MICRO #276
General and Molecular Virology
1/2/13 – 3/23/13
Course Director: Martin Muggeridge, Ph.D.
Department of Microbiology and Immunology
Office: 2-333
Ph: 675-7571
e-mail: mmugge@lsuhsc.edu
Lecturers (all in the Dept. of Microbiology and Immunology):
Dr. Michelle Arnold
marnol@lsuhsc.edu
Dr. Jason Bodily
jbodil@lsuhsc.edu
Dr. Lindsey Hutt-Fletcher
lhuttf@lsuhsc.edu
Dr. Jeremy Kamil
jkamil@lsuhsc.edu
Dr. Seong Kim
skim1@lsuhsc.edu
Dr. Martin Muggeridge
mmugge@lsuhsc.edu
Dr. Dennis O'Callaghan
docall@lsuhsc.edu
Dr. Martin Sapp
msapp1@lsuhsc.edu
Dr. Rona Scott
rscott1@lsuhsc.edu
Dr. Ikuo Tsunoda
itsuno@lsuhsc.edu
Dr. Andrew Yurochko
ayuroc@lsuhsc.edu
Lecture Time and Place: 8:00 - 8:55 am, Rm 2-201
Exam Time and Place: 10:00 am - such time as needed , Rm 4-326 (lecture hall)
There will be four written exams
Micro #276 Course Objectives
Students should understand and be able to describe the following aspects of
virology.
(1) The classification of viruses into families based on shared properties and the
physical and biological properties of these viruses, particularly those that cause
human diseases.
(2) The aspects of virus replication that each virus must accomplish (such as entry
into a cell, replication of its genome, egress from the cell) and the variety of ways in
which these steps can be achieved.
(3) The ways in which viruses interact with and manipulate cell components and
processes in order to enhance their replication.
(4) Where appropriate, the experimental approaches that have been (or are being)
used to address questions related to the first three objectives.
8:00 AM
MICRO 276: General and Molecular Virology
Date
Day
Lecture Topic
Lecturer
1
2
3
Jan 2
Jan 3
Jan 4
Wed
Thu
Fri
Overview of the virus world – 1
Overview of the virus world – 2
Nature and characterization of viral DNA genomes
Dr. O’Callaghan
Dr. O’Callaghan
Dr. O’Callaghan
4
5
6
7
8
Jan 7
Jan 8
Jan 9
Jan 10
Jan 11
Mon
Tue
Wed
Thu
Fri
Nature and characterization of viral RNA genomes
Icosahedral capsids and icosadeltahedral symmetry
Helical capsids, complex capsids, and other viral structures
Virus purification and methods
Cultivation, assays, quantitation, and molecular methods
Dr. O’Callaghan
Dr. O’Callaghan
Dr. O’Callaghan
Dr. O’Callaghan
Dr. Kim
9
10
11
12
13
Jan 14
Jan 15
Jan 16
Jan 17
Jan 18
Jan 19
Mon
Tue
Wed
Thu
Fri
Sat
Functions and characterization of viral proteins – 1
Functions and characterization of viral proteins – 2
Viral genetics and molecular genetics – 1
Viral genetics and molecular genetics – 2
Virus attachment and entry – 1
EXAM 1 (lectures 1 - 10)
Dr. Bodily
Dr. Bodily
Dr. Kamil
Dr. Kamil
Dr. Muggeridge
14
15
16
17
Jan 21
Jan 22
Jan 23
Jan 24
Jan 25
Mon
Tue
Wed
Thu
Fri
ML King Holiday
Virus attachment and entry – 2
Virus attachment and entry – 3
Herpesviruses: overview
Herpesviridae: alphaherpesvirinae
Dr. Muggeridge
Dr. Muggeridge
Dr. Hutt-Fletcher
Dr. Hutt-Fletcher
18
19
20
21
22
Jan 28
Jan 29
Jan 30
Jan 31
Feb 1
Mon
Tue
Wed
Thu
Fri
Herpesviridae: betaherpesvirinae
Herpesviridae: gammaherpesvirinae
Herpesvirus latency – 1
Herpesvirus latency – 2
Adenoviridae – 1
Dr. Yurochko
Dr. Scott
Dr. Scott
Dr. Scott
Dr. Hutt-Fletcher
23
24
25
26
27
Feb 4
Feb 5
Feb 6
Feb 7
Feb 8
Feb 9
Mon
Tue
Wed
Thu
Fri
Sat
Adenoviridae – 2
Parvoviridae
Poxviridae – 1
Poxviridae – 2
Polyomaviridae
EXAM 2 (lectures 11 - 24)
Dr. Hutt-Fletcher
Dr. Scott
Dr. Sapp
Dr. Sapp
Dr. Sapp
28
29
30
31
Feb 11
Feb 12
Feb 13
Feb 14
Feb 15
Mon
Tue
Wed
Thu
Fri
Mardi Gras Holiday
Papillomaviridae
Retroviridae: simple viruses
Retroviridae: deltaretroviruses
Retroviridae: lentiviruses – 1
Dr. Sapp
Dr. O’Callaghan
Dr. O’Callaghan
Dr. O’Callaghan
32
33
34
35
36
Feb 18
Feb 19
Feb 20
Feb 21
Feb 22
Mon
Tue
Wed
Thu
Fri
Retroviridae: lentiviruses – 2
Hepadnaviridae – 1
Hepadnaviridae – 2
Overview of RNA virus replication strategies
Picornaviridae – 1
Dr. O’Callaghan
Dr. Hutt-Fletcher
Dr. Hutt-Fletcher
Dr. Muggeridge
Dr. Tsunoda
37
Feb 25
Mon
Picornaviridae – 2
Dr. Tsunoda
38
39
40
41
Feb 26
Feb 27
Feb 28
Mar 1
Mar 2
Tue
Wed
Thu
Fri
Sat
Flaviviridae
Togaviridae
Astroviridae and Caliciviridae
Hepeviridae and hepatitis delta virus
EXAM 3 (lectures 25 - 37)
Dr. Tsunoda
Dr. Tsunoda
Dr. Kamil
Dr. Bodily
42
43
44
45
46
Mar 4
Mar 5
Mar 6
Mar 7
Mar 8
Mon
Tue
Wed
Thu
Fri
Coronaviridae
Paramyxoviridae
Rhabdo-, Filo-, and Bornaviridae
Orthomyxoviridae – 1
Orthomyxoviridae – 2
Dr. Sapp
Dr. Tsunoda
Dr. Arnold
Dr. Muggeridge
Dr. Muggeridge
47
48
49
50
51
Mar 11
Mar 12
Mar 13
Mar 14
Mar 15
Mar 23
Mon
Tue
Wed
Thu
Fri
Sat
Reoviridae
Arenaviridae and Bunyaviridae
Antiviral drugs
Innate immune response to viruses – 1
Innate immune response to viruses – 2
EXAM 4 (lectures 38 - 51)
Dr. Arnold
Dr. Arnold
Dr. Muggeridge
Dr. Yurochko
Dr. Yurochko