MEETING NOTES OF THE ADHB CHARITABLE TRUST RESEARCH GRANTS COMMITTEE MEETING HELD MONDAY 24, APRIL, 2007 ROOM 534, ADMIN SUITE, LEVEL 5 AUCKLAND CITY HOSPITAL, GRAFTON Commenced at 4.00 pm All minutes of this meeting are subject to ratification at the next RGC meeting as a result of a quorum not being present. Present: In Attendance: Roger Jarrold Janet Latimer Richard Frith (Chair) Colin McArthur David St George David Sage Ralph Stewart Gayl Humphrey (ex Officio) Apologies: Tut Than 1 Minutes of Previous Meeting Resolved That the minutes of the A+ Trust Research Grants Committee meeting Monday 10 April 2007 be approved by the members and confirmed as a true and accurate record of that meeting. Moved: Richard Frith Seconded: Roger Jarrold 2 Matters Arising Projects from previous meeting: 3546 – Carry forward from RGC meeting 10 April 2007, a review of the budget has been requested as drugs provided at no charge therefore costs should be excluded from the budget, which will then be in surplus. Vernon Harvey to review & revise. 3761 – Carry forward from RGC meeting 10 April 2007, David Knight to submit applications for funding support to A+ Trust cover research costs of $18,500. Meeting Notes of A+ Trust Research Grants Committee Meeting held Monday, 23 April 2007 3 Projects Reviewed Proj # 3621 PI and Title Budget John Kolbe Yes Status Approved Project has been approved A Phase 3, Open-Label, by the RRC. Concerns were Follow-On Study Of raised Courses Of issues arising out of projects Aztreonam Lysinate For returning large surpluses. Inhalation (AI) In Cystic The trial will terminate if the Fibrosis drug becomes commercially Multiple Patients (AIR- CF3) CP-AI-006 3629 Comments probity available. Jocelyn Benatar Yes DORADO-AC Optimized regarding Approved – Doses The project is an add-on to current of standard care treatment. Project will return Darusentan as Compared a significant surplus. to an Active Control in Resistant Hypertension A Phase 3 Randomised, Double-Blind, and Placebo- Active-Controlled, Multi-centre, Parallel Group Study to Evaluate the Safety and Efficacy of Darusentan in Subjects with Resistant Hypertension Receiving Combination with Therapy Three or Antihypertensive More Drugs, Including a Diuretic, as Compared to Guanfacine or Placebo 3688 Shay McGuiness. Early parental nutrition Yes Approved Project will return a surplus. Yes Approved Project will return a surplus. vs. standard care in critical illness: an investigator led level I randomised RCT 3695 Ernie Willoughby A Randomized, Multicenter, Double-Blind, Placebo- Controlled, Dose - Comparison Study to Determine the Safety andResearch EfficacyGrants of BG00012 Meeting Notes of A+ Trust Committee Meeting held Monday, 23 April 2007 in Subjects Relapsing with Remitting Multiple Sclerosis. Proj # 3696 PI and Title Budget Peter Browett: A Phase II Study Status No of MK-0457 in Patients with BCRABL T3151 Mutant Not Project has been submitted on behalf approved of Uniservices, However as it relates Chronic to patient care it should be an ADHB and project. Request will be made to PI to Philadelphia Chrmosome -positive submit a project budget and project Acute Lymphoblastic Leukaemia. ownership will remain with ADHB. Myelogenous 3709 Sue Leukaemia Stott Of CT Determination Of increase should additional CT scans Screw Position After Percutaneous be required, but these costs will be Screw Fixation Of Slipped Capital fully recovered from the University of Scanning The In Role Yes Approved Femoral Epiphysis 3736 Protocol There is a potential for a cost Auckland. Richard Doocey. Use Compassionate RRC receiving used and how they generate a Blood Stem Cells for Collection and drug Transplantation savings De Mobilise Boer: The A of Approval subject to total Determine Use Approved Peripheral Sally the – additional information on drugs being to for Yes claiming AMD3100 3745 Comments Study To Relationship Of Yes from savings for ADHB. Approved application being made to the A+ Exercise Intolerance And Dyspnoea To Clinical Function Appearances Features, Trust MG Martin fund Pulmonary Parameters, And Approval is given subject to funding HRCT Psychological Factors In Sarcoidosis 3771 Colin McArthur Yes Approved Small deficit which will be internally Atorvastatin treatment in severe funded from the DCCM accumulated infection funds. Meeting Notes of A+ Trust Research Grants Committee Meeting held Monday, 23 April 2007 4 Draft Savings Policy The draft savings policy is on the SMT agenda and will be discussed as time permits. 5 Financial Update 5.1 Monthly status report Reports from 10 April meeting have been included for information only 5.2 Monthly reimbursements Reports from 10 April meeting have been included for information only 5.3 Conversion of research projects to A+ Trust Target completion date remains 30 June 2007. 5.4 Applications for A+ Trust general funds to support Research Project 3284 – Research Nurse 0.2 FTE UoA salary funding. Budget top up has been approved using A+ trust fund 7554. 6 General Business 6.1 Project report tabled from David Herd for information only. 6.2 Meeting times will be moved up by 30 minutes so meeting will now commence at 3.30 pm. Meting concluded 5.10 pm ………………………………………… Chair Next Meeting: Venue: ……………………………………… Date Monday, 28th May 2007 at 3:30 pm Room 534, Admin Suite, Level 5, Auckland City Hospital, Grafton Meeting Notes of A+ Trust Research Grants Committee Meeting held Monday, 23 April 2007