Chemistry 235 Organic Chemistry Spring 2009 This course is a continuation of Chemistry 231 (Introductory Organic Chemistry). It completes the second half of a full academic year of introductory organic chemistry, and is intended for those students in programs that require further chemistry courses. In addition to completing a survey of organic functional groups, synthetic methodology involving carbanions will be introduced, as well as concepts in π-conjugation, aromaticity, and the chemistry of benzene. Prerequisites: Chemistry 102 and Chemistry 231 are the prerequisites for this course. Students must ensure that they have the proper prerequisites; they will be deregistered without warning at any time if found not to have the required courses. Chemistry 213 is recommended, principally for the lab component, but you will not be deregistered if you do not have Chemistry 213. Textbook: Organic Chemistry, Seventh Edition, John McMurry, Thompson*Brooks/Cole, 2007. Students who already have the sixth edition may continue to use it for this course. The library has other introductory organic chemistry texts that offer a (somewhat) different perspective on the topics covered in Chemistry 235. A study guide is highly recommended, as is a molecular model kit. Laboratory: You are required to be co-registered in a laboratory section of Chemistry 235 while you are registered in the lecture. A current laboratory manual (green cover) is required, and is available in the bookstore. Laboratories start the week of January 5. Students who have previously passed the laboratory portion of either Chemistry 232 or 235 may apply for a passed lab credit by registering in section LS99. Lecturer: Dr. Devin Mitchell, Elliott 327, (devinpm@uvic.ca). Office hours will be announced during the first week. You can also contact me by e-mail. The second year drop-in centre (Ell 038) can also provide help, check their website for a schedule (http://web.uvic.ca/~berryde/2ndyrdropin/index.htm). Web site: Lecture: http://members.shaw.ca/devinmitchell/chemistry235/, the link to the lab web site for thelaboratory portion is at the top of that page. Grading: The grading formula consists of three components; laboratory, quizzes and final exam. The percentage component of each is shown in the table below. Both the lecture and laboratory portions of the course must be passed independently of each other in order to successfully complete the course. Laboratory Quizzes Final Exam Total 33 25 (5 x 5%) 42 100 1) Quizzes will be written in class, and ALL quizzes count towards the lecture grade. Quizzes are compulsory. The final exam mark will not, under any circumstances, be taken as a replacement for the lecture mark calculated from the percentages listed above. 2) The mark for any quiz or exam which is not written, and for which no official medical excuse is provided will be zero. The excuse must be dated within the week of the quiz and must be handed in within two weeks of the quiz date. The medical excuse must provide sufficient information to establish that the student was not able to write the quiz or Component % exam due to his/her medical condition on the date of the quiz or exam in question. The student will also be required to give written consent for information about her/his medical condition to be disclosed to the instructor. Any such information obtained is treated as confidential. Certain other types of personal or family circumstances may be considered as equivalent to a medical excuse if accompanied by appropriate documentation. There is no requirement for us to provide make-up quizzes. Students with medical excuses for missed quizzes will have their quiz scores averaged on the remaining quizzes written. Quiz writing time is 20 minutes during a regular lecture period. 3) Quizzes will test your knowledge of the material covered over a short span of chapters/ sections. The fi nal examination will cover the entire course. 4) Conversion of numerical percentage scores to letter grades will be based on the following approximate scale. A+ > 90 A 8589.9 A8084.9 B+ 7579.9 B 7074.9 B6569.9 C+ 6064.9 C 5559.9 D 5054.9 F < 49.9 5) Quiz dates (and chapter coverage) are as follows: Friday, January 23 (Chapters 5, 10 & 14), Friday, February 6 (Chapters 15 & 16), Friday, February 27 (Chapter 19), Friday, March 13 (Chapters 20 & 21), Friday, March 27 (Chapters 22 & 23). 6) It has been departmental practice to post a list of course marks and quiz marks by student number. If you desire that your grade and student number NOT be posted, notify your instructor. 7) The date of the final examination is set by Records Services. Students are advised not to make travel plans until their exam schedule is known. Exceptions/exemptions based on travel plans will not be made. Course Topics and Suggested Problems Organic Chemistry can only be learned by actively engaging in the course material. This requires attending the lectures, laboratories, and doing the suggested problems. Keeping up with the course material will make studying for the quizzes and exams easier. Use the learning resources available (second-year drop in centre, textbook web site (see the front of the book), etc.). Organic chemistry is a subject that cannot be crammed the night before the exam. It is imperative that you try as many problems as possible —the lists below are a suggested minimum. The key to learning is to find insight and realize that certain principles are being followed in what appear to be unrelated reactions. Chapter 5; An Overview of Organic Reactions This chapter is intended as a review chapter, no specific problems are assigned. The topics in this chapter are fundamental to the rest of the course. The material will be on the first quiz. Chapter 10; Organohalides All sections are covered as review topics, the material will be on the first quiz. Problems: 6th edition: 10.3 - 10.13, 10.17, 10.23, 10.35, 10.37, 10.39, 10.42. Problems: 7th edition: 10.3 - 10.13, 10.17, 10.23, 10.33, 10.35, 10.37, 10.39. Chapter 14; Conjugated Compounds Covered sections: 6th edition: 14.1 - 14.6, 7th edition: 14.1 - 14.5. Problems: 6th edition: 14.1 - 14.10, 14.20 - 14.23, 14.27, 14.33, 14.34, 14.40, 14.43, 14.44, 14.55. Problems: 7th edition: 14.1 - 14.10, 14.21 - 14.23, 14.26, 14.32, 14.33, 14.40, 14.43, 14.44, 14.55. Chapter 15; Benzene and Aromaticity Covered sections: 6th edition: 15.1 - 15.8, 7th edition: 15.1 - 15.7. Problems: 6th edition: 15.1 - 15.8, 15.10, 15.11, 15.25, 15.26, 15.30, 15.33, 15.37, 15.40, 15.41. Problems: 7th edition: 15.1 - 15.8, 15.10, 15.11, 15.25, 15.26, 15.29, 15.32, 15.36, 15.41, 15.42. Chapter 16; Chemistry of Benzene: Electrophilic Aromatic Substitution All sections are covered. Problems: 6th edition: 16.1 - 16.24, 16.30, 16.31, 16.34, 16.35, 16.36, 16.54, 16.73. Problems: 7th edition: 16.1 - 16.24, 16.31, 16.32, 16.35, 16.36, 16.37, 16.55, 16.73. Chapter 19; Aldehydes and Ketones: Nucleophilic Addition Reactions Covered sections: 6th edition: 19.1 - 19.12, 19.14, 7th edition: 19.1 - 19.11, 19.13. Problems: 6th edition: 19.1 - 19.20, 19.28, 19.32, 19.33, 19.41, 19.48, 19.49, 19.53, 19.56, 19.58. Problems: 7th edition: 19.1 - 19.22, 19.30, 19.34, 19.35, 19.42, 19.50, 19.51, 19.54, 19.57, 19.59. Chapter 20; Carboxylic Acids and Nitriles Covered sections: 6th edition: 20.1 - 20.9, 7th edition: 20.1 - 20.7, omit 20.3. Problems: 6th edition: 20.1 - 20.13, 20.23, 20.24, 20.33 - 20.36, 20.49, 20.50. Problems: 7th edition: 20.1 - 20.4, 20.6 - 20.13, 20.25, 20.26, 20.36 - 20.39, 20.52, 20.53. Chapter 21; Carboxylic Acid Derivatives Covered sections: 6th edition: 21.1 - 21.7, 7th edition: 21.1 - 21.7. Problems: 6th edition: 21.1 - 21.11, 21.13 - 21.22, 21.36, 21.37, 21.42, 21.54, 21.55, 21.57. Problems: 7th edition: 21.1 - 21.21, 21.36, 21.37, 21.43, 21.56, 21.57, 21.62. Chapter 22; Carbonyl Alpha-Substitutions All sections are covered. Problems: 6th edition: 22.1 - 22.9, 22.11 - 22.17, 22.21, 22.24, 22.37, 22.44, 22.48, 22.49. Problems: 7th edition: 22.1 - 22.16, 22.20, 22.23, 22.35, 22.44, 22.49, 22.50. Chapter 23; Carbonyl Condensation Reactions Covered sections: 6th edition: 23.1 - 23.13, 7th edition: 23.1 - 23.12. Problems: 6th edition: 23.1 - 23.22, 23.28, 23.39, 23.42, 23.43, 23.45, 23.54, 23.56. Problems: 7th edition: 23.1 - 23.22, 23.28, 23.39, 23.42, 23.43, 23.45, 23.56, 23.57. Chapter 24: Amines Covered sections: 6th edition: 24.1 - 24.8, 7th edition: 24.1 - 24.8. Problems: 6th edition: 24.1 - 24.19, 24.29, 24.30, 24.32, 24.38, 24.39, 24.41, 24.45, 24.57, 24.59. Problems: 7th edition: 24.1 - 24.19, 24.33, 24.34, 24.36, 24.42, 24.43, 24.47, 24.52, 24.63, 24.64.