Perception of Faces and Bodies Similar or Different? Virginia Slaughter,1 Valerie E. Stone,2 and Catherine Reed3 1Early Cognitive Development Unit and 2Cognitive Neuroscience, School of Psychology, University of Queensland, Brisbane, Australia, and 3Developmental Cognitive Neuroscience Program, Psychology Department, University of Denver ABSTRACT—Human faces and bodies are both complex and interesting perceptual objects, and both convey important social information. Given these similarities between faces and bodies, we can ask how similar are the visual processing mechanisms used to recognize them. It has long been argued that faces are subject to dedicated and unique perceptual processes, but until recently, relatively little research has focused on how we perceive the human body. Some recent paradigms indicate that faces and bodies are processed differently; others show similarities in face and body perception. These similarities and differences depend on the type of perceptual task and the level of processing involved. Future research should take these issues into account. KEYWORDS—object recognition; face perception; body schema; social information processing 1 Probably the most important and complex objects we perceive are other humans. From the time we are born, other humans capture our attention and elicit complex behaviors from us. We can identify other humans as humans because they possess both a human face and a human body. Further, we identify specific individuals not only on the basis of their unique faces and body shapes, but also on the basis of their characteristic expressions, postures, and movements. Given these functional similarities between faces and bodies, how similar are the visual processing mechanisms used to recognize them? FACES AS SPECIAL OBJECTS It has long been argued that the visual system uses special perceptual processing for faces that is different from the processing used for other objects. The rationale is that faces are such significant social stimuli that natural selection acted to create dedicated face-processing mechanisms in the brain. There is evidence consistent with the idea that faces are special: From early in development, infants are biased to look at faces more than other complex objects (Johnson & Morton, 1991). Also, adult perception of faces reveals unique effects, including the inversion effect (upside-down faces are more difficult to recognize than other complex inverted stimuli) and the caricature effect (a face with its distinctive features exaggerated is easier to 2 recognize than the original face). Event-related potential studies, which measure the timing of the brain’s electrical responses to stimuli, show that the brain responds differently to faces than to other objects within 170 ms after they are presented. Functional magnetic resonance imaging (fMRI) research, showing activity in the brain while participants are actively performing perceptual or cognitive tasks, further suggests that distinct brain areas respond to faces compared with other objects. However, not all researchers agree that these apparently facespecific phenomena genuinely reflect unique processing of faces. Some authors suggest that responses to faces are driven by the abstract perceptual features of faces, such as symmetry or high contrast, rather than their face-ness per se (Turati, Simion, Milani, & Umilta, 2002). Others argue that the apparently special processing faces receive simply reflects the ubiquity and importance of faces, and that the perceptual effects adults exhibit when viewing faces will be evident for any objects that they are highly practiced at perceiving (e.g., cars for car enthusiasts or dogs for dog breeders; Tanaka & Gauthier, 1997). These authors propose that visual expertise changes the way that objects are processed: Within a given domain, novices recognize objects by focusing on their distinctive parts, but experts rely on configural processing, focusing on the spatial relationships between parts. 3 The argument is that configural processing in general can explain perceptual effects that appear to distinguish faces. BODIES ARE SPECIAL, TOO Another class of objects that may be subject to special processing is human bodies. Although there has been relatively little research on perception of the human body compared with Address correspondence to Virginia Slaughter, School of Psychology, University of Queensland, Brisbane, 4072 Australia; e-mail: vps@ psy.uq.edu.au. CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE Volume 13—Number 6 Copyright r 2004 American Psychological Society 219 that of faces, several similarities between faces and bodies suggest that they may be processed similarly. First, bodies and faces share a number of abstract configural properties that may make the perceptual system treat them similarly. All faces share the same set of parts (eyes, nose, mouth, etc.), as do all bodies (arms, legs, torso, etc.). As a result, for both faces and bodies, perceptual distinctions depend on the exact shape and position of component parts. Also, from the front, both faces and bodies are symmetrical along the vertical axis. Further, the spatial relationships between parts of faces and between parts of bodies are relatively fixed. Across individuals, the configural arrangement of the eyes, nose, and mouth of the 4 face is relatively unchanging, as is the arrangement of the head, torso, and limbs. Second, faces and bodies are both salient conveyors of social information. Both provide information about other individuals’ attentional and emotional states, and inform basic social categorizations, including attributions of age, gender, and attractiveness. Faces and bodies are both used for communication. Finally, our embodied internal experience of both faces and bodies could distinguish them as special object classes. Our ability to move and functionally use our faces and bodies could influence the visual recognition of other faces and bodies. Recent neurophysiological studies with monkeys have revealed a class of mirror neurons, so called because the same neurons are active whether a given motor action is performed or observed. There is some indirect evidence that similar motor-mirroring structures exist in humans (see Gallese & Goldman, 1998, for a review), suggesting that visual and motor representations interact. The ability both to see faces and bodies and to move our own faces and bodies may make them similarly unique compared with other perceptual objects. Despite these arguments for special perceptual processing of bodies, there are also reasons to suppose that faces and bodies may be treated differently by the visual system. The nature of 5 the information conveyed by faces and bodies is arguably different. Faces, although often moving, are perceptually informative even while still. We can make judgments about another person’s gender, identity, emotion, attractiveness, and direction of attention (conveyed most saliently in eye gaze) from a still photograph of the face. Bodies, in contrast, are typically moving, and much of the information that bodies convey is in dynamic movement. We can identify another person’s gender, emotion, and direction of attention from that person’s body most easily if it is in motion. Thus, it remains an open question whether the visual system applies similar or different perceptual processes to faces and bodies. Insight into this question may be gained by considering two factors. First, the various ways that scientists measure face and body perception may place more or less difficult demands on the visual system. Second, patterns in the development of face perception and of body perception may give insight into how and when faces are treated similarly by the visual system. LEVELS OF PERCEPTUAL PROCESSING OF FACES AND BODIES Perception of faces or bodies is a multistage process. The extent to which faces and bodies are treated similarly by the perceptual system depends on the stage of processing, and thus the 6 type of perceptual task participants are asked to perform. It may be useful to distinguish two stages of perceptual processing and two types of perceptual tasks: detection versus recognition. Face or body detection refers to the ability to determine whether a particular stimulus is a face or a body rather than something else, and is an early stage of visual processing. Paradigms that compare participants’ responses to faces or bodies with their responses to other types of objects are measuring detection. Face or body recognition is a later stage of visual processing and involves making distinctions between individuals within a category. Recognition is often tested by asking participants to distinguish individual faces or bodies. Recognition processes are invoked not only for identifying individual persons, but also for identifying specific body postures (e.g., sitting vs. running) and specific facial expressions (e.g., happy vs. angry). Detection of Faces and Bodies Recent work has shown that the developmental time courses for detecting human faces and bodies are different. When young infants are presented with a typical human face image and a scrambled human face image in which the eyes, nose, and mouth are moved to noncanonical locations, they prefer to look at the typical face (Johnson & Morton, 1991). Thus, in this task, infants detect the presence of a face (as opposed to a scrambled 7 nonface). A recent study used a similar experimental procedure to investigate development of human body perception (Slaughter, Heron, & Sim, 2002). Infants between the ages of 12 and 18 months were shown typical and scrambled images of human bodies (see Fig. 1) as well as facelike stimuli, and their looking preferences were measured. The data indicated differences in the way infants responded to faces and bodies. Infants younger than 18 months of age did not show a preference for typical or scrambled body pictures, suggesting that they did not notice the differences between them, yet these young infants clearly preferred the typical face to the scrambled face. By 18 months of age, infants looked longer at the scrambled than at the typical body pictures, presumably because they found the scrambled images novel or surprising. These developmental data indicate that infants’ perceptual expectations about typical human faces develop much earlier than their expectations about human bodies. Adults also show a dissociation between face and body detection. In recent fMRI studies, distinct brain regions were activated when participants viewed pictures of faces, bodies, or body parts. Detection of faces consistently correlated with activation in the fusiform face area, located in the ventral temporal 220 Volume 13—Number 6 8 Face and Body Perception lobe (the underneath surface of the brain toward the back; Kanwisher, McDermott, & Chun, 1997). In contrast, the extrastriate body area, located in the lateral occipitotemporal cortex (the lower left or right outside surface of the brain toward the back), was active only when participants were shown images of the human body or body parts (Downing, Jiang, Shuman, & Kanwisher, 2001). The extrastriate body area does not respond to images of faces. Thus, both in infancy and in adulthood, there are demonstrated differences in basic perceptual detection of human faces and bodies. Recognition of Faces and Bodies In contrast to the data on detection, data on face and body recognition reveal some similarity in how adults process faces and bodies. Without explicit training, people should be experts at recognizing both individual faces and individual body postures, because of their ubiquity in everyday life. If perceptual expertise means that visual recognition relies on configural processing, then one would expect that both faces and bodies would be most easily recognized by the spatial arrangement of their component parts. The inversion effect, in which recognition of objects is disrupted by turning them upside down, is 9 traditionally considered an indicator of configural processing because inverting a familiar object makes it more difficult to recognize relations between the parts. The inversion effect has been demonstrated for faces and also for other objects when viewed by experts (e.g., dog breeders, car experts). A recent study (Reed, Stone, Bozova, & Tanaka, 2003) demonstrated that adults show similar inversion effects for faces and body postures: Both faces and bodies are more difficult to recognize when presented upside down than when presented right side up, but the same is not true of other complex stimuli, such as houses (see Fig. 2). It appears that both face and body-posture recognition depend on mentally representing the spatial configuration of stimulus parts. Despite this similarity in the recognition of faces and bodies, there are suggestions of differences in recognition processes as well. Evidence from neuropsychological patients indicates a dissociation between face and body recognition. In prosopagnosia, patients are unable to recognize individual faces—a recognition problem that can be independent from difficulties with recognition of other objects. This pattern of visual recognition problems suggests that these patients have damage to a specialized face-processing area in the brain. The disorder autotopagnosia (or somatotopagnosia) affects patients’ ability to 10 recognize, point to, or name specific body parts within the context of a whole body, although these patients have no difficulty naming parts of other complex objects (e.g., Ogden, 1985). Though each of these disorders is distinct from general object recognition problems, prosopagnosia and autotopagnosia do not typically occur together. The existence of these two distinct neuropsychological disorders, one affecting face recognition and the other body-part recognition, suggests that recognition of faces and recognition of bodies involve some distinct processes. CONCLUSIONS The studies reviewed here provide evidence for both similarities and differences in the way we perceive faces and bodies. Detection tasks have demonstrated mostly differences: developmental differences in responses to typical and scrambled faces versus bodies, and activation of different brain areas for face versus body processing in adults. Recognition tasks have shown similarity between perception of faces and perception of bodies, in the effects of expertise and inversion. But there are also some differences in face and body recognition: Prosopagnosia and autotopagnosia reveal independent deficits for recognition of faces and bodies and do not co-occur. 0 500 11 1000 1500 2000 2500 3000 3500 4000 4500 LOOKING TIMES LOOKING TIMES 12-month-olds 15-month-olds 18-month- olds 0 1000 2000 3000 4000 5000 6000 12-month-olds 15-month-olds 18-month-olds Fig. 1. Mean looking times (in milliseconds) to images of human bodies (top) and facelike stimuli (bottom) with typical (white bars) and scrambled (black bars) arrangements of parts. Results are presented separately for 12-, 15-, and 18-month-olds. From Slaughter, Heron, and Sim (2002). Volume 13—Number 6 221 12 Virginia Slaughter, Valerie E. Stone, and Catherine Reed This complex pattern may be explained in terms of the levels of processing involved. Detection tasks appear to tap into relatively basic visual categorization processes, possibly processes depending on simple spatial properties. Thus, the evidence from such tasks suggests the initial identification of faces and bodies as such occurs in distinct areas of the brain. Recognition tasks, in contrast, may recruit several different complex processes that analyze configural properties, identify individuals, and assign meaning. Some processing, such as the configural processing affected by expertise, may operate similarly for faces and bodies. Other recognition processing (e.g., how parts are represented relative to the whole or how the motion of parts is represented) may operate differently for faces and bodies. DIRECTIONS FOR FUTURE RESEARCH Understanding the extent to which faces and bodies are treated similarly in visual processing will require more work that explicitly contrasts responses to faces, bodies, and other complex objects. Furthermore, it will be important for such work to define carefully the level of processing being tested. Detection paradigms involve differentiating faces and bodies from other objects or scrambled stimuli. The developmental work to date has focused on body detection, but can be expanded to explore the 13 development of body recognition. At what stage of development would infants recognize individual, meaningful body postures? Recognition encompasses a variety of processes, depending on what about the face or body is being represented in the mind. Inversion and discrimination studies, for example, test whether participants are sensitive to relatively small changes in configuration, and performance in these studies thus may not depend on representing the whole object. Paradigms that test how well parts are recognized within the whole or individually (e.g., tests used with autotopagnosics) may tap into a different level of processing, at which the structure of the whole object and the relationship of parts to that whole are represented. Processing of bodies and processing of faces may therefore be similar in some recognition tasks, but different in others, depending on the level of processing involved. Detailed work testing recognition at Fig. 2. Examples of stimuli and results from a study on ability to recognize upright and inverted stimuli. On each trial, two stimuli, which could be either the same or different, were presented in either upright or inverted orientation. The task was to indicate whether the stimuli were identical. The graphs show the percentage of trials on which participants responded incorrectly. From Reed, Stone, Bozova, and Tanaka (2003). 222 Volume 13—Number 6 Face and Body Perception 14 different levels of processing can help clarify the levels at which bodies and faces share processing and mental representations and the levels at which they do not. Finally, further work on this topic should consider the importance of motion. The studies reviewed here all involved detection or recognition of static human faces and bodies. However, static and dynamic information are arguably weighted differently in face and body processing; as noted, static information is more meaningful in faces, whereas dynamic information is more crucial to body perception. For example, static images easily afford recognition of individual faces, but recognition of individual bodies probably has less to do with body shape than with characteristic motion patterns. Prosopagnosics report using motion patterns to recognize familiar people. Recent evidence suggests that facial information is processed by two distinct cognitive streams: a ventral stream (through the lower parts of the temporal lobes, corresponding to brain areas below the ears) that recognizes individuals by static features and a dorsal stream (through the upper parts of the parietal lobes, corresponding to brain areas above the ears) that processes dynamic information (O’Toole, Roark, & Abdi, 2002). Different brain areas are activated by static versus dynamic displays of facial expressions. The brain also responds differently 15 to displays of the biomechanical motion of human bodies than to static human bodies, but this may not be a dorsal-ventral differentiation (Vaina, Solomon, Chowdhury, Sinha, & Belliveau, 2001). Thus, perhaps one of the most important future directions for research in this area is the exploration of how visual processes involved in the perception of faces and bodies depend on dynamic information. Recommended Reading Bentin, S., Allison, T., Puce, A., Perez, E., & McCarthy, G. (1996). Electrophysiological studies of face perception in humans. Journal of Cognitive Neuroscience, 8, 551–565. Downing, P., Jiang, Y., Shuman, M., & Kanwisher, N. (2001). (See References) Kanwisher, N., & Moscovitch, M. (2000). The cognitive neuroscience of face processing: An introduction. Cognitive Neuropsychology, 17, 1–11. Reed, C.L., Stone, V.E., Bozova, S., & Tanaka, J. (2003). (See References) Slaughter, V., Heron, M., & Sim, S. (2002). (See References) Acknowledgments—We thank Derek Moore for his insightful comments on an early version of this article. REFERENCES Downing, P., Jiang, Y., Shuman, M., & Kanwisher, N. (2001). A cortical area selective for visual processing of the human body. Science, 16 293, 23–26. Gallese, V., & Goldman, A. (1998). Mirror neurons and the simulation theory of mind-reading. Trends in Cognitive Sciences, 2, 493–501. Johnson, M.H., & Morton, J. (1991). Biology and cognitive development: The case of face recognition. Oxford, England: Basil Blackwell. Kanwisher, N., McDermott, J., & Chun, M. (1997). The fusiform face area: A module in human extrastriate cortex specialized for face perception. The Journal of Neuroscience, 17, 4302–4311. Ogden, J. (1985). Autotopagnosia: Occurrence in a patient with nominal aphasia and with an intact ability to point to parts of animals and objects. Brain, 108, 1009–1022. O’Toole, A., Roark, D., & Abdi, H. (2002). Recognizing moving faces: A psychological and neural synthesis. Trends in Cognitive Sciences, 6, 261–266. Reed, C.L., Stone, V.E., Bozova, S., & Tanaka, J. (2003). The bodyinversion effect. Psychological Science, 14, 302–308. Slaughter, V., Heron, M., & Sim, S. (2002). Development of preferences for the human body shape in infancy. Cognition, 85(3), B71–B81. Tanaka, J., & Gauthier, I. (1997). Expertise in object and face recognition. In R. Goldstone, P. Schyns, & D. Medin (Eds.), Psychology of learning and motivation: Vol. 36. Perceptual mechanisms of learning (pp. 83–125). San Diego, CA: Academic 17 Press. Turati, C., Simion, F., Milani, I., & Umilta, C. (2002). Newborns’ preference for faces: What is crucial? Developmental Psychology, 38, 875–882. Vaina, L., Solomon, J., Chowdhury, S., Sinha, P., & Belliveau, W. (2001). Functional neuroanatomy of biological motion perception in humans. Proceedings of the National Academy of Sciences, USA, 98, 11656–11661. Volume 13—Number 6 223 Virginia Slaughter, Valerie E. Stone, and Catherine Reed 560 TINS Vol. 20, No. 12, 1997 Copyright © 1997, Elsevier Science Ltd. All rights reserved. 0166 - 2236/97/$17.00 PII: S0166-2236(97)01136-3 REVIEW THE CAPABILITY OF OUR BRAIN to represent the body and to entertain a model of human anatomy has probably a quite precocious if not downright innate origin. Hours or even minutes after delivery, neonates can imitate orofacial and head movements performed by adults in front of them1. To the extent that they identify a movement of a specific bodily part of the adult model, and then produce a similar movement in the corresponding part of their own anatomy, 18 babies must in some sense be cognisant of the general body structure. A neural basis for this deceptively simple visuomotor performance is probably constituted by neurones that become active either during the observation of a specific movement made by another individual, or during the performance of the same movement2. It is conceivable that primates are born equipped with this mechanism for the imitation of elementary actions, and that during maturation the mechanism undergoes a gradual refinement as a consequence of systematic interactions between tactile, proprioceptive and vestibular inputs, as well as between such inputs and the visual perception of the structure and movements of one’s own and other people’s bodies. The final result, a mental construct that comprises the sense impressions, perceptions and ideas about the dynamic organization of one’s own body and its relations to that of other bodies, is variously termed body schema, body image and corporeal awareness3. Somatosensory inputs to the brain, especially from proprioceptors, are no doubt essential for bodily awareness, as attested by enduring changes caused in it by short-lasting muscle vibration and 19 other somatic manipulations4; however, the importance of vision is attested by the anatomical distortions evident in the misshapen attempts of congenitally blind subjects at drawing or sculpting their own and other people’s bodies3. The finding that normally sighted adults are facilitated in the visual discrimination of postural changes in another person’s arms during movements of their own arms but not legs, and vice versa5, argues for the existence of at least partly common, mutually reinforcing mechanisms for the representation of corresponding parts of one’s own and other people’s bodies. Brain lesions affect the representation of the body Brain lesions can induce profound changes in the way the body is perceived and represented. In some cases such changes can be ascribed to a disorder of a specific cognitive domain, such as language or spatial attention. Disturbances of body awareness that are caused by lesions of the left posterior parietal lobe, such as autotopagnosia, finger agnosia and left–right disorientation, seem to depend on an altered conceptual, mainly linguistic representation of body parts6. Similarly, neglect of the left hemisoma that follows 20 right posterior parietal lesions usually occurs within the context of a general neglect of the left hemispace, and appears to depend on an impairment of spatial attention or space representation rather than on selective disruption of the body schema. Some disturbances, however, might reflect a specific alteration of the body schema or parts of it, as, for example, in those stroke patients who are anosognosic for their motor and sensory defects so as to deny that they are impaired at all7,8. When it occurs in the absence of extrapersonal neglect, personal neglect in the form of hemisomatoagnosia suggests a specific alteration in the body schema9. Feelings of non-belonging, denial of ownership of a body part and misoplegia (hatred of hemiparetic limbs) can occur following right brain damage10,11. The neglected or disowned body parts are expunged from the mental body representation, and the material existence of these parts is justified with confabulatory explanations12,13. Although anosognosia for hemiplegia and somatoparaphrenia have occasionally been observed after large left-hemisphere lesions14, they occur mostly following right-hemisphere The body in the brain: neural bases of 21 corporeal awareness Giovanni Berlucchi and Salvatore Aglioti Recent studies have begun to unravel the brain mechanisms that underlie the mental representation of the body. Imitation of movements by neonates suggests an implicit knowledge of the body structure that antedates the adult body schema.This can include inanimate objects that bear systematic relations to the body, as shown by the elimination from self awareness of a body part and its associated paraphernalia after selective brain lesions. Dynamic aspects of the body schema are revealed by spontaneous sensations from a lost body part as well as by orderly phantom sensations elicited by stimulation of body areas away from the amputation line and even by visual stimulation. The mechanisms of the body schema exhibit stability, since some brain regions seem permanently committed to representing the corresponding body parts in conscious awareness, and plasticity, since brain regions deprived of their natural inputs from a body part become reactive to inputs from other body parts. Trends Neurosci. (1997) 20, 560–564 22 Giovanni Berlucchi and Salvatore Aglioti are at the Dipartimento di Scienze Neurologiche e della VisioneSezione Fisiologia Umana, Strada Le Grazie, 8, Università di � 78 � Tokai J Exp Clin Med., Vol. 31, No. 2, pp. 78-82, 2006 INTRODUCTION Balint’s syndrome is clinically designated in a category containing three major signs: inability to scan the visual field in spite of normal eye-movement (fixed gaze or psychic paralysis), impaired simultaneous perception of more than one or a few objects (simultagnosia), and defection of visual guided reach (optic ataxia or misreaching). A defective estimation of distance is considered to be another major symptom [1]. The majority of patients with Balint’s syndrome do not show 23 all three of these major signs. Balint’s syndrome can be seen in a variety of clinical conditions, like Alzheimer’s disease, multiple strokes, traumatic brain injuries, tumors, HIV infections, etc. It is, however, rarely seen in a patient with a nondementing neurological disease [3]. Balint’s syndrome is commonly accompanied by various neuropsychological problems such as amnesia, apraxia, unilateral spatial neglect, aphasia, etc. [2]. They vary in degree depending on the lesions and frequently aggravate the patient’s handicap in their social life. The rehabilitative intervention for such cases, however, has not been fully discussed in literature. This case report represents the more than four-year clinical course of a patient with Balint’s syndrome and aphasia, but with well preserved attentional, intellectual and memory function. The authors discuss the effects and limitations of rehabilitative intervention on the impairment and disability, and also comment on the problems with the social and legal system in relation to the social participation of such a patient. Minoru TOYOKURA, Department of Rehabilitation Medicine, Tokai Universtiy Oiso Hospital, 21-1 Gakkyo, Oisomachi, Nakagun, Kanagawa 259-0198, 24 Japan�Tel: +81-463-72-3211�Fax: +81-463-72-2256�E-mail: toyokura@juno.dti.ne.jp A CASE REPORT A 43-year-old salesman in a company dealing in office equipment, with a history of cerebral infarction at the age of 9 was admitted to a hospital emergency room due to sudden unconsciousness on April 28, 2001. Although detailed information on the old apoplexy from his childhood was not obtainable, no clinical aftereffects remained and he had living a normal life without any difficulties. Neuroradiological examination revealed a fresh cerebral hemorrhage at the left temporal subcortical area. After surgical treatment, he was transferred to the authors� hospital for rehabilitative intervention on May 22, 2001. On admission he was alert and fully oriented, but showed a little difficulty with communication due to mild aphasia. The major signs and symptoms of his speech were frequent letter paraphasia, difficulty in word-finding, and disturbed repetition of letters as well as words and short sentences. Grammar and verbal comprehension were relatively preserved. The clinical diagnosis of the language disturbance was considered 25 to be conduction aphasia. A neurological examination also clarified that he showed no abnormality in the cranial nerves except the right hemianopsia. Gross motor palsy was not found. Superficial and deep sensation were mildly disturbed on the right side of his body. Tendon reflex was slightly increased on the right upper and lower extremities. Memory, intelligence, and attention were well preserved. Color identification and recognition of the faces of famous people were not impaired. There was no finding of apraxia, finger agnosia, autotopagnosia, Rehabilitative Intervention and Social Participation of a Case with Balint’s syndrome and aphasia Minoru TOYOKURA, Tomoharu KOIKE� Department of Rehabilitation Medicine, Tokai University Oiso Hospital and � Ohta-Atami General Hpospital (Received April 10, 2006; Accepted April 25, 2006) Balint’s syndrome is characterized by three major disorders of spatial analysis: fixed gaze or psychic paralysis, simultagnosia, and optic ataxia or misreaching. Most patients with Balint’s syndrome generally do not 26 show all three of these signs. The authors herein reported the more than four-year clinical course of a case (a 43-year-old man) with Balint’s syndrome presenting these three disorders. The patient also had a mild type of conduction aphasia, but his attentional, intellectual and memory functions were well preserved. SPECT showed cerebral hypoperfusion in the bilateral parieto-occipital areas. Whereas rehabilitative intervention with process specific approach for the impaired visual cognition seemed to be significantly ineffective, a functional adaptation approach successfully promoted the patient’s social participation. However, the present patient could not help having to resign from his job. Additionally, double impairment of visual (including optic ataxia) and language functions made it impossible for him to obtain a new work. Like the present case, those who have a higher brain dysfunction, but retain good physical ability can hardly receive the benefit of the social welfare system in Japan. Legislation addressing this problem is a matter of great urgency. Key words: Balint’s syndrome, aphasia, rehabilitation, participation M. TOYOKURA et al. /A case with Balint’s syndrome and aphasia � 79 � 27 The copying of objects was defective. He was able to draw simple figures but could not close the lines in the figure. He could not locate a point in the center of a circle. His reading ability was moderately disturbed. One reason for this dyslexia may be aphasia, but the main reason was his inability to properly trace the next line or paragraph, which lead to skipping whole lines due to impaired visual cognition. The abnormal findings above were thought to be compatible with a typical form of Balint’s syndrome with three major spatial disorders of misreaching, ocular apraxia, and simultagnosia. Because of his visual and language dysfunctions, he could not undergo standard neuropsychological tests such as WAIS-R and WMS-R. Laboratory data showed no abnormalities except for mild hyperlipidemia (total cholesterol, 230 mg/dl). Antinuclear antibodies were negative. The T2-weighted MR images showed subcortical high-signal-areas in the right parieto-occipital and left temporo-parietal regions. The left one was considered a new lesion (Fig. 1). Bilateral hypo-perfusion of the parieto-occipital areas together with the left temporal 28 lobe was detected in SPECT (Fig. 2). right-left agnosia, or unilateral spatial neglect. He, however, was unable to reach target objects with either hand. Although the ADL (activities of daily living) was almost independent, he showed some difficulties in visually-guided performances (such as picking up small foods, inserting coins into vending machines, dialing the telephone, etc.) because of this misreaching. He could not scan moving objects. Saccades and pursuit eye movements under verbal command were also impaired. The patient often reported a great deal of difficulty in visually perceiving more than one object at a time and said that objects in the visual field disappeared when he put his visual attention toward other things. He showed difficulties in fixing on a target object that was not placed within his central vision. These were considered to be typical signs and symptoms of simultagnosia. He was not able to count dots, nor compare the size and length of two or more objects. Perspective was lost, as well. Thus he walked like a blind man with his hands stretched out in front. He showed great difficulties with walking in the darkness, walking on a 29 road covered with snow, and climbing and descending stairs. Fig. 1 MR images (6/2001). There are subcortical high-signal-areas in the right parieto-occipital and left temporo-parietal areas. Fig. 2 SPECT (6/2001). Bilateral hypo-perfusion of the parieto-occipital and left temporal regions is found. M. TOYOKURA et al. /A case with Balint’s syndrome and aphasia � 80 � The rehabilitative intervention and clinical course The patient was treated with rehabilitation programs using visuoperceptual retraining and a functional adaptation program in divisions of occupational therapy and of clinical neuropsychology. For visuoperceptual retraining, the patient was required to find target objects in a scene painting or photograph in order to improve visual scanning. For treating simultagnosia, we developed a program in which the patient should compare attributes (i.e. size, shape, length, etc.) among two or more objects. A dot-counting task was also administered. Visually guided hand performance (picking 30 up small things, inserting a stick into a hole, etc.) was trained to lessen misreaching. In contrast to the visuoperceptual retraining above, which aim to restore the basic functions of visual cognition, the purpose of the functional adaptation program is to facilitate restoration of functional behaviors in the patient’s real world. He was instructed to repeatedly practice several social and housekeeping activities in a safe way and place. The tasks included going for frequent strolls (around his neighborhood at first), commuting to the hospital alone using the hospital’s shuttle bus (he was not able to use public transportation), washing dishes, cleaning the house, mopping the floor, etc.A fter his leaving the hospital and returning home on September 30, 2001, we continued these programs in the outpatient clinic twice a week. During and after an 18-month training period, his visual cognition and hand performance under visual guidance were reevaluated using the Visual Perception Test for Agnosia (VPTA) (Shinko Igaku Shuppann, Co., 1997) and Simple Test for Evaluating Hand Function (STEF) (Sakai Iryo, Co., 1985), respectively. The VPTA has been established by the Japan Society for Higher Brain 31 Dysfunction as a Japanese standard test for examining the impairment of visual cognition. The STEF is a standardized test for upper-extremity functions, in which time required for completing a manual task is measured (Fig. 3). Table 1 shows the changes in the subtests of the VPTA and total score of the STEF. Although his hand performance seemed to slightly improve, his visual cognitive function was almost unchanged. The Fig. 3 A subtest of STEF. The subject is required, as fast as possible, to pick up balls one by one from a right side storage space with the right hand and put them in a space on the left side (five balls in all). The completion time is measured. Both hands are evaluated separately. STEF consists of ten subtests using ten objects of different size and shape. The completion time of each subtest is rated on a scale from 1 (the slowest) to 10 (the quickest). The sum of each score (ranging from 10, the poorest to 100, the best) indicates the functional ability of the hand. period for the rehabilitative intervention Month / year VPTA & STEF 7/01 3/02 8/02 1/03 7/03 1/04 32 VPTA discrimination (length) 0 0 0 0 0 0 discrimination (shape) 17 50 67 50 67 50 counting dots 0 0 0 0 0 0 naming object 100 100 100 100 100 100 recognizing photos of famous people’s faces 100 100 100 100 100 100 naming colors 100 100 100 100 100 100 copying figures 0 0 0 0 33 0 STEF (rt./lt. hands) (/100) 38/49 33/51 54/72 69/70 Visually cognitive function evaluated by VPTA is shown to be almost unchanged throughout the time course. In STEF, hand function slightly improved although the best performance is still far below a normally functional level. �1, The cut-off score for the patient’s age is 96. Table 1 Changes in the performance of VPTA and STEF VPTA: corrrect answer (%), STEF: total score of ten subtests�1 M. TOYOKURA et al. /A case with Balint’s syndrome and aphasia � 81 � paraphasia, word-finding difficulty, and dyslexia were 33 still present, which resulted in only a minor improvement in the communication ability. Table 2 shows the change in his functional behaviors and community independence between two occasions, at discharge (September, 2001) and at the present time, December, 2005. His repertoire of functional behaviors were expanded and he was able to do housekeeping work more quickly and precisely. Thus, social participation and QOL significantly improved. The patient, however, was ultimately forced to resign from his job, and was unable to obtain new work because of the double impairments of visual (including optic ataxia) and language functions. Thus, his financial problems resulting from his loss of income, should be addressed using the economical support establishment of the social welfare system. Because of his preserved motor function, however, he could not obtain a physically disabled persons� certificate or pension. The authors, therefore, applied those reserved for mentally disabled persons. The medical certificate application was initially rejected, but after repeatedly insisting on the legitimacy of the application to the local health center, he was finally able to obtain the mentally disabled 34 persons� pension and reduce his financial burden. DISCUSSION The present case shows Balint’s syndrome in a relatively pure form. Aside from the aphasia, no neuropsychological problems accompanied it. His intellectual and memory functions were well preserved. The brain damage to the parieto-occipital area has been pointed out as the critical locus of the lesion for Balint’s syndrome [1]. Diffuse lesions in both hemispheres due to cerebral anoxia, encephalitis, trauma, and degenerative diseases may also cause this syndrome [3]. In the present case, the recurrence of cerebrovascular accidents produced Balint’s syndrome and aphasia. Although the lesions detected in MR imaging were located in subcortical areas, SPECT showed decreased cortical blood flow in bilateral parieto-occipital regions. No effective and specific intervention of cognitive rehabilitation for Balint’s syndrome has yet been established [3]. Sohlberg [6] described three forms of cognitive rehabilitation: the functional adaptation approach (FAA), general stimulating approach (GSA), and process specific approach (PSA). FAA promotes functional performance in a certain living or work 35 environment. This includes the development of environmental manipulation or a compensatory strategy. In this form of approach, neurological impairment itself is not expected to improve. GSA generally uses nonspecific, intellectual tasks such as games or puzzles. It can be easily conducted in any treatment environment. The basic underlying theoretical orientation, however, is not clear. In addition, functional ability to practice realworldbehaviors sometimes fails to improve. In contrast, the purpose of PSA is to restore particular function in one particular cognitive area. Although the positive impact of the treatment is limited to that specific cognitive area, one can expect a secondary improvement of functional performance that has been impaired by the cognitive dysfunction (i.e., little generalizations). For example, improvement of an attentional deficit (specific cognitive dysfunction) can also produce better performance in cooking that had been difficult because of the attention disturbance. For the present case, the authors practiced both FAA and PSA (visuoperceptual retraining). Even after the 18 months of treatment, visual cognition did not significantly improve. However, through repetitive practice in 36 the community he has been expanding his repertoire of functional behaviours in his social life. During the treatment he increased his self-confidence, self-esteem and ability to cope with his disability. These effects seemed to have considerably improved his QOL. Well preserved intellectual and memory functions may have a positive effect on the learning process. Perez et al. [4] have reported three cases of Balint’s syndrome and the individualized rehabilitation approaches of multicontext treatment with intensive verbal cuing and organizational strategies. These patients, however, initially identified objects correctly only 20 to 75% of the time. This finding suggests a coexistence month / year 9/01 12/05 �coming to the hospital alone�1 impossible possible �housework�2 possible but taking time more quickly �using a push-button phone impossible somehow possible �walking around the neighborhood slowly and carefully much faster �area for daytime walking only neighborhood expanded area �walking at night with difficulty with difficulty �riding a bicycle impossible impossible �driving a car impossible impossible 37 �shopping impossible possible �work suspended retired �mentally disabled person’s certificate not received received �disabled person’s pension not received received �1, using the hospital’s shuttle bus �2, washing dishes, cleaning the house, sweeping and mopping the floor, etc. Table 2 Changes in functional behaviors and community indepedence M. TOYOKURA et al. /A case with Balint’s syndrome and aphasia � 82 � of visual agnosia that is sometimes accompanied by Balint’s syndrome. Although the response accuracy rose to 80 to 95% after 6 to 12 months of rehabilitation, the change possibly resulted from the improvement of visual agnosia rather than impaired visual cognition by Balint’s syndrome. Thus, if the patients had not had visual agnosia like our patient, the rehabilitation program could not have produced a significant improvement. In this sense it seems acceptable that rehabilitation produced little effect on visual function in our patient. Rosselli et al. [5] also reported the effects of a neuropsychological treatment on a patient with a fat embolism following a serious traffic accident. The patient 38 showed Balint’s syndrome in addition to alexia without agraphia, visual agnosia, prosopagnosia, or memory impairment. Rehabilitative intervention commenced one year after the onset. The treatment protocol was based on PSA and attempted to specifically retrain the impaired visual spatial function. FAA was also developed to improve the adaptive skills of ADL in everyday life. One year after the treatments, he showed an improvement in community independence and was finally able to return to his former job. A significant improvement was also shown in several neuropsychological tests that were sensitive to visual scanning deficits and simultagnosia. Although this may indicate functional recovery of visual impairment, the test-retest learning effects of the tasks cannot be denied because the tasks were also used for the rehabilitation. The report suggests that a productive life can be attained by a rehabilitative approach even after the period in which the majority of spontaneous recovery is likely to occur. The accumulation of newly learned functional behaviors in a patient’s social life with FAA can persist for quite a long period. In this sense FAA is very valuable for improving QOL. 39 FAA, however, has some disadvantages or limitations. Depending on the behaviors, it takes a long time to establish community independence. Focusing on the practical adaptation of specific behaviors, FAA shows a restricted generalizability. The present patient could not avoid resigning from his job. In April this year the law for employment promotion of persons with disabilities is revised. The new law gives a wider opportunity for disabled people who have a mentally disabled persons� certificate to get a job. The authors consider that the revision is appropriate and expect the good results in the Japanese welfare situation for the disabled. Unfortunately the double impairment of visual (including optic ataxia) and language was so severe that he could not receive the benefit from the revised law. From the view-point of rehabilitation medicine, social participation is the most important of concerns. In this sense, this patient, despite loosing his job, could acquire various social skills by rehabilitative intervention. Loss of income is a critical financial problem that should be worked out. For those without psychiatric disease, and with good motor function, official 40 compensation for their financial problems had been hardly obtainable in Japan even if they had great difficulties in their social life because of the higher brain dysfunction, like our patient. Recently, however, the law concerning mental health and welfare for the mentally disabled has been revised and these patients mentioned above have become to be able to apply for a mentally disabled persons� certificate and pension. The present patient finally acquired the qualification for the pension. Although the situation has been somewhat improved, it seems still strange that a patient without any lunacy has a mentally disabled certificate. Legal welfare system specialized for such patient that suffers higher brain dysfunction but no physical and mental disabilities has not yet been established in Japan. Legislation against this problem is a political matter of great urgency. REFERENCES 1) De Renzi E: Disorders of spatial orientation. In: Handbook of Clinical Neurology. vol. 1 (45) (ed, Frederiks JAM), Elsevier Science Publishers, Amsterdam, 1985: 405-422. 2) Hecan H, De Ajuriaguerra J: Balint’s syndrome (psychic paralysis of visual fixation and its minor forms). Brain 1954; 77: 373-400. 41 3) Kerkhoff G: Neurovisual rehabilitation: recent developments and future directions. J Neurol Neurosurg Psychiatry 2000; 68: 691-706. 4) Perez FM, Tunkel RS, Lachmann E A, Nagler W: Balint’s syndrome arising from bilateral posterior cortical atrophy or infarction: rehabilitation strategies and their limitaion. Disability Rehabil 1996; 18: 300-6. 5) Rosselli M, Ardila A, Beltran C: Rehabilitation of Balint� s syndrome: A single case report. Appl Neuropsychol 2001; 8: 242-7. 6) Sohlberg MM, Matter CA: Attention Process Training. Association for Neuropsychological Research and Development, Washington DC, 1986. 42