Medical University of Warsaw
2nd Faculty of Medicine - English Division
61 Żwirki i Wigury Street
02-091 Warsaw
Phone: + 48 (22) 5720 502
Fax:+48 (22) 5720 562
e-mail: english@wum.edu.pl
http: www.wum.edu.pl
2nd YEAR CURRICULUM
6-year program
2010/2011
BIOCHEMISTRY
Chair and Department of Biochemistry
Address: 1 Banacha Street, 02-097 Warsaw
Phone: 022 572 06 93
Head: Prof. Anna Barańczyk-Kuźma, MD, PhD.
Person responsible for teaching: Prof. Anna Barańczyk-Kuźma, MD, PhD.
Web site of Department of Biochemistry: http://biochemia.wum.edu.pl
Number of teaching hours: 210
Winter semester: total: 105h: lectures: 45 h, seminars: 20 h, lab. classes: 40 h
Spring semester: total: 105h: lectures: 38 h, seminars: 22 h, lab. classes: 45 h
Assessment of student performance:
On completion of the course students are expected to take the final examination (MCQ).
Aim of the course: knowledge of macromolecules structure, biosynthesis and degradation, regulation and
integration of metabolic pathways.
Winter semester
Topics of lectures:
Protein structure.
Enzymes, tissue oxidation, citric acid cycle.
DNA & RNA structure, DNA replication & mutation, Transcription, Protein biosynthesis, Regulation of
gene expression, viruses.
Carbohydrates metabolism, digestion.
Cell Structure & Energy Production; DNA & Protein Synthesis; Genetic Engineering - video films.
Topics of laboratory classes:
1. Proteins I
2. Proteins II
3. Enzymes I
4. Enzymes II
5. Nucleic acids I
6. Carbohydrates
7. Assessment test (proteins, enzymes, nucleic acids).
8. Assessment test (carbohydrates).
Topics of seminars
1. Proteins.
2. Enzymes.
3. Tissue oxidation, ATP biosynthes.
4. Nucleic acids, DNA replication & repair.
5. Transcription, translation.
6. Regulation of gene expression, viruses.
7. Metabolism of carbohydrates.
8. Metabolism of carbohydrates (cont.).
Spring semester
Topics of lectures
Lipids metabolism.
Protein turnover, amino acids metabolism, ammonia inactivation.
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Blood.
Metabolism in the kidney.
Metabolism in the liver.
Purine metabolism.
Pyrimidine metabolism.
Vitamins.
Hormones.
Regulation of metabolism.
Biotransformation.
Metabolism of ethanol.
Seminars:
1. Lipids I.
2. Lipids II.
3. Ureogenesis, amino acids metabolism.
4. Catabolism of amino acids.
5. Blood.
6. Vitamins.
7. Hormones.
8. Liver metabolism and biotransformation.
9. Consultation
Laboratory classes
1. Lipids
2. Assessment (lipids metabolism)
3. Digestive enzymes
4. Constituents of blood
5. Constituents of urine
6. Blood and urine nitrogen constituents
7. Assessment test (digestion, AAs, nucleotides, blood, hormones, vitamins, receptors, liver and kidney
metabolism, biotransformation)
8. Retakes of assessment tests.
9. Retake of all labs
Fianal retake of all tests at the end of IInd semester.
Basic textbooks:
1. R.K. Murray, D.K. Granner, P.A. Mayers, V.W. Rodwell, Harpers’ Biochemistry,
last edition, 1996, Appleton & Lange.
2. L. Stryer, Biochemistry, last edition, W.H. Freeman & Company, New York.
3. G. Meisenberg, W.H. Simmons, Principles of Medical Biochemistry, Elsevier, 2nd Edition
2006, (online access + interactive extras, studentconsult.com).
4. J.W. Baynes, M.H. Dominiczak, Medical Biochemistry, Elsevier, 3rd Edition 2009, (online
access + interactive extras, studentconsult.com).
5. P.C. Champe, R.A. Harvey, Lippincott’s Illustrated Reviews: Biochemistry, I.B. Lippincott
Company, Philadelphia.
Complementary textbooks:
T.M. Devlin, Textbook of Biochemistry with clinical correlations, Willey-Liss, Inc. last edition.
3
CYTOPHYSIOLOGY
Chair & Department of Histology and Embryology, Center for Biostructure Research
Address: 5 Chałubińskiego Street (Anatomicum Bldg.), 02-004 Warsaw
phone/fax: 022 629-52-82
Head: Prof. Jacek Malejczyk, MD, PhD
Curricular affairs: Prof. Jacek Malejczyk, MD, PhD – phone 022 629 5282, 022 622 0029.
Number of teaching hours:
lectures: 13 hrs
seminars: 12 hrs
practical classes: 24 hrs
Assessment of student performance:
On completion of the course students are expected to take written final examination (MCQ).
Aim of the course:
In the course of lectures, seminars and classes in Histology & Embryology students had obtained basic
information concerning structure and function of cells, tissues and organs. During seminars and classes in
cytophysiology we shall present complex processes involved in regulation of function of particular cells
and their populations. We shall particularly stress those processes occurring in cells and tissues, which
have direct relation to clinical problems and which are involved in pathogenesis of most important
diseases occurring in contemporary societies. Students will get acquainted with mechanisms governing
cell cycle and controlling cell proliferation as well as with results of their disturbances, frequently leading
to cancer development. We shall also present molecular mechanisms of apoptosis and importance of its
monitoring in therapy. Students will be taught how signals from the environment reach the cells and how
cells respond to them. Moreover, we shall present current views concerning cell ageing, its relation to
senescence of the whole organism and hypotheses explaining why neoplastic cells are immortal. To
facilitate understanding of methods used in recent years in research and in diagnostics we will demonstrate
basic histochemical and immunocytochemical procedures and examples of exfoliative cytology. Finally,
owing to the participation of the Department of Transplantology and Central Tissue Bank students will be
able to learn about techniques used for tissue preservation for transplantation and fate of such transplants
in an organism.
Recent years witness rapid development of molecular medicine and thus, the purpose of cytophysiology
teaching is to ensure that students are informed about its most important trends. To fulfil this goal
compendium containing latest data is provided.
The educational aim of the Department will be archived when students comprehend discussed
processes and understand their importance for the wellbeing of the patient. They should be able to link
acquired knowledge to pathogenesis of diseases and understand the principles of molecular tests used for
their diagnostics.
GENERAL REGULATIONS
 Students should read respective chapters in the textbook(s) before practical classes. Students have to
participate in discussion during practical classes and follow instructions of their professors. These
include inspection of histological slides or other materials provided as illustrations to given topic.
Class is dismissed when professor checked and approved the notes of students.
 No more than 3 absences are allowed during the course, irrespective of the cause (justified or
unjustified absence). Students who miss more than 3 classes will not get a credit and will not qualify
for the final examination.
 Students should be aware that coming more than 15 minutes late to the class is considered an absence.
 Final examination consists of 50 questions in MCQ format. Each question is scored 1 point. The
minimal score required to pass the exam is 30.
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 Final examination will be scheduled in January, the retake in February. The dates of these
examinations are appointed by the Dean’s Office and are not subjects of change.
Department’s policy regarding cheating on examinations
Cheating on examinations is unethical and violates University law. Individuals who actively or
passively participate in this activity will be removed from the examination and fail the exam.
Active cheating includes copying answers given by other students or using illegal notes or electronic
devices that can be used for of communication or data storage. In general no electronic devices are
allowed during examination in our Department.
Examples of passive cheating include giving answers to other students during test or facilitating the act
of cheating by other means (such as unjustified displaying of the answers to others). Therefore Students
should take all precautions to prevent an occurrence of such situation.
Chair of the Department obliges examiners and examinees to exercise this policy rigorously.
Lectures:
1. Cyto- & Histochemistry.
2. Cell & Tissue Culture. Cell Ageing.
3. Cell Membranes - Synaptic Transmission.
4. Cell Motility & Intracellular Movement.
5. Cellular Receptors & Signal Transduction.
6. Structure & Function of Cell Adhesion Molecules.
7. Cell Cycle.
8. Apoptosis.
9. Growth & Differentiation Factors
10. Differentiation of Cells.
11. Oncogenes & Antioncogenes.
12. Cell therapy
13. Tissue & Organ Conservation.
Seminars and practical classes:
1. DNA and chromosomes. DNA replication, repair and recombination.
2. From DNA to protein. Control of gene expression.
3. Membrane structure. Membrane transport.
4. Intracellular compartments and transport.
5. Cytoskeleton and cell movement.
6. Cell communication.
7. Cell cycle control and cell death. Cell division.
8. Cell aging.
9. Tissues and cancer.
10. How cells are studied.
11. Cell therapy.
12. Tissue banking.
13. Concluding remarks.
14. Final Examination.
15. Final Examination - retake.
Textbooks
1. 1.
B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts, K. J. D. Warson Essential Cell
Biology, Garland Publishing, New York, 3rd edition.
2. Kierszenbaum A: Histology and Cell Biology: An Introduction to Pathology, Elsevier 2nd edition
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IMMUNOLOGY
Department of Immunology, Center of Biostructure Research
The Medical University of Warsaw
Address: 1 Banacha Street., F Building, 02-097 Warsaw
Phone : 022 599 2199, fax : 022 599 2194, e-mail: immune@ib.amwaw.edu.pl
Head: Prof. Jakub Gołąb, MD, PhD
Curricular affairs: Prof. Jakub Gołąb, MD, PhD, Tomasz Stokłosa, MD, PhD
Number of teaching hours:
Lectures
20 hrs
Seminars
40 hrs
Assessment of student performance:
Colloquium after 8 seminars
On completion of the course students are expected to take a final MCQ test
The aim of the course:
The program offers the knowledge of the functions of the immune system in health and disease
Topics of lectures:
1. Introduction. The structure of antibodies. Monoclonal antibodies; 2. The human major
histocompatibility complex and its significance. Populations of lymphocytes; 3.Lymphocyte development;
4. Circulation of lymphocytes; 5.Components of innate immunity; 6.Cytokines and natural regulation of
immune response; 7.Cytotoxic T lymphocytes, K cells and NK cells; 8.Mucosa-associated lymphoid
tissue; 9. Materno-fetal immunologic relations; 10. Immunologic memory. Immunity to infection; 11.
Psychoneuroimmunology; 12. Transplantation immunology; 13. Mechanisms of type I hypersensitivity;
14. Basic immunopathology of allergic diseases; 15.Autoimmunity; 16. Tumor immunology; 17.Tumor
immunotherapy; 18.Immunology in modern diagnostics and research; 19. Gene therapy; 20. Acquired
Immunodeficiency Syndrome (AIDS)
Topics of seminars:
1.Introduction. The role of immune system. Components of immune system. Basic definitions.
Morphology of lymphoid organs; 2.The structure of antibodies, generation of diversity. Structure and
function of T cell receptor; 3. Monoclonal antibodies and their derivatives. Immunological tests and
techniques employing monoclonal antibodies. Monoclonal antibodies in therapy; 4.Major
histocompatibility complex. Antigen presentation and recognition; 5. Immune response, its induction and
development. Lymphocyte activation. Subpopulations of lymphocytes; 6.Cytokines – functions and
clinical applications. Regulation of immune response; 7. Effector mechanisms of the immune response.
Mechanisms of cytotoxicity; 8.Innate immunity; 9.Complement system. Phagocytic system. Interferons –
role and clinical applications; 10.Colloquium; 11. Immunity to infectious diseases. Principle mechanisms
of immune response to bacterial, viral and fungal infections. Vaccines – successful approaches and new
challenges.; 12. Transplantation immunology. Mechanisms of allogeneic transplant rejection, induction of
transplantation tolerance; 13. Hypersensitivity: types; atopic diseases – pathogenesis and current
treatment; immunotherapy; 14. Tolerance, autoimmunity; mechanisms preventing autoimmune response.
Prospects for specific therapies; 15.Introduction to tumor biology. Immunology and immunotherapy of
tumors; 16. Primary and secondary immunodeficiencies; prospects for treatment and prevention of AIDS.
Basic textbook:
“Immunology” (5th edition) by R.A. Goldsby, T.J. Kindt, B.A. Osborne, J. Kuby. Freeman & Co 2002,
New York
Supplementary textbook:
“Immunology” (6th edition) by I. Roitt, J. Brostoff, D. Male. Mosby 2001, London.
6
MEDICAL FIRST AID
Department of Anaesthesiology and Intensive Therapy
Address: 4 Lindleya Street, 02-005 Warsaw
Phone: 022 502 1721 fax: 022 502 2103; e-mail: katedra@anest.pl
Head: Prof. Bogumiła Wołoszczuk-Gębicka, MD, PhD
Curricular affairs: Marcin Rawicz, MD, PhD
Department of Paediatric Anaesthesia
Address: 24 Marszalkowska Street, 00-576 Warsaw
Phone: 022 629 9418 fax: 022 628 2988 e-mail: rawicz@supermedia.pl; mobile 0601 246 386
Lecturers:
Remigiusz Gelo, MD, Katarzyna Kierul, MD, Marcin Kołacz, MD, Teresa Korta MD, PhD, Dariusz
Koson, MD, PhD, Małgorzata Mikaszewska MD, PhD, Magdalena Mierzewska-Schmidt, MD,
Agata Paczkowska MD, PhD, Marcin Rawicz MD, PhD, Tomasz Siegel, MD, Ass. Prof. Bogumiła
Wołoszczuk-Gębicka, MD, PhD
Seminars and practical classes
Clinical Hospital and Trauma Centre, 4 Lindleya St, Department of Anaesthesiology and Intensive Care;
Central Clinical Hospital, 1a Banacha St, Department of Anaesthesiology and Intensive Care,
Department of Paediatric Anaesthesiology and Intensive Care, 24 Marszalkowska St, ICU 1st floor
Number of teaching hours:
Lectures:
14 hrs
Practical classes:
51 hrs
Assessment of student’s performance: pass/fail
The aim of the course:
To teach the basic life support and basics of first aid in common medical situations
Topics of lectures:
Ethical aspects of CPR and ECC
Adult Basic Life Support
Paediatric Basic Life Support
Life-threatening electrolyte disorders, intoxication
Hypothermia, drowning, near-drowning
Anaphylaxis, near-fatal asthmatic episodes, electric shock and lighting
Life-threatening conditions associated with pregnancy
Life-threatening conditions associated with trauma
Emergency Medical Services
Practical classes
Principles of resuscitation and first aid. Resuscitation equipment. Management of victims of common
traumatic accidents. Fractures. Burns. Near-drowning. Wounds. Electric shock. Hypothermia.
Intoxications. Common paediatric disorders.
Required textbooks
1. Krohmer J: American College of Emergency Physicians First Aid Manual, 2nd Edition, Dorling
Kindersley Publishing, 2004 (available at http://www.medbookstore.com)
2. International Guidelines 2005 for CPR and ECC - a consensus on science. European Resuscitation
Council (available at http://www.erc.edu)
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HUMAN PHYSIOLOGY
Department of Experimental and Clinical Physiology
Address: 3 Pawińskiego Street, 02-106 Warsaw
phone: 022 572 0708, fax: 022 8831352
Head: Prof Ewa Szczepańska – Sadowska, MD, PhD.
Curricular affairs: Ewa Koźniewska – Kołodziejska, MD, PhD, phone: 608 6489
Number of teaching hours: 200
Lectures - 75 hrs
Seminars - 75 hrs
Classes - 50 hrs
Assessment of student performance:
Students knowledge of physiology is assessed 4 times during the course in a form of MCQ. On
completion of the course students are expected to take a final MCQ examination.
Objectives of teaching:
The objective of teaching of general physiology is to acquaint the students with the mechanisms
responsible for normal function of the human body and give them the physiological basis for prophylaxis,
diagnosis, treatment and rehabilitation. During the course of clinical physiology the students will be
acquainted with adaptive capabilities of the healthy subjects and patients to various challenges of the
everyday life.
Program of teaching:
Topics of lectures:
1. Introduction to physiology. Principles of regulation of physiological processes at cellular, organ and
whole body level. Examples of transmission and transformation of biological signals. Basic
mechanisms of integration of physiological processes.
2. Structure and characteristics of the cell membrane. Dynamic ultrastructure of the cell membrane.
Mechanisms of action on the cell of biologically active substances. Membrane and intracellular
receptors. Molecular mechanisms of their activation. Regulation of receptors.
3. Systems of intracellular messengers. Impairment of function of receptors and intracellular transmitters
in pathological states.
4. Classification of ionic transport through the cell membrane. Regulation of active and passive transport
of ions. Genetic abnormalities of ion transport. Regulation and genetic abnormalities of the transport
of water, glucose and urea.
5. Resting potential of the cell membrane. Structure, classification and function of voltage - dependent
membrane ionic channels: sodium, calcium, potassium and chloride channels.
6. Generation and function of action potential in nerve cells, dendrites, axons, pacemaker cells, cardiac
and smooth muscle cells. Classification and mechanism of excitation of receptors for
neurotransmitters in the central and in the peripheral nervous system.
7. Definition of the neuronal reflex. Components of the neuronal reflex, function and mechanism of
excitation of sensory receptors. Classification and function of sensory and motor fibres. Mechanism of
transmission of the action potential.
8. Mechanisms of signal transmission through electrical and chemical synapses. Short- and long-term
regulation of the synaptic transmission.
9. Structure and function of the contractile system in the skeletal, cardiac and smooth muscles.
Electromechanical coupling in the skeletal and heart muscle. Mechanism of excitation and contraction
in the smooth muscle.
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10. Growth factors. Classification, mechanisms of action and interactions of growth factors. Regulatory
and pathogenic role of growth factors in the nervous system, cardiovascular system and bone tissue.
Antiproliferative factors.
11. Organisation of the autonomic nervous system. Synaptic transmission through the autonomic ganglia.
Transmitters, co-transmitters and neuromodulators in the autonomic nervous system. Specific
inhibitors of transmission in the autonomic nervous system.
12. Generation and conduction of excitation in the heart. Disturbances of impulse conduction in the heart.
Mechanism of cardiac arrhythmia.
13. Mechanics and hemodynamics of the heart. Regulation of rhythm and of force of contraction of the
heart. Work of the heart.
14. Principles of blood circulation in the cardiovascular system. Arterial blood pressure. Vascular
resistance. Autoregulation of the blood flow. Venous circulation. Regulation of the venous return.
15. Neural regulation of the cardiovascular system. Reflex regulation of the blood flow. Baro- and
chemoreflexes. Central mechanisms of regulation of blood pressure.
16. Regulation of secretion and action of eicosanoids and nitric oxide. Their role in regulation of function
of the cardiovascular, nervous and endocrine systems.
17. Regulation of volume and composition of body fluids by the kidney. Neural and hormonal regulation
of the kidney function.
18. Role of the renin-angiotensin-aldosterone system in regulation of water-electrolyte balance and
arterial blood pressure.
19. Regulation of secretion and mechanism of action of vasopressin. Role of vasopressin in regulation of
water balance and arterial blood pressure. Regulation of thirst. Hypo- and hyperosmolar states.
20. Regulation of secretion and mechanism of action of other hormones controlling water balance and
arterial blood pressure (atrial natriuretic peptides, endothelin, inhibitors of Na +-K+-ATP-ase,
adrenomedullin).
21. Hormonal regulation of calcium homeostasis. Parathyroid hormone, calcitonin and vitamin D.
Impairment of calcium homeostasis.
22. Integrated neurohormonal regulation of water-electrolyte balance. Neurohormonal mechanisms of
arterial hypertension.
23. Neural and chemical control of respiration. Integration of central control of circulatory and respiratory
system.
24. Hormonal regulation of reproduction. Regulation of secretion and mechanisms of action of sex
hormones in male and female. Function of hormones during pregnancy. Endocrinology of the fetus.
25. Adaptation to physical exercise in healthy subjects and in patients with metabolic, cardiovascular and
respiratory diseases.
26. Structure and function of the sensory systems with the special emphasis on the sensation of pain.
Somatic and visceral sensation.
27. Neurophysiology of the motor system. Spinal reflexes. Supraspinal regulation of the skeletal muscle
tension and movement. Role of the cerebellum, the basal ganglia and cerebral cortex in the control of
posture and locomotion.
28. Biological rhythms. Physiology of sleep and wakefulness. Physiology of the higher psychic functions.
Plasticity of the brain. Physiological correlates of the consciousness. Lateralization of the brain
function.
29. Learning and memory. Neurobiology of speech.
30. Homeostatic mechanisms in the central nervous system. Structure and function of the barrier systems
in the brain. Circulation of the cerebrospinal-fluid. Intracranial pressure. Regulation of the cell volume
in the brain.
31. Role of the nervous system in regulation of the hormonal function. Hypothalamic neurohormones and
their role in regulation of the endocrine function of adenohypophysis. Opioid peptides.
32. Hormonal regulation of growth and metabolism. Regulation of secretion and mechanism of action of
growth hormone. Disturbances of synthesis and of mechanism of action of growth hormone.
9
33. Synthesis, release and action of thyroid hormones. Interaction with other hormones. Disorders of
release of thyroid hormones.
34. Synthesis, release and action of corticotropin releasing factor, ACTH and glucocorticoids. Clinical
consequences of disorders of their secretion and action.
35. Pancreatic hormones. Regulation of secretion and mechanism of action of insulin, glucagon and
somatostatin. Disturbances of synthesis and of mechanism of action of insulin. Disturbances of the
body function during hypo- and hyperinsulinemia.
36. Integrated neurohormonal regulation of carbohydrate, lipid and protein metabolism. Disturbances of
energy balance. Obesity and malnutrition.
37. Physiological criteria of physical performance in health and disease. Work overload. Fatigue.
Negative results of inadequate physical activity.
Topics of seminars:
1. Physiology of blood I. Hemostasis and coagulation. Physiological basis of immune defence.
2. Physiology of blood II. Red blood cells. Hemoglobin. Types of anemias. Transport of gases in the
blood. Blood and acid-base balance.
3. Physiology of excitable cells I. Physiology of skeletal and smooth muscle fibers. Demonstration of
fatigue in human. Effect of underperfusion of skeletal muscles on fatigue. Characteristics of tonic
contraction. Single twitch, tetanic contractions. Electromiography.
4. Physiology of excitable cells II. Electrophysiology of periphral nervous fibers. Resting potential and
its dependence on the characteristics of cell membrane and ionic environment. mechanism of
generation and propagation of action potential in nerve fibers. Impairment during demielinization.
Transmission of signals through neuro-neronal and neuro-muscular synapse.
5. Physiology of the circulatory system I. Hemodynamics cycle of the heart. Heart sounds. Arterial
blood pressure. Vascular resistance.
6. Physiology of the circulatory system II. Spreading of the excitation in the heart. Electrocardiography.
Generation of ECoG waves. Non-invasive methods of examination of mechanical activity of the heart.
7. Physiology of the circulatory system III. Regulation of blood flow through the specific vascular
beds: coronary, cerebral, pulmonary and hepatic circulation.
8. Physiology of the circulatory system IV. Microcirculation. Regulation of blood flow in the
microcirculation. Effect of neurotransmitters of the autonomic nervous system, circulating hormones
and locally secreted factors. Characteristics of capillary endothelium in different vascular beds.
Filtration and reabsorption in capillaries. Types of edema. Functions of limphatics.
9. Physiology of the circulatory system V. Neural regulation of the cardiovascular system, orthostatic
reaction, diving test, Valsalva maneuver, examination in the hypobaric chamber.
10. Kidney physiology. Tubular transport. Mechanism of concentration and dilution of urine. Role of the
kidney in the regulation of arterial blood pressure. Participation of the kidney in the acid-base balance.
11. Physiology of the respiratory system I. Neural and chemical regulation of respiration. Peripheral
chemoreceptors. Chemosensitive areas of the brain. Diffusion capacity of the lung. Changes of the
pattern of respiration during sleep and with age.
12. Physiology of the respiratory system II. Biomechanics of respiratory system. Assessment of the
ventilatory efficiency of the respiratory system. Spirography. Assessment of airway resistance.
13. Physiology of the central nervous system I. Characteristics and function of receptors. Evoked
potentials in the sensory system. Vision and hearing. Organisation of visual and auditory pathways.
Disturbances of vision and hearing.
14. Physiology of the central nervous system II. Physiology of pain. Pain transmission and inhibition.
Disturbances of pain reception.
15. Physiology of the central nervous system III. Organisation and function of the reticular formation.
Sleep and wakefulness. Principles of electroencephalography.
16. Physiology of the central nervous system IV. Control of muscle tension, movements and posture.
Spinal reflexes. Assessment of spinal reflexes. \
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17. Physiology of the central nervous system V. Regulatory functions of the limbic system. Physiology of
drives and emotions. Physiological basis of sexual behaviour.
18. Physiology of the central nervous system VI. Conditioned reflexes. Learning and memory.
Assessment of attention and memory consolidation.
19. Physiology of the gastrointestinal tract. Gastrointestinal hormones. Regulation of diagestion and
absorption of food. Regulation of the gastric secretion. Functions of liver and pancreas.
20. Basal and resting metabolic rate. Energy balance of the organism. Nutrition and civilisation diseases.
21. Thermoregulation. Hypothermia, hyperthermia and fever.
Topics of practical classes:
1. Physiology of blood: Red blood cells. White blood cells. Hemostasis and coagulation.
2. Reflex regulation of the cardiovascular system: orthostatic reaction, diving test, Valsalva maneuver.
3. Principles of electrocardiography.
4. Assessment of the ventilatory efficiency of the respiratory system. Spirography. Assessment of airway
resistance.
5. Physiology of skeletal and smooth muscle fibers. Electromiography
6. Assessment of spinal reflexes, neurological examination of the motor system.
7. Characteristics and function of receptors. Evoked potentials in the sensory system. Vision and hearing.
8. Principles of electroencephalography.
9. Learning and memory. Assessment of attention and memory consolidation.
10. Basal and resting metabolic rate. Energy balance of the organism.
Basic textbooks:
1. Berne M., Levy M.N., Koeppchen B.M., Stanton B.A. Physiology, 5th edition, 2003, Mosby Co.
2. Guyton AC, Hall AC. Textbook of Medical Physiology, 11th edition, 2005, W.B. Saunder’s Co.,
Philadelphia.
Complementary textbooks:
1.
Kandel E, Schwartz JH, Jessell TM. Principles of Neural Science. 4th edition, 2000,
New York.
2.
Willmore JH , Costill DL. Physiology of Sport and Exercise, 1999, Human Kinetics.
11
Elsevier,
BIOPHYSICS
Department of Biophysics and Human Physiology
Address: 5 Chałubińskiego Street., 02-004 Warsaw
Phone/fax: 022 628 78 46
Head: Prof. Jacek Przybylski, MD, PhD, DSc.
Curricular affairs: Piotr Jeleń, MD, PhD, phone: 022 628 78 46
Number of teaching hours:
Lectures:
20 hrs
Seminars:
4 hrs
Practical classes:
36 hrs
Assessment of student performance:
On the completion of the course students are expected to take a final assessment test.
The aim of the course:
The course program offers to students the basic information concerning physical phenomena occurring in
living organisms and application of physics in medicine.
Topics of lectures:
1.
Basic features and parameters of flow: laminar and turbulent flows, velocity and pressure fields,
hydrostatic pressure.
2.
Flow phenomena in the main arterial trees and in microcirculation
3.
Electric potentials
4.
Electromagnetic fields
5.
Physical properties of biological membranes
6.
Characteristics of sound waves
7.
Ultraviolet and infrared radiation
8.
X-rays and gamma radiation
9.
Radiation protection.
10.
Environmental hazard for health
Topics of practical classes:
1. Muscle and joint biomechanice. 2. Acoustical measurements. 3. Physical basis of ultrasonography. 4.
Diffusion and electrodiffusion. 5. Spirometry. 6. Blood flow characteristics in arterie. 7. Physical basis
of ECG. 8. Lenses. Biophysics of Visio. 9. Assessment of X-radiation absorption
Basic textbooks:
1. P.Daviodovits, Physics in Biology and Medicine. Harcourt Academic Press, 2001
2. L.Berkes, et al., An Introduction to Biophysics with Medical Orientation, G.Ronto, I. Tarjan (Eds.),
Akademiai Kiado 1994
3. R.Glaser, Biophysics, Springer-Verlag 2005
Complementary textbooks:
1. Hobbie R.K., Roth B.J.: Intermediate Physics for Medicine & Biology (4-th ed.), Springer, 2007
2. Malmivuo J., Plonsey R.: Bioelectromagnetism, - Principles and Applications of Bioelectric and
Biomagnetic Fields. New York, Oxford University Press, 1995.
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MEDICAL BIOLOGY
Department of General Biology and Parasitology
Address: 5 Chałubińskiego Street, 02-004 Warsaw
Phone: 022 621 26 07; fax: 022 628 53 50; e-mail: mon.tu@gmx.net
Head: Prof. Barbara Grytner-Zięcina, MD, Ph.D.
Curricular affairs: Monika Dybicz, MD, PhD.
Number of teaching hours:
lectures
- 10 hours
seminars
- 30 hours
Assessment of student performance:
On completion of the course students are expected to take the test of 30 multiple choice questions.
The aim of course:
The aim is to acquaint the students with the principles of heredity, background of genetic diseases and
molecular methods used in diagnosis of human disorders.
Topics of lectures:
1. Organization of the human genome. Model organisms.
2. Principles and methods of DNA cloning. Reproductive and therapeutic cloning.
3. Plant transformation, its role in agriculture and safety of GMO.
4. Transgenic animals and their benefits to human health.
5. Gene therapy: therapeutic mechanisms and strategies.
Topics of seminars:
1. Classical genetics; Mendel’s laws and variations in Mendelian inheritance.
2. Unifactorial inheritance of autosomal traits (dominant and recessive normal traits and diseases).
Multifactorial inheritance (continuous and discontinuous traits).
3. Chromosome sex determination (normal sex determination and its disorders). Sex-linked inheritance
of dominant and recessive traits.
4. Inheritance of blood group systems. Hemoglobinopathies. Genetics of tissue compatibility systems.
5. Mechanisms of gene mutations. Somatic vs. germline mutations. Spontaneous and environmental
damage to DNA. Disorders of metabolism.
6. Chromosomal aberrations (numerical and structural abnormalities; syndromes induced by
chromosomal aberrations).
7. Cytogenetics. Banding techniques, normal and abnormal karyotype study. Molecular techniques
(FISH, chromosome painting etc.).
8. Molecular biology techniques as a tool for gene mutations identification. Southern blotting, PCR,
RFLP, sequencing. Forensic medicine and DNA fingerprinting.
9. Population genetics. Hardy-Weinberg equation. Principles of pedigree analysis.
10. Final assessment test.
Basic textbook:
1. Thompson & Thompson Genetics in Medicine Revised Reprint, 6th Edition. R. L. Nussbaum, R. R.
McInnes, H. F. Willard. W. B. Saunders Company, 2004;
2. Medical Genetics 3rd Edition. L.B. Jorde, J.C. Carey, M.J. Bamshad, R.L. White. Mosby, 2003.
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PHILOSOPHY
Department of Bioethics
Address: 81 Zwirki and Wigury Street, 02-091 Warsaw
phone/fax: 022 827 0307
Head: Alicja Domańska, MD, Ph.D.
Curricular Affairs: Paweł Łuków, MD, PhD.
Number of teaching hours:
30 hours of lecture
Assessment of student performance:
On completion of the course students are expected to take a written test.
Aim of the course:
To acquaint students with basic philosophical problems of knowledge. Special attention is paid to the
questions of scientific method, nature of truth, and the relationships between science, technology and
medicine. Against this theoretical background classical metaphysical theories are discussed.
Topics of lectures:
1. The subject matter and divisions of philosophy;
2. Theory and practice. The role of scientific knowledge in medicine;
3. A. J. Ayer and the problem of knowledge;
4. The social and historical aspects of science. T. Kuhn;
5. The nature and objectivity of sciences. P. Feyerabend;
6. Deduction and deductive systems;
7. J. S. Mill and induction. K. R. Popper’s theory of scientific discovery;
8. The classical interpretation of truth. B. Russell;
9. A. Tarski’s theory of truth. Coherence theory of truth;
10. C. S. Peirce and pragmatic theory of truth;
11.R. Descartes’ rationalism;
12. The mind-body problem;
13. Empiricisms of J. Locke and G. Berkeley;
14.Critical epistemology of I. Kant.
Basic textbook:
R. Scruton, Modern Philosophy. An Introduction and Survey, Mandarin 1996, chap. 1 sec. 2 & 3 (pp. 611); chap. 2 sec. 1 (pp. 16-17); chap. 3 (pp. 23-33); chap. 9, sec. 2-4 (pp. 99-108); chap. 17 (pp. 227-236);
chap. 20 (pp. 271-298); chap. 22 sec. 1-4 (pp. 317-232).
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POLISH LANGUAGE
The Language Centre
Address: 2A Trojdena Street, 02-109 Warsaw
Phone: 022 5720 863
Head: Joanna Ciecierska MA
Curricula affairs: Maria Janowska MA; Świetlana Sikorska. MA; Małgorzata Kierepka MA
Number of teaching hours:
The course covers 80 hours of classes:45 hours in autumn semester and 35 hours in spring
semester.
Assessment of student performance:
To obtain a credit after each semester a student has to attend classes regularly and pass all the assigned
written tests successfully. Please be informed, that according to the academic rules
students are obliged to take part in all the classes.Any absence will not be accepted except the
one for which he has the valid medical note.
Polish speaking students who want to be released from regular language classes will have to contact the
teacher, and if necessary, sit the evaluation test paper at the beginning of the academic year. They will be
obliged to keep improving their writing,reading,listening and speaking skills on their own. They will have
to sit the final credit test paper at the end of the winter term and at the end of the spring term..The
language materials for the exam will be available from the teacher.The student’s absence on the assigned
day of the test paper will result in not obtaining the credit. The student will be given a chance to sit a
retake paper twice,on the days set by the teacher.
The aim of the course
Second year students are expected to their skills in Polish Language, master basic medical terminology
and be able to communicate with the patient at the bedside(ask simple questions and give instructions).
Topics of classes:
1. Review of the basic language structures and vocabulary introduced during the first year of
studies.
2. Hospital vocabulary. Dative Case.
3. Medical specialities and specialists.
4. At the doctor’s surgery.(Giving information about health. Asking for assistance).
5. The human body: parts of the human body cavities and organs they contain systems and organs and the
most common diseases of the systems(signs, symptoms and diagnostic tests).
6. Examining an adult patient- doctor’s instructions. Proszę + Perfect and Imperfect Infinitives.
7. Examining a paediatric patient- doctor’s instructions to a child. Imperative Mood.
8. Basic bedside conversations:
-greeting a patient
- introducing oneself to a patient
-asking some general questions
-taking the patient’s history( short version)
- examining the patient:giving instructions and making comments.
Basic textbook:
Maria Janowska, Świetlana Sikorska “Proszę oddychać”part I
Complementary materials:
Handouts prepared by the teachers.
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SUMMER MEDICAL TRAINING PROGRAMME
Second year students are expected to have their summer training according to following rule:
a) a two-week nursing training in the outpatients’ department at a teaching hospital,
b) a two-week training in the diagnostic department.
The head of the department or an appointed supervisor assigns a detailed program of the training and
scheduled duties and also evaluates students’ performance.
Responsible for the appropriate course of the training is a fully qualified specialist in a particular medical,
laboratory or nursing area.
Students are expected to perform under supervision, all the nursing procedures typical of the outpatients’
departments and to be involved in carrying out examinations or investigations in particular diagnostic
laboratories and departments.
The ultimate goals of instruction provided in the outpatients’ department are:
1. to acquaint students with procedures concerning patients’ registration, types of records and filing
system used in the outpatients’ departments,
2. to provide information on rules of referring patients on sick leaves, releasing sickness certificates,
referrals to specialists, filling in particular forms and letters,
3. to teach the techniques of repairing surgical dressing materials and surgical instruments for
sterilization,
4. to acquaint students with the functioning of the treatment room, to teach them to give subcutaneous,
intracutaneous and intramuscular injections, to perform diagnostic tests and to interpret the results,
5. to teach the technique of application of plaster of Paris,
6. to teach the theory and, if possible, the practical application of the first aid in emergencies,
7. to prepare students to assist the physician in minor procedures,
8. to prepare students to assist the physician in examining outpatients and participating in home rounds.
The goals of instruction provided in the laboratory diagnostic departments are:
1. to widen the students’ knowledge of basic aspects of chemistry and practical skills gained in their first
and second year of study (e.g., preparation of basic fluids and reagents),
2. to demonstrate the system of providing laboratory and diagnostic services on an outpatient as well as
hospital basis including aspects of moral and legal responsibility,
3. to provide understanding of following safety precautions and work hygiene regarding the specific
work of laboratories,
4. to acquaint students with the range of investigations (analytical, chemical, biological, cytochemical,
haematologic,serologic, immunologic, bacteriologic, virologic, toxicologic routine examinations and
highly specific tests),
5. to emphasize the aspects of cooperation between the physician and laboratory (ordering
investigations, collections of specimens, registering and sending the results),
6. to perform simple laboratory procedures,
7. to participate in performing more complex investigations.
The goals of instruction the pathomorphological department are:
1. to demonstrate the system of providing diagnoctic techniques on an outpatient and
2. hospital basis including the aspects of moral and legal responsibility,
3. to deepen the understanding of following safety precautions and work hygiene associated with the
specific work of the laboratory
4. to emphasize the need for cooperation between the physician and pathomorphologist,
5. to acquaint students with diagnostic intravital techniques (intraoperative investigation, biopsy,
oligobiopsy, cytologic, histochemical,immunomorphologic and ultrastructural evaluation),
6. to invite students’ participation in performing intraoperative investigation,
7. to invite students to participate in the postmortem examination.
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The goals of instruction provided in the department of diagnostic imaging are:
1. to acquaint students with the system of employing this particular technique both on an outpatient and
hospital basis,
2. to emphasize the understanding of following safety precautions and work hygiene regarding the
specific aspects of the department,
3. to demonstrate the principles of protection of both the patient and the personnel during examination,
4. to emphasize the need for cooperation between the physician in charge of the patient and that from the
department,
5. to discuss and, possibly, to demonstrate the diagnostic techniques e.g., conventional radiology,
angiography, employingcontrast materials, dental radiology, endoscopy (ERCP),ultrasonography
(USG), computerized tomography (CAT), magnetic resonance imaging (MRI).
Throughout the course of the training students are expected to make records of their activities and
procedures performed. They are also assessed by the instructor in charge and are finally granted
their passing mark by the head of the department. Certificates written in English or translated
should be submitted to the Dean’s Office of the Medical University of Warsaw by October 5th of the
subsequent academic year.
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