Genome-Wide Study of Age-related Macular Degeneration (AMD)
in the Personalized Medicine Research Project
Below is a flowchart and pseudo code used to select Marshfield’s Age-related Macular Degeneration
(AMD) cohort. Pseudo code can be found on the following pages. Included is information specific to
each reference identified within the applicable flowchart symbols.
If you have questions regarding any of the information presented on this page, you may contact
either:
Peggy Peissig at peissig.peggy@marshfieldclinic.org or call: 715.221.9880
James Linneman at linneman.james@marshfieldclinic.org or call 715.221.7271
FLOWCHART of AMD Phenotyping Process
AMD case
(1) PMRP
(2) AMD Dx
Yes
(3) Within
ophthalmology
Yes
(4) 2 or more
diagnoses
Yes
(5) Dx >=
14 days apart
Yes
Yes
(7) Within
ophthalmology
Yes
(8) 2 or more
diagnoses
Yes
(9) Dx >=
14 days apart
Yes
AMD Case
Drusen case
(1) PMRP
(6) Drusen Dx
Control
(1) PMRP
(10) AMD/
Drusen Dx
Yes
No
(11) Exclusion
Dx
Yes
No
(12) Eye exam
Last 2 years
No
Yes
(13) Age 50 +
at last eye
exam
No
Yes
(14) 1+ Comp
eye exam
(ever)
No
Yes
Control
1
Exclude
Drusen Case
Pseudo code for the “AMD” Phenotype
ID
Step
Description
1
a
-Select all subjects from the PMRP cohort who have:
 Consented
 Did not withdraw from the study
 Include subjects with contact_for_research = ‘N’
 Include subjects where questionnaires have been scanned.
2
a
-Select subjects with the following diagnoses codes:
-Use diagnoses from 1979 to present.
Diagnoses of any AMD
'ICD 9' - BETWEEN '362.50' AND '362.52'
3
a
-Select from subjects having AMD ICD9 codes given by
ophthalmologist/optometrist within ophthalmology/optometry department(s).
4
a
-Select subjects having two or more AMD diagnoses (see 2a above); within
ophthalmology/optometry (see 3a above).
5
a
-Select subjects having two or more AMD diagnoses (see 2a above) within
ophthalmology/optometry (see 3a above), where the earliest and most recent
diagnosis are at least fourteen days apart.
6
a
-Select subjects (see step 1a above) with the following diagnoses codes:
-Use diagnoses from 1979 to present.
Diagnoses of any Drusen
'ICD 9' - BETWEEN '362.57' AND '362.57'
7
a
-Select from subjects having Drusen ICD9 codes given by
ophthalmologist/optometrist within ophthalmology/optometry department(s).
8
a
-Select subjects having two or more Drusen diagnoses (see 6a above); within
ophthalmology/optometry (see 7a above).
9
a
-Select subjects having two or more Drusen diagnoses (see 6a above) within
ophthalmology/optometry (see 7a above), where the earliest and most recent
diagnosis are at least fourteen days apart.
10
a
-Select from subjects (see step 1a above) having no AMD diagnoses (see step 2a
above) and having no Drusen diagnoses (see step 6a above).
11
a
-Select subjects (see step 10a above) having none of the following diagnoses codes:
-Use diagnoses from 1979 to present.
Diagnoses of any Retinopathy/Diabetic Retinopathy
'ICD 9' IN('362.11','363.31','362.20','364.89','362.30','362.01','362.02','362.03',
'362.04','362.05','362.06','362.07','362.10','250.50','250.51','250.52','250.53')
2
Pseudo code for the “AMD” Phenotype
ID
Step
Description
12
a
-Select from subjects (see step 11a above) having at least one eye exam within the
last two years if living or the last two years prior to date of death if deceased, using
CPT codes: 92002, 92004, 92012, 92014, 92018, 92019,
or 99201, 99202, 99203, 99204, 99205, 99211, 99212, 99213, 99214, 99215,
99241, 99242, 99243, 99244, 99245 where provider specialty is Ophthalmology or
Optometry.
13
a
-Select from subjects age 50 years or older at most recent eye exam (within last two
years).
14
a
-Select from subjects having one or more comprehensive type eye exams (ever)
using CPT codes: 92004, 92014,
or 99204, 99205, 99214, 99215, 99244, 99245 where provider specialty is
Ophthalmology or Optometry.
Last updated: May 1, 2012
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