Online Appendix for the following JACC article
TITLE: Incidence of Heart Failure or Cardiomyopathy After Adjuvant Trastuzumab Therapy for Breast Cancer
AUTHORS: Jersey Chen, MD, MPH, Jessica B. Long, MPH, Arti Hurria, MD, Cynthia Owusu, MD, MS, Richard M. Steingart, MD, Cary P. Gross,
MD
APPENDIX
Breast Tumor Histology Consistent with Epithelial
Origin
Breast Conserving Surgery
Breast Cancer
Surgery
Modified Radical Mastectomy
Trastuzumab
Anthracycline
Adjuvant Therapy
Other, Non-Anthracycline
Chemotherapy
Coronary Artery Disease
Cardiovascular
Conditions
Ischemic Stroke
Transient Ischemic Attack
Hypertension
Renal Failure
ICD-0-3 Histology: 8000, 8001, 8010, 8140, 8211, 8230, 8255, 8480,
8481, 8490, 8500, 8503, 8520, 8521, 8522, 8523, 8524, 8525, 8530,
8541, 8574, 8575
HCPCS: 19110, 19120, 19125, 19126, 19160, 19162, 19301, 19302
ICD-9 Procedure: 85.20-85.23, 85.25
HCPCS: 19180, 19182, 19200, 19220, 19240, 19303, 19304, 19305,
19306, 19307
ICD-9 Procedure: 85.41-48
HCPCS: J9355
HCPCS: doxorubicin (J9000, J9001) or epirubicin (J9178, J9180). No
patients were treated with daunorubicin (J9150) or idarubicin (J9211).
HCPCS: cyclophosphamide (J8530, J9070, J9080, J9090, J9091-J9097),
methotrexate (J8610, J9250, J9260), 5-fluorouracil (J9190), paclitaxel
(J9264, J9265),docetaxel (J9170, J9171), cisplatin (J9060, J9062), and
carboplatin (J9045).
CABG HCPCS: 33510, 33511, 33512, 33513, 33514, 33516, 33517,
33518, 33519, 33520, 33521, 33522, 33523, 33525, 33533, 33534,
33535, 33536
CABG ICD-9 Procedure: 36.1x
PCI HCPCS: 92973, 92980, 92981, 92982, 92984, 92995, 92996
PCI ICD-9 Procedure: 00.66, 36.01, 36.02, 36.05, 36.06, 36.07, 36.09
AMI/ACS ICD-9 Diagnosis: 410.x1, 411.1, 411.8, 411.81, 411.89
Angina ICD-9 Diagnosis:413.x
ICD-9 Diagnosis: 433.x, 434.x
ICD-9 Diagnosis: 435.x
ICD-9 Diagnosis: 401.x-405.x
ICD-9 Diagnosis: 403.01, 403.11, 403.91, 404.02, 404.03, 404.12,
404.13, 404.92, 404.93, 588.0, V42.0, V45.1, 585.x, 586.x, V56.x,
Other Elixhauser
Conditions
Assessed
Atrial Fibrillation / Flutter
427.3x
Hyperlipidemia
272.x
Valvular Disease, Pulmonary Circulation Disorders, Peripheral Vascular Disorders, Paralysis, Other Neurological
Disorders, Chronic Pulmonary Disease, Liver Disease, AIDS/HIV, Rheumatoid Arthritis, Coagulopathy, Weight
Loss, Fluid and Electrolyte Disorders, blood Loss Anemia, Deficiency Anemia, Alcohol Abuse, Drug Abuse,
Psychoses, Depression (14)
Abbreviations: ACS, acute coronary syndrome; AIDS, acquired immunological deficiency syndrome; AMI, acute myocardial infarction; CABG,
coronary artery bypass graft; HCPCS, Healthcare Common Procedure Coding System; HIV; human immunodeficiency virus; ICD, International
Classification of Disease; PCI, percutaneous coronary intervention
Online Table 1. Other patient characteristics, by adjuvant therapy group
All Breast
Cancer
patients
N
%
Total Sample
45,53
7
Trastuzu
mab
N
%
437
Anthracycline +
Trastuzumab
N
%
431
Anthracyc
line
N
%
Other
Chemothe
rapy
N
%
2,71
2
5,257
None
N
%
p
36,7
00
Cancer-free
patients
N
%
p vs
No
ne
36,700
Year of Diagnosis
2000
5,726
12.6
14
3.2
>14
>3.
2
671
12.
8
434
16.
0
<4,5
93
<12 <.00
.5
1
<4,59
3
<12.5
2001
6,014
13.2
14
3.2
<11
<2.
6
705
13.
4
464
17.
1
>4,8
20
>13
.1
>4,82
0
>13.1
2002
5,716
12.6
12
2.7
13
3.0
678
12.
9
408
15.
0
4,60
5
12.
5
4,605
12.5
2003
5,451
12.0
12
2.7
13
3.0
675
12.
8
301
11.
1
4,45
0
12.
1
4,450
12.1
2004
5,606
12.3
21
4.8
35
8.1
763
14.
5
231
8.5
4,55
6
12.
4
4,556
12.4
2005
5,497
12.1
75
17.2
115
26.
7
662
12.
6
179
6.6
4,46
6
12.
2
4,466
12.2
2006
5,687
12.5
118
27.0
130
30.
2
584
11.
1
282
10.
4
4,57
3
12.
5
4,573
12.5
2007
5,840
12.8
171
39.1
100
23.
2
519
9.9
413
15.
2
4,63
7
12.
6
4,637
12.6
Registry*
NA
San Francisco
1,643
3.6
19
4.3
18
4.2
169
3.2
50
1.8
1,38
7
3.8
Connecticut
3,318
7.3
18
4.1
37
8.6
272
5.2
183
6.7
2,80
8
Detroit
3,039
6.7
22
5.0
31
7.2
464
8.8
237
8.7
Iowa
3,477
7.6
18
4.1
25
5.8
382
7.3
145
New Mexico
1,072
2.4
13
3.0
17
3.9
131
2.5
Seattle
2,777
6.1
28
6.4
25
5.8
213
Utah
1,131
2.5
11
2.5
18
4.2
San Jose
1,112
2.4
12
2.7
11
Los Angeles
3,283
7.2
38
8.7
Greater California
8,786
19.3
109
Kentucky
3,532
7.8
Louisiana
3,070
New Jersey
7,229
Median
Household
<.00
1
1,387
3.8
7.7
2,808
7.7
2,28
5
6.2
2,285
6.2
5.3
2,90
7
7.9
2,907
7.9
60
2.2
851
2.3
851
2.3
4.1
163
6.0
2,34
8
6.4
2,348
6.4
153
2.9
74
2.7
875
2.4
875
2.4
2.6
106
2.0
56
2.1
927
2.5
927
2.5
28
6.5
345
6.6
206
7.6
2,66
6
7.3
2,666
7.3
24.9
71
16.
5
1,033
19.
6
501
18.
5
7,07
2
19.
3
7,072
19.3
24
5.5
31
7.2
420
8.0
211
7.8
2,84
6
7.8
2,846
7.8
6.7
34
7.8
35
8.1
453
8.6
158
5.8
2,39
0
6.5
2,390
6.5
15.9
70
16.0
72
16.
7
855
16.
3
503
18.
5
5,72
9
15.
6
5,729
15.6
NA
Income
$0 to <$33,000
8,649
19.0
88
20.1
73
16.
9
1,078
20.
5
542
20.
0
6,86
8
18.
7
$33,000 to
<$40,000
6,630
14.6
45
10.3
54
12.
5
765
14.
6
372
13.
7
5,39
4
$40,00 to
<$50,000
9,425
20.7
104
23.8
98
22.
7
1,119
21.
3
580
21.
4
$50,000 to
<$63,000
9,114
20.0
77
17.6
103
23.
9
1,038
19.
7
508
≥ $63,000
11,71
9
25.7
123
28.1
103
23.
9
1,257
23.
9
Married
19,97
9
43.9
194
44.4
240
55.
7
2,797
Unmarried
23,83
9
52.4
232
53.1
179
41.
5
Other
1,719
3.8
11
2.5
12
2.8
0.00
1
6,896
18.8
14.
7
6,223
17.0
7,52
4
20.
5
8,970
24.4
18.
7
7,38
8
20.
1
7,338
20.0
710
26.
2
9,52
6
26.
0
7,273
19.8
53.
2
1,35
2
49.
9
15,3
96
42.
0
2,297
43.
7
1,25
3
46.
2
19,8
78
54.
2
163
3.1
107
3.9
1,42
6
3.9
Marital Status
<.00
1
20,74
41.
36. 1,20 44. 17,2 46.
45.5
204
46.7
177
1,937
0
1
8
8
5
14
9
* Registries: Hawaii, Atlanta, and Greater Georgia not shown because of cell sizes <11. Cell sizes <11 are suppressed per SEER-Medicare policy
None
<.0
01