male rhesus monkey. The 5th Int
Congr Neuroendocrinol, Bristol, UK, abst # FC1
28. Shahab M, C Mastronardi, TM Plant, SR Ojeda, WF Crowley Jr and SB Seminara 2004
Hypothalamic GPR-54 expression and signaling during the peripubertal period in the rhesus
monkey, Macaca mulatta. Program of the 86th Annual Meeting of The Endocrine Society, New
Orleans, LA, USA, P3-269.
CV: Shahab M
Page 9
29. Shahab M, MJ Cunningham, RA Steiner and TM Plant 2004 Central administration of galaninlike peptide (GALP) elicits a robust discharge of growth hormone (GH) in the adult male rhesus
monkey. Program of the 86th Annual Meeting of The Endocrine Society, New Orleans, LA, USA,
P3-153.
30. Shibata M, RL Friedman, M Shahab and TM Plant 2004 KISS-1, but not GPR54, expression in
the hypothalamus of the adult male rhesus monkey (Macaca mulatta) is regulated by testosterone.
Program of the 34th Annual Meeting of the Society for Neuroscience, San Diego, CA, USA.
Program No. 143.7
31. Shibata M, RB Gibbs, M Shahab and TM Plant 2005 GnRH neurons in the peripubertal male
rhesus monkey (Macaca mulatta) express GPR54: Implication for the control of primate puberty.
Program of the 87th Annual Meeting of The Endocrine Society, San Diego, CA, USA, P1-98
32. Shibata M, S Ramaswamy, M Shahab, RB Gibbs and TM Plant 2005 Further studies of
kisspeptin/GPR54 signaling in the control of the onset of puberty in the rhesus monkey (Macaca
mulatta). Sixth Puberty Conference, 26-28 May, Evian, France
33. Shahab M, C Pohl, A barker-Gibbs and TM Plant 2005 Is the pubertal resurgence in pulsatile
GnRH release in agonadal male monkeys (Macaca mulatta) associated with augmented episodic
GH secretion? Sixth Puberty Conference, 26-28 May, Evian, France, Poster# 23
34. Shahab M and Plant TM 2006 Neurobiological mechanisms underlying the pubertal activation of
the HPG axis at puberty in higher primates. 6th Inter Congress of Neuroendocrinology, 19-22 June,
Pittsburgh, USA.
35. Irfan S, M Anees, W Zaman and M Shahab 2007 Kisspeptin does not directly stimulate
testosterone secretion in the adult male rhesus monkey. Symposium on recent Trends in
Endocrinology and Reproductive Sciences, 13-14 February, Lahore, Pakistan
36. Wahab F, F Aziz, S Irfan and M Shahab 2007 Short term fasting attenuates GnRH neuronal
response to kisspeptin challenge in the adult male rhesus monkey. Symposium on recent Trends in
Endocrinology and Reproductive Sciences, 13-14 February, Lahore, Pakistan
37. Plant TM and M Shahab 2007 The ability of hypothalamic GPR54 signaling to elicit release of
hypophysiotropic factors may be limited to gonadotropin releasing hormone: Evidence from the
male rhesus monkey (Macaca mulatta). Program of the 89th Annual Meeting of The Endocrine
Society,Toronto, Canada
38. Irfan S, M Anees M, F Wahab, Waheed-uz Zaman, TM Plant and M Shahab. 2008 Evidence for a
direct intratesticular action of kisspeptin in the adult rhesus monkey (Macaca mulatta). Program of
the 90th Annual Meeting of The Endocrine Society, San Francisco, CA, USA, OR52-6
39. F Wahab, F Aziz, Irfan S, Waheed-uz Zaman and M Shahab. 2008 HPG axis response to
kisspeptin challenge attenuates in shot-term fasting while remains preserved under hypoglycemic
condition in the adult male rhesus monkey (Macaca mulatta). Program of the 90th Annual Meeting
of The Endocrine Society, San Francisco, CA, USA, P1-677
40. Wahab F, Salahuddin H, Anees M, Leprince J, Vaudry H, Tena-Sempere M, Shahab M. 2008.
Study of the effect of 26 RF and 43 RF amides on neuroendocrine reproductive axis in adult male
CV: Shahab M
Page 10
rhesus monkey (Macaca mulatta). 13th Congress of the European Neuroendocrine Association
(ENEA), Antalya, Turkey.
41. Wahab F, Irfan S, Zaman W, Shahab M. 2008. Differential response of primate HPG axis to
kisspeptin and NMA challenge in hypoglycemic conditions. 1st World Conference on Kisspeptin
Signaling in the Brain, Cordoba, Spain.
42. Javaid A, Wahab F, Irfan S, Shahab M. 2008. Stimulatory effect of kisspeptin on oxytocin
secretion in the adult male rhesus monkey (Macaca mulatta). 1st world conference on kisspeptin
signaling in the brain, Cordoba, Spain.
43. Wahab F, Farzana Aziz, Muhammad Shahab. 2008. Peripheral kisspeptin challenge inhibits
fasting and hypoglycemia stimulated cortisol secretion in the adult male rhesus monkey (Macaca
mulatta). 1st South Asian Conference of Physiological Societies & 11th Biennial Conference of
Pakistan Physiological Society, Islamabad, Pakistan.
44. Salahuddin H, Wahab F, Anees M, Leprince J, Vaudry H , Tena-Sempere M, Shahab M. 2008.
Evidence that evolutionary conserved RF amide neuropeptides stimulate prolactin secretion in the
adult male rhesus monkey (Macaca mulatta). 1st South Asian Conference of Physiological
Societies & 11th Biennial Conference of Pakistan Physiological Society, Islamabad, Pakistan.
45. Wahab F, Bano R, Riaz T, Huma T, Irfan S, Shahab M. 2008. Study of the effect of peripheral
kisspeptin administration on insulin and leptin secretion under fed and fasting condition in adult
male rhesus monkey (Macaca mulatta). 1st South Asian Conference of Physiological Societies &
11th Biennial Conference of Pakistan Physiological Society, Islamabad, Pakistan.
46. Bano R, F Wahab F, Riaz T, Jabeen S, Irfan S, Arslan M and Shahab M. 2009 Peripheral metastin
(kisspeptin 54) levels change during different stages of puberty in boys. Program of the 91th
Annual Meeting of The Endocrine Society, Washington, DC, USA, P3-287
47. SMITH JT, SHAHAB M, PAU KYF, I. J. CLARKE IJ 2009 Kisspeptin neurons in the arcuate
nucleus and preoptic area are central regulators for the preovulatory luteinizing hormone surge in
the sheep and monkey. Program of the 39th Annual Meeting of the Society for Neuroscience,
Chicago, IL, USA. Program No. 665.13
48. Mubeen H, S Irfan, A Niaz, F Wahab and M Shahab 2010 Immunocytochemical detection of
GPR-54 receptor in the adult male monkey (Macaca mulatta) pituitary gland. The 7th
International Congress of Neuroendocrinology, 11-15 July. Rouen, France (accepted)
49. Wahab F, F Ullah, S Irfan, Y-M Chan, SB Seminara and M Shahab 2010 Decrease in
hypothalamic Kiss1r expression: a potential mechanism for fasting-induced suppression of the
HPG axis in the adult male rhesus monkey. The 7th International Congress of
Neuroendocrinology, 11-15 July. Rouen, France (accepted)
50. Smith JT, M Shahab 2010 Kisspeptin antagonist reveals an important role for kisspeptin in the
generation of the estrogen-induced GnRH/LH surge in the ewe. The 7th International Congress of
Neuroendocrinology, 11-15 July. Rouen, France (accepted)
-------------------------------------------------------------------------------------------------------------------------
CV: Shahab M
Page 11
RESEARCH GRANTS
Grant Number
1158-PAK
Grant Title
Role in Project
and % Effort
Years
Inclusive
Studies on Pubertal Development Research Officer;1985-1988
In Buffalo Bulls: Regulation of
20%
Testicular Function and
Relationship of Endocrine Criteria
With Fertility
Source
PARC/World
Bank Cr.
Role of Follicle-Stimulating
Co-PI; 30%
Hormone (FSH) on Gonadal
Function in the Immature
Monkey: Specific and Synergistic
Effects
Regulation of Prolactin
Co-PI; 30%
Secretion and its
Relationship to PituitaryGonadal Axis Using Monkey
As a Primate Model
1992-1994
Pakistan
Science
Foundation
1990-1993
National
Scientific
Research
and Develop.
Board
Studies on the Role of
PI; 50%
Excitatory Amino Acid
Neurotransmitters in
Regulating Secretion of Growth
Hormone in Non-Human Primates
1997-1999
Pakistan
Science
Foundation
Studies on the Role of Inhibitory
and Excitatory Amino Acid
Neurotransmitters in Mediation
of Fasting-Induced Hypogonadotropism in Primates
PI; 50%
1997-1998
Quaid-i-Azam
University
Research Fund
Role of Androgens in Regulating
Secretion of Growth Hormone
in Primates
PI; 50%
1998-1999
Quaid-i-Azam
University
Research Fund
Studies of the Role of Thyroid
Hormones in Affecting Gonadal
Structure and Function
Co-PI; 30%
1998-1999
Quaid-I-Azam
University
Research Fund
Role of GPR54 receptor in
testicular function in Primates
PI; 50%
2004-2005
Quaid-I-Azam
University
Research Fund