List of publications used in an ongoing meta analysis of clinical

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1. Olsson MG, Davidsson S, Muhammad ZD, et al. Increased levels of hemoglobin and
alpha1-microglobulin in Huntington's disease. Front Biosci (Elite Ed) 2012; 4:950-957.
2. Rosenblatt A, Kumar BV, Mo A, et al. Age, CAG repeat length, and clinical progression in
Huntington's disease. Mov Disord 2012; 27:272-276.
3. Hart E, Middelkoop H, Jurgens CK, Witjes-Ané MN, Roos RA. Seven-year clinical followup of premanifest carriers of Huntington's disease. PLoS Curr. 2011 Nov 30;3:RRN1288.
doi: 10.1371/currents.RRN1288.
4. Cubo E, González M, del Puerto I, de Yébenes JG, Arconada OF, Gabriel y Galán JM;
European Huntington's Disease Initiative Study Group Placebo effect characteristics
observed in a single, international, longitudinal study in Huntington's disease. Mov Disord.
2012 Mar;27(3):439-42. doi: 10.1002/mds.24062. Epub 2011 Dec 9.
5. Saft C, Andrich J, Fälker M, Gauda S, Küchler S, Woitalla D, Goetze O.No evidence of
impaired gastric emptying in early Huntington's Disease.PLoS Curr. 2011 Oct
25;3:RRN1284.
6. Vaccarino AL, Sills T, Anderson KE, Borowsky B, Craufurd D, Giuliano J, Goodman L,
Guttman M, Kupchak P, Ho AK, Paulsen JS, C Stout J, van Kammen DP, Evans K.
Assessment of Cognitive Symptoms in Prodromal and Early Huntington Disease. PLoS
Curr. 2011 Oct 25;3:RRN1250.
7. Hubers AA, Reedeker N, Giltay EJ, Roos RA, van Duijn E, van der Mast RC. Suicidality in
Huntington's disease. J Affect Disord. 2012 Feb;136(3):550-7. doi:
10.1016/j.jad.2011.10.031. Epub 2011 Nov 25.
8. Scahill RI, Hobbs NZ, Say MJ, Bechtel N, Henley SM, Hyare H, Langbehn DR, Jones R,
Leavitt BR, Roos RA, Durr A, Johnson H, Lehéricy S, Craufurd D, Kennard C, Hicks SL,
Stout JC, Reilmann R, Tabrizi SJ; the TRACK-HD investigators. Clinical impairment in
premanifest and early Huntington's disease is associated with regionally specific atrophy.
Hum Brain Mapp. 2011 Nov 18. doi: 10.1002/hbm.21449. [Epub ahead of print]
9. Meyer C, Landwehrmeyer B, Schwenke C, Doble A, Orth M, Ludolph AC; EHDI Study
Group. Rate of change in early Huntington's disease: a clinicometric analysis. Mov Disord.
2012 Jan;27(1):118-24. doi: 10.1002/mds.23847. Epub 2011 Nov 17.
10. Patel SS, Jankovic J, Hood AJ, Jeter CB, Sereno AB. Reflexive and volitional saccades:
biomarkers of Huntington disease severity and progression. J Neurol Sci. 2012 Feb
15;313(1-2):35-41. doi: 10.1016/j.jns.2011.09.035. Epub 2011 Oct 21.
11. Gatto E, Parisi V, Persi G, Converso DP, Etcheverry JL, Varela V, Alba L, Fretchel G.
Clinical and genetic characteristics in patients with Huntington's Disease from Argentina.
Parkinsonism Relat Disord. 2012 Feb;18(2):166-9. doi: 10.1016/j.parkreldis.2011.09.011.
Epub 2011 Oct 1.
12. Chen JJ, Salat DH, Rosas HD. Complex relationships between cerebral blood flow and
brain atrophy in early Huntington's disease. Neuroimage. 2012 Jan 16;59(2):1043-51. doi:
10.1016/j.neuroimage.2011.08.112. Epub 2011 Sep 16.
13. Seibert TM, Majid DS, Aron AR, Corey-Bloom J, Brewer JB. Stability of resting fMRI
interregional correlations analyzed in subject-native space: a one-year longitudinal study in
healthy adults and premanifest Huntington's disease. Neuroimage. 2012 Feb 1;59(3):245263. doi: 10.1016/j.neuroimage.2011.08.105. Epub 2011 Sep 10.
14. Vaccarino AL, Sills T, Anderson KE, Endicott J, Giuliano J, Guttman M, Ho AK, Kupchak
P, Paulsen JS, Warner JH, Williams J, Evans K. Assessment of Day-to-Day Functioning in
Prodromal and Early Huntington Disease. PLoS Curr. 2011 Sep 12;3:RRN1262.
15. Aylward EH, Liu D, Nopoulos PC, Ross CA, Pierson RK, Mills JA, Long JD, Paulsen JS;
PREDICT-HD Investigators and Coordinators of the Huntington Study Group.Striatal
volume contributes to the prediction of onset of Huntington disease in incident cases. Biol
Psychiatry. 2012 May 1;71(9):822-8.
16. Williams J, Downing N, Vaccarino AL, Guttman M, Paulsen JS. Self Reports of Day-toDay Function in a Small Cohort of People with Prodromal and Early HD. PLoS Curr. 2011
Aug 11;3:RRN1254. doi: 10.1371/currents.RRN1254.
17. Majerová V, Kalinčík T, Laczó J, Vyhnálek M, Hort J, Bojar M, Růžička E, Roth J.
Disturbance of real space navigation in moderately advanced but not in early Huntington's
disease. J Neurol Sci. 2012 Jan 15;312(1-2):86-91. doi: 10.1016/j.jns.2011.08.016. Epub
2011 Aug 27.
18. Zhang BR, Tian J, Yan YP, Yin XZ, Zhao GH, Wu ZY, Gu WH, Xia K, Tang BS. CCG
polymorphisms in the huntingtin gene have no effect on the pathogenesis of patients with
Huntington's disease in mainland Chinese families. J Neurol Sci. 2012 Jan 15;312(1-2):926. doi: 10.1016/j.jns.2011.08.015. Epub 2011 Aug 27.
19. Vaccarino AL, Anonymous, Anderson KE, Borowsky B, Coccaro E, Craufurd D, Endicott
J, Giuliano J, Groves M, Guttman M, Ho AK, Kupchak P, Paulsen JS, Stanford MS, van
Kammen DP, Watson D, Wu KD, Evans K. Assessing Behavioural Manifestations Prior to
Clinical Diagnosis of Huntington Disease: "Anger and Irritability" and "Obsessions and
Compulsions"PLoS Curr. 2011 Jul 11;3:RRN1241.
20. Wild E, Magnusson A, Lahiri N, Krus U, Orth M, Tabrizi SJ, Björkqvist M. Abnormal
peripheral chemokine profile in Huntington's disease. PLoS Curr. 2011 Apr 13;3:RRN1231.
doi: 10.1371/currents.RRN1231.
21. Ready RE, O'Rourke JJ, Paulsen JS. Quality of Life in Prodromal HD: Qualitative Analyses
of Discourse from Participants and Companions. Neurol Res Int. 2011;2011:958439. doi:
10.1155/2011/958439. Epub 2011 Jul 21.
22. Vaccarino AL, Sills T, Anderson KE, Biglan K, Borowsky B, Giuliano J, Guttman M, Ho
AK, Kennard C, Kupchak P, Landwehrmeyer GB, Michell A, Paulsen JS, Reilmann R, van
Kammen DP, Warner JH, Evans K. Assessment of motor symptoms and functional impact
in prodromal and early huntington disease. Version 2. PLoS Curr. 2011 Jun 14 [revised
2011 Jul 11];2:RRN1244.
23. Jurgens CK, van der Hiele K, Reijntjes RH, van de Wiel L, Witjes-Ané MN, van der Grond
J, Roos RA, Middelkoop HA, van Dijk JG. Basal ganglia volume is strongly related to P3
event-related potential in premanifest Huntington's disease. Eur J Neurol. 2011
Aug;18(8):1105-8. doi: 10.1111/j.1468-1331.2010.03309.x. Epub 2011 Jan 25.
24. Ho AK, Hocaoglu MB; European Huntington's Disease Network Quality of Life Working
Group. Impact of Huntington's across the entire disease spectrum: the phases and stages of
disease from the patient perspective. Clin Genet. 2011 Sep;80(3):235-9. doi:
10.1111/j.1399-0004.2011.01748.x. Epub 2011 Aug 4.
25. Vaccarino AL, Sills T, Anderson KE, Bachoud-Lévi AC, Borowsky B, Craufurd D, Duff K,
Giuliano J, Groves M, Guttman M, Kupchak P, Ho AK, Paulsen JS, Pedersen KF, van
Duijn E, van Kammen DP, Evans K. Assessment of Depression, Anxiety and Apathy in
Prodromal and Early Huntington Disease. PLoS Curr. 2011 Jun 17;3:RRN1242.
26. Kassubek J, Pinkhardt EH, Dietmaier A, Ludolph AC, Landwehrmeyer GB, Huppertz HJ.
Fully automated atlas-based MR imaging volumetry in Huntington disease, compared with
manual volumetry. AJNR Am J Neuroradiol. 2011 Aug;32(7):1328-32. doi:
10.3174/ajnr.A2514. Epub 2011 Jun 16.
27. Brožová H, Stochl J, Klempíř J, Kucharík M, Růžička E, Roth J. A sensitivity comparison
of clinical tests for postural instability in patients with Huntington's disease. Gait Posture.
2011 Jun;34(2):245-7. doi: 10.1016/j.gaitpost.2011.05.006. Epub 2011 Jun 8.
28. Henderson T, Georgiou-Karistianis N, White O, Millist L, Williams DR, Churchyard A,
Fielding J. Inhibitory control during smooth pursuit in Parkinson's disease and Huntington's
disease. Mov Disord. 2011 Aug 15;26(10):1893-9. doi: 10.1002/mds.23757. Epub 2011
May 31.
29. Rosas HD, Reuter M, Doros G, Lee SY, Triggs T, Malarick K, Fischl B, Salat DH, Hersch
SM. A tale of two factors: what determines the rate of progression in Huntington's disease?
A longitudinal MRI study. Mov Disord. 2011 Aug 1;26(9):1691-7. doi:
10.1002/mds.23762. Epub 2011 May 24.
30. Aylward E, Mills J, Liu D, Nopoulos P, Ross CA, Pierson R, Paulsen JS. Association
between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal
Huntington Disease. PLoS Curr. 2011 May 11;3:RRN1235. doi:
10.1371/currents.RRN1235.
31. Esmaeilzadeh M, Kullingsjö J, Ullman H, Varrone A, Tedroff J. Regional cerebral glucose
metabolism after pridopidine (ACR16) treatment in patients with Huntington disease. Clin
Neuropharmacol. 2011 May-Jun;34(3):95-100. doi: 10.1097/WNF.0b013e31821c31d8.
32. Wolf RC, Grön G, Sambataro F, Vasic N, Wolf ND, Thomann PA, Saft C, Landwehrmeyer
GB, Orth M. Magnetic resonance perfusion imaging of resting-state cerebral blood flow in
preclinical Huntington's disease. J Cereb Blood Flow Metab. 2011 Sep;31(9):1908-18. doi:
10.1038/jcbfm.2011.60. Epub 2011 May 11.
33. Hobbs NZ, Pedrick AV, Say MJ, Frost C, Dar Santos R, Coleman A, Sturrock A, Craufurd
D, Stout JC, Leavitt BR, Barnes J, Tabrizi SJ, Scahill RI. The structural involvement of the
cingulate cortex in premanifest and early Huntington's disease. Mov Disord. 2011 Aug
1;26(9):1684-90. doi: 10.1002/mds.23747. Epub 2011 May 6.
34. Rosenblatt A, Kumar BV, Margolis RL, Welsh CS, Ross CA. Factors contributing to
institutionalization in patients with Huntington's disease. Mov Disord. 2011 Aug
1;26(9):1711-6. doi: 10.1002/mds.23716. Epub 2011 Apr 29.
35. De Tommaso M, Serpino C, Difruscolo O, Cormio C, Sciruicchio V, Franco G, Farella I,
Livrea P. Nociceptive inputs transmission in Huntington's disease: a study by laser evoked
potentials. Acta Neurol Belg. 2011 Mar;111(1):33-40.
36. Gaughwin PM, Ciesla M, Lahiri N, Tabrizi SJ, Brundin P, Björkqvist M. Hsa-miR-34b is a
plasma-stable microRNA that is elevated in pre-manifest Huntington's disease. Hum Mol
Genet. 2011 Jun 1;20(11):2225-37. doi: 10.1093/hmg/ddr111. Epub 2011 Mar 19.
37. Vaccarino AL, Anderson K, Borowsky B, Duff K, Giuliano J, Guttman M, Ho AK, Orth M,
Paulsen JS, Sills T, van Kammen DP, Evans KR; PREDICT-HD and REGISTRY
Investigators Coordinators. An item response analysis of the motor and behavioral
subscales of the unified Huntington's disease rating scale in huntington disease gene
expansion carriers. Mov Disord. 2011 Apr;26(5):877-84. doi: 10.1002/mds.23574. Epub
2011 Mar 2.
38. Klempíř J, Zidovská J, Stochl J, Ing VK, Uhrová T, Roth J. The number of CAG repeats
within the normal allele does not influence the age of onset in Huntington's disease. Mov
Disord. 2011 Jan;26(1):125-9. doi: 10.1002/mds.23436. Epub 2010 Nov 10.
39. Lovrecic L, Slavkov I, Dzeroski S, Peterlin B. ADP-ribosylation factor guanine nucleotideexchange factor 2 (ARFGEF2): a new potential biomarker in Huntington's disease. J Int
Med Res. 2010 Sep-Oct;38(5):1653-62.
40. Dumas EM, van den Bogaard SJ, Ruber ME, Reilman RR, Stout JC, Craufurd D, Hicks SL,
Kennard C, Tabrizi SJ, van Buchem MA, van der Grond J, Roos RA. Early changes in
white matter pathways of the sensorimotor cortex in premanifest Huntington's disease. Hum
Brain Mapp. 2012 Jan;33(1):203-12. doi: 10.1002/hbm.21205. Epub 2011 Jan 24.
41. Panzera R, Salomonczyk D, Pirogovosky E, Simmons R, Goldstein J, Corey-Bloom J,
Gilbert PE. Postural deficits in Huntington's disease when performing motor skills involved
in daily living. Gait Posture. 2011 Mar;33(3):457-61. doi:10.1016/j.gaitpost.2010.12.025.
Epub 2011 Jan 20.
42. Politis M, Pavese N, Tai YF, Kiferle L, Mason SL, Brooks DJ, Tabrizi SJ, Barker RA,
Piccini P. Microglial activation in regions related to cognitive function predicts disease
onset in Huntington's disease: a multimodal imaging study. Hum Brain Mapp. 2011
Feb;32(2):258-70. doi: 10.1002/hbm.21008.
43. Tomasi G, Bertoldo A, Cobelli C, Pavese N, Tai YF, Hammers A, Turkheimer FE. Globaltwo-stage filtering of clinical PET parametric maps: application to [(11)C]-(R)-PK11195.
Neuroimage. 2011 Apr 1;55(3):942-53. doi: 10.1016/j.neuroimage.2010.12.056. Epub 2010
Dec 30.
44. Jesse S, Brettschneider J, Süssmuth SD, Landwehrmeyer BG, von Arnim CA, Ludolph AC,
Tumani H, Otto M. Summary of cerebrospinal fluid routine parameters in
neurodegenerative diseases. J Neurol. 2011 Jun;258(6):1034-41. doi: 10.1007/s00415-0105876-x. Epub 2010 Dec 25.
45. Bombard Y, Palin J, Friedman JM, Veenstra G, Creighton S, Paulsen JS, Bottorff JL,
Hayden MR; Canadian Respond-HD Collaborative Research Group. Factors associated
with experiences of genetic discrimination among individuals at risk for Huntington
disease. Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):19-27. doi:
10.1002/ajmg.b.31130. Epub 2010 Nov 10.
46. Panegyres PK, Goh JG. The neurology and natural history of patients with indeterminate
CAG repeat length mutations of the Huntington disease gene. J Neurol Sci. 2011 Feb
15;301(1-2):14-20. doi: 10.1016/j.jns.2010.11.015. Epub 2010 Dec 13.
47. Krogias C, Strassburger K, Eyding J, Gold R, Norra C, Juckel G, Saft C, Ninphius D.
Depression in patients with Huntington disease correlates with alterations of the brain stem
raphe depicted by transcranial sonography. J Psychiatry Neurosci. 2011 May;36(3):187-94.
doi: 10.1503/jpn.100067.
48. Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox
NC, Johnson H, Hicks SL, Kennard C, Craufurd D, Frost C, Langbehn DR, Reilmann R,
Stout JC; TRACK-HD Investigators. Biological and clinical changes in premanifest and
early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal
analysis. Lancet Neurol. 2011 Jan;10(1):31-42. doi: 10.1016/S1474-4422(10)70276-3.
Epub 2010 Dec 2.
49. Say MJ, Jones R, Scahill RI, Dumas EM, Coleman A, Santos RC, Justo D, Campbell JC,
Queller S, Shores EA, Tabrizi SJ, Stout JC; TRACK-HD Investigators. Visuomotor
integration deficits precede clinical onset in Huntington's disease. Neuropsychologia. 2011
Jan;49(2):264-70. doi: 10.1016/j.neuropsychologia.2010.11.016. Epub 2010 Nov 20.
50. Bombard Y, Palin J, Friedman JM, Veenstra G, Creighton S, Paulsen JS, Bottorff JL,
Hayden MR; Canadian Respond-HD Collaborative Research Group. Factors associated
with experiences of genetic discrimination among individuals at risk for Huntington
disease. Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):19-27. doi:
10.1002/ajmg.b.31130. Epub 2010 Nov 10.
51. Klempíř J, Zidovská J, Stochl J, Ing VK, Uhrová T, Roth J. The number of CAG repeats
within the normal allele does not influence the age of onset in Huntington's disease. Mov
Disord. 2011 Jan;26(1):125-9. doi: 10.1002/mds.23436. Epub 2010 Nov 10.
52. Bechtel N, Scahill RI, Rosas HD, Acharya T, van den Bogaard SJ, Jauffret C, Say MJ,
Sturrock A, Johnson H, Onorato CE, Salat DH, Durr A, Leavitt BR, Roos RA,
Landwehrmeyer GB, Langbehn DR, Stout JC, Tabrizi SJ, Reilmann R. Tapping linked to
function and structure in premanifest and symptomatic Huntington disease. Neurology.
2010 Dec 14;75(24):2150-60. doi: 10.1212/WNL.0b013e3182020123. Epub 2010 Nov 10.
53. Klein A, Sacrey LA, Dunnett SB, Whishaw IQ, Nikkhah G. Proximal movements
compensate for distal forelimb movement impairments in a reach-to-eat task in
Huntington's disease: new insights into motor impairments in a real-world skill. Neurobiol
Dis. 2011 Feb;41(2):560-9. doi: 10.1016/j.nbd.2010.11.002. Epub 2010 Nov 5.
54. Kloos AD, Kegelmeyer DA, Young GS, Kostyk SK. Fall risk assessment using the Tinetti
mobility test in individuals with Huntington's disease. Mov Disord. 2010 Dec
15;25(16):2838-44. doi: 10.1002/mds.23421.
55. Stout JC, Paulsen JS, Queller S, Solomon AC, Whitlock KB, Campbell JC, Carlozzi N,
Duff K, Beglinger LJ, Langbehn DR, Johnson SA, Biglan KM, Aylward EH.
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Jan;25(1):1-14. doi: 10.1037/a0020937.
56. Orth M, Handley OJ, Schwenke C, Dunnett SB, Craufurd D, Ho AK, Wild E, Tabrizi SJ,
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57. Aylward EH, Nopoulos PC, Ross CA, Langbehn DR, Pierson RK, Mills JA, Johnson HJ,
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58. Salvatore E, Rinaldi C, Tucci T, Di Maio L, Di Somma C, Savastano S, Lombardi G, Filla
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59. Jurgens CK, Jasinschi R, Ekin A, Witjes-Ané MN, Middelkoop H, van der Grond J, Roos
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60. Reilmann R, Bohlen S, Klopstock T, Bender A, Weindl A, Saemann P, Auer DP,
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61. Salomonczyk D, Panzera R, Pirogovosky E, Goldstein J, Corey-Bloom J, Simmons R,
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62. Ginestroni A, Battaglini M, Diciotti S, Della Nave R, Mazzoni LN, Tessa C, Giannelli M,
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demonstrates degeneration of the subcortical and cortical gray matter in Huntington disease.
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63. Goldberg A, Schepens SL, Feely SM, Garbern JY, Miller LJ, Siskind CE, Conti GE.
Deficits in stepping response time are associated with impairments in balance and mobility
in people with Huntington disease. J Neurol Sci. 2010 Nov 15;298(1-2):91-5. doi:
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64. Gamez J, Lorenzo-Bosquet C, Cuberas-Borrós G, Carmona F, Hernández-Vara J, Castilló J,
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65. Huntington Study Group DOMINO Investigators. A futility study of minocycline in
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