員山榮民醫院處方集
Yuanshan Veterans Hospital
Formulary
中 華 民 國 九 十 八年
2009.07
編輯說明
一、本手冊分二部分：第一部分為本院現行常備藥品之分
類及說明，包括藥品學名、用法及劑量、劑型。第二
部分為索引，係依照藥品的商品名字首英文字母順序
排列，並註明其本文之頁數，以方便查閱。
二、本手冊所載藥品之分類係以藥理作用為主，另以治療
分類為輔，但同一藥品有兩類以上之作用者，則依其
主要作用歸類。每類藥品在依其次分類及學名之英文
字母順序列述。
三、本手冊所載之劑量倘無特別指明時，係指成人用量：
用法倘未寫明給藥途徑時，係指口服。
四、本手冊每二年再版一次，每年將新增或刪除藥品以增
刊（supplement）方式補充。
五、本手冊編輯時，格式以學名為先，下接商品名及單位
劑量。再其次是一般使用的劑量（usual dose）。懷孕
用藥級數以[ ]表示。管制麻醉藥品於學名前有＊標
示，2 表示管制藥品級數。內含藥品於商品名前有@
標示。例如：
管制藥品級數
學名
懷孕用藥級數
管制麻醉藥品 *2Codeine Phosphate [C]
"Codeine Injection" 15mg/ml/amp
商品名
單位劑量，劑型
六、 本手冊所使用的英文簡寫如下：
C/I：禁忌症（Contraindication）;
D/I：藥品交互作用(Drug interaction)；
S/E：副作用（Side effect）；
D5W：Dextrose 5% in water；
NS：Normal Saline (0.9% Sodium chloride);
PO：口服；IM：肌肉注射；IV：靜脈注射；IVF：靜脈輸
注；SC：皮下注射；IA：動脈注射。
CONTENTS
DRUGS AND PREPRATIONS
A) GENERAL ------------------------------------------------------1
I. Drugs Acting on Nervous System -----------------------------1
1. Analgesics, Antipyretics and Anti-inflammatory Agents--1
1) Analgesics ------------------------------------------------------1
a) Narcotic Analgesics -------------------------------------------1
b) Non-narcotic Analgesics ------------------------------------6
i) Analgesics/Antipyretics ----------------------------------------6
ii) Analgesics/Antipyretics/Nonsteroidal Anti-inflammatory
Agents --------------------------------------------------------------6
2) Anti-rheumatic Agents ---------------------------------------12
a) Non-steroidal Anti-inflammatory Agents -----------------12
b) Others ---------------------------------------------------------12
3) Drugs Used in Gout ------------------------------------------12
a) Drugs Used in Acute Gout -----------------------------------12
b) Drugs Used in Hyperuricemia --------------------------------13
4) Drugs Used in Migraine---------------------------------------13
5) Drugs Used in Central Pain Syndrome ---------------------14
6) Urinary Tract Analgesics/Anti-infective Agents ----------14
2. Psychopharmacologic Drugs --------------------------------15
1) Anxiolytics, Sedatives and Hypnotics ---------------------15
a) Benzodiazepines ----------------------------------------------15
b) Benzodiazepines like-------------------------------------------19
c) Barbiturates -----------------------------------------------------19
d) Others -----------------------------------------------------------19
2) Antipsychotics--------------------------------------------------20
3) Drugs Used in Affective Disorders ------------------------25
a) Antidepressants ----------------------------------------------25
i) Tricyclics -----------------------------------------------------25
ii) Selective Serotonin Reuptake Inhibitors (SSRIs)----------26
iii) Triazolopyridine ----------------------------------------------28
iv) Selective serotonin-norepinephrine reuptake inhibitors--28
v) Noradrenergic and specific serotonergic antidepressant--28
b) Antimanic -----------------------------------------------------28
4) Drugs Used in Other Mental Disorders ---------------------29
3. Neurologic Drugs ----------------------------------------------31
1) Anticonvulsants ----------------------------------------------31
a) Barbiturates------------------------------------------------------31
b) Benzodiazepines ----------------------------------------------31
c) Hydantoins -----------------------------------------------------32
d) Miscellaneous Anticonvulsants ----------------------------32
2) Antiparkinsonian Agents -----------------------------------35
a) Centrally Active Anticholinergics ------------------------35
b) Drugs Elevating Brain Dopamine Level -----------------35
c) Dopamine Receptor Agonists --------------------------------37
d) Catechol-O-Methyltransferase Inhibitor--------------------37
3) Skeletal Muscle Relaxants -----------------------------------37
4) Drugs Used in Myasthenia Gravis ------------------------38
5) Anti-vertigo Agents ------------------------------------------39
6) Others ---------------------------------------------------------40
4. Agents Used in Anesthesia -----------------------------------41
1) Local Anesthetics ----------------------------------------------41
2) General Anesthetics ------------------------------------------42
a) Inhalation Anesthetics ---------------------------------------42
b) Parenteral Anesthetics ---------------------------------------42
3) Neuromuscular Blocking Agents ----------------------------44
4) Miscellaneous Adjuncts to Anesthetics---------------------46
II. Cardiovascular-renal Agents --------------------------------47
1. Digitalis Glycosides ------------------------------------------47
2. Antiarrhythmics ----------------------------------------------48
２
1) Class Ib ---------------------------------------------------------48
2) Class Ic ---------------------------------------------------------49
3) Class II ---------------------------------------------------------49
4) Class III----------------------------------------------------------49
5) Class IV ---------------------------------------------------------50
6) Miscellaneous Antiarrhythmics ----------------------------51
3. Antianginal Agents ------------------------------------------51
4. Antihypertensives ----------------------------------------------53
1) Sympatholytic Depressants-----------------------------------53
a) α-blockers -----------------------------------------------------53
b) Selective β-blockers ------------------------------------------55
c) Nonselective β-blockers --------------------------------------56
d) Mixed Adrenergic Antagonists ----------------------------57
2) Direct-acting Vasodilators -----------------------------------59
3) Angiotensin-converting Enzyme Inhibitors -------------59
4) Angiotensin II Receptor Antagonists ---------------------60
5) Calcium Channel Antagonists--------------------------------61
6) Miscellaneous---------------------------------------------------63
5. Vasodilators-----------------------------------------------------63
6. Diuretics ---------------------------------------------------------64
1) Carbonic Anhydrous Inhibitors ----------------------------64
2) Loop Diuretics --------------------------------------------------65
3) Osmotic Agents ----------------------------------------------66
4) Thiazides -----------------------------------------------------66
5) Potassium Sparing Diuretics -------------------------------67
7. Agents Used to Treat Circulatory Failure -----------------68
8. Antiplatelets and Thrombolytics ----------------------------69
1) Antiplatelets --------------------------------------------------69
9. Agents Used to Treat Hyperlipidemia ---------------------71
1) HMG-CoA Reductase Inhibitors ----------------------------71
３
2) Fibrates ---------------------------------------------------------72
3) Combinations lipid-lowering Agents------------------------73
10. Hemorrheologic Agents -----------------------------------73
III. Nutritional Agents ------------------------------------------73
1. Replenishers and Regulators of Water and Electrolytes
--------------------------------------------------------------------73
1) Minerals and Electrolytes -----------------------------------73
2) Intravenous Nutritional Therapy ----------------------------74
3) Potassium Lowering Agents----------------------------------79
2. Vitamins ---------------------------------------------------------80
3. Others ---------------------------------------------------------83
IV. Hematological Agents ---------------------------------------85
1. Antianemia Drugs----------------------------------------------85
1) Iron Supplements ----------------------------------------------85
2) Vitamin B-Complex ------------------------------------------85
2. Anticoagulants -------------------------------------------------86
1) Heparin ---------------------------------------------------------86
2) Coumarin and Indandione Derivatives ---------------------87
3. Blood Components and Blood Substituents --------------87
1) Blood Components---------------------------------------------87
2) Blood Substituents---------------------------------------------87
4. Hemostatics -----------------------------------------------------88
V. Hormones and Agents Affecting Hormonal Mechanism
--------------------------------------------------------------------89
1. Gonadotropin Releasing Hormone Analogues-------------89
1) Hypothalamic Related Hormones----------------------------89
2) Posterior Pituitary Hormones --------------------------------89
3) Others ---------------------------------------------------------89
2. Adrenal Corticosteroids ---------------------------------------89
1) Glucocorticoids ----------------------------------------------89
４
3. Androgens and Anabolic Steroids ------------------------92
4. Antiandrogens --------------------------------------------------92
5. Estrogens, Progestins, Contraceptives and Related Agents
--------------------------------------------------------------------93
1) Estrogens -----------------------------------------------------93
2) Progestins -----------------------------------------------------95
3) Combinations of Estrogens and Progestins --------------96
4) Other related agents ------------------------------------------97
5) Antiprogesterones----------------------------------------------98
6. Uterine Stimulants----------------------------------------------98
7. Antidiabetic Agents ------------------------------------------99
1) Insulins ---------------------------------------------------------99
2) Oral Hypoglycemic Agents----------------------------------100
a) Sulfonylureas ------------------------------------------------100
b) Biguanides ----------------------------------------------------101
c) Alpha-Glucosidase Inhibitor ------------------------------101
d) Thiazolidinedione---------------------------------------------102
e) Meglitinide ----------------------------------------------------102
f) Others-----------------------------------------------------------103
8. Agents Used to Treat Thyroid Disorders ----------------103
1) Thyroid Hormones -----------------------------------------103
2) Antithyroid Agents -----------------------------------------104
9. Calcium Regulator -----------------------------------------104
10. Miscellaneous------------------------------------------------106
VI. Antiallergic Agents and Antihistamines ----------------107
1. Antiallergic Agents -----------------------------------------107
2. Antihistamines ------------------------------------------------107
VII. Respiratory Tract Drugs ----------------------------------110
1. Drugs Used in Asthma -------------------------------------110
1) Bronchodilators-----------------------------------------------110
５
a) β-2-agonists ---------------------------------------------------110
b) α,β-agonists ---------------------------------------------------111
c) Xanthine Derivatives ----------------------------------------111
d) Anticholinergic Agents -------------------------------------116
e) Asthma Prophylatic and Anti-Inflammatory Agents ----117
2. Antitussive Agents -----------------------------------------118
3. Expectorants and Cough Preparations -------------------118
4. Mucolytic Agents---------------------------------------------120
5. Miscellaneous ------------------------------------------------121
VIII. Gastrointestinal Agents ----------------------------------122
1. Agents Used in Peptic Ulcer Disease-----------------------122
1) Antacids ------------------------------------------------------122
2) H2 Receptor Antagonists ----------------------------------124
3) Agents to Hasten the Healing of Ulcer -------------------125
4) Proton Pump Inhibitors -------------------------------------125
2. Anticholinergic Antispasmodics----------------------------127
3. Antidiarrheals ------------------------------------------------128
4. Laxatives ----------------------------------------------------130
1) Bulk-forming Laxatives -------------------------------------130
2) Stimulant Laxatives -----------------------------------------131
3) Saline Laxatives ---------------------------------------------132
4) Hyperosmotic Laxatives ----------------------------------132
5. Antiemetics ----------------------------------------------------133
1) Antidopaminergics -----------------------------------------133
2) Anticholinergics/Antihistamines --------------------------135
3) Miscellaneous ------------------------------------------------135
6. Digestants ----------------------------------------------------135
7. Agents Used to Treat Hemorrhoid--------------------------136
8. Prokinetic Drugs ---------------------------------------------136
9. Miscellaneous Gastrointestinal Agents -------------------138
６
IX. Immunologic Agents -------------------------------------140
1. Agents for Active Immunity (Vaccines and Toxoids)---140
1) Vaccines -------------------------------------------------------140
2) Toxoids -------------------------------------------------------141
2. Immunomodulators -----------------------------------------141
1) Immunosuppressants -----------------------------------------141
X. Antineoplastic Agents -------------------------------------142
XI. Antiinfective Agents -------------------------------------143
1. Penicillins ---------------------------------------------------143
1) Natural Penicillins ----------------------------------------143
2) Penicillinase-resistant Antistaphylococcal Penicillins--144
3) Aminopenicillins --------------------------------------------146
4) β-lactam +β-lactamase Inhibitors --------------------------146
2. Cephalosporins------------------------------------------------148
1) First Generation Cephalosporins --------------------------148
2) Second Generation Cephalosporins -----------------------150
3) Third Generation Cephalosporins -----------------------150
4) Fourth Generation Cephalosporins-------------------------151
3. Carbapenem ------------------------------------------------152
4. Macrolides ----------------------------------------------------153
5. Glycopeptides ------------------------------------------------154
6. Lincosamides ------------------------------------------------155
7. Tetracyclines ------------------------------------------------156
8. Aminoglycosides ---------------------------------------------158
9. Sulfonamides, Sulfones and Trimethoprim----------------161
10. Quinolones ------------------------------------------------162
11. Miscellaneous Antibacterial Agents -------------------163
12. Antituberculosis Agents ----------------------------------164
13. Antifungal Agents -----------------------------------------167
14. Antiviral Agents ---------------------------------------------168
７
15. Antiprotozoals ---------------------------------------------169
XII. Urologic Agents -----------------------------------------170
1. Drugs For Urinary Retention ------------------------------170
2. Drugs For Urinary Incontinence --------------------------170
3. Agents for Impotence -------------------------------------171
4. Adrenergic blocking agents ---------------------------------172
5.Alkalizing agents-----------------------------------------------172
XIII. Antidotes in Poisoning ---------------------------------173
1. General Antidote --------------------------------------------173
2. Speciflc Antidotes------------------------------------------- -173
XIV. Enzymes ----------------------------------------------------176
XV. Miscellaneous ---------------------------------------------177
B) DENTAL PREPARATIONS ------------------------------179
I. Throat and Oral Cavity Preparations------------------------179
II. Dental Antiseptics -----------------------------------------179
C) DERMATOLOGICAL PREPARATIONS ------------180
I. Analgesics and Anti-inflammatory Agents ----------------180
II. Antipruritics ------------------------------------------------180
III. Keratolytics ------------------------------------------------180
IV. Antifungals---------------------------------------------------181
V. Anti-infectives------------------------------------------------182
1. Antivirals ----------------------------------------------------182
2. Antibacterials, Antiseptics ----------------------------------182
3. Antibiotics ----------------------------------------------------183
VI. Antipsoriatics ------------------------------------------------184
VII. Steroids ----------------------------------------------------184
VIII. Scabicides and Pediculicides-----------------------------186
IX. Miscellaneous------------------------------------------------186
D) ENT PREPARATIONS ----------------------------------187
I. Ear Drops ----------------------------------------------------187
８
II. Nasal Sprays or Drops -------------------------------------188
E) OPHTHALMIC PREPARATIONS -----------------------189
I. Agents for Glaucoma -----------------------------------------189
II. Mydriatics and Cycloplegics ------------------------------190
III. Ocular Anti-infectives and Anti-inflammatory
agents--------------------------------------------------------------190
1. Ocular Antimicrobial Preparation--------------------------190
2. Steroids -------------------------------------------------------191
3. Ocular Antiallergic Agents ----------------------------------192
4. Miscellaneous Ophthalmic Preparations ----------------193
INDEX -----------------------------------------------------------
DRUGS AND PREPARATIONS
９
A) GENERAL
I. Drugs Acting on Nervous System
1. Analgesics, Antipyretics and Anti-inflammatory Agents
1) Analgesics
a) Narcotic Analgesics
NOTE:
D/I: Alcohol, CNS depressants, antidiarrheals, MAOIs.
C/I: Diarrhea associated with pseudomembraneous colitis or
poisoning; acute Respiratory Depression.
S/E: Histamine release, blurred or double vision,
constipation.
a
Narcotic Equivalent Guidelines
Drugs
Parenteral Equivalent Transdermal Duration
equivalent oral dose equivalent of action
dose (mg)
(mg)
dose
(hr)
b
c
Fentanyl
na
25mcg/hr
0.1-0.2
1-3
Morphine
10
20-30
na
3-6
Codeine
120-130
180
na
4-6
Meperidine 75-100
300
na
2-4
Tramadol
100
120
na
4-6
a. A narcotic equivalent is defined as the amount of analgesia
produced by 1mg of parenteral morphine.
b. Empirically: transdermal fentanyl 100mcg/hr = IM
morphine 2-4mg/h.
c.Single-dose data. Continual infusion produces lipid
accumulation & prolonged terminal excretion.
1
na. Not available orally.
*2Codeine Phosphate [C]
"Codeine Tablet" 30mg/tab
Usual Dose: PO
Analgesic:
Adults, 15-60mg q4h as needed; max. 360mg/day.
Children, 3mg/kg/day or 100mg/m2/day in 6 doses; max.
60mg/day.
Antitussive: PO.
Adults, 10-20mg q4-6h; max. 120mg/day.
Children 6-12yr, 5-10mg q4-6h; max. 60mg/day.
Children 2-6yr, 2.5-5mg q4-6h; max. 30mg/day.
STORAGE: Protect from light.
*2Fentanyl Citrate [C]
"Fentanyl Injection " 0.05mg/ml, 10ml/amp
"Durogesic Transdermal System "5.0mg/patch (50mcg/hr)
Usual Dose:
An adjunct to general anesthesia: IV, 2-50mcg/kg,
depending on the surgical procedures, additional doses
may be given if necessary.
An adjunct to regional anesthesia: 50-100mcg,IV 1-2min;
Postoperative pain, restless, tachypnea, and emergence
delirium: IM, 50-100mcg q1-2h as needed.
Preoperative medication: IM, 50-100mcg.
During the induction and maintenance phase of general
anesthesia in children 2-12yr, IV, 2-3mcg/kg.
STORAGE : Protect inj from light
2
Transdermal System:
Each system may be worn continuously for 72hr.
Dose selection: Unless the patient has pre-existing
opioid tolerance, use the lowest dose, 25mcg/hr as the
initial dose. Titration may be done 3 days after the
initial dose.
Corresponding Doses of Oral/Intramuscular
Morphine and Durogesic
Oral 24 hr
IM 24 hr
Durogesic
Morphine(mg/day) Morphine(mg/day) dose(mcg/hr)
<135
<23
25
135-224
28-37
50
225-314
38-52
75
315-404
53-67
100
405-494
68-82
125
495-584
83-97
150
585-674
98-112
175
675-764
113-127
200
765-854
128-142
225
855-944
143-157
250
945-1034
158-172
275
1035-1124
173-187
300
*2Meperidine HCl (Pethidine HCl) [B]
"Demerol Injection" 50mg/ml/amp
Usual Dose:
Analgesia: IM, IV or SC.
3
Adults, 50-150mg q3-4h as needed.
Children, 1-1.5mg/kg/dose q3-4h as needed; max.
100mg/dose.
Obstetrical analgesia: IM or SC, 50-100mg, may be
repeated at 1-3h intervals.
Preoperative medication: IM or SC.
Adults, 50-100mg.
Children, 1.0-2.2mg/kg/dose up to the adult dose;
30-90min before the beginning of anesthesia.
Support of anesthesia: The dose should be titrated to the
needs of the patients.
STORAGE: Protect from light.
*1Morphine HCl [C]
"Morphine Tablet" 10mg/tab
"Morphine Injection" 10mg/1ml/amp
Usual Dose:
PO: 10-30mg q4h as needed.
IV: Adults, 2.5-15mg; In 4-5ml water for injection, given
slowly over 4-5min; children, 0.05-0.1mg/kg.
Intrathecal injection: 0.2-1mg may provide 24hr relief.
Epidural injection: Initial 5mg/24hr if needed; max.
10mg/24hr.
IM or SC:
Adults, 5-20mg q4h as needed;
Children, SC, 0.1-0.2mg/kg q4h; max. 15mg/dose.
STORAGE: Protect from light.
*2Alfentanil [C/D]
"Alfentanil(Rapifen)Injection" 1.088mg/2ml/amp
4
Usual Dose:
Narcotic analgesic & anesthesia induction agent: short
duration procedure & outpatients: 7-15 mcg/kg IV, repeat
every 10-15 mins. Medium duration procedures: 20-150
mcg/kg IV, 15 mcg/kg every 10-15 mins, if required.
Induction of anesthesia. 120 mcg/kg IV.
*4Tramadol HCl [C]
" Tramadol Stada Capsule" 50mg/cap
Usual Dose:
PO, 50-100mg q4-6h, max. 400mg/day
*4Tramadol HCl,Acetaminophen
"Ultracet Tablet, " 37.5,325mg/tab
Each Tablet contain:
Tramadol HCl ---------------------------------------37.5mg
Acetaminophen---------------------------------------325mg
Usual Dose:
PO, 1-2tabs q4-6h as needed, max. 8tabs/day
Clcr ≦30 mL/min: increase the dose interval to q12h,
max 4 tabs/day
NOTE: concurrent use MAOIs or SSRI enhanced risk of
adverse effects, including serotonin syndrome and seizures
*4 Propoxyphene HCl[C/D] and Acetaminophen
"Dacoton Tablet"
Each tab contains:
Propoxyphene HCl ---------------------------------------32mg
Acetaminophen ------------------------------------------325mg
Usual Dose: 1~2 tab every 4 hr. max:12 tab daily
5
b) Non-narcotic Analgesics
i) Analgesics/Antipyretics
Acetaminophen [B]
"Scanol Tablet, " 500mg/tab
" Acetaminophen syr. " 24mg/ml,60ml/btl
Usual Dose: PO.
Adults & children > 11yr, 325-650mg q4-6h as needed;
max. 4g/day; long term therapy; max. 2.6g/day.
Children 11yr, 480mg; 9-10yr, 400mg; 6-8yr, 320mg;
4-5yr, 240mg; 2-3yr, 160mg; 1-2yr, 120mg; 4-11mo,
80mg; < 3mo, 40mg; q4-6h as needed.
ii) Analgesics/Antipyretics/Nonsteroidal Anti-inflammatory
Agents
NOTE (Aspirin and other salicylates):
D/I: NSAIDs, urinary alkalizers, anticoagulants,
antiplatelets and thrombolytics, antidiabetes agent,
methotrexate, valproic acid, vancomycin, probenecid.
C/I: Hemophilia; active hemorrhagic state. ASA
(Acetylsalicylic Acid): Angioedema, anaphylaxis,
thrombocytopenia.
S/P: Erosive gastritis, peptic ulcer. ASA: Asthma; G6PD
deficiency.
S/E: Anemia, hemolytic anemia, bronchospastic allergic
reaction, GI irritation.
6
NOTE (NSAID):
D/I: Anticoagulants, thrombolytic agents, Oral
hypoglycemic agents, lithium, ASA, valproic Acid,
cyclosporine, methotrexate.
C/I: Diclofenac: Active or history of blood dyscrasias, bone
marrow depression.
S/P: Third trimester of pregnancy.
S/E: Fluid retention/edema.
Acetylsalicylic Acid (Aspirin) [C]
"Bokey Enteric-microencapsulated Capsule" 100mg/cap
Usual Dose: PO.
Fever and pain:
Adults & children > 11yr, 325-650mg q4h as needed;
max. 4g/day; children, 2-11yr, 65mg/kg/day in 4-6
doses; < 2yr, dosage must be individualized.
Kawasaki syndrome (during the febrile phase):
80-100mg/kg/day in 4 doses; when fever subsides,
reduced to approx. 3-8mg/kg daily.
Myocardial infarction risk reduction: 160-325mg qd.
Rheumatic disease:
Adults, initially, 2.4-3.6g/day; maintenance,
3.6-5.4g/day in divided doses; children, initially, >
25kg, 2.4-3.6g/day; ≦25kg, 60-90mg/kg/day;
maintenance, 80-100mg/kg/day, may be up to
130mg/kg/day in divided doses.
Transient ischemic attacks (TIAs):
1.3g/day in 2-4 divided doses, lower dosage may also be
effective (eg. 30-150mg q24-48h).
7
Lysine Acetylsalicylate [C]
"Stin Injection" 500mg/vial
Each vial contains:
Lysine Acetylsalicylate ------------------------------------0.9g
(Equivalent to aspirin 0.5g)
Glycine ------------------------------------------------------ 0.1g
Usual Dose:
Adult: IV or IM 0.5-2g/day; severe pain, IV 1g, max. 4g
(aspirin)/day.
Children: 6-10yr, 0.25g-0.5g/day; > 11yr, 0.5g-1g/day.
Diclofenac Potassium [B/D if used at 3rd trimester]
"Voren-EMC Sugar-coated Capsule " 50mg/ Cap
"Meitifen S.R Tablet " 75mg/Tab
Usual Dose:PO.
Ankylosing spondylitis: 100-125mg/day; max.
125mg/day.
Osteoarthritis: 100-150mg/day in 2-3 doses; max.
150mg/day
Pain and dysmenorrhea: 50mg tid as needed; max. 200mg
on the first day, 150mg/day thereafter.
Rheumatoid arthritis: 150-200mg/day in 2-4 doses; max.
225mg/day.
Etodolac [C/D if used at 3rd trimester]
"Lacoxa SR Tablet" 400mg/tab
Usual Dose: PO.
Osteoarthritis: 800-1200mg/day in 2-4 divided doses, max.
1200mg/day; < 60kg, max. 20mg/kg/day.
Acute pain: 200-400mg q6-8h, max. 1200mg/day; < 60kg,
8
max. 20mg/kg/day.
Etofenamate
"Teiria Gel" 5%, 40g/tube
Usual Dose: Apply several times daily.
Piroxicam
"Focus Gel" 10mg/g, 40g/tube
Usual Dose: Apply several times daily.
Flurbiprofen [B]
"Lefenine Tablet" 100mg/tab
"Fubifen PAP" 40mg/10g/patch
Usual Dose: Apply 1 patch bid to the affected area.
PO 200-300mg/d (in 2-3 divided doses; max. 300mg/d)
Indomethacin [B/D if used > 48hr or after 34wk gestation]
"Indocid Capsule" 25mg/cap
Usual Dose:
PO:
Acute gout: 50mg tid until pain is tolerable. The dose
should then be rapidly reduced to complete cessation
of the drug.
Pain: Initially, 75-150mg/day in 3-4 doses; maintenance,
25mg tid-qid.
Rheumatic disease: Initially, 25mg bid-tid, increase
daily dose by 25mg or 50mg at weekly intervals; max.
150-200mg/day.
Rectally: Adults, 50mg bid.
9
Ketorolac Tromethamine [B/D if used at 3rd trimester]
"Keto Injection" 30mg/ml/amp
"Keto EMC Capsule" 10mg/cap
Usual Dose:
IM: Initial 30-60mg, then 15-30mg q6h as needed for up
to 5 days.
IV: Initial 30mg, then 15-30mg q6h as needed for up to 5
days. Max. 120mg/day.
Elderly > 65yrs, body weight < 50kg, renal insufficiency:
1/2 usual dose.
PO: 10 mg q4-6h for up to 7 days. Max. 40 mg/day.
NOTE: Therapy should not exceed 5 days.
STORAGE: Protect from light.
Meloxicam [C]
"Melocam Tablet" 7.5mg/tab
"Melicam,Monic Tablet" 15mg/tab
"Achefree Injection" 15mg/1.5ml/amp
Usual Dose: PO, 7.5 or 15mg qd; max. 15mg/day
"Achefree Injection" 不可以靜脈注射方式給藥，應以深層
肌肉注射給藥，為避免可能的配伍禁忌，注射液不應與
其他藥物在同一注射筒中混合。肌肉注射給藥只能用於
治療的前幾天，持續治療時，應使用口服劑型。
Aceclofenac
"Tonec Tablets" 100mg/tab
Usual Dose:PO, 1 tab bid
C/I: Rhinitis, urticaria, asthma, or allergic reactions to aspirin
or other anti-inflammatory agents
10
Etoricoxib [C/D]
" Arcoxia Tablets" 60mg/tab
Usual Dose:PO,
Osteoarthritis: 60mg once daily
Rheumatoid arthritis: 90mg once daily
Acute gouty arthritis: 120mg once daily
Dysmenorrhea: 120mg once daily
禁忌：1. CHF(NYHA II-IV) 2. 患有缺血性心衰竭疾病,
週邊動脈疾病和/或腦血管疾病(包括最近 做過冠狀動
脈繞道手術或血管修復手術
Tenoxicam
"Sutondin F.C. Tablets" 20mg/tab
Usual Dose:PO, 20mg once daily.
Piroxicamβ-Cyclodextrin
"Brexin Sachets" 191.2mg/Sachet,vu;相當於 Piroxicam 20mg
Usual Dose:每天 1 包
Parecoxib
" Dynastat Injection" 40mg/vial
Usual Dose: IM,IV
建議劑量為 40mg, IM or IV,接著視需要每 12~24 小時可
再給予 20mg。
對於老年病人（≧65 歲），通常無須調整劑量，但對於
體重低於 50 ㎏的老年病人，起始劑量應為一般建議劑量
的二分之一，每日最高劑量降至 40mg。
11
2) Anti-rheumatic Agents
a) Non-steroidal Anti-inflammatory Agents
Aspirin
See "Bokey Enteric-microencapsulated Capsule" 100mg/cap
Flurbiprofen Sodium
See "Lefenine Tablet" 100mg/tab
Indomethacin
See "Indocid Capsule" 25mg/cap
b) Others
Glucosamine Sulphate
" Viartril-S Powder" 1500mg/pk
" Viartril-S Capsule" 314mg/cap (250mg Glucosamine
Sulphate, 64mg Sodium Chloride)
" Glucosamine Capsule" 250mg/cap
Usual dose: PO, 15min before meal.
Glucosamine 500mg tid.or 1pk qod
3) Drugs Used in Gout
a) Drugs Used in Acute Gout
Colchicine [D]
"Colchicine(景德), Colchicine(信東) Tablet" 0.5mg/tab
Usual Dose: PO.
Acute gout: Initially, 0.5-1.3mg then 0.5-0.65mg q1-2h or
12
1-1.3mg q2h until articular symptoms subside, or until
nausea, vomiting or diarrhea occurs; total amount,
4-8mg.
Prophylaxis of gout: 0.5-0.65mg daily, 1-4 times/wk.
Maximum dose: A minimum of a 3 day intervals between
treatments should ensue to minimize the potential for
cumulative toxicity.
b) Drugs Used in Hyperuricemia
Allopurinol [C]
" Allopurinol Tablet" 100mg/tab
Usual Dose: PO.
Gout: Initially, 100mg/day, increased by 100mg weekly;
maintenance, 300mg/day; max. 800mg/day.
Myeloproliferative neoplastic disorders:
Adults, 600-800mg/day for 2-3 days.
Children< 6yr, 150mg/day; 6-10yr, 300mg/day.
Benzbromarone
"Narcaricin Cap, Benzon Tablet" 50mg/Cap,tab
"Uricin Tablet" 100mg/tab
Usual Dose: 50mg qd-tid.
NOTE: Should not be started during an acute attack of gout;
Ccr < 20ml/min or evidence of urinary stone is not
recommended.
4) Drugs Used in Migraine
Flunarizine HCl
13
"Sibelium Tab" 5mg/tab
Usual Dose: PO.
Vertigo: 5-20mg/day in divided dose.
Migraine prophylaxis: Adults,10mg daily; children and
elderly, 5mg daily.
Sumatriptan Succinate[C]
"Imigran FDT Tab" 50mg/tab
Usual Dose: PO.
PO, initially, 50 mg; repeated q2h as needed; max. 100
mg/dose, 3 doses or 200 mg or 3 doses/day.
Propranolol HCl
See "Inderal Tablet" 10mg/tab
5) Drugs Used in Central Pain Syndrome
Carbamazepine
See "Camapine Tablet" 200mg/tab
Phenytoin Sodium
See "Dilantin Tab" 100mg/cap
"Phenytoin Injection" 250mg/5ml/amp
6) Urinary Tract Analgesics/Anti-infective Agents
Phenazopyridine HCl [B] and Sulfacarbamide
"Spasmo-Euvernil Sugar-coated Tablet"
Each tablet contains:
Sulphaurea (Sulfacarbamide)---------------------------500mg
14
Phenazopyridine HCl-------------------------------------50mg
Usual Dose:
Adult and Children >6yr: 2 tab tid, max. 10 tab/day;
children <6yr: 1 tab tid.
NOTE: Spasmo-Euvernil should be swallowed whole and
not be crushed. A reddish orange color may be imparted to
the urine & feces.
2. Psychopharmacologic Drugs
1) Anxiolytics, Sedatives and Hypnotics
a) Benzodiazepines
NOTE:
1. The lowest effective dose should be employed (decrease
initial dosage in geriatric or debilitated patients) and the
need for continued treatment should reassess frequently.
2. Dosage should be reduced gradually when discontinuing
therapy or when decreasing the daily dosage.
3. Benzodiazepines may impair ability to perform hazardous
activities requiring mental alertness or physical
coordination.
4. Benzodiazepines should be used with caution in patients
with chronic pulmonary insufficiency or sleep apnea.
5. Tolerance and psychological and physical dependence
may occur following prolonged use.
4Alprazolam [D]
"Kinax Tablet" 0.5 ,1mg/tab
" Alpraline Tablet" 0.5 mg/tab
" Alpragin SR Tablet" 1mg/tab
15
Usual Dose: PO.
Anxiety: 0.25-0.5mg tid, increased q3-4d; max. 4mg/day.
Panic disorder: 0.5mg tid, increased q3-4d in increment of
< 1mg/day; range 1-10mg/day.
4Clobazam
"Frisium Tablet" 10mg/tab
Usual Dose: PO.
Adult: initially, 20 mg/day, max. 60mg/day.
Children > 3yr: Half the adult dose.
Elderly: 10-20mg/day.
4Diazepam [D]
"Valium Tablet" 2mg/tab
Usual Dose:
Anxiety: PO.
Adults: 2-10mg bid-qid.
Children > 6mo: initially, 1-2.5mg tid-qid or
0.12-0.8mg/kg/day, then adjust as needed.
Agitation associated with acute alcohol withdrawal:
PO, adults, 10mg tid-qid x 1 day, then 5mg tid-qid as
needed.
Epilepsy in children: PO, 6-15mg/day in divided doses, up
to 30mg/day.
Painful musculoskeletal conditions & spasticity:
PO, adults, 2-10mg bid-qid; children,
0.12-0.8mg/kg/day in divided doses.
Febrile convulsion: Rectal.
Children < 10kg, 5mg; >10kg, 10mg.
16
4Estazolam [X]
"Eurodin Tablet" 2mg/tab
Usual Dose: PO, 1-2mg hs.
4Fludiazepam [D]
"Erispan Tablet" 0.25mg/tab
Usual Dose: PO, 0.25mg tid
4Flurazepam [X]
"Syndoman Capsule" 30mg/cap
Usual Dose: Adult 15-30mg at bedtime prn.
Child over 15yrs, 15mg at bedtime prn
3Flunitrazepam [D]
"Modipanol Tablet" 2mg/tab
Usual Dose: PO, 0.5-2mg hs.
3Nimetazepam
"Lavol Tablet" 5mg/tab
Usual Dose: PO, 3-5 mg hs.
4Lorazepam [D]
" Ativan Tablet" 0.5mg/tab
" Larpam Tablet" 2mg/tab
"Neuropam Injection" 2mg/ml/amp
Usual Dose:
Antiemetic:
Children 2-15 years: IV: 0.05mg/kg (up to 2 mg/dose)
prior to chemotherapy.
Adults: Oral, IV: 0.5-2mg q4-6h as needed.
17
Anxiety and sedation:
Infants and Children: Oral, IV: Usual: 0.05mg/kg q4-8h
Adults: Oral, 1-10mg/day in 2-3 divided doses; usual
dose: 2-6mg/day in divided doses.
Insomnia: Adults: Oral: 2-4mg hs.
Preoperative: Adults:
IM: 0.05mg/kg (max. 4mg) 2 hours before surgery.
IV: 0.044mg/kg (max. 2mg) 15-20 min before surgery.
Operative amnesia: Adults: IV, up to 0.05mg/kg; max.
4mg.
Status epilepticus:IV
Infants and Children: 0.1mg/kg slow IV over 2-5
minutes, max. 4mg/dose.
Adolescents: 0.07mg/kg slow IV over 2-5 minutes; max.
4mg/dose; may repeat in 10-15 minutes.
Adults: 4mg/dose given slowly over 2-5 minutes; may
repeat in 10-15 minutes; usual max. 8mg.
STORAGE: Injection, protect from light.
4Midazolam HCl
See "Dormicum Injection" 5mg/1ml/amp
4Nordazepam
"Calmday Tablet" 5mg/tab
Usual Dose: PO, 5mg 2-3 times daily.
4Oxazepam [D]
"Alepam Tablet" 15mg/tab
"Selars Tablet" 30mg/tab
Usual Dose: PO, 15-30mg tid or qid
18
3Triazolam [X]
"Halcion Tablet" 0.25mg/tab
Usual Dose: PO, adults, 0.125-0.25mg hs.
b) Benzodiazepines like
4Zopiclone [C]
" Imovane,Insopin,Genclone Tablet" 7.5mg/tab
Usual Dose: PO, 7.5mg hs; severe cases, 15mg; elderly &
patients with hepatic or renal insufficiency: 3.75mg hs.
NOTE: Contraindicated in severe hepatic insufficiency.
4Zolpidem [B]
"Zoldox,Zolman, Stilnox Film-coated Scored Tablet"
10mg/tab
Usual Dose: PO, adults, 10mg hs, max. 10mg; elderly, 5mg
hs.
c) Barbiturates
4Phenobarbital [D]
"Phenobarbital Tablet " 30mg/tab
Usual Dose: PO.
Epilepsy: Adults, 100-300mg/day; max. 600mg/day;
children, 3-5mg/kg/day in divided doses.
Sedation: Adults, 30-120mg/day in 2-3 doses; children,
6mg/kg in 3 doses.
d) Others
19
Buspirone HCl [B]
"Busp Tablet" 10mg/tab
PO, initially, 10-15mg/day in 2-3 doses; maintenance,
15-30mg/day in 2 or 3 doses; max. 60mg/day.
2) Antipsychotics
Chlorpromazine HCl [C]
"Wintermin Tablet" 100mg/tab
Usual Dose: PO.
Intermittent porphyria: Adults, 25-50mg tid-qid.
Intractable hiccups: Adults, 25-50mg tid-qid.
Nausea and vomiting: Adults, 10-25mg q4-6h as needed;
children > 6mo, 0.55mg/kg q4-6h.
Psychotic disorder: Adults, initially, 30-75mg/day in 2-4
doses x 1-2 days; increased twice weekly by 20-50mg;
maintenance, 200-400mg/day; children > 6mo,
0.55mg/kg q4-6h as needed.
Clozapine [B]
"Mezapine,Uspen Tablet" 100mg/tab
Usual Dose: PO, initially, 25mg qd-bid, increased by
25-50mg/day over a 2wk period; maintenance, 200-600
mg/day; max. 900mg/day.
NOTE:
1.Agranulocytosis is a serious adverse effect which has
been associated with clozapine use.
2.Monitoring is performed at weekly intervals for the first
18wk & then at least q2w for the duration of therapy.
3.Clozapine should be withdrawn immediately if the
20
WBC < 3000/mm3 and/or the ANC < 1500/mm3.
Flupentixol Di-HCl
"Fluanxol,Fuxitol Tablet" 3mg/tab
Usual Dose:
Schizophrenia: 3-9mg/day bid, max. 18mg/day.
Paraphrenia: Initially, 0.5mg bid; maintenance,
1-1.5mg/day.
Mental deviations in oligophrenics and epileptics: Initially,
1-2mg/day; max. 4mg/day.
cis(Z)-Flupentixol Decanoate
"Fluanxol Depot Injection" 20mg/1ml/amp
Usual Dose:
Schizophrenia: IM, 20-40mg q2-4wk.
Daily oral Fluanxol x 4 = mg Fluanxol depot; q2wk, oral
Fluanxol should be continued during the first week.
Zuclopenthixol Decanoate[C]
"Clopixol-Acuphase Injection" 50mg/1ml/amp
Usual Dose: Administ 200 - 400mg IM at interval of 2-4
wk.
Haloperidol [C]
"Haldol Tablet" 0.5mg/tab
"Haldol Tablet" 5mg/tab
"Haldol drop" 0.1mg/drop, 2mg/1ml, 30mg/15ml/btl
"Binin-U Injection" 5mg/1ml/amp
Usual Dose:
Psychotic disorder:
21
PO, adults, 0.5-2mg bid-tid; max. 100mg/day; children,
3-12yr, 0.05-0.15mg/kg/day in 2-3 doses.
IM, 2-5mg ql-8h as needed.
Tourette's syndrome:
PO, adults, initially, 0.5-2mg bid-tid; max. 100mg/day;
children, 3-12yr, 0.05-0.075mg/kg/day in 2-3 doses.
STORAGE: Injection and oral solution, protect from light.
Prochlorperazine Mesylate
See "Novamin Tablet" 8mg/tab
Quetiapine [C]
"Seroquel Tablet" 25mg/tab
"Seroquel Tablet" 100mg/tab
"Utapine Tablet" 200mg/tab
Usual Dose: PO.
Adults: Initially, 25mg bid, on the 2nd or 3rd day, increased
the dose by 25-50mg bid or tid. By the 4th day, target
dose of 300-400mg/day in divided doses is
recommended. Alternatively, day 1, 50mg; day 2,
100mg; day 3, 200mg and day 4, 300mg in 2 divided
doses. Max. 800mg/day.
Geriatric and patient with hepatic impairment: Initially,
25mg/day, increased daily by 25-50mg to an effective
dose.
NOTE:
1. Patients with hepatic impairment have a 30% lower
mean oral clearance of quetiapine than subjects with
normal hepatic clearance.
2. Oral clearance of quetiapine was reduced by 40% in
22
patients older than 65 years
Risperidone [C]
"Rispal,Perisdone Tablet" 2mg/tab
"Spiterin Tablet" 3mg/tab
" Spiterin Tablet" 1mg/tab
"Risperdal Oral Solution " 1mg/ml,30mg/30ml/btl
Usual Dose: PO.
Initially, 1mg bid, increases 1mg bid on second and third
day to a target dose of 2-3mg bid by the third day, max.
16mg/day. Daily dosages > 6mg does not appear to
confer any additional benefit.
Sulpiride
"Betamac Tablet" 200mg/tab
"Sulgin Tablet" 400mg/tab
"Dogmatyl Tablet" 50mg/tab
Usual Dose: PO.
Anxiety with depression: 150-300mg/day in divided doses,
max. 600mg/day.
GI disorder: 50mg tid.
Neuroses: Adults, 150mg/day.
Schizophrenia: Adults, initially, 200-400mg bid; max.
1.2g bid; children 3-5mg/kg.
Zotepine
"Lodopin Tablet" 50mg/tab
Usual Dose: PO, 75-150mg/day in divided doses; may up to
450mg/day
23
Amisulpride
"Solian Tablet" 200mg/tab
Usual Dose: PO.
Acute psychotic episodes: 400 to 800 mg/day. Daily dose
may be increased up to 1200mg. Doses up to 300 mg
may be given once daily, while higher doses should be
divided into two doses.
Schizophrenia predominantly characterized by negative
symptoms: 50 to 300 mg/day.
Renal insufficiency: Clcr 30-60mg/min, dose reduce 50%;
Clcr 10-30mg/min, dose reduce to 33%
Aripiprazole [C]
"Abilify Tablet" 10mg/tab
Usual Dose: PO.
Schizophrenia, schizoaffective disorder: initially, 10-15
mg /day; maintenance, max. 30mg/day.
Olanzapine [C]
"Zyprexa Tablet" 5mg/tab
Usual Dose:
PO:Schizophrenia : Adults, initially, 5-10mg qd, increase to
10mg qd within 5-7 days, thereafter adjust by 5mg/day
at 1-week intervals, up to a max. 20mg/day.
Acute mania associated with bipolar disorder: initially,
10-15 mg qd. Adjust dosage at 5mg increment in
intervals not < 24hr if indicated.
Paliperidone
" Invega ER Tablet" 3mg/tab
24
Usual Dose: PO:
3-6 mg once daily, administered in the morning. Dose
increases above 6 mg/day should be made only after
clinical reassessment and generally should occur at
intervals of more than 5 days. When dose increases are
indicated, small increments of 3 mg/day are recommended.
Max. 12 mg/day
3) Drugs Used in Affective Disorders
a) Antidepressants
i) Tricyclics
NOTE:
1. May require 4-6wk to obtain optimal effects.
2. Avoid simultaneous use of MAOI.
Imipramine HCl [D]
"Tofranil Tablet" 10mg/tab
Usual Dose: PO.
Childhood enuresis: 6-12yr, 25-50mg lhr before bedtime;
>12yr, up to 75mg/night; max. 2.5mg/kg/day; early
night bedwetters, 25mg midafternoon & hs.
Depression:
Adults, 75-150mg/day in divided doses or hs; max.
200mg/day (outpatient), or 300mg/day (inpatient).
Adolescents & geriatric patients, initially, 30-40mg/day;
rarely exceeds 100mg/day.
Amitriptyline[D]
"Tryptanol Tablet" 25mg/tab
25
Usual Dose: PO.
Adults: PO 75mg/day divided to start, followed by increase
in late-afternoon or bedtime dose, up to a total of
150mg/day , if needed.
ii) Selective Serotonin Reuptake Inhibitors (SSRIs)
NOTE: Not to be used during using MAOIs or within 14 days
of discountinuing MAOIs
Fluoxetine [B]
"U-zet,Sinzac Capsule" 20mg/cap
Usual Dose:
Initially, 20 mg PO in the morning; may be given bid in the
morning and at noon. Max : 80 mg/day.
Paroxetine HCl [D]
" Caremod FC Tablet" 20mg/tab
Usual Dose: PO
Major depression:Initially, 20mg/day in the morning,
increased by 10mg/day q7d; max. 50mg/day.
Obsessive-compulsive disorder:Initially, 20mg/day,
increased by 10mg/day q7d; max.
60mg/day.
Panic disorder: Initially, 10mg/day, increased by
10mg/day q7d; max. 60mg/day
Citalopram [C]
"Kitapram, Sitalo Tablet" 20mg/tab
"Apo-Citalopram Tablet" 40mg/tab
26
Usual Dose:
Initially 20mg/day, may tirtrate the dose in 20mg
increment at intervals of no less than 1 week. Max.
60mg/day.
Elderly or hepatic impairment: Reduce dose.
Escitalopram [C]
"Lexapro Tablet" 10mg/tab
Usual Dose:
PO 1# qd, the dose may be increased to 20 mg once daily
after at least one week of treatment.
Fluvoxamine Maleate [C]
"Lote Enteric-coated Tablet" 50mg/tab
Usual Dose:
Initially 50mg hs, adjust in 50mg increments at 4-7 day
intervals. Maintenance dose, 100-300mg/day divided
into 2 doses; give larger portion at bedtime.
Elderly or hepatic impairment: Reduce dose, titrate slowly
Sertraline HCl [C]
"You-Jet,Zapline Film-coated Tablet" 50mg/tab
Usual Dose: PO.
Major depression & OCD: Initially, 50mg qd in the
morning, then increase 50mg/day increments q2-3d if
tolerated to 100mg/day, max. 200mg/day; if somnolence,
give at bedtime.
Panic disorder: Initially, 25mg qd, then titrate as above.
Elderly: Start treatment with 25mg qd in the morning.
27
iii) Triazolopyridine
Trazodone HCl [C]
"Mesyrel Tablet" 50mg/tab
"Trazo,Trazone Tablet" 100mg/tab
Usual dose: PO, initially, 150mg/day in divided doses pc;
increased by 50mg/day q3-4d; max. 400mg/day
(outpatient), or 600mg/day (inpatient).
NOTE: Decrease initial dosage in geriatric patients.
iv) Selective serotonin-norepinephrine reuptake inhibitors
Venlafaxine HCl [C]
"Calmdown Tablet " 37.5mg/Tab
"Valosine SR,Venforspine XR Capsule" 75mg/cap
Usual Dose: 75mg qd, taken with food; dose may be
increased in 75mg/day increments at intervals of at least 4
days; maintenance, 150-225mg/day; max. 350mg/day.
v) Noradrenergic and specific serotonergic antidepressant
Mirtazapine [C]
"U-zepine Tablet" 30mg/tab
Usual Dose: PO. Initially, 15mg hs, titrate up to 15-45mg/day
with dose increases made no more frequently than every 1-2
weeks.
b) Antimanic
Carbamazepine
See "Camapine Tablet" 200mg/tab
28
Lithium Carbonate [D]
"LiCO3" 300mg/tab
Usual Dose: PO.
Acute mania: Adults, 900-1800mg/day or
20-30mg/kg/day in 2-3 doses;
Maintenance: 900-1200mg/day in divided doses; max.
2.4g/day.
4) Drugs Used in Other Mental Disorders
Donepezil HCl [C]
"Aricept Tablet" 5mg/tab
Usual Dose: PO, adults, initially 5mg hs; may increase to
10mg/day after 4-6 wk.
Rivastigmine [B]
"Exelon Cap" 1.5mg/cap
"Exelon Cap" 3mg/cap
"Exelon Cap" 4.5mg/cap
"Exelon Cap" 6mg/cap
Usual Dose: PO, 6 to 12 mg daily are recommended for the
treatment of mild to moderate dementia of the Alzheimer's
type
Memantine [B]
"Witgen Tablet" 10mg/tab
Usual Dose: PO, adults, initially 5mg hs; increase dose at
minimum 1 week intervals in 5 mg increments to 10
mg/day, 15 mg/day, and 20 mg/day in two dose, to target
29
dose of 20 mg/day.
3Methylphenidate HCl [C]
"Ritalin Tablet" 10mg/tab
"Concerta Extended Release Tablet" 36mg/tab
Usual Dose: PO.
Ritalin:
Attention deficit hyperactivity disorder (ADHD):
Children > 6yr, initially, 5mg 30-45min before
breakfast and lunch, no drug after 6pm; max.
2mg/kg/day or 60mg/day.
Narcolepsy: Adults, 10-60mg/day 30-45min before
meals in 2-3 doses.
Concerta Extended Release Tablet: New patients, 18mg in
the morning.
Patients converting from immediate- release (IR):
Previous methylphenidate daily dose Recommended
Concerta dose
5 mg IR bid or 5 mg IR tid
18mg in the morning
10 mg IR bid or 10 mg IR tid
36mg in the morning
15 mg IR bid or 15 mg tid
54mg in the morning
NOTE:
1. Concerta should be swallowed whole with the aid of
liquids. Tablet should not be chewed, divided or
crushed.
2. Concerta is administered orally once daily. As the
effect has been shown to be present 12 hours after
dosing, the product should be taken in the morning.
Piracetam
30
"Nootropil,Noopol Tablet" 1200mg/tab
Usual Dose: PO.
Cerebrovascular insufficiencies and age related cognitive
impairment: Loading dose, 4.8g daily; maintenance,
1.2-2.4g daily.
Cortical myoclonus: Initially 7.2g/day, increased by
4.8g/day every 3-4 days to a maximum of 24g/day.
Doses should be divided to 2-3 times daily.
3. Neurologic Drugs
1) Anticonvulsants
a) Barbiturates
Phenobarbital
See "Phenobarbital Tablet " 30mg/tab
b) Benzodiazepines
4Clonazepam [C]
"Rivotril Tablet" 0.5mg, 2mg/tab
"Clonopam Tablet" 0.5mg/tab
Usual Dose: PO.
Adults, initially, < 1.5mg/day in 3 divided doses,
increased by 0.5-1.0mg q3d; max. 20mg/day.
Infants and children (up to 10yr or 30kg), initially,
0.01-0.03mg/kg/day (max. 0.05mg/kg/day) in 2-3 doses;
increased by < 0.5mg q3d; max. 0.2mg/kg/day.
4Diazepam
See "Valium Tablet" 2mg/tab
31
c) Hydantoins
Phenytoin Sodium (Diphenylhydantoin) [D]
"Dilantin Tab" 100mg/cap
"Phenytoin Injection" 250mg/5ml/amp
Usual Dose:
PO:
Epilepsy:
Adults, initially, 100mg tid; dosage should be carefully
& slowly adjusted; maintenance, 6-7mg/kg/day
(300-600mg/day).
Children, initially, 5mg/kg/day in 2-3 doses;
maintenance, 4-8mg/kg/day; max. 300mg/day.
IM or Slow IV:
Status epilepticus:
Adults, loading dose 10-15mg/kg (rate < 50mg/min);
followed by maintenance dose of 100mg q6-8h PO
or IV; max. 1.5g/day.
Children, loading dose 15-20mg/kg (rate <1-3mg /kg/
min); max. 20mg/kg/day.
d) Miscellaneous Anticonvulsants
Acetazolamide
See " Diamox Tablet" 250mg/tab
Carbamazepine [C]
"Camapine Tablet" 200mg/tab
Usual Dose: PO.
32
Epilepsy:
Adults & children > 12yr, initially, 200mg bid, increased
by 200mg/day q1w; maintenance, 800-1200mg/day in
divided doses; max. 13-15yr, 1g/day, > 15yr, 1.2g/day.
Children 6-12 yr, initially, 100mg bid; increased by
100mg/day q1w; maintenance, 400-800mg/day; max.
1g/day.
Trigeminal neuralgia: 100mg bid x 1 day, increased by
100mg q12h; maintenance, 400-800mg/day; max.
1.2g/day.
NOTE:
1. Complete pretreatment hematological testing should be
obtained as a baseline.
2. Discontinuation of the drug, should be considered if any
evidence of significant bone marrow depression
develops.
Gabapentin [C]
"Neurontin Cap" 300,400mg/cap
Usual Dose: PO.
Initial dose: 300mg daily at the first day; 300mg twice
daily at the second day; titrate to 900mg/day over 3 days,
maintenance dose, 300mg tid.
Magnesium Sulfate
See "Magnesium Sulfate Injection"
Valproate Sodium (Sodium Valproate) [D]
"Dipachro SR,Depatec FC Tablet" 500mg/tab
Usual dose: PO, initially, 15mg/kg/day; increased by 5-10
33
mg/kg/day q7d in divided doses; max. 60mg/kg/day.
Valproic Acid [D]
"Convulex Capsule" 500mg/cap
Usual dose: PO.
Epilepsy: initially, 15mg/kg/day; increased by 5-10
mg/kg/day q7d in divided doses; max. 60mg/kg/day.
Acute Mania: 750 mg/day in divided doses. Max. 60
mg/kg/day.
Migraine prophylaxis: 250 mg bid; max. 1000 mg/day.
Lamotrigine [C]
" Lamotrix Tablet" 100mg/tab
Usual Dose: PO.
Adults & children > 16yr receiving enzyme inducing
anticonvulsants.
Without concomitant valproic acid: Initially, 50qd x 2
wks, then 50mg bid x 2 wks, then increased by 100mg
q1w; maintenance, 300-500mg/day.
With concomitant valproic acid therapy: Initially, 25qod
x 2wks, then 25mg qd x 2wkds, then increased by
25-50mg q1-2wks; maintenance, 50-200mg/day in 2
divided doses.
Children 2-12 yr:
Without concomitant valproic acid: Initially,
0.6mg/kg/day bid x 2 wks, then 1-2mg/kg/day bid x 2
wks, may increased by 1.2mg/kg/day at 1- to 2- week
intervals; maintenance dose: 5-15mg/kg/day; max.
400mg/day.
With concomitant valproic acid: Initially,
34
0.15mg/kg/day in 1-2 divided doses x 2 wks, increased
by 0.3mg/kg/day in 1-2 divided doses x 2 wks, then
increased by 0.3mg/kg/day at 1- to 2- week intervals;
maintenenance dose: 1-5mg/kg/day, max.200mg/day.
2) Antiparkinsonian Agents
a) Centrally Active Anticholinergics
Biperiden HCl [C]
"Akineton Tablet" 2mg/tab
Usual Dose: PO.
Drug induced extrapyramidal reactions: 2mg qd-tid.
Parkinsonian syndrome: 2mg tid-qid, adjusted as needed
and tolerated; max. 16mg/day.
Biperiden Lactate [C]
" Akineton Injection" 5mg/1ml/amp
Usual Dose: Slow IV or IM, 2mg q30min as needed; max.
8mg/day.
Trihexyphenidyl HCl (Benzhexol HCl) [C]
"Artane Tablet" 2mg/tab
Usual Dose: PO.
Drug induced extrapyramidal reactions: 5-15mg/day in
divided doses.
Parkinsonian syndrome: 1mg x 1day, increased by 2mg
q3-5d; maintenance, 6-15mg/day in divided doses.
b) Drugs Elevating Brain Dopamine Level
35
Amantadine Sulfate [C]
"Amantadine Tablet " 100mg/tab
Usual Dose: PO.
Influenza A virus infections:
Adults, 100mg bid or 200mg qd; > 65yr, 100mg qd.
Children 1-9yr, 4.4-8.8mg/kg/day; max. 150mg/day; >
9yr or > 45kg, 100mg bid or 200mg qd.
Parkinsonian syndrome:
Initially, 100mg qd-bid; maintenance, 100mg bid; max.
400mg/day. (reduced dose in > 65yr)
NOTE: The last daily dose should preferably be taken at
7pm to avoid sleep disturbance.
Levodopa and Benserazide HCl [C]
"Madopar Tablet" 100mg levodopa & 25mg benserazide/tab
"Madopar HBS Capsule" 100mg levodopa & 25mg
benserazide/cap
Usual Dose: PO.
Madopar: Initial : 100mg of levodopa and 25mg of
benserazide 1-2 times daily; the dosage per day being
increased gradually by 1 cap every third or fourth day
MD : 400-800mg of levodopa and 100-200mg of
benserazide daily in div. Doses,
Max. 1g of levodopa and 250mg benserazide daily
Madopar HBS: Combination of Madopar standard and
Madopar HBS is recommended, especially for early
morning dose. After 2 to 3 days of therapy the total daily
dose of Madopar HBS generally needs to be increased
by 40% to 50% compared to therapy with Madopar
standard. Max. levodopa 800mg, Benserazide 200mg
36
NOTE:
1. Use in pregnant women needs cautions.
2. Madopar HBS (hydrodynamically balanced system)
should be swallowed whole and not be chewed or
dissolved in mouth.
Selegiline HCl [C]
"Parkryl Tablet" 5mg/tab
Usual Dose: PO, 5-10mg/day taken at breakfast and lunch;
max. 10mg/day.
c) Dopamine Receptor Agonists
Bromocriptine Mesylate
See "Syntocriptine Tablet" 2.5mg/tab
d) Catechol-O-Methyltransferase Inhibitor
Entacapone [C]
"Comtan Tablet" 200mg/tab
Usual Dose: PO, 200mg is taken with each levodopa/dopa
carboxylase inhibitor dose, max. 1600mg daily.
3) Skeletal Muscle Relaxants
Baclofen [C]
" Baclon Tablet" 10mg/tab
" Befon Tablet" 5mg/tab
Usual Dose: PO.
Children: 2-7yr, initially, 10-15mg/day q8h, titrate every 3
37
days in increments of 5-15mg /day, max. 40mg/day; ≧
8 yrs, max. 60mg/day in 3 divided doses.
Adults: 5mg tid, increase 5mg/dose every 3 days to a
maximum of 40-80mg/day; max. 80mg/day.
Tizanidine HCl [C]
"Tizan Tablet" 2mg/tab
Usual Dose: PO, 6-36mg/day in 3 divided doses
Cyclobenzaprine [B]
"Musgud Tablet" 5mg/tab
Usual Dose: PO, adults, 20-40mg/day in 2-4 divided doses;
max. 60mg/day.
Tolperisone HCl
"Mydocalm Sugar-coated Tablet" 150mg/tab
" Muscone Tablet" 50mg/tab
Usual Dose: PO, 50~150mg tid.
Mephenoxalone [C]
"Suflex Tablet" 200mg/tab
"Noxalone Tablet" 500mg/tab
Usual Dose: PO, adults, 200-400mg tid; may increased to
1600-2000mg; children > 6-15yr, 100mg tid.
4) Drugs Used in Myasthenia Gravis
NOTE: The nicotinic effect of the following agents may cause
paralysis of respiratory muscle with overdose.
38
Pyridostigmine Bromide [C]
"Mestinon Tablet" 60mg/tab
Usual Dose: PO.
Initially, adults, 60mg tid; children, 7mg/kg/day or
200mg/m2 in 5-6 doses; titrate at intervals of 48hr or
more; adults maintenance dose, 60mg-1.5g/day (average
600mg).
5) Anti-vertigo Agents
Diphenidol HCl
" Diphenidol Tablet " 25mg/tab
Usual Dose: PO.
Adults, 25-50mg q4h as needed; max. 300mg/day.
Children > 6mo or > 11 kg, 0.9mg/kg, may be repeated in
lhr with subsequent doses of q4h as needed; max.
5.5mg/kg/day.
NOTE: May cause hallucinations, disorientation or
confusion.
Betahistine Mesylate
" Merislon Tablet" 12mg/tab
"Nilasen Tablet" 24mg/tab
Usual Dose: PO.
initially, 12mg tid with meals; maintenance,
24-48mg/day.
Flunarizine HCl
See "Sibelium Tab" 5mg/tab
39
Meclizine HCl [B]
" Bonamine( Clizine ) Tablet" 25mg/tab
Usual Dose: PO.
Motion sickness: 25-50mg 1hr before travel, may be
repeated q24h.
Vertigo: 25-100mg/day in divided doses.
6) Others
Botulinum Toxin Type A (Clostridium) [C]
"Botox Dried Powder Injection" 100units/vial
Usual Dose:
Blepharospasm: 1.25-5units (0.05-0.2ml) injected into the
orbicularis oculi muscle.
Subsequent doses: Each treatment lasts approx. 3
months; at repeat treatment sessions, increments to
twofold if initial treatment is insufficient. The
cumulative dose < 200units within 30 days.
Strabismus: 1.25-5units (0.05-0.2ml) injected into any one
muscle.
Subsequent doses for residual/recurrent strabismus:
Assess the response of patients after 7-14 days of
injection; increments to twofold if the patients
experience incomplete paralysis; max. 25units.
Pediatric Cerebral Palsy: Use 23-26 gauge needle,
Hemiplegia: 4units/kg; diplegia, 6units/kg.
NOTE: Inject using 27-30 gauge needle.
STORAGE: -5 oC . Reconstituted solution stored at 2-8 oC,
discard after 4hr.
40
4. Agents Used in Anesthesia
1) Local Anesthetics
NOTE:
D/I: CNS depressants, vasoconstrictors,β-hydrocarbon
inhalation anesthetics
S/P: Coagulation defects
S/E: Methemoglobulinemia, cardiac depression
Bupivacaine HCl [C]
"Marcaine Injection" 0.5%, 20ml/btl
"Marcaine Spinal Injection" 0.5%, 4ml/amp
Lidocaine HCl (Lignocaine HCl) [B]
"Xylocaine 2% for IV Injection" 100mg/5ml/amp
"Xylocaine 2% Injection" 20ml/btl (injection for local
anesthesia)
Lidocaine and Epinephrine [B]
"Xylocaine 2% and Epinephrine 1:200,000" 20ml/btl
Usual Dose:
Percutaneous infiltration anesthesia: 0.5-30ml (5-300mg).
NOTE: Avoid intravascular injection.
Lidocaine [B] and Prilocaine
"EMLA Cream 5%" 5g/tube
Each g contains:
Lidocaine---------------------------------------------------25mg
Prilocaine---------------------------------------------------25mg
Polyoxyethylene, Carboxypolymethylene, Sodium
41
hydroxide and water.
Usual Dose:
1 hr prior injection, apply 2g locally and cover with a pad.
2) General Anesthetics
a) Inhalation Anesthetics
NOTE:
D/I: Systemic aminoglycosides, lincomycins.
Isoflurane
"Isoflurane" 100ml/btl
Usual Dose:
Induction: inspired concentration of 1-3% isoflurane usually
produce surgical anesthesia in 7-10 minutes
Maintenance: surgical levels of anesthesia may be sustained
with a 1 -2.5% concentration when N2O is use
concomitantly. An additional 0.5-1% may be required
when isoflurane is given using O2 alone
b) Parenteral Anesthetics
*2Fentanyl Citrate
See "Fentanyl Injection " 0.05mg/ml, 10ml/amp
4Midazolam HCl [D]
"Dormicum Injection" 5mg/1ml/amp
Usual Dose: IV, IM.
Induction of anesthesia or for conscious sedation for
endoscopy: IV, individualized. Titrate dosage to the
42
desired clinical effect; maintenance, give 25% of the
dose used to first reach the sedative endpoint but again
only by slow titration.
Preoperative sedation: IM, 0.07-0.08mg/kg (5mg for an
average adults) 30-60min before surgery. Oral,
0.2-0.4mg/kg, max. 15mg 30-45min before surgery
NOTE: Patients should be continuously monitored for early
signs of underventilation or apnea.
STORAGE: Protect from light.
Propofol [B]
" Anesvan 1% Injection" 200mg/20ml/amp
Usual Dose: Induction, IV, 2.0-2.5mg/kg; maintenance IVF,
6-12mg/kg/hr or intermittent IV bolus, 25-50mg.
NOTE:
1. Diprivan can be used for infusion undiluted or diluted
with 5% dextrose only. The prepared solution must be
used within 8hr.
2. Each ampoule should be shaken before use and unused
portion should be discarded.
Thiamylal Sodium
"Citosol for Injection" 0.3g/15ml/amp
Usual Dose: IV.
Induction: 2.5% soln. 2ml as test dose, then 2-4ml
q30-40sec or 3-5mg/kg single injection; maintenance,
2.5% 2-4ml as needed; max. 1g.
STORAGE: Protect from light.
3) Neuromuscular Blocking Agents
43
NOTE:
D/I: Aminoglycosides, citrated-anticoagulated blood,
clindamycin, lincomycin, quinidine, procainamide,
botulinum toxin type A.
Succinylcholine: Cholinesterase inhibitors, neurotoxic
insecticides, digoxin.
Pancuronium: Digoxin.
S/P: Avoid in patients with myasthenia gravis.
Succinylcholine: Malignant hyperthermia.
S/E: BP elevation, tachycardia, salivation, edema, rash,
flushing or itching of skin.
Atracuronium Besylate [C]
" Genso Injection" 25mg/2.5ml/amp
Usual Dose:
IV, 0.25-0.5mg/kg initially
Maintenance doses of 0.08-0.1mg/kg may be administered
20-45 mins following the initial dose, then every
15-25mins or as required by clinical conditions
Rocuronium [B]
"Esmeron Injection" 50mg/5ml/amp
Usual Dose:
Adults, initially, IV, 0.6mg/kg; maintenance, IV,
0.1-0.2mg/kg or continuous IVF, 0.01-0.012mg/kg/min.
Children, initially, IV, 0.6mg/kg; maintenance, IV,
0.075-0.125mg/kg or continuous IVF, 0.012mg/kg/min.
STORAGE: 2-8 oC, do not freeze; if store under 25 oC, use
within 30 days.
44
Succinylcholine Chloride (Suxamethonium Chloride) [C]
"Lysthenon for Injection" 500mg/vial
Usual Dose: Skeletal muscle relaxation
Prolonged procedures:
IV, adults, initially, 0.3-1.1mg/kg, followed by
0.04-0.07mg/kg as needed.
IVF, adults, 0.5-10mg/min depending on the response.
IM, 2.5-4mg/kg; max. 150mg.
Short procedures:
IV, adults, 0.3-1.1mg/kg over 10-30sec; children,
1-2mg/kg, additional doses may be given if necessary
IM, 2.5-4mg/kg; max. 150mg.
Vecuronium Bromide [C]
"Norcuron for Injection" 10mg/vial
Usual Dose: IV.
Initially, 0.08-0.1mg/kg IV bolus, the initial dose may be
reduced by about 15% (0.06- 0.085mg/kg) when it is
administered more than 5min after the initiation of
general anesthetics or after steady-state anesthesia has
been achieved.
Following the use of succinylcholine for endotracheal
intubation, a reduced dose of 0.005-0.06mg/kg with
balanced anesthesia or 0.04-0.06mg/kg with inhalation
anesthesia may be necessary. Use of a small test dose of
0.005-0.02mg/kg may be of value in patients with
neuromuscular disease.
Maintenance:
Patients receiving balanced anesthesia:
45
0.01-0.015mg/kg.
Patients receiving inhalation anesthesia:0.008-0.012 mg
/kg. After the initial dose, the first maintenance dose
generally is necessary within 25-40min. The
subsequent maintenance dose may be administered at
12-15min intervals in patients under balanced
anesthesia and at slightly longer intervals in patients
under inhalation anesthesia.
4) Miscellaneous Adjuncts to Anesthetics
Atropine Sulfate
See "Atropine Sulfate Injection" 1mg/1ml/amp
Flumazenil [C]
"Anexate Injection" 0.5mg/5ml/amp
Usual Dose: IV.
Management of benzodiazepine overdose: 0.2mg over 30
sec, 0.3mg after 30sec as needed; then 0.5mg at 1min
intervals; max. 3mg or 5mg for partial response. If
resedation occurs, repeated doses may be administered
at 20min intervals; max. 1mg/time or 3mg/hr.
Reversal of benzodiazepine-induced sedation: 0.2mg over
15sec, then 0.2mg at 1min intervals as needed , max.
1mg/5min. If resedation occurs, repeated doses may be
administered at 20min intervals; max. 3mg/hr.
NOTE: Flumazenil has been associated with the occurrence
of seizures.
*2Meperidine HCl
46
See "Demerol Injection" 50mg/ml/amp
II. Cardiovascular-renal Agents
1. Digitalis Glycosides
Digoxin [C]
"Digoxin Tablet" 0.25mg/tab
"Digoxin Injection" 0.25mg/1ml/amp
Usual Dose: Loading doses are administered in divided
doses, approximately 50% of the total loading dose given
as the first dose; additional fraction of the loading dose are
administered at 4-8hr intervals with careful assessment of
clinical response before each additional doses.
Usual digitalizing and maintenance dosages for oral
digoxin (based on lean body weight)
Age
Digitalizing Dose Oral Maintenance Dosage
(mcg/kg)
(mcg/kg/day)
Premature neonates
20-30
20-30% of oral loading dose
Full-term neonates
25-35
25-35% of oral loading dose
1-24 months
35-60
2-5 years
30-40
5-10 years
20-35
Older than 10 years
10-15
47
Usual digitalizing and maintenance dosages for IV digoxin
(based on lean body weight)
Age
Premature
neonates
Full-term neonates
1-24 months
2-5 years
5-10 years
Older than 10
years
Digitalizing Dose
IV Maintenance Dosage
(mcg/kg)
(mcg/kg/day)
15-25
20-30% of IV loading dose
20-30
30-50
25-35
15-30
8-12
25-35% of IV loading dose
NOTE:
1. IV digitalizing doses are 80% of oral digitalizing doses.
2. Dosage should be based on lean body weight.
D/I: Amiodarone, cyclosporine, erythromycin, propafenone,
quinidine, tetracyclines, verapamil.
STORAGE: Injection, Protect from light.
2. Antiarrhythmics
1) Class Ib
Lidocaine HCl (Lignocaine HCl) [B]
"Xylocaine 2% for IV Injection" 100mg/5ml/amp
Usual Dose: IV, IVF.
Adults, loading by 50-100mg or 1-1.5mg/kg at a rate of
25-50mg/min repeated in 5min as needed; max. 300mg
/hr; maintenance, 20-50mcg/kg/min.
Children, loading by 0.5-lmg/kg, may be repeated not
exceed 3-5mg/kg; maintenance, 10-50mcg/kg/min.
48
Mexiletine HCl [C]
"Mexitil Capsule" 100mg/cap
Usual Dose: PO, initially, 200mg q8h, adjust as 50-100 mg
increment, with a minimum of 2-3 days between
adjustments; usually controlled with 200-300mg q8h; max.
1.2g/day.
2) Class Ic
Propafenone HCl [C]
"Rytmonorm Tablet" 300mg/tab
Usual Dose:
Ventricular arrhythmias & supraventricular arrhythmias:
PO, initially, 150mg q8h, dose may be increased at
intervals of 3-4 days up to 300mg q8h.
3) Class II
Esmolol HCl [C]
See "Brevibloc Injection" 100mg/10ml/vial
Propranolol HCl
See "Inderal Tablet" 10mg/tab
4) Class III
Amiodarone HCl [D]
"Cordarone Injection" 150mg/3ml/amp
"Cordarone Tablet" 200mg/tab
49
Usual Dose:
PO:
Adults:
Ventricular arrhythmias: Loading by 800-1600mg/day
x 1-3wk; reduced to 600-800mg/day for about 1 mo;
maintenance, less than 400-600mg/day.
Supraventricular arrhythmias: Loading by
600-800mg/day for about 1-4wk; maintenance,
100-400mg/day.
Children, loading by 10-15mg/kg/day for about 4-14
days, then reduced to 5mg/kg/day.
IVF: Ventricular arrhythmias.
Starting dose over the first 24hr is approx.1000mg; first
rapid loading infusion: 150mg over 10min (max. rate
30mg/min); slow loading phase infusion; 360mg over
6hr; first maintenance phase infusion; 540mg over
18hr.
After the first 24hr, maintenance infusion rate,
0.5mg/min (720 mg over 24hr).
NOTE: Amiodarone is a highly toxic drug, and the lowest
effective dosage should be used to minimize the risk and
occurrence of adverse effect.
D/I: Calcium channel blocker, β-blocker, oral
anticoagulant, digoxin, phenytoin.
STORAGE: Injection, protect from light.
5) Class IV
Verapamil HCl
See "Verelan" 120mg/cap
50
Diltiazem HCl
See "Herbesser Tablet" 30mg/tab
6) Miscellaneous Antiarrhythmics
Adenosine [C]
"Adenocor Injection" 6mg/2ml/vial
Usual Dose:
PSVT including Wolff-Parkinson-White syndrome: Rapid
IV over 2sec, initially 3mg; if no response, second dose
6mg; if no response after second dose, third dose 12mg.
Atropine Sulfate
See "Atropine Sulfate Injection"
Digoxin
See "Digoxin Tablet" 0.25mg/tab
"Digoxin Injection" 0.25mg/1ml/amp
Phenytoin Sodium
See "Dilantin Tab" 100mg/cap
"Phenytoin Injection" 250mg/5ml/amp
3. Antianginal Agents
Amlodipine Besylate
See "Norvasc Tablet"
Atenolol
51
See "Tenolol
Tablet" 100mg/tab
Diltiazem HCl
See "Herbesser Tablet" 30mg/tab
Isosorbide Mononitrate [C]
"Ismo Tablet" 20mg/tab
Usual Dose: PO, 20mg twice daily, with the two doses
given 7hr apart.
D/I: Sildenafil, Tadalafil and Vardenafil; concomitant use is
contraindicated
Nicorandil
" Silvinol Tablet" 5mg/tab
Usual Dose: PO, 5mg tid.
Nifedipine
See "Adalat Capsule"
Nitroglycerin (Glyceryl Trinitrate) [C]
"Nitrostat Sublingual Tablet" 0.6mg/tab
"Millisorl Injection" 5mg/10ml/amp
Usual Dose:
Sublingually, 0.15-0.6mg repeated at 5min intervals as
needed, no more than 3 tab should be given within
15min.
IVF, initially, 5mcg/min; may be increased by 5mcg/min
q3-5min until a blood pressure response is obtained or
until the infusion rate is 20mcg/min; if no effect is
obtained with 20mcg/min, dosage may be increased by
52
increments of 10mcg/min, and if later necessary, by
increments of 20mcg/min, up to 200mcg/min.
NOTE:
1.The dilution and storage of NTG for IVF should be
made only in glass bottles.
2.Continuous monitoring of physiological parameter
measurements such as PCWP must be performed to
achieve the correct dose in IV use.
3.Concomitant administration of phosphodiesterase type 5
(PDE5) and organic nitrates in any form is
contraindicated as potentiation of hypotensive effect
may produced.
STORAGE: Injection and tablet, protect from light.
Propranolol HCl
See "Inderal Tablet"
Verapamil HCl [C]
"Verelan" 120mg/cap
Usual Dose:
Angina: PO, initially, 80mg q6-8h; maintenance,
240-480mg/day in 3-4 doses.
Hypertension: PO, 40mg bid to 80mg tid; max.
360mg/day. Sustained-release tablet, 120-240mg qd in
the morning; max. 480mg/day.
4. Antihypertensives
1) Sympatholytic Depressants
a) α-blockers
53
Doxazosin Mesylate [C]
"Doxazon, Doxazosin Tablet" 2mg/tab
"Doxaben XL Tablet" 4mg/tab
Usual Dose: PO.
Benign Prostatic Hyperplasia:
1mg qd, morning or evening, may be increased in a
stepwise manner to 2, 4, and 8mg daily as necessary;
max. 8mg/day.
Hypertension:
Initially, 1mg qd, may be increased to 2mg qd and
thereafter, if necessary, to 4, 8, 16mg qd to achieve the
desired effects; max. 16mg qd.
Terazosin HCl [C]
"Weson Tablet" 2mg/tab
Usual Dose: PO.
Benign Prostatic Hyperplasia: 1mg hs, increased in a
stepwise manner to 2, 5 and 10mg/day as needed; max.
20mg qd.
Hypertension: Initially, 1mg hs; maintenance, 1-5mg/day;
max. 20mg/day.
Phenoxybenzamine HCl [C]
"Dibenyline Capsule" 10mg/cap
Usual Dose: PO.
Pheochromocytoma:
Adults, initially, 10mg bid, increased q2d to 20-40mg bid
or tid as judged by BP control.
Children, initially, 0.2mg/kg or 6mg/m2 qd, not exceed
54
10mg; maintenance, 0.4-1.2mg/kg/day or
12-36mg/m(2)/day.
b) Selective -blockers
NOTE:
D/I: Sympathomimetics, clonidine, calcium channel
blockers, insulin, xanthines, oral hypoglycemics.
C/I: Cardiogenic shock, sinus bradycardia, AV conduction
abnormalities.
Acebutol [B]
"Sincer Tablet" 400mg/tab
Usual Dose: PO
For hypertension: 400-800mg/d
For ventricular arrhythmia: initially, 400mg; then
increase gradually to 600-1200mg/d.
Atenolol [D]
"Tenolol Tablet" 100mg/tab
Usual Dose: PO.
Angina:
Initially, 50mg qd; maintenance, 100mg qd, some
patients may require 200mg qd.
Hypertension:
Initially, 25-50mg qd; maintenance, 100mg qd.
NOTE: If atenolol therapy is to be discontinued, dosage of
the drug should be reduced gradually over a period of
about 2 weeks.
Esmolol HCl [C]
55
"Brevibloc Injection" 100mg/10ml/vial
Usual Dose: IV requires an infusion pump
Supraventricular tachycardia: Loading, 500mcg/kg/min
over 1 min, follow by a 4 min maintenance infusion of
50-200mcg/kg/min; average dose is 100mcg/kg/min.
Max. 200mcg/kg/min.
Postoperative hypertension after coarctation of aorta
repair: Loading dose 500mcg/kg/min over 1 minute with
maximal doses of 50-250mcg/kg/min in addition to
Nitroprusside .
Guidelines for withdrawal of therapy: Transfer to
alternative antiarrhythmic drug. Infusion should be
reduced by 50% 30min following the first dose of the
alternative agent. Following the second dose of the
alternative drug, patient’s response should be monitored
and if control is adequate for the first hours, esmolol
may be discontinued.
Metoprolol [C]
"Betaloc Zok Tablet" 25mg/tab
"Betaloc Zok Tablet" 100mg/tab
Usual Dose: PO.
Angina pectoris: Initially, 100mg metoprolol in single or 2
divided doses; maintenance, 100-400mg metoprolol qd;
max. 400mg/day.
Hypertension: Initially, 50-100mg metoprolol qd or bid;
maintenance, 50-400mg metoprolol qd; max.
400mg/day.
c) Nonselective -blockers
56
Propranolol HCl [C]
"Inderal Tablet" 10mg/tab
Usual Dose: PO.
Angina: initially, 10-20mg tid-qid; maintenance,
160-240mg/day.
Arrhythmias:
Adults: 10-30mg tid-qid.
Children: Initially, 1.5-2mg/kg/day, titrate up to a max.
16mg/kg/day in 4 doses.
Essential tremor: Initially, 40mg bid; maintenance,
120-320mg/day in 3 doses; max. 320mg/day.
Hypertension:
Adults, initially, 20-40mg bid; maintenance, 160-480
mg/day; max. 640mg/day.
Children, initially, 1mg/kg/day in 2 doses; maintenance,
1-5mg/kg/day in 2-4 doses.
Migraine: Initially, 80mg/day in divided doses;
maintenance, 160-240mg/day.
Pheochromocytoma: 60mg/day in divided doses for 3 days
before surgery; 30mg/day in divided doses with an
-adrenergic blocker as an adjunct to prolonged
treatment of intolerable pheochromocytoma.
Post-MI: 180-240mg/day in divided doses, beginning 5-21
days after MI.
Hypertrophic subaortic stenosis: PO, 20-40mg tid-qid.
STORAGE: Protect from light.
d) Mixed Adrenergic Antagonists
57
NOTE:
D/I:β-adrenergic agonists, cimetidine, halothane,
nitroglycerin.
C/I: Asthma, cardiac failure, heart block, cardiogenic shock,
bradycardia.
Labetalol HCl [C]
"Trandate Tablet" 200mg/tab
"Trandate Injection" 25mg/5ml/amp
Usual Dose:
Hypertension:
PO, initially, 100mg bid, increment, 100mg bid q2-3d;
maintenance, 200-400mg bid; geriatric maintenance,
100-200mg bid.
Severe hypertension and hypertension emergencies:
Slow IV, initially, 20-80mg; then 40-80mg at 10min
intervals until total dose of 300mg or desired supine
blood pressure is achieved.
IVF, initially, 2mg/min, then adjust the infusion rate
according to response; usual effective, cumulative
dose is 50-200mg, up to 300mg.
PO (following IV therapy), initially, 200mg, followed in
6-12hr by an additional 200-400mg.
STORAGE: Protect from light.
Carvedilol [C, D if used at 2nd and 3rd trimester]
"Dilatrend, Carvedil Tablet" 25mg/tab
Usual Dose: PO.
Hypertension: Initially, 6.25mg bid for 7-14 day, then
12.5mg bid; max. 50mg/day.
58
Congestive heart failure: Initially, 3.125mg bid for 2 wk;
subsequently 6.25mg bid for 2 wk, then titrate every two
weeks; max. 12.5-50mg bid.
Angina pectoris: 25-50mg bid.
Idiopathic cardiomyopathy: 6.25-25mg bid.
2) Direct-acting Vasodilators
Hydralazine, Hydrochlorothiazide, Resepine
"Esidri Tablet"
Each tab contain:
Hydralazine----------------------------------10mg
Hydrochlorothiazide------------------------10mg
Resepine--------------------------------------0.1mg
Usual Dose: PO.
3-6 tab/day in 2-3 divided doses
3) Angiotensin-converting Enzyme Inhibitors
Captopril [C](1st trimester), [D](2nd& 3rd trimester)
"Captopin Tablet" 25mg/tab
Usual Dose: PO.
CHF: Initially, 6.25-25mg bid-tid; maintenance,
50-100mg tid; max. 450mg/day.
Hypertension: Initially, 6.25-25mg bid-tid; maintenance,
25-150mg bid-tid; max. 450mg/day.
Cilazapril [D]
"Inhibace Tablet" 2.5mg/tab
Usual Dose: PO.
59
CHF: 1-5mg qd.
Hypertension: Initially, 0.5-lmg qd; maintenance, 2.5-5
mg qd.
Enalapril Maleate [C](1st trimester), [D](2nd& 3rd
trimester)]
"Fonitec Tablet" 20mg/tab
Usual Dose: PO.
CHF: Initially, 2.5mg qd-bid; maintenance, 5-20mg/day in
2 doses; max. 40mg/day.
Hypertension: Initially, 2.5-5mg qd; maintenance,
10-40mg/day in 1-2 doses.
Perindopril [D]
"Acertil Tablet" 4mg/tab
Usual Dose: PO.
For mild to moderate hypertension: PO 4-8mg
For congestive heart failure: PO 4mg. Dose reduction
are indicated in renal insufficiency and in elderly
patients
Ramipril [C/D]
"Ramitace Tablet" 2.5mg/tab
Usual Dose: PO, 2.5 mg daily, Max: 10 mg daily.
4) Angiotensin II Receptor Antagonists
Candesartan [C/D]
"Blopress Tablet" 8mg/tab
Usual Dose:
60
Initial dose: 4mg qd; usual mainatinance dose: 8mg qd;
maximum dose: 16 mg/day.
Losartan Potassium [C](1st trimester), [D](2nd& 3rd
trimester)
"Cozaar Tablet" 50mg/tab
Usual Dose: PO, 25-100mg/day in 1-2 doses.
Hepatic impairment: reduce the initial dose to 25mg;
divide dosage intervals into two.
NOTE: Cozaar 50mg contains potassium 4.24mg
(0.108mEq)
Telmisartan [C/D]
"Micardis Tablet" 40mg/tab
Usual Dose: PO, The effective dose range is 20 to 80 mg
once daily, with a usual starting dose of 40 mg once
daily. No dose adjustment is needed for the elderly or
those with mild-to- moderate renal insufficiency
Olmesartan medoxomil [D]
"Olmetec Tablet" 20mg/tab
Usual Dose: PO, 20mg once daily; after 2 wk, may titrate to
40mg once daily
5) Calcium Channel Antagonists
NOTE:
D/I:β- blockers, quinidine, digoxin, carbamazepine,
cyclosporine, procainamide.
61
Amlodipine Besylate [C]
"Norvasc, Amilo Tablet" 5mg/tab
"Amcopine Tablet" 10mg/tab
Usual Dose: PO, 2.5-5mg qd; max. 10mg qd.
Nifedipine [C]
"Adalat Capsule" 5mg/cap
Usual Dose: PO.
Adalat cap: 10-20mg tid PO or sublingual.
; max. 180mg/day.
Diltiazem HCl [C]
"Herbesser Tablet" 30mg/tab
"Hesor Tablet" 60mg/tab
Usual Dose:
Angina, Hypertension: PO.
Oral: 20 - 40mg TID. being adjusted after 14 days as needed
and tolerated. Max. 360mg/day.
Felodipine [C]
"Felopine-SR,Fedil-SR Tablet" 5mg/tab
Usual Dose: PO. Initial 5mg qd, maintenance: 5-10 mg
once daily. Angina pectoris 5mg once daily May be
increase to 10mg once daily.
Nitrendipine
"Suncue Tablet "10mg/tab
Usual Dose: PO.10mg bid.or 20mg qd
Lacidipine [B]
62
"Lasyn Tablet" 4mg/tab
Usual Dose: PO. 2-8 mg QD
Lercanidipine
"Zanidip Tablet "10mg/tab
Usual Dose: 10-20 mg once daily.
Verapamil HCl
See "Verelan" 120mg/cap
6)Miscellaneous
Valsartan and Hydrochlorothiazide[C/D]
"Co-Diovan Tablet"
Each tablet contains:
Valsartan --------------------------------------------------80mg
Hydrochlorothiazide ---------------------------------12.5mg
Usual Dose: PO, 1 or 2 tablets qd
Amlodipine Besylate and Benazepril Hydrochloride
"Amtrel Tablet"
Each tablet contains:
Amlodipine Besylate -------------------------------------5mg
Benazepril Hydrochloride ----------------------------10mg
Usual Dose: PO, 1 tablets qd
5. Vasodilators
Nicametate Citrate
"Euclidan Tablet" 50mg/tab
63
Usual Dose: PO, 50-100mg tid.
Alprostadil (Prostaglandin E1) [C]
"Promostan for Injection" 20mcg/amp
Usual Dose:
Promostan:
Ductal-dependent congenital heart disease: IV,
intraarterial or intraaortic infusion, initially,
0.05-0.1mcg/kg/min may be reduced to the minimum
dose maintaining the response; maintenance, usually
0.025-0.05mcg/kg/min.
Peripheral vascular disease:
IVF, 40-60mcg at a rate of 5-10ng/kg/min qd or bid.
IA infusion, 10-15mcg via infusion pump at a rate of
0.1-0.15ng/kg/min qd.
STORAGE: Protect from light.
Tocopherol Nicotinate
See "Juvela-N Soft Capsules"
6. Diuretics
1) Carbonic Anhydrous Inhibitors
Acetazolamide [C]
" Diamox Tablet" 250mg/tab
Usual Dose: PO.
Adults:
Acute angle-closure glaucoma: 250mg q4h.
Edema: 5mg/kg/day in the morning.
Epilepsy: 8-30mg/kg/day in 1-4 doses; max. 1g/day.
64
Open-angle glaucoma: 250mg qd-qid.
Children:
Edema: 5mg/kg/day in the morning.
Epilepsy: 8-30mg/kg/day in 1-4 doses; max. 1g/day.
Glaucoma: 8-30mg/kg/day in 3-4 doses.
2) Loop Diuretics
NOTE:
D/I: Amphotericin B, anticoagulants, lithium, nephrotoxic
agents, hypokalemia agents.
S/E: Blurred vision, electrolyte imbalance.
Furosemide (Frusemide) [C]
"Lasix Tablet" 40mg/tab
" Lasix Injection" 20mg/2ml/amp
Usual Dose:
PO:
Antihypertensive: 40mg bid.
Edema: Adults, 20-80mg qd in the morning, may be
repeated q6-8h; max. 600mg/day in 2 doses; children,
initial 1-2mg/kg qd, may be repeated q6-8h; max.
6mg/kg.
CHF: Adults, 250-4000mg/day.
IV:
Acute pulmonary edema: Adults, slow IV 40mg over
1-2min, may be repeated in 60-90min; children,
lmg/kg; max. 6mg/kg/day.
Edema: Adults, slow IV or IM, 20-40mg, may be
repeated after 2hr.
65
CHF: Adults, 250-4000mg/day
STORAGE:
1. Protect from light.
2. Oral solution should be stored at 2-4oC, use within 3
weeks of opening bottle.
3) Osmotic Agents
Glycerin (Glycerol) [C]
" Glycerol Injection" 10% glycerol & 5% fructose & NS,
300ml/btl
Inj 300ml/bot (Glycetose): glycerin 30gm, fructose 15gm,
sod. chloride 2.7gm
Usual Dose: IVF, 200-500ml qd-bid at a rate of 500ml over
2-3hr.
NOTE:
1. Use in diabetic patients may cause HHNK.
2. Too rapid infusion may cause hemolysis.
4) Thiazides
NOTE:
D/I: Cholestyramine, cyclosporine, digoxin, lithium.
S/E: Electrolyte imbalance.
Indapamide [B]
"Milix SR Tablet" 1.5mg/tab
"Nakamid Tablet" 2.5mg/tab
Usual Dose: PO, 1.25-5mg qd in the morning; max. 5mg qd.
66
Hydrochlorothiazide [D]
"D50 Tablet" 50mg/tab
Usual Dose: PO.
Hypertension: initial 25-100mg/day as a single or divided
doses. maintenance 25-100mg/day up to
200mg/day in divided doses.
Edema: initially 50-100mg daily, usual dose 25-50mg/day
as a single or divided doses
5) Potassium Sparing Diuretics
Spironolactone [D]
"Spironolactone Tablet" 25mg/tab
Usual Dose: PO.
Edema: Adults, initially, 25-200mg/day for at least 5 days;
children, 3.3mg/kg/day.
Hypertension: 25-100mg/day.
Hypokalemia: 25-100mg/day.
Primary hyperaldosteronism: 100-400mg/day.
D/I: K supplements, K-containing Agents, or K sparing
diuretics, lithium, digoxin, anticoagulant, ACE inhibitor.
S/E: Hyperkalemia, antiandrogenic or endocrine effect,
hyponatremia.
Amiloride [B] and Hydrochlorothiazide [D]
"Moduretic Tablet" 5mg/50mg/tab
Each tablet contains:
Amiloride----------------------------------------------------5mg
Hydrochlorothiazide--------------------------------------50mg
Usual Dose: PO.
67
Hypertension, edema: Initially, 1-2 tab/day; max. 4 tab.
D/I: K supplemant or K-sparing diuretics,lithium, ACE
inhibitors.
S/E: Photosensitivity, blood dyscrasia.
7. Agents Used to Treat Circulatory Failure
NOTE:
D/I:β-blockers, TCAs, maprotiline, MAOIs, hydrocarbon
inhalation anesthetics, digoxin, ergotamine.
C/I: Asymmetric septal hypertrophy, pheochromocytoma.
Dobutamine HCl [B]
"Dobutrex" 250mg/5ml/amp
Usual Dose: IVF.
Acute myocardial infarction: 8-24mcg/kg/min.
Increase cardiac output: 2-20mcg/kg/min; max. 40mcg/
kg/min if necessary.
Dopamine HCl [C]
"Dopmin Injection" 200mg/5ml/amp
Usual Dose: IVF, in general, initially, 1-5mcg/kg/min and
then increased by 1-4mcg/kg/min at 10-30min intervals
until optimal response is attained; severely ill patients,
5mcg /kg/min & gradually increased in increment of 5-10
mcg/kg/min, up to 20-50mcg/kg/min.
STORAGE: Protect from light.
Epinephrine HCl (Adrenaline HCl) [C]
" Epinephrine Injection" 1mg/lml/amp
68
Usual Dose:
SC for anaphylaxis 0.2-0.5mg (1:1000), may repeat
q 10-15 min prn; if SC is ineffective, then IV 0.1-0.25mg
(1:10000) q5-15 min may be given and followed by an IV
infusion if necessary.
SC for asthma same dosage as SC for anaphylaxis; may
repeat q20min to 4 hr as needed.
IV infusion for hemodynamic support 1mcg/min initially,
adjust to hemodynamic response (usually 2-10mcg/min).
Children. SC for anaphylaxis or asthma 0.01ml/kg/dose of
1:1000 aqueous sol’n, to a maximum of 0.5ml; may repeat
q15-20 min for 2 doses, then q4h prn
STORAGE: Protect from light.
Norepinephrine Bitartrate (Noradrenaline Acid Bitartrate)
[D]
"Levophed Injection" 0.2% (0.1% base) 4mg/4ml/amp
Usual Dose: IVF.
Hypotension:
Adults, initially, 8-12mcg/min; maintenance,
2-4mcg/min.
Children, 2mcg/kg/min.
NOTE:
1. Care must be taken to avoid extravasation because local
necrosis may result.
2. Dosage of norepinephrine bitartrate is expressed in
terms of norepinephrine.
STORAGE: Protect from light.
8. Antiplatelets and Thrombolytics
69
1) Antiplatelets
Aspirin
See "Bokey Enteric-microencapsulated Capsule"
Cilostazol [C]
"Pletaal Tablet" 50mg/tab
Usual Dose: PO, 100mg bid.
NOTE: Take 30 minutes before meals or 2 hours after
meals.
D/I: Ketoconazole, itraconazole, erythromycin, diltiazem,
omeprazole, grape fruit juice.
Clopidogrel [B]
"Plavix Tablet" 75mg/tab
Usual Dose: PO.
Adults: 75mg once daily.
Dipyridamole [B]
"Persantin Tablet" 25mg/tab
"Sancin FC Tablet" 50mg/tab
"Peysan Tablet" 75mg/tab
Usual Dose: PO.
Chronic angina pectoris: 50mg tid, ac.
Prevention thromboembolism after cardiac valve
replacement: 75-100mg qid.
D/I: Anticoagulants, thrombolytic agents, platelet
aggregation inhibitors, valproic acid.
Ticlopidine HCl [B]
70
"Declot, Licodin Tablet" 100mg/tab
Usual Dose: PO, 200-600mg/day in 2-3 doses with meals.
NOTE: The most serious adverse hematologic effect of
ticlopidine is neutropenia. Regular hematological
monitoring is recommended for at least the first 12 weeks
of treatment.
9. Agents Used to Treat Hyperlipidemia
1) HMG-CoA Reductase Inhibitors
Fluvastatin Sodium [X]
"Lescol XL Tablet" 80mg/tab
Usual Dose: PO, 80mg extended release tablet once daily in
the evening.
Rosuvastatin [X]
"Crestor Tablet" 10mg/tab
Usual Dose: 5 to 10 mg once daily; consider 20 mg once
daily for patients with LDL >190 mg/dL and when
aggressive lipid targets are desired,max 40mg
NOTE: lower initial dose should be considered for patients
requiring less aggressive LDL-C reductions, who have
predisposing factors for myopathy, taking cyclosporine,
gemfibrozil, or lopinavir/ritonavir, Asian patients, and
patients with severe renal insufficiency
Simvastatin [X]
" Sivasin,Vatatin FC Tablet" 20mg/tab
"Zova Tablet" 40mg/tab
Usual Dose: PO.
71
Initially, 5-10mg hs; 5mg/day if LDL ≦ 190mg/dL,
10mg/day if LDL > 190mg/dL; increase every 4 weeks
as needed; usual range: 5-80mg/day.
Pravastatin [X]
"Pavatin Tablet" 20mg/tab
"Melstatin Tablet" 40mg/tab
Usual Dose: PO.
Initially, 5-10mg daily hs
Adjust dosage q 4 weeks based on patient tolerance and
response; Max:40mg/day and 20mg/day in elderly.
Lovastatin [X]
"Leslipid Tablet" 20mg/tab
Usual Dose: PO.
Initial: 20mg QD; 40mg QD for patients whose
cholesterol level > 300mg/dl. Dosing range: 20 - 80mg,
given by QD or BID.
Maximum dose: 80mg/day; 20mg/day for patients taking
immunosuppressive drugs concomitantly.
Atorvastatin [X]
"Lipitor Tablet" 10mg/tab
"Lipitor Tablet" 40mg/tab
Usual Dose: PO, initially, 10mg qd; titrate up to 80mg/day
if needed.
2) Fibrates
Fenofibrate [C]
72
"Fenolip" 200mg/cap
Usual Dose: PO, adults, 200-400mg/day in divided doses
with meals
3) Combinations lipid-lowering Agents
Ezetimibe+Simvastatin
"Vytorin Tablet "10/20mg/Tab
Usual Dose: PO,
Familial hypercholesterolemia – homozygous,Primary
hypercholesterolemia: 1 tab once daily in the evening
NOTE: Take with or without food as a single daily dose in
the evening ； Safety and efficacy have not been established
in pediatric patients
10. Hemorrheologic Agents
Pentoxifylline (Oxpentifylline) [C]
"Fylin,Trentl Sustained-release Tablet" 400mg/tab
Usual Dose: PO: Sustained release tab 400mg bid-tid.
Extract of Ginkgo Biloba
"Gina，ex Tablet"40mg/tab
Usual Dose: PO, 40mg tid-qid.
Buflomedil HCl
"Lomedil,Buflo Tablet"150mg/tab
Usual Dose: PO. Cerebrovascular and peripheral vascular
disease: 300-600mg/day.
73
III. Nutritional Agents
1. Replenishers and Regulators of Water and Electrolytes
1) Minerals and Electrolytes
Calcium Citrate
"Calbo,Jia-Cal Tablet" 950mg/tab (Ca: 200mg)
Usual Dose: PO. PO 1-2# bid
Calcium Carbonate [C]
"CaCO3 Tablet" 500mg/tab (Ca 200mg, 10mEq)
Usual Dose: PO in 3-4 doses daily, take 1-1.5hr after meals,
except as phosphate binder.
As phosphate binder: 3-8g CaCO3/day; max. 8g
CaCO3/day, take with meals.
Prevention of hypocalcemia: 1g of Ca/day.
Prevention of primary osteoporosis in women: 1-1.5g of
Ca/day.
Treatment of Calcium depletion: 1-2g of Ca/day
Tricalcium phosphate, Cholecalciferol
"Bio-cal Tablet"Chewable tab
Each tablet contains:
Tricalcium phosphate 802mg (elemental Ca 300mg)
Cholecalciferol 62.5IU (1.56g)
Usual Dose: PO, PO 2-4# qd
2) Intravenous Nutritional Therapy
Calcium Gluconate [C]
74
" Cal. Gluconate Injection" 10% 10ml/amp
(Ca 0.465mEq/ml)
Each amp contains:
Calcium Gluconate-----------------------------------------10%
Calcium Saccharate--------------------------------------0.35%
Usual Dose:
Advanced cardiac life support during CPR: IV,
2.3-3.7mEq of Ca when using Ca Gluconate, repeat as
needed.
Emergency elevation of serum Ca: IV, initially, 7-14mEq,
repeat q1-3d depending on response.
Hyperkalemia with secondary cardiac toxicity: IV,
2.25-14mEq while monitoring the ECG, repeat after
1-2min if necessary.
Hypocalcemia tetany: IV, 4.5-16mEq until therapeutic
response occurs.
Magnesium intoxication: IV, initially, 7mEq; adjust doses
according to response.
NOTE: IV rate not exceeding 0.7-1.8mEq/min.
Dextrose (Glucose)
"Dextrose, Glucose and Vitagen Injection" 5% 500ml/ btl,
10% 500ml/btl, 20% 20ml/amp, 50% 20ml/amp
Dextrose and Sodium Chloride (Dextrose in Saline)
"Dext-Saline 5%, 0.9%" 500ml/btl(D5S)
Each 100ml contains:
Dextrose------------------------------------------------------5.0g
Sodium Chloride--------------------------------------------0.9g
75
"Dext-Saline 5%, 0.33%" 500ml/btl(D5S.33)
Each 100ml contains:
Dextrose------------------------------------------------------5.0g
Sodium Chloride--------------------------------------------0.3g
" Lactated Ringer`s Injection (L.R)" 500ml/btl
Electrolyte content: (mEq/L)
Na K Ca Cl Lactate
130 4 3 109
28
76
Magnesium Sulfate (MgSO4.7H2O) [B]
"Magnesium Sulfate Injection" 10%, 20ml/amp (Mg
0.8mEq/ml, 8.1mEq/g salt; 123.2 mg salt/mEq)
Usual Dose:
Mild Mg deficiency: IM, 8mEq q6h for 4 doses.
Severe Mg deficiency:
IVF, 40mEq in 1L of D5W or NS over 3hr.
IM, as much as 2mEq/kg over 4hr.
Severe preeclampsia or eclampsia:
IVF, initially, 32mEq, then 8-16mEq/hr continuously;
max. 240-320mEq/day.
Management of seizures, hypertension: IM, IV
Children, 20-100mg/kg/dose, q4-6hr as needed, severe
case: 200mg/kg/dose.
NOTE: IV rate not exceeding 1.2mEq/min (1-2g/hr). Max.
dose should not exceed 30-40g/day
Potassium Chloride [A]
"Slow-K Sugar-coated Tablet" 600mg/tab (8mEq of K and Cl)
''Potassium Chloride Injection" 15% 5ml/amp (2mEq/ml)
Usual Dose:
PO:
Potassium depletion: 40-100mEq/day in 2-4 doses.
Prevention of hypokalemia: 20mEq/day in 2-4 doses.
IVF:
Generally, conc. < 40mEq/L, rate < 20mEq/hr, monitor
the ECG when rate > 20mEq/hr.
NOTE: NEVER IV PUSH.
77
Sodium Bicarbonate [C]
"NaHCO3 Injection" 7%, 20ml/amp (0.83mEq of Na and
bicarbonate/ml)
Usual Dose:
Acidosis associated with chronic renal failure: PO,
initially, 20-36mEq/day in divided doses.
Alkalization of urine: PO, adults, initially, 48mEq, then
12-24mEq q4h; children 1-10mEq/kg/day.
Cardiac arrest: IV, adults, initially, 1mEq/kg; maintenance,
0.5mEq/kg; may be repeated q10min during continued
arrest.
Less urgent form of metabolic acidosis: IVF, 2-5mEq/kg
over 4-8hr.
Extreme cases of lactic acidosis associated with a pH
below 6.8 may benefit from a continuous infusion of
about 400 mEq over 4 to 6 hours until the pH reaches
7.2, then the infusion should be stopped to avoid
overshooting and causing metabolic alkalosis.
Sodium Chloride [A]
"Normal Saline Injection, 0.9%" 20ml/amp, 500ml/bag,
(154mEq of Na and Cl/L)
"Sodium Chloride Injection, 3%" 500ml/bag (513mEq of Na
and Cl/L)
"Sodium Chloride Injection, 0.45%" 500ml/btl (77mEq of
Na and Cl/L)
Water for Injection
20ml/amp
78
3) Potassium Lowering Agents
Calcium Polystyrene Sulfonate
"Kalimate Powder" Each gram exchanges about
1.36-1.82mEq of K (in vitro)
Usual Dose:
PO, 15-30g/day suspended in 30-50ml water or syrup
divided in qd-tid.
Rectally, 30g suspended in 100ml aqueous vehicle as
needed (water or 2% methycellulose), retained for at
least 30-60min and followed by a cleansing enema.
NOTE:
1. Calcium ions are released from the resin in
gastrointestinal tract and this may reduce the absorption
of tetracycline given by mouth.
79
2. Vitamins
Ascorbic Acid (Vitamin C) [A] [C if doses exceed RDA]
" Vitamin C Injection" 100mg /2ml/amp
Usual Dose:
Prophylactic: PO, IM, 50-100mg/day.
Therapeutic: PO, IV or IM, 100-250mg qd-bid.
Folic Acid [A] [C if doses exceed RDA]
"Folic Acid Tablet" 5mg/tab
Usual Dose: PO, Initial: 10-20mg/day, in divided dose
Maintenance: 2.5-10mg/day, in divided dose.
S/P: Pernicious anemia.
Mecobalamin [A] [C if doses exceed RDA]
"Hito-M Injection " 0.5mg/1ml/amp
" Hito-M Cap" 500ug/cap
Usual Dose:
IM or deep SC (IV is not recommended due to more rapid
elimination) Pernicious anemia, congenital (if evidence of
neurologic involvement): 1000 mcg/day for at least 2 wks;
maintenance: 50 mcg/month. Vit B12 deficiency:
Children: 100 mcg/day for 10-15 days (total dose of 1-1.5
mg), then once or twice weekly for several months. Adult:
30 mcg/day for 5-10 days initially; maintenance: 100-200
mcg/month.
PO 1500ug/day in 3 divided dose
80
Phytonadione
See "Vitamin K1 Injection"
Pyridoxine HCl (Vitamin B6) [A] [C if doses exceed RDA
recommendation]
"Vit B6 Tablet" 50mg/tab
Usual Dose: PO.
Drug-induced deficiency anemia or neuritis:
100-200mg/day x 3wk, then 25-100mg/day.
Prevention of isoniazid or penicillamine-induced
pyridoxine deficiency: 10-50mg/day.
Pyridoxine deficiency: 2.5-10mg/day.
Multiple-Vitamine
"Undeca Tablet"
Each tablet contains:
Vit.A----------------------------------------------- 4000 Units
Vit.B1 ----------------------------------------------- 2 mg
Vit.B2 ----------------------------------------------- 2 mg
Vit.B6 ---------------------------------------------- 2 mg
Vit.B12 ---------------------------------------------1 mcg
Vit.C ------------------------------------------------- 70 mg
Vit.D ------------------------------------------------ 400 Units
Vit.E - ----------------------------------------------- 11 mg
Calcium pantothenate ----------------------------- 10 mg
Folic acid ------------------------------------------- 50 mcg
Nicotinamide --------------------------------------- 20 mg
Usual Dose: PO. 1# tid
81
Vitamin B Complex [A] [C if doses exceed RDA]
"Vitamin B Complex Injection" 10ml/vial
Each ml contains:
Thiamine HCl ------------------------------------------- 100mg
Riboflavin -------------------------------------------------- 5mg
Niacinamide--------------------------------------------- 50mg
Sodium Pantothenate ------------------------------------ 5mg
Pyridoxine HCl -------------------------------------------- 5mg
Usual Dose: IM or IV, 1-2ml qd-bid.
STORAGE: protect from light.
Vitamin B Complex
" Vitamin B complex tablet(元宙)"
Each tablet contains:
Thiamine HCl ------------------------------------------ 10mg
Riboflavin ---------------------------------------------- 15mg
Pyridoxine HCl ------------------------------------------ 2mg
Calcium Pantothenate----------------------------------- 5mg
Nicotinamide ------------------------------------------ 50mg
Cyanocobalamin-------------------------------------------2mcg
Usual Dose: PO, 1 tab tid.
Vitamin B1, Vitamin B6 and Vitamin B12
"Felinamin Injection" 10ml/Amp
Each 10ml contains:
Thiamine Disulfide ------------------------------------ 50mg
Pyridoxine HCl ------------------------------------------100mg
Hydroxocobalamin-----------------------------------1000mcg
Usual Dose:成人 1 日 1 次，每次 10ml，靜脈內緩慢注射。
82
3. Others
Glycal - Amin Inj.
500ml/Bottle.
Each 100ml contains:
L-Isolencine....……………210mg
L-Lysine Acetate....……….310mg
L-Phenylanine....………….170mg
L-Tryptophan...………….…46mg
L-Alanine....………………210mg
L-Arginine---------------------290mg
L-Histidime....……………..85mg
L-Proline-----------------------340mg
L-Serine....………………..180mg
Sodium Acetate.3 H2O------200mg
Calcium Acetate.H2O....…26mg
Potassium Chloride----------150mg
Potassium Metabisulfite...….50mg
Glycine-------------------------420mg
L-Leucine....……………….270mg
L-Methionine....……………160mg
L-Threonine....……………..120mg
L-Valine....…………………200mg
Magnesium Acetate.4 H2O—54mg
Sodium Chloride---------------120mg
Phosphoric Acid-----------------41mg
Usual Dose:
Variable, as determined by the use. Injected by IV
infusion
83
Tital No.3 injection
500ml/btl
Each liter of Taita No. 3.contains:
Na ----------------------------------------------------75mEq
Cl ----------------------------------------------------61mEq
Acetate-----------------------------------------------20mEq
K ----------------------------------------------------12mEq
P ----------------------------------------------------6mEq
Glucose----------------------------------------------10gm
Usual Dose:
Taita No. 3: IV infusion 500ml daily, dosage depends on
the situation of the patients..
Silymarin
"Silygen-H Capsules" 150mg/cap
"Sirin SC Tab" 35mg/tab
Usual Dose: 1# PO,tid
Sodium Chloride
"Normal Saline Irrigation" 0.9% 1000ml/bot, 2000ml/bag
Sterile water for Irrigation
2000ml/bag
84
IV. Hematological Agents
1. Antianemia Drugs
1) Iron Supplements
Ferrous fumarate
"Ferall soft Cap "
Each tab contains:
Ferrous fumarate -------------------------- 460mg (151mgFe)
Foliic Acid ----------------------------------- 1mg
Ascorbic acid ------------------------------ 60mg
Vitamin B12 ---------------------------------10μg
Usual Dose: PO. 1-2 cap daily.
2) Vitamin B-Complex
Folic Acid
See "Folic Acid Tablet"
Leucovorin Calcium (Calcium Folinate) [C]
" Leucovorin(Rescuvolin) Tablet" 15mg/tab
Usual Dose:
Leucovorin rescue after high-dose MTX therapy: PO, IV
or IM 15mg (approx. 10mg/m2) q6h x 10 doses (60hr)
starts 24hr after the beginning of the MTX infusion, or
-8
until the MTX level < 10 M.
Megaloblastic anemia: IM up to 1mg/day.
NOTE: Because of calcium content of leucovorin, the
infusion rate should not exceed 160mg/min. Reconstituted
85
solution use within 24hr.
D/I: Anticonvulsant, CNS depressant, 5-FU
C/I: Pernicious anemia, Vit.B12 deficiency.
Mecobalamin
See "Hito-M Injection " 0.5mg/1ml/amp
" Hito-M Cap" 500ug/cap
2. Anticoagulants
1) Heparin
Heparin Sodium [C]
"Heparin Injection" 25000units/5ml/vial (preservative free)
Usual Dose:
Therapeutic anticoagulant effect with full-dose heparin:
IV, adults, initially, 10000 units, then 5000-10000 units,
q4-6h; children, initially, 100 units/kg, then 50-100
units/kg q4h.
IVF, adults (based on 68kg), initially, IV 5000 units,
then IVF, 20000-40000 units/day (in 1L of NS);
children, initially, 50 units/kg, then 100 units/kg (IV
drip) q4h or 20000 units/m2/day.
SC, adults, initially, IV 5,000 units and SC
10,000-20,000 units in a concentrated solution, then
SC 8,000-10,000 units q8h or 15,000-20,000 units
q12h in a concentrated soln.
DIC (Disseminated intravascular coagulation): IVF or IV,
adults, 50-100 units/kg q4h; children 25-50 units/kg q4h.
If there is no improvement after 4-8hr, the drug should
be discontinued.
86
2) Coumarin and Indandione Derivatives
Warfarin Sodium [X]
"Coumadin (Orfarin) Tablet" 5mg/tab
Usual Dose: PO.
Adults, initially, 2-5mg/day (based on PT & INR);
maintenance, 2-10mg/day, adjusted according to the
prothrombin time level and INR.
Children, loading 0.2mg/kg for 2 days (based on PT &
INR), 0.05-0.34mg/kg/day.
3. Blood Components and Blood Substituents
1) Blood Components
Albumin [C]
" Albumin (Plasbumin) Injection" 20%, 50ml/btl
Usual Dose:
Adults, 25g initially, repeated in 15-30min if necessary;
no more than 250g should be administered within 48hr.
Children, nonemergency treatment, 25-50% of adult dose;
in emergencies, 25g.
2) Blood Substituents
Colloidal plasma substitute [C]
" Gelofusine Injection" 500ml/btl
每 1000ml 溶液含
Succinylated gelatin (Modified Fluid gelatin) 40.00g
87
Sodium Chloride 7.01g
Sodium hydroxide 1.36g
適 應 症： 急性出血、手術或外傷所引起之休克
Infusion. 500-1500ml/day.
4. Hemostatics
Phytonadione (Phytomenadione, Vitamin K1) [C]
"Vitamin K1 Injection" 10mg/1ml/amp
Usual Dose:
Anticoagulant-induced hypoprothrombinemia:
When bleeding is not present, IM, initially, 2.5-10mg,
up to 25mg.
When bleeding is present, slow IV, 10-50mg.
Hemorrhagic disease of the newborn: IM, 0.5-1mg,
immediately after delivery.
Hypoprothrombinemia from other causes: IM, 2-25mg.
STORAGE: Protect from light.
Tranexamic Acid [B]
"Transamin(Tren) Capsule" 250mg/cap
Usual Dose:
PO, 750-2000mg/day in 3-4 doses.
e-Aminocaproid acid[C]
"Plaslloid Injection" 200 mg/ml,5ml/amp
Usual Dose:IVF
1 日 1~4g,1~2 回靜脈注射,手術中、手術後之出血等,
必要時點滴靜脈注射。
88
V. Hormones and Agents Affecting Hormonal Mechanism
1. Gonadotropin Releasing Hormone Analogues
1) Hypothalamic Related Hormones
Bromocriptine Mesylate [B]
"Syntocriptine Tablet" 2.5mg/tab
Usual Dose: PO, take with meals.
Acromegaly: 20-30mg/day in 3-4 doses.
Hyperprolactinemic indications: 2.5mg bid-tid.
Parkinson's disease: Initially, 1.25mg bid, if necessary, the
dosage may be increased q14-28d by 2.5mg/day, max.
100mg/day.
Prevention of physiological lactation: 2.5mg bid for 14
days.
Leuprolide Acetate (Leuprorelin Acetate) [X]
"Leuplin Depot S.C. Injection" 3.75mg/vial (with amp of 2ml
diluent)
"Leuprolide acetate 5mg/ml Injection" 2.8ml/vial
Usual Dose: SC.
Endometriosis: 3.75mg monthly.
Advanced prostatic cancer, palliative treatment: 3.75mg
monthly.
Test tube ovum fertilization: 1.88mg started on cycle day
21-23 or 0.5 mg/day started on cycle day 21-23
2) Posterior Pituitary Hormones
Oxytocin
See "Piton-S Injection"
89
3) Others
Danazol
See "Danazol Capsule"
2. Adrenal Corticosteroids
C/I: Systemic fungal infections.
NOTE: There is a probability of impending perforation of
peptic ulcer, renal insufficiency, hypertension, osteoporosis.
There may be decreased resistance to localized infection
when corticosteroids are used. The lowest possible dose of
corticosteroid should be used to control the condition under
treatment and when reduction in dosage is possible the
reduction should be gradual.
Anti-inflammatory equivalent dose (mg)
Betamethasone
Dexamethasone
Hydrocortisone
Methylprednisolone
Paramethasone
Prednisolone
Triamcinolone Acetonide
0.6
0.75
20
4
2
5
4
1)Glucocorticoids
Dexamethasone Sodium Phosphate [C]
"Decadron Inj" 5mg dexamethasone phosphate/1ml/vial
Usual Dose: IV or IM, adult, 0.5-24mg/day; children,
90
6-40mcg/kg qd-bid.
STORAGE: Protect from light.
Hydrocortisone Sodium Succinate [C]
"Saxizon injection" 100mg hydrocortison/vial
Usual Dose: Slow IV, IVF or IM.
Adults, 100-500mg q2-10h as needed; children,
0.16-1mg/kg qd-bid.
Methylprednisolone
"Mep Tablet" 2mg/tab
Usual Dose: PO.
Adults, 4-48mg/day; multiple sclerosis, 160mg daily for 1
wk, 64mg qod for 1 mo.
Children: 0.5-1.7mg/kg/day in 2-4 divided doses.
Methylprednisolone Sodium Succinate
"Medason for Injection" 125mg/vial
"Belon for Injection" 40mg/vial
Usual Dose: IV, IM or IVF over 30min.
Adults, 10-250mg up to 6 times/day; children, 0.03-0.2
mg/kg 1-2 times/day.
High dose therapy: IV, 30mg/kg over 30min q4-6h, not
beyond 48-72hr.
Prednisolone [B]
"Prednisolone Tablet" 5mg/tab
Usual Dose: PO, initially, 5-60mg/day.
Triamcinolone Acetonide [C]
91
"Kenacort-A Injection" 50mg/5ml/vial for intraarticular &
intradermal injection
Usual Dose: Not for IV.
Intraarticular, 2.5-40mg; intralesional, < 1mg per site; IM,
adults & children > 12yr, initially 60mg; then additional
20-100mg at 6 week intervals; children 6-12yr,
0.03-0.2mg/kg or 1-6.25mg/m2 at 1-7 day intervals.
3. Androgens and Anabolic Steroids
C/I: Androgens are contraindicated in male patients with
prostatic or breast cancer, in elderly patients in whom
overstimulation is to be avoided, and in cases of benign
prostatic hypertrophy with obstructive symptoms, in
patients with nephrosis or the nephrotic phase of nephritis.
Danazol [X]
"Danazol Capsule" 200mg/cap
Usual Dose: PO.
Endometriosis: Therapy begin during menstruation.
Moderate to severe cases, initially, 400mg bid. Mild
cases, initially, 100-200mg bid and adjust the dose by
3-6mo.
Fibrocystic breast disease: 50-200mg bid.
Hereditary angioedema: Initially, 200mg bid-tid, adjust
the dose by 1-3mo.
4. Antiandrogens
Cyproterone Acetate
"Androcur Tablet" 50mg/tab
92
Usual Dose: PO.
Control of libido in severe hypersexuality: 50mg bid.
Prostatic carcinoma: Initially, 300mg/day in 2-3 doses,
maintenance, 150-300mg/day.
Finasteride [X]
" Kinscar Tablet" 5mg/tab
Usual Dose: PO.
Benign prostatic hyperplasia: 5mg qd for 6-12mo.
Male pattern baldness: 1mg qd.
NOTE: Women who are or may potentially be pregnant
must not use Finasteride and should not handle crushed or
broken tablets of Finasteride.
5. Estrogens, Progestins, Contraceptives and Related
Agents
NOTE:
1. Estrogens have been reported to increase the risk of
endometrial carcinoma.
2. Estrogens should not be used during pregnancy.
3. There is an increased risk of birth defects in children
whose mothers take progestins during the first three
months of pregnancy.
C/I: Estrogens and progestins should not be used in
thrombophlebitis, liver dysfunction, known or suspected
malignancy of breast or genital organs, undiagnosed vaginal
bleeding, and known or suspected pregnancy.
1) Estrogens
93
Conjugated Estrogens [X]
"Premarin, Estromon Tablet" 0.625mg/tab
"Premarin Vaginal Cream" 42.5g/tube
Usual Dose:
Dysfunctional uterine bleeding: PO, 2.5-5mg/day in
divided doses x 7 days.
Female castration or primary ovarian failure: PO,
1.25mg/day.
Female hypogonadism: PO, 2.5-7.5mg/day in divided
doses x 20 consecutive days/cycle.
Menopausal symptoms:
PO, 0.3-l.25mg/day cyclically; reduce or discontinue
dose at 3-6mo intervals.
Intravaginally, 2-4g/day; reduce or discontinue dose at 3
to 6 month intervals.
Osteoporosis: PO, 0.625mg/day.
Breast carcinoma in women more than 5 years after
menopause: PO, 10mg tid for at least 3mo.
Prostatic carcinoma: PO, 1.25-2.5mg tid.
Vulvular and vaginal atrophy:
PO, 0.3-1.25mg daily.
Intravaginally, 0.5-2g/day given cyclically.
Estradiol [X]
" Ediol Tablet" 1mg/tab
Usual Dose:PO
Abnormal vasomotor function, Atrophic vaginitis: 1 to 2mg
qd in a cyclical pattern: 3 weeks on, 1 week off.
Breast cancer: 10mg tid for at least 3 months.
Carcinoma of prostate: 1 to 2mg tid.
94
Decreased estrogen level: 1-2mg qd
Postmenopausal osteoporosis; Prophylaxis: 0.5 mg qd in a
cyclical pattern, 23 days on, 5 days off.
Estradiol [X]
"Oestrogel Gel" 0.6mg/g, 30g/tube
Usual Dose:
Gel, 1.25-2.5g qd, applied topically to the skin of the
lower part of the abdomen.
The administration should be cyclic (e.g. 3wk on and 1wk
off), reduce or discontinue dose at 3-6mo intervals.
2) Progestins
Dydrogesterone
"Duphaston Tablet" 10mg/tab
Usual Dose: PO, 10mg twice daily.
Threaten abortion: 40mg at once then 10mg q8h until
symptom remit, if symptoms persist the dose can be
increased by 5-10mg q8h, continued for a week after
symptoms cease.
Medroxyprogesterone Acetate [D]
"Provera Tablet" 5mg/tab
Usual Dose: PO.
Amenorrhea and uterine bleeding: 5-10mg for 5-10days
beginning of day 16 or day 21 of the menstrual cycle.
Endometriosis: 30mg/day.
Precocius puberty: 20-40mg/day.
95
Progesterone [D]
"Progesterone Injection" 25mg/ml/amp
Usual Dose:
IM:
Amenorrhea: 5-10mg/day for 6-8 days usually
beginning 8-10 days before anticipated start of
menstruation.
Abnormal uterine bleeding: 5-10mg/days for 6-8days
Micronised Progesterone[X]
"Utrogestan" 100mg/cap
Usual Dose: PO 100mg tid.
Norethisterone [X]
"Primolut-Nor Tablet" 5mg/tab
Usual Dose: PO.
Contraception: Norethindrone 0.35mg qd, starting on first
day of menstruation.
Amenorrhea and abnormal uterine bleeding:
2.5-10mg/day on days 5-25 of menstrual cycle.
Endometriosis: 5mg/day for 2 weeks, increase at
increments of 5mg/day every 2 weeks until 15mg/day;
continue for 6-9 months.
3) Combinations of Estrogens and Progestins
Estradiol valerate and Norgestrel [X]
"Progyluton Tablet" 21tab/pk
Each white tablet contains: (11tab)
Estradiol valerate --------------------------------------2mg
Each brown tablet contains: (10tab)
96
Estradiol valerate --------------------------------------2mg
Norgestrel --------------------------------------------0.5mg
Usual Dose: PO, 1 tab/day.
Conjugated estrogens and Medroxyprogesterone [X]
"Premelle Tablet" 28tab/pk
Each tablet contains:
Conjugated estrogens ---------------------------------- 0.625mg
Medroxyprogesterone ---------------------------------- 2.5mg
Usual Dose: PO, 1 tab/day.
Estradiol Valerate and Medroxyprogesterone acetate [X]
"Indivina Tablet" 28 tab/pk
Each tablet contains:
Estradiol Valerate-----------------------------------------1mg
Medroxyprogesterone acetate------------------------2.5mg
Usual Dose: PO, 1 tab/day.
Estradiol Valerate and
Medroxyprogesterone Acetate [X]
"Divina Tablet" 21tab/pk
Each white tablet contains: (11tab)
Estradiol Valerate-------------------------------------------2mg
Each blue tablet contains: (10tab)
Estradiol Valerate-------------------------------------------2mg
Medroxyprogesterone Acetate ------------------------- 10mg
Usual Dose: PO, 1 tab/day.
4) Other related agents
97
Clomiphene Citrate [X]
"Clomid Tablet" 50mg/tab
Usual Dose: PO, initially, 50mg/day x 5 days starting on the
5th day of the cycle. If ovulation does not occur, the
dosage is increased by 50mg in each cycle; max.
150mg/day.
Tibolone
"Livial Tablet" 2.5mg/tab
Usual Dose: PO, 1 tab daily.
5) Antiprogesterones
4Mifepristone RU486 [X]
"Apano Tablet" 200mg/tab
Usual Dose: PO.
For pregnancy termination through day 49 of pregnancy
600mg as a single dose, followed in 3 days by
misoprostol 200mcg PO.
NOTE: Patients should return on day 14 to assess efficacy
of the procedure and bleeding.
6. Uterine Stimulants
Ergonovine Maleate (Ergometrine Maleate)[X]
" Ergonovine Tablet" 0.2mg/tab
Usual Dose: PO, 0.2-0.4mg bid-qid x 2-7 days.
Oxytocin
98
"Piton-S Injection" 10IU/1ml/amp
Usual Dose:
IVF: (mU=0.001 IU)
Induction of labor: A dilute solution (with NS or
Ringer’s soln.) 10mU/ml at an initial rate of
0.5-1mU/min & may be increased by 1-2mU/min
q30-60min (rate > 9-10mU/min are rarely required).
Prevention of postpartum uterine atony & hemorrhage:
A total of 10IU may be infused at 20-40mU/min or a
rate sufficient to control uterine atony.
IM: To control postpartum uterine bleeding: 3-10IU.
7. Antidiabetic Agents
1) Insulins
Insulin Preparations Available in LPAH
Generic Name
Trade Name
Type
Insulin Inj
Actrapid HM
Reg
Isophane
Insulatard HM
Insulin Susp.
Insulin Inj +
Mixtard 30HM
Isophane
Insulin Susp.
Rapid Insulin + NovoMix 30 Penfill
Isophane
Insulin Susp.
Insulin detemir Levemir FlexPen
NPH
Onset Duration Route
(hr)
(hr)
0.5
8
SC/IV
1.5
24
1.0-1.5 18-24
0.5
24
Reg(3)
+
NPH(7)
Aspart (3) 10-20
+
min
Aspart
Protamine
(7)
Insulin
1.0
Detemir
24
SC
24
SC
Source: Human (recombinant DNA origin): 100U/ml,
99
SC
SC
SC
10ml/vial.
Usual Dose: Individualized.
STORAGE: 2-8 oC.
2) Oral Hypoglycemic Agents
a) Sulfonylureas
Glimepiride [C]
"Amaryl,Glimaryl, Grumed Tablet" 2mg/tab
Usual Dose: individualized, take with breakfast or the first
main meal, initially, 1-2mg qd, increase by less than
2mg/day at 1-2 week intervals; maintenance, 1-4mg qd;
max. 8mg/day.
NOTE: Do not chew to avoid being stuffed between the
teeth.
Glyburide (Glibenclamide) [C]
"Apo-Glyburide Tablet" 5mg/tab
Usual Dose: Initially 1.25-5mg/day increased by less than
2.5mg/day weekly; maintenenace, 1.25-20mg/day before
breakfast; daily dose above 10mg should be given in 2
doses; max. 20mg/day, ac 30min.
Gliclazide [C]
" Diamin,Dail Tablet" 80mg/tab
Usual Dose: PO, 80-160mg/day, max. 320mg in divided
dose, ac 30min.
Gliclazide [C]
" Diamicron MR, Dicron MR, Hanazide MR Tablet" 30mg/tab
100
Usual Dose: PO, 1-4 tab taken once daily. Max: 120 mg daily.
Elderly diabetic Starting dose: 1/2 tab in the morning & 1/2 tab
in the evening.
Glipizide [C]
" Minidiab Tablet" 5mg/tab
Usual Dose: PO,
Adult: Initially, 5 mg PO daily before breakfast.
Elderly or those with liver disease may be started on 2.5
mg.
Usual maintenance dosage is 10 - 15 mg. Max. is 40 mg
daily.
b) Biguanides
Metformin HCl [B]
" Glucomin XR Tablet" 500mg/tab
"Antigluco, Henformin Tablet" 850mg/tab
Usual Dose: PO, 250-500mg qd-tid pc; max. 3g/day.
Extended-release：initial, 500 mg-1 g once daily，
maintenance, 1-2.5 g once daily ; MAX 2000 mg/day
NOTE: Extended-release give with the evening meal
and swallow whole; never crush or chew
c) Alpha-Glucosidase Inhibitor
Acarbose [B]
"Glucobay,Glubose Tablet" 50mg/tab
Usual Dose: PO, individualized, take with the first bite of
each main meal, initially, 25mg tid , increase at 4-8week
101
intervals; max. ≦ 60kg, 50mg tid; ≧ 60kg, 100mg tid.
NOTE: Oral glucose (not sucrose) should be used to treat
mild to moderate hypoglycemia in patients using
acarbose.
d) Thiazolidinedione
Pioglitazone [C]
"Actos,Pioglit Tablet" 30mg/tab
Usual Dose: PO, individualized, take with or without meals.
Monotherapy: Initially, 15-30mg qd, increase to 45mg qd
if the response is inadequate; max. 45mg/day.
Combination therapy: 15-30mg qd.
e) Meglitinide
Nateglinide [C ]
"Glunat Tablet" 60mg/tab
Usual Dose: PO.
Monotherapy: 120mg tidac.
Patients with near goal glycosylated Hb may begin
therapy with 60mg 3 times daily.
NOTE: Take the medication 1-30 minutes prior to a meal.
If patient skips a meal, skip the dose for that meal.
Repaglinide [C]
"Supernide Tablet" 1mg/tab
Usual Dose: PO,
Starting dose: for patients not previously treated or
whose HbA1c is <8%: 0.5mg. For previously treated
102
with blood glucose-lowering agents and whose HbA1c 
8%: 1-2mg before each meal.
Dose range: 0.5 to 4 mg take with meals; it may be
dosed preprandially 2, 3 or 4 times a day in
response to changes in the paatients meal pattern.
The maximum total daily dose should not exceed 16
mg.
f) Others
Glyburide and Metformin
"GlucoMet F.C Tablet"
Each tablet contains:
Glyburide----------------------------------------------------5 mg
Metformin-------------------------------------------------500mg
Usual Dose: PO.
Initial: 1 tab qd-tid.
8. Agents Used to Treat Thyroid Disorders
1) Thyroid Hormones
Levothyroxine Sodium (Thyroxine Sodium, T4) [A]
"Eltroxin Tablet" 100mcg/tab, 65mg thyroid/100mcg Eltroxin
Usual Dose: PO.
Adults, initially, 50mcg/day, increased by 25-50mcg
q2-4wk; maintenance, 100-200mcg/day.
Children:
0-6mo, 25-50mcg or 8-10mcg/kg;
6-12mo, 50-75mcg or 6-8mcg/kg;
1-5yr, 75-100mcg or 5-6mcg/kg;
103
6-12yr, 100-150mcg or 4-5mcg/kg;
> 12yr, 100-200mcg or 2-3mcg/kg.
For children, crush the proper dose tablet and suspend in a
small amount of water, but do not store the suspension
for any period of time.
2) Antithyroid Agents
Carbimazole [D]
" Carbimazole Tablet" 10mg/tab
Usual Dose: PO.
Adults, initially, 20-60mg/day in divided doses;
maintenance, 5-15mg/day.
Children, initially, 0.5-0.7mg/kg/day in divided doses.
Propylthiouracil (PTU) [D]
"Procil Tablet" 50mg/tab
Usual Dose: PO.
Adults, initially, 300-450mg/day in 2 doses; maintenance,
100-150mg/day.
Children 6-10yr, initially, 50-150mg/day; > 10yr, initially,
150-300mg/day or 5-10mg/kg/day. Give orally in 3
divided dose, maintenance dosage is determined by
patient response.
9. Calcium Regulator
Calcitonin (Salcatonin, Synthetic Salmon Calcitonin) [C]
"Miacalcic Injection" 50IU/1ml/amp
"Cadotin Nasal Spray" 200IU/puff, 2800IU/btl
104
Usual Dose:
Hypercalcemia: IM or SC, initially, 4IU/kg ql2h, if
unsatisfactory in 1-2 days, the dose may be increased to
8IU/kg ql2h. If response is still unsatisfactory after two
or more days, max. 8IU/kg may be given q6h. IVF,
2-16IU/kg ql2h.
Paget's disease:
IM or SC, initially, 100IU/day; maintenance, 50IU/day
or q2d. For relapse, large doses (100IU/day) should be
tried but do not consistently improve clinical response.
Intranasal, 100IU bid for 4-6 mo.
Pain from bone metastases: IM, SC or Intranasal, 100-200
IU/day in divided doses.
Postmenopausal osteoporosis: IM or SC, 100IU/day;
intranasal, 50-100U bid.
NOTE:
1. When volume of injection exceeds 2ml, IM is preferred
and multiple sites of injection should be used. SC is
preferred for patients self-administration.
2. Prior to the use of calcitonin salmon (but not human) a
skin test should be considered. The appearance of more
than mild erythema or wheal within 15min indicates a
positive reaction and it should not be administered.
STORAGE: 2-8 oC.
Sodium Alendronate [C]and Vit D
"Fosamax plus Tablet" 70mg/tab
Each tablet contains:
Sodium Alendronate-----------------------------------70mg
Vit D ----------------------------------------- 2800IU
105
Usual Dose: PO.
Osteoporosis in postmenopausal women: Treatment,
70mg qw ac; prophylaxis, 35mg qw.
Osteoporosis in men: Treatment, 70mg qw ac.
Paget’s disease of bone: 40mg qd for 6 mo.
NOTE: Must be taken at least 30 minutes before the first
food, beverage, or medication of the day with full glass of
water and not to lie down for at least 30 minutes.
10. Miscellaneous
Somatostatin Acetate
"Somatosan Curamed for IV Infusion" 3mg/amp
Usual Dose: IVF, diluent: isotonic Sodium Chloride.
Severe acute bleeding of esophageal varices,
gastroduodenal ulcer, gastritic: 3.5mcg/kg/hr, < 5 days.
NOTE: The absorption of somatostatin occurs when
administered via polypropylene (PPC) bags.
106
VI. Antiallergic Agents and Antihistamines
NOTE: Oral inhalation and nasal spray should be shaken
before use.
1. Antiallergic Agents
Fluticasone Propionate [C]
"Flixonase Nasal Spray" 50mcg/100mg/dose, 120metered
sprays/btl
Usual Dose: Adults & children > 12yr, 1-2 sprays in each
nostril/day in 1-2 doses; max.  4 sprays into each nostril.
Children 4-11yr, 1 sprays in each nostril/day in 1-2 doses;
max  2 sprays into each nostril.
2. Antihistamines
Cetirizine [B]
"Symitec,Cemine Tablet" 10mg/tab
Usual Dose: PO.
Adults& children > 12yr: 5-10mg qd; max. 20mg/day.
Children 2-6yr: 5mg qd.
Desloratadine [C]
"Denosin Tablet" 5mg/tab
Usual Dose: PO.
Adults & children > 12yr: 5mg once daily.
Children 6-11yr: 2.5mg, 12month-5yr: 1.25mg,
6-11month: 1mg once daily.
107
Levocetirizine [B]
"Xyzal Tablet" 5mg/tab
Usual Dose: PO, Children≧12 yrs and adults: 5mg qd
Cyproheptadine [B]
"Periactine Syrup" 2mg/5ml (0.4mg/ml), 60ml/btl
"Periactine Tab" 4mg/tab
Usual Dose: PO.
Allergies and Pruritus:
Adults: 4mg tid; max. 32mg.
Children: 0.25mg/kg/day in 2-3 divided dose; 2-6yr:
2mg q8-12h; max. 12mg/day; 7-14yr: 4mg q8-12h;
max. 16mg/day.
NOTE: Dosage reduced in hepatic dysfunction.
Diphenhydramine HCl [B]
"Bena Injection" 30mg/1ml/amp
Usual Dose: IV or deep IM.
Adults, 10-50mg tid-qid; max. 400mg/day.
Children > 9kg, 5mg/kg/day in 3-4 doses; max.
300mg/day.
STORAGE: Protect from light.
Diphenhydramine HCl , vit B6 , Ca bromide
"VenaCal-B6 injection"5mL/amp
Per 5 mL Diphenhydramine HCl 20 mg, vit B6 5 mg, Ca
bromide 200 mg.
Usual Dose: Adult 5 mL IV.
Chlorpheniramine [B]
108
"CTM Tablet" 4mg/tab
Usual Dose: PO.
Adults-Oral: 4mg q4-6h. Up to 24mg daily
Children-PO, 0.0875mg/kg or 2mg/㎡ q6h
2-6 years:1 mg q4-6h
Loratadine [B]
"Genadine Tablet" 10mg/tab
Usual Dose:
Adults & children > 6yr: 10mg qd on an empty stomach.
Children 2-5yr: 5mg qd on a empty stomach.
Patient with GFR < 30ml/min or hepatic function
impairment: 10mg qod.
NOTE:
1. Loratadine will be excreted into milk.
2. Safety & efficacy in children  2yr have not been
established.
Loratadine [B] and Pseudoephedrine [C]
"Finska-Lp" 5mg Loratadine, 120mg Pseudoephedrine/tab
Usual Dose: PO.
Adults & Children > 12yr: 1 tab bid; max. 2 tab/day
NOTE: Use with caution in patients > 60yr. Overdose may
cause hallucinations, seizures, CNS depression and death.
Ebastine
" Ebastin Tablet" 10mg/tab
Usual Dose: PO.
Adults & children > 12yr: 10mg once daily.
Children 6-11yr: 5-10mg; 2-5yr: 2.5mg once daily.
109
Meclizine HCl
See " Bonamine( Clizine ) Tablet"
VII. Respiratory Tract Drugs
1. Drugs Used in Asthma
NOTE:
Oral inhalation and Nasal spray should be shaken before
use.
1) Bronchodilators
NOTE:
1. All bronchodilator should be protected from light.
2. All  agonists are contraindicated in patients with
hyperthyroidism; caution when patients with
cardiovascular diseases or DM.
3. Short acting -2 agonists are the first line drugs for the
relief of asthma symptoms.
a) β-2-agonists
Bambuterol
"Baburol Tablet" 10mg/tab
Usual Dose: PO.
Adults: Initially, 10mg hs, may increased to 20mg after 1-2
wk; renal function impairment (GFR > 50ml/min):
initially 5mg/day.
Salbutamol [C]
"Ventolin Tablet" 2mg/tab
110
" Ventolin Nebules 4mg/2.5ml"
Usual Dose:
Adults and children >13 years: 2-4mg tid or qid; max.
dosage is 8mg qid.
Children 6 to 13 years: 2mg tid or qid.
Children 2 to 5 years: 0.1mg/kg PO tid, not to exceed
2mg tid.
Solution for inhalation: 2mg tid or qid by nebulizer
Procaterol HCl
"Meptin Tab " 50mcg/tab
"Meptin Liquid "5mcg/ml,60ml/bt
Usual Dose:Adults, 50-100mcg bid.Children > 6yr,
25-50mcg; < 6yr, 1.25mcg/kg/dose; bid or hs.
b) α,β-agonists
Ephedrine HCl [C]
"Ephedrine HCl Injection" 40mg/1ml/amp
Usual Dose:
Adults, IM or SC 10-50mg; slow IV 10-25mg, repeated as
needed q5-10min; max. 150mg/day.
Children, IV or SC, 3mg/kg/day in 4-6 doses.
STORAGE: Protect from light.
Epinephrine HCl
See " Epinephrine Injection"
c) Xanthine Derivatives
111
Salt
Theophylline Anhydrous
Theophylline monohydrate
Aminophylline
% Theophylline Content
100%
91%
80%
Aminophylline [C]
"Aminophylline Injection" 250mg/10ml/amp
Usual Dose:
Acute asthma:
IVF at a rate < 25mg/min.
Loading dose: 6mg/kg (decrease by 1/2 in those who
are currently receiving theophylline).
112
Maintenance dose:
Patients Group
Children 6mo-9yr
Children 9-16yr & young
adult smokers
Otherwise healthy nonsmokers
Older patients & those with
cor pulmonale
Patients with congestive heart
failure, liver failure
Infusion Rate
(mg/kg IBW/hr)
First 12hr
Beyond 12hr
1.2
1
1
0.8
0.7
0.5
0.6
0.3
0.5
0.1-0.2
PO: Plain tablet (IVF is preferred).
Loading dose: 6mg/kg (decrease by 1/2 in those who
are currently receiving theophylline).
Maintenance dose:
Patients Group
1st 12-16hr Maintenance Dosage
Children 6mo-9yr
5mg/kg q4h 5mg/kg q6h
x 3 doses
Children 9-16yr & young 3.75mg/kg 3.75mg/kg q6h
adult smokers
q4h x 3 doses
Otherwise healthy non3.75mg/kg 3.75mg/kg q8h
smokers
q6h x 2 doses
Older patients & those
2.5mg/kg 2.5mg/kg q8h
with cor pulmonale
q6h x 2 doses
Patients with congestive
2.5mg/kg 1.25-2.5mg/kg ql2h
heart failure, liver failure q8h x 2 doses
113
Chronic asthma: PO.
Plain tablet, daily dose in 3-4 doses.
Sustained-release tablet, daily dose may be given in 2-3
doses.
Starting dose for adults and children > lyr:
The lesser of 500mg/day total or 20mg/kg/day, increase
the dose if tolerated at 3-day intervals by no more than
25% increments.
Maximum dose for age:
Children 1-9yr, 30mg/kg/day; 9-12yr, 25mg/kg/day; 12-16
yr, 22.5mg/kg/day; > 16yr, 16mg/kg/day or 1125mg total
/day, whichever is less.
Obtain peak serum theophylline concentration after no doses
have been missed for at least 48 hours on the final dose
tolerated.
**Dose using IBW or real body weight, whichever is less.
These dosages do not apply if liver disease, heart failure,
or pulmonary edema are present.
Neonatal apnoea:
Loading: 4-6mg/kg.
Maintenance: 0-4wk, 1-2mg/kg ql2h; 4-8wk, 1-2mg/kg
q8h; > 8wk, 1-3mg/kg q6h; keep serum theophylline
level 5-10mcg/ml.
Theophylline [C]
"Theolin SR Tablet" 250mg theophylline anhydrous/tab
"Xanthium Capsule" 200mg theophylline monohydrate/cap
NOTE:
114
1. Caution: patients with cardiovascular disease.
2. Dose using IBW or real body weight, whichever is less.
These dosages do not apply if liver disease, heart
failure, or pulmonary edema are present.
3. The capsule or tablet should not be chewed.
4. For other information, refer to the section of
aminophylline. See p.
for TDM guidelines.
Usual Dose:
Acute asthma:
Maintenance dose:
Patients group
1st 12-16hr
Maintenenance
Dosage
Premature neonates up to
1mg/kg q12h
40wk post conception age
0- 4wk
1-2mg/kg/q12h
4-8wk
1-2mg/kg q8h
> 8wk
1-3mg/kg q6h
Children 6mo-9yr
4mg/kg q4h x 3
4mg/kg q6h
doses
Children 9-16yr & young 3mg/kg q4h x 3
3mg/kg q6h
adult smokers
doses
Otherwise healthy
3mg/kg q6h x 2
3mg/kg q6h
non-smokers
doses
Older patients & those
2mg/kg q6h x 2
2mg/kg q8h
with cor pulmonale
doses
Patients with congestive
2mg/kg q8h x 2 1-2mg/kg q12h
heart failure, liver failure
doses
115
Chronic asthma: PO.
Daily dose can be divided in 3-4 doses for oral solution,
or 1-2 doses for tablets or capsules.
Starting dose for adults and children > lyr:
The lesser of 400mg/day total or 16mg/kg/day or 12mg/kg
for extended-released tablet, increase the dose if tolerated
at 3-day intervals by no more than 25% increments.
Maximum dose for age:
Children 1-9yr, 24mg/kg/day; 9-12yr, 20mg/kg/day;
12-16yr, 18mg/kg/day; >16yr, 13mg/kg/day or 900mg
total/day, whichever is less.
Obtain peak serum theophylline concentration after no doses
have been missed for at least 48 hours on the final dose
tolerated.
d) Anticholinergic Agents
Ipratropium Bromide [B]
" Atrovent Nebulizer Solution UDV" 500mcg/2ml/vial
"Atrovent MDI" MDI 200 puff/10ml/bot (20mcg/puff)
Usual Dose:
Nebulizer:
Adults, 0.4-2.0ml (100-500mcg) up to qid.
Children 3-14yr, 0.4-2.0ml (100-500mcg) up to tid.
The usual dose for MDI is 2 puff 3-4 times daily.
NOTE: The dose of nebulizer solution may need to be
diluted with sterile normal saline in order to obtain a final
volume suitable for the particular nebulizer being used.
116
Tiotropium [C]
"Spiriva 18mcg inhalation powder, hard capsule with
handihaler device" 18mcg/cap, 30cap/box
Usual Dose: 1 cap daily.
e) Asthma Prophylatic and Anti-Inflammatory
Agents:Steroids/Bronchodilator Combination
Salbutamol sulphate and Ipratropium Bromide
"Combivent Nebulizer Solution UDV" 500mcg
Atrovent ,2500mcg Salbutamol/ 2.5ml/vial
Usual Dose:
Nebulizer: 1 vial tid-qid.
NOTE: The dose of nebulizer solution may need to be
diluted with sterile normal saline in order to obtain a final
volume suitable for the particular nebulizer being used.
Salmeterol Xinafoate and Fluticasone Propionate
"Seretide Accuhaler"250mcg fluticasone, 50mcg
salmeterol/dose, 60dose/box
Usual Dose:
Seretide Accuhaler 250: Adults and children > 12yr, 1
puff bid.
Budesonide and Formoterol [B]
"Symbicort Turbuhaler"120 doses/bot
Budesonide 160 mcg, Formoterol 4.5mcg/dose
Usual Dose:
Adult and children >12yr: 1-2 puffs bid.
Children >6y: 1 puff bid.
117
NOTE: 1.使用後以清水漱口，避免口腔念珠菌感染
2.＜4 yrs 禁用
2. Antitussive Agents
Sodium Dibunate
"Becantex Sugar-coated Tablet" 30mg/tab
Usual Dose: PO, 30mg tid-qid.
Dextromethorphan [C]
" Regrow SR Tablet" 60mg/tab
Usual Dose: PO, 60 mg qd-bid; max. 120 mg/day.
3. Expectorants and Cough Preparations
Dextromethorphan Glyceryl guaiacolate Phenylephrine
Chlorpheniramine
"Nocough Syrup" 120ml/btl
Each ml contains:
Dextromethorphan-----------------------------------1mg
Glyceryl guaiacolate---------------------------------5mg
Phenylephrine-----------------------------------------1mg
Chlorpheniramine------------------------------------0.2mg
Usual Dose: PO.
Adults: 10-15ml tid-qid.
Children: 6-12yr, 5ml tid-qid
Compound Opium and Glycyrrhiza Mixture
"Brown Mixutre Liq. (with Opium) " 120ml/btl
"Brown Mixutre Tab (with Opium) "
118
Liq. Each ml contains:
Extract Glycyrrhiza--------------------------------------0.12ml
Potassium Antimony Tartrate--------------------------0.24mg
Tincture Opium Camphor------------------------------0.12ml
Spirit Ethylnitrile-----------------------------------------0.03ml
Glycerin---------------------------------------------------0.12ml
Tab. Each tab contains:
Extract Glycyrrhiza-----------------------------------0.48mg
Potassium Antimony Tartrate-----------------------1mg
Tincture Opium Camphor----------------------------2.5mg
Camphor------------------------------------------------1.5mg
Benzoic Acid-------------------------------------------2.5mg
Usual Dose: PO, 2-10ml tid.(Liq)
1-2 tab tid or qid. (Tab.)
Dextromethorphan HBr [C], K-Cresolsulfonate and
Lysozyme
"Fucou Capsule" Dextromethorphan HBr 20mg,
K-Cresolsulfonate 90mg, Lysozyme Cl 20mg/cap
Usual Dose: PO.
Adults & children > 12yr, 3-6 cap/day in 3-6 doses; max.
6 cap/day.
Children 6-12yr, 1-3 cap/day in 3-6 doses; max. 3
cap/day.
Children 2-6yr, 0.5-2 cap/day in 3-6 doses; max. 2
cap/day.
119
Dextromethorphan HBr , Methoxyphenamine HCl,
Quaiacol glycerol ether, Chlorpheniramine maleate
"Methon-S Inj"10 mg/2 ml/amp
each 2 ml contain:
Dextromethorphan HBr------------------------------10mg
Methoxyphenamine HCl-----------------------------60mg
Quaiacol glycerol ether-------------------------------80mg
Chlorpheniramine maleate--------------------------- 4mg
Usual Dose: Adult, 1-2 ml IM or SC
4. Mucolytic Agents
Acetylcysteine Sodium [B]
"Acetin Granule" 100mg/1.5g/pack
"Flutafin Granule" 100mg/5g/pack
"Flucil Granule" 200mg/5g/pack
Usual Dose: PO.
Acetaminophen poisoning: Loading dose, 140mg/kg;
maintenance dose, 70mg/kg q4h x 17 doses; repeat dose
if patient vomits within 1 hr of administration
Mucolytic: Adult, 200mg tid; children, 100-200mg bid to
qid.
Acetylcysteine Sodium [B]
" Fluimucil A Effervescent Tablets " 600mg/tab
Usual Dose: PO,1~2tab,Qd
Ambroxol HCl
"Amsol Tablet" 30mg/tab
"Musco Solution, Losolvan Liquid " 3mg/ml, 60ml/bot
120
Usual Dose: PO.
Tablet:
Adults: 60-180mg/day in 2-3 divided dose.
Children: Tablet, 60-90mg/day; 5-12yr, 30-45mg/day;
2-5yr, 15-30mg/day; 2yr, 15mg/day in 2-3 divided
dose.
SR:Adults:1 Tablet qd.
Musco Solution:
Adults and >10yr Children: 10ml tid.
Children: 5-10yr 5ml tid, 2-5yr 2.5ml tid, <2yr 2.5ml
bid.
5. Miscellaneous
Serrapeptase
See "Danzen Tablet"
121
VIII. Gastrointestinal Agents
1. Agents Used in Peptic Ulcer Disease
1) Antacids
Usual Dose:
As single agent for PUD:
High dose: ANC 144mEq 1 & 3hr pc & hs.
Low does: ANC 20-40mEq 1 & 3hr pc & hs
(120-280mEq/day).
Dosage is lower when used prn for relief of pain as an
adjunct therapy to H2 blocker or sucralfate.
NOTE:
1. ANC = acid neutralizing capacity.
2. Tablet should be chewed before swallowed.
Aluminium Hydroxide, Magnesium Hydroxide, Antifoam
AF Emulsion
"Lederscon Tablet" 500mg/tab
Each tablet contains:
Aluminium Hydroxide dried gel------------------------334mg
Magnesium Hydroxide--------------------------------166.0mg
Antifoam AF Emulsion---------------------------------36.7mg
Usual Dose: PO, 1-2tab qid.
Oxethazaine, Aluminium Hydroxide and Magnesium
Carbonate [C]
"Strocain Tablet"
Each tablet contains
Oxethazaine -----------------------------------------------5mg
Hydrated Alumina Powder Spray Dried -----------165mg
122
(Equivalent to Aluminium Hydroxide 126mg)
Magnesium Carbonate-------------------------------87.5mg
Usual Dose: 1-2 tab tid-qid, 15min ac; max. 15mg/dose,
45mg/day.
NOTE:
1. Long term use should be avoided.
2. Do not chew or crush the tablet.
Calcium Carbonate [C]
[ANC = 9mEq/tab]
See "CaCO3 Tablet"
Magnesium Oxide (MgO) [B]
"Magnesium Oxide Tablet" 250mg/tab [ANC = 12.5mEq/tab]
Usual Dose:
Antacid: 400-800mg/day. See Usual Dose under Antacids.
Saline laxative: 1-4g/day.
Aluminum hydroxide dried gel, Magnesium Oxide,
Dicyclomine HCL,Methylmethionine sulfonium chloride
"Wilcon-U Tablet"
Tab Contains:
Aluminum hydroxide dried gel------------------------200mg
Magnesium Oxide---------------------------------------100mg
Dicyclomine HCL---------------------------------------2.5mg
Methylmethionine sulfonium chloride----------------12.5mg
Usual Dose:
PO 1-2 Tab, well chewed, 1hr after meals & hs.
Aluminum Silicate, Oxethazaine
123
"Easygo Tablet"
Tab Contains:
Aluminum Silicate---------------------------------------100mg
Oxethazaine -------------------------------------------------5mg
Usual Dose:1~2tab,tid
Homatropine Methylbromide,Magnesium Aluminum
Hydroxide Monohydrate, Magnesium Trisilicate
"Peptidin Tablet"
Tab Contains:
Homatropine Methylbromide ---------------------------------2mg
Magnesium Aluminum Hydroxide Monohydrate--------400mg
Magnesium Trisilicate --------------------------------------300mg
Usual Dose:1~2tab,tid
Metamagnesium aluminum silicate, Aluminum dihydoxy
allantoinate
"Gowell Tablet"
Tab Contains:
Metamagnesium aluminum silicate------------------------450mg
Aluminum dihydoxy allantoinate --------------------------50mg
Usual Dose: 1~2tab,tid
2) H2 Receptor Antagonists
Famotidine [B]
"Ulstop, Famulcer Tablet" 20mg/tab
"Suwefue Tablet" 40mg/tab
Usual Dose:
Adults: PO.
124
Pathological hypersecretory conditions: Initially, 20mg
q6h; then individualized; max. 640mg/day.
Peptic ulcer disease, GERD: 40mg hs or 20mg bid for
4-8wk.
Prophylaxis of recurrent PUD: 20mg hs.
Ranitidine HCl [B]
" Nicewe Inj" 50mg/5ml/Amp
Usual Dose:
Parenteral: 50mg IV or IM q6 to q8h.
When administering IV push, dilute to a total volume of
20 ml and inject over a period of 5 minutes. Dilute
50mg ranitidine in 100ml of D5W and infuse over 15 to
20 minutes.
3) Agents to Hasten the Healing of Ulcer
Sucralfate[B]
"Sucrate Gel" 1gm/5ml/sachet
"Sucral Tablet " 500mg/tab
Usual Dose: 1g bidac.
4) Proton Pump Inhibitors
Omeprazole [C]
"Omezol Capsule" 20mg/cap
Usual Dose: PO,
For short-term treatment of active duodenal ulcer :
20- 40 mg qd for 2-8 wks
For gastroesophageal reflux disease (GERD) :
125
20-40 mg qd for 4-12 wks
For pathological GI hypersecretory conditions (eg,
Zollinger-Ellison syndrome) :
Initial 60 mg qd, Max.120 mg tid, daily dosage > 80 mg
should be administered in div. Doses
Lansoprazole [B]
"Takepron OD Tablet" 30mg/tab
"Lanpo Cap" 30mg/cap
Usual Dose: PO, ac.
GERD: 30mg qd for up to 8wk.
PUD: 15-30mg qd x 4wk, up to 8wk in GU.
Pathological hypersecretory condition: Initially, 60mg qd;
maintenance, 60mg qd-90mg bid.
Prophylaxis of recurrent PUD: 15mg qd up to 1 yr.
NOTE:
1. Maintenance therapy of PUD should not be longer than
1yr.
2. Daily dose > 120mg should be administered in 2
divided doses.
Pantoprazole [B]
"Pantoloc Injection" 40mg/vial
"Gastroloc,Pozola Tablet " 40mg/tab
Usual Dose:
Peptic ulcer
Adults: 40-80mg qd for 4-8 wks
Hypersecretory conditions
PO: 40mg qd-bid or IV infusion: 80mg q12h, can increase
to q8h; max: 240mg/day
126
NOTE: Pantoprazole injection admixture should be infused
intravenously over 15 min at a rate not to exceed
3mg/min or 6 mg/min.
2. Anticholinergic Antispasmodics
C/I: Glaucoma, obstructive disease of GI tract, obstructive
uropathy, paralytic ileus, myasthenia gravis, severe
ulcerative colitis.
Atropine Sulfate [C]
"Atropine Sulfate Injection" 1mg/1ml/amp
Usual Dose:
Antidote to anticholinesterase (eg. organic phosphate):
Adults, initially, IV (preferred), 1-2mg; additional 2mg
IM or IV q5-60min titrated to response.
Children, IM or IV, 0.05mg/kg; repeated q10-30min
titrated to response.
Block adverse muscarinic effects of anticholinesterase:
IV.
Adults, 0.6-1.2mg for each 0.5-2.5mg neostigmine
methylsulfate, or 10-20mg pyridostigmine Br;
administered a few min prior to anticholinesterase
agent.
Children < lyr, 0.02mg/kg for each 0.04mg/kg
neostigmine methylsulfate.
Bradyarrhythmia: IV.
Adults, 0.5-1mg q3-5min prn; max. 0.04mg/kg
(complete vagal blockade).
Children, 0.02mg/kg q5min (up to lmg); max. 1mg.
GI anticholinergic effect: IV, IM, or SC.
127
Adults, 0.3-1.2mg q4-6h.
Children, 0.01mg/kg or 0.3mg/m2 q4-6h; max. 0.4mg
q4-6h.
Hypotonic radiography of GI tract: IM, adults, lmg.
Preanesthetic medication: IM or SC.
Adults & children > 20kg, 0.4mg (0.2-1mg); children
12-16kg, 0.3mg; 7-9kg, 0.2mg; 3kg, 0.1mg; 0.5-1hr
prior to induction of anesthesia.
Hyoscine Butylbromide (Hyoscine-N-Butylbromide)[C]
"Buscopan Sugar-coated Tablet" 10mg/tab
" Buscopan Injection" 20mg/1ml/amp
Usual Dose:
PO, adults & children > 6yr, 10-20mg 3-5 times/day.
IV or IM or SC:
Adults, 10-40mg, repeated after 30min prn; max.
100mg/day.
Infants & children < 6yr, 5mg tid.
Pipoxolan
"Rowapraxin Tablet" 10mg/tab
Usual Dose: PO 10-30mg tid.
Pinaverium Bromide
"Delibs FC Tablet" 50mg/tab
Usual Dose: PO 50mg tid-qid
3. Antidiarrheals
Kaolin and Pectin [C]
128
"Pecolin Suspension" 120ml/btl
Each ml contains:
Kaolin --------------------------------------------------200mg
Pectin-----------------------------------------------------10mg
Usual Dose: PO.
Adults, 20-30ml tid-qid.
Children 3-10yr, 10-20ml tid-qid; 1-3yr, 10ml tid-qid;
6-12mo, 5ml tid-qid.
Loperamide HCl [B]
"Imodium Tab" 2mg/tab
Usual Dose: PO.
Adults:
Acute diarrhea, initially, 4mg; followed by 2mg after
each loose stool; max. 16mg/day.
Chronic diarrhea, 4-8mg/day.
Children, 1st day, 2-5yr (13-20kg), 1mg tid; 6-8yr
(20-30kg), 2mg bid; 8-12yr (> 30kg), 2mg tid;
maintenance, 0.1 mg/kg only after a loose stool. Total
daily dose should not exceed the recommended 1 st day
dose. 0.08-0.24mg/kg/day in 2-3 doses in chronic
diarrhea, max. 2mg/dose.
Lactobacteria (Streptococcus faecalis), Glycobacteria
(Bacillus natto)
"Biofermin Tablet"
Each tablet contains:
Lactobacteria (Streptococcus faecalis)--------------------3mg
Glycobacteria (Bacillus natto)------------------------------2mg
Usual Dose: PO, Adults: 3-10 tab tid. Children: 1-3 tab tid.
129
Lactobacillus Casei
"Antibiophilus Cap" 250mg/cap
Usual Dose: Preventive treatment 2 cap/day. Intestinal transit
disorders 4-8 cap/day.
4. Laxatives
NOTE:
1. Do not use when abdominal pain, nausea, or vomiting is
present.
2. Adequate fluid intake is recommended.
1) Bulk-forming Laxatives
C/I: Patients with intestinal obstruction, fecal impaction or
total atony of the colon.
Sterculia and Frangula [B]
"Normacol Plus Granules" 7g/sachet
Each sachet contains:
Sterculia ---------------------------------------------------- 62%
Frangula ------------------------------------------------------ 8%
Usual Dose: PO.
Adults, 1-2 sachets qd or bid.
Children 6-12yr, half the adult dose.
NOTE:
1. The granules should not be chewed or crushed and
should be swallowed immediately with plenty of water.
2. Frangula is an anthraquinone stimulant laxative,
sterculia is a bulk-forming agent; prolonged use is not
recommended.
130
C/I: Intestinal obstruction, ulcerative colitis.
2) Stimulant Laxatives
NOTE:
1. Do not use in patients with intestinal obstruction.
2. Stimulant laxatives are habit-forming & long term use
may result in laxative dependence & loss of normal
bowel function.
Bisacodyl [B]
" Dulcolax Tablet" 5mg/tab
Usual Dose:
PO:
Adults & children > 12yr, 5-15mg qd, up to 30mg for
bowel evacuation.
Children 3-1lyr, 5-10mg (0.3mg/kg) qd.
For surgical, radiological proctoscopic or sigmoidoscopic
preparation: Usual laxative dose orally (up to 30mg in
the night preceding and rectally on the surgery or
examination).
NOTE:
1. Bisadyl tab should be swallowed whole, and should not
be taken within 1hr after ingestion of antacids or milk.
2. The recommended dosages should not be exceeded.
Sennoside A+B and Senna glycoside
"Through Tablet"
Each tablet contains: Sennosides 20mg equivalents to
sennoside A+B 12mg.
Usual Dose: PO, adults, 2-4 tab/day; children, 1-2 tab hs.
131
3) Saline Laxatives
NOTE: Serious/potentially life-threatening electrolytes
disturbances may occur with long-term use or overdosage of
saline laxative.
Magnesium Oxide
See "Magnesium Oxide Tablet"
4) Hyperosmotic Laxatives
Sodium Biphosphate and Sodium Phosphate
"Evac Enema" Sodium Biphsphate 19gm, Sodium Phosphate
7g, 118ml/btl
Usual Dose: Rectally, adults, 1 btl; children 2-12yr: 0.5 btl.
Magnesium Carbonate, Citric Acid Anhydrous and
Potassium Bicarbonate [B]
"Magvac Oral Solution" 250ml/btl
Each 100ml contains:
Magnesium Carbonate ------------------------------4.29gm
Citric Acid Anhydrous-------------------------------7.83gm
Potassium Bicarbonate-----------------------------0.714gm
Usual Dose: PO.
Acute constipation: 20-50ml/dose.
X-Ray, Endoscopy: Adults and children >12yr; 250ml
after 1hr of fluid dinner; children 6-11yr, half of the
adult dose; children 2-5yr, 1/4 of adult dose.
NOTE: Drink adequate water after each dose.
132
Lactulose [B]
"Lactul Syrup" 666mg/ml, 500ml/btl
Usual Dose:
Portal-systemic encephalopathy.
PO:
Chronic: Adults, 10-45ml tid-qid, < lyr, 2.5-10ml/day
in divided doses; 1-18yr, 40-90ml/day in
divided doses; adjusted q 1-2d to produce 2-3
soft stools daily.
Acute: Initially, 30-45ml ql-2h; when laxation occurs,
reduced to amount required to produce 2-3 soft
stools.
Retention enema: 300ml mixed with 700ml H20 or NS,
retained for 30-60min; may be repeated q4-6h.
Chronic constipation: Adults, 15-30ml qd; max.
60ml/day, children, 7.5ml qd.
NOTE: When administered via a NG tube, it should be well
diluted to prevent induction of vomiting.
5. Antiemetics
1) Antidopaminergics
Chlorpromazine HCl
See "Wintermin Tablet"
Metoclopramide HCl
See "Primperan Injection" 10mg/2ml/amp (7.67mg
metoclopramide/amp)
133
Domperidone
"Costi,DMP Tablet" 10mg/tab
Usual Dose: PO ac, adults, 1 tab tid; children, 0.3mg/kg tid..
Prochlorperazine Maleate (Prochlorperazine Dimaleate)
[C]
"Novamin Tablet" 8mg/tab (5mg prochlorperazine/tab)
Usual Dose: PO.
Nausea and vomiting:
Adults, 5-10mg tid-qid, max. 40mg/day.
Children, 9-12kg, 2.5mg qd-bid, up to 7.5mg/day;
13-18kg, 2.5mg bid-tid, up to 10mg/day; 19-40kg,
2.5mg tid or 5mg bid, up to 15mg/day.
Psychotic disorder:
Adults, initially, 5-10mg tid-qid, increased q2-3d;
maintenance, 50-150mg/day.
Children 2-12yr, 2.5mg bid-tid; max. first day, 10mg;
2-5yr, 20mg/day; 6-12yr, 25mg/day.
NOTE & STORAGE: See Novamin Injection.
Prochlorperazine Mesylate (Prochlorperazine
Dimethanesulfonate) [C]
"Novamin Injection" 5mg prochlorperazine/1ml/amp
Usual Dose: IM.
Adults:
Nausea and vomiting, 5-10mg q3-4h as needed, up to
40mg/day.
Psychotic disorder, 10-20mg q1-4h as needed, up to 3-4
doses, then switch to oral form; prolong use 10-20mg
q4-6h.
134
Children < 12yr, deep IM, 0.13mg/kg once, then switched
to oral form at the same dosage.
NOTE:
1. Not recommended for children < 9kg or < 2yr.
2. It is a potent inducer of EPS especially in children and
young women.
STORAGE: Protect from light.
2) Anticholinergics/Antihistamines
Meclizine HCl
See " Bonamine( Clizine ) Tablet"
Diphenhydramine HCl
See "Bena Injection" 30mg/1ml/amp
3) Miscellaneous
Diphenidol HCl
See " Diphenidol Tablet "
6. Digestants
Lactobacteria (Streptococcus faecalis), Glycobacteria
(Bacillus natto)
"Biofermin Tablet"
Each tablet contains:
Lactobacteria (Streptococcus faecalis)--------------------3mg
Glycobacteria (Bacillus natto)------------------------------2mg
Usual Dose: PO, Adults: 3-10 tab tid. Children: 1-3 tab tid.
135
Lactobacillus Casei
"Antibiophilus Cap" 250mg/cap
Usual Dose: Preventive treatment 2 cap/day. Intestinal transit
disorders 4-8 cap/day.
7. Agents Used to Treat Hemorrhoid
NOTE: Suppositories should be moistened with lukewarm
water before being inserted high into the rectum.
Sodium oletate and Polidocanol and Chlorcarvacrol
"Alcos-Anal Suppository"
Each supp contains:
Sodium oletate ---------------------------------------200mg
Polidocanol -------------------------------------- 20mg
Chlorcarvacrol-------------------------------------0.7mg
Usual Dose: Rectally, 1supp in the morning, evening and
after evacuation.
Lidocaine, Aluminium Acetate, Zinc Oxide and
Hydrocortisone Acetate
"Hemodin Ointment" 10g/tube
Each g contains:
Lidocaine---------------------------------------------------25mg
Phenylephrine-------------------------------------------1mg
Betamethasone--------------------------------- 500mg
Usual Dose: Rectally, apply with an applicator once in the
morning, evening and after evacuation.
8. Prokinetic Drugs
136
Metoclopramide HCl [B]
"Primperan Injection" 10mg/2ml/amp (7.67mg
metoclopramide/amp)
Usual Dose: Dosages are expressed in term of base.
Diabetic gastroparesis: For severe cases, adults & children,
slow IV over 1-2min, 0.1mg/kg qid 30min ac & hs, up
to 0.5mg/kg/day; for mild to moderate case, PO,
0.1mg/kg, qid 30min ac & hs x 2-8wk.
Gastroesophageal reflux: PO, adults, 5-15mg, up to qid
30min ac & hs; children, 0.1-0.2mg/kg/dose up to qid,
max. 0.5mg/kg/day.
Prevention of cancer chemotherapy induced emesis:
IVF, adults & children, diluted with 50ml NS, IVF over
15min, given 30min before beginning C/T and
repeated q2h x 2 doses, then q3h x 3 doses. The initial
2 doses should be 2mg/kg for highly emetogenic drugs
and lmg/kg for less emetogenic drugs. If EPS occur,
give 50mg diphenhydramine HCl IM.
PO, adults, short acting tablet 0.5-2mg/kg 1 hr before
C/T, repeated q2h x 3 doses; 2 additional doses q3h if
necessary, up to 12mg/kg/day (reduced to 6 mg/kg/day
in patients with severe side effect).
To facilitate small bowel intubation: Slow IV over 1-2min,
adults, 10mg; children, 6-14yr, 2.5-5mg; < 6yr,
0.1mg/kg.
Prevention of postoperative nausea and vomiting: IM,
10mg near the end of surgery, repeated q4-6h as needed.
NOTE: Dosage should be reduced by 50% when Ccr <
40ml/min. Oral solution should be diluted (e.g. with
137
water, juice, carbonate beverage) or mixed with semisolid
food (eg. Apple sauce, pudding).
Mosapride[B]
"Mopride F. C. Tablet" 5mg/tab
Usual Dose: PO ac, adults, 1 tab tid
9. Miscellaneous Gastrointestinal Agents
Simethicone (Dimethylpolysiloxane) [C]
"Gascon Tablet" 40mg/tab
"Gascon Drop" 20mg/ml, 300ml/btl
Usual Dose: PO.
Flatulence:
Adults & children > 12yr, 40-125mg qid, max.
500mg/day.
Children 2-12yr, 40mg qid; children < 2yr, 20mg qid; pc
& hs, max. 240mg/day.
Prior to gastroscopy or radiography: Adults, 67mg as drop
in 2.5ml of water or 2ml of gascon drop with some
water 15 min before examination.
Amylase, Lipase, Protease, Metoclopramide HCl
"Primtase Tablet"
Each tablet contains:
Amylase ------------------------------------------------6500 unit
Lipase --------------------------------------------------8000 unit
Protease ------------------------------------------------ 450 unit
Metoclopramide HCl ------------------------------------5 mg
Usual Dose：1-2 tab. tid with meals.
138
Orlistat [B]
"Xenical Cap" 120mg/cap
Usual Dose:
PO, 120mg tid with each main meal containing fat (during
or up to 1 hr after the meal); omit dose if meal is
occasionally missed or contains no fat.
Sulpiride
See "Dogmatyl Tablet" 50mg/tab
Ursodiol (Ursodeoxycholic Acid, UDCA) [B]
"Urso Tab " 100mg/tab
Usual Dose: PO.
Dissolution of cholesterol gallstones (without
calcification): 8-10mg/kg/day in divided doses.
Primary biliary cirrhosis: 13-15mg/kg/day in 2-3 doses.
139
IX. Immunologic Agents
1. Agents for Active Immunity (Vaccines and Toxoids)
1) Vaccines
Hepatitis B Virus Vaccine Inactivated [C]
"Engerix-B Injection" recombinant HBsAg, 20mcg/ml/vial
Usual Dose: IM, 3 doses at 0, 1, 6 mo.
Adults > 20yr, 20mcg/dose; children & adolescents
11-19yr, 10 or 20mcg/dose; children < 11yr,
20mcg/dose.
Adults hemodialysed or immunocompromised, 40mcg
/dose, inject at 2 sites.
NOTE: Should be well shaken before use.
STORAGE: 2-8 oC.
Inactivated Influenza Vaccine (Split virion) [C]
"Vaxigrip" 0.5ml/prefilled syringe
Usual Dose: IM.
Children:
6-35mo: 1-2 doses of 0.25 ml with  4 wk between
3-8yr: 1-2 doses of 0.5ml with  4 wk between doses
Children  9yr & adults: 0.5ml each year of appropriate
vaccine
STORAGE: Protect from light, 2-8 oC.
Quadrivalent HPV Vaccine (Type 6.11.16.18) [B]
"Gardasil injection " 0.5ml/vial
Usual Dose: 0.5 mL IM X 3 doses at 0, 2, and 6 months
140
NOTE:
1. Safety and efficacy not evaluated in adults older than 26
years of age and in children younger than 9 years.
2. Storage 2-8℃,protect from light, do not freeze.
3. Do not inject IV; SC and intradermal administration
have not been studied, cannot be recommended.
HPV 16,18-L1 protein (Human Papillomavirus Recombinant
Vaccine)
" Cervarix injection " 0.5ml/vial
Usual Dose: IM. For girls and women 10-25 yr: 0.5 ml x 3
doses at 0, 1, and 6 months.
2) Toxoids
Tetanus Toxoid Adsorbed [C]
"Tetanus Toxoid Alum Precipitated Injection" 3ml/vial
(contains Thimerosal 0.01%)
Usual Dose: Deep IM or SC, 0.5ml/dose.
Primary immunization: 3 doses, the 2nd dose is given 4-8wk
after the 1st dose, the 3rd dose is given 6-12mo after the 2nd
dose.
Booster dose: Once every 10 years or at the time of injury or
exposure when history of immunization is < 3 doses.
2. Immunomodulators
1) Immunosuppressants
Adrenal Corticosteroids
141
See p.81
X. Antineoplastic Agents
1. Cytotoxic Agents
1) Antimetabolites
Tegafur and Uracil (Fotrafur and Uracil, FT-207 and
Uracil)
"UFUR Capsule" tegafur 100mg & uracil 224mg/cap
Usual Dose: PO, based on tegafur, 300-600mg/day (or
300-350mg/m2/day ) in 2-3 doses.
2. Hormones and Antagonists
1) Gonadotropin Releasing Hormone Analogues
Leuprolide Acetate (Leuprorelin Acetate) [X]
"Leuplin Depot S.C. Injection" 3.75mg/vial (with amp of 2ml
diluent)
"Leuprolide acetate 5mg/ml Injection" 2.8ml/vial
Usual Dose: SC.
Endometriosis: 3.75mg monthly.
Advanced prostatic cancer, palliative treatment: 3.75mg
monthly.
Test tube ovum fertilization: 1.88mg started on cycle day
21-23 or 0.5 mg/day started on cycle day 21-23
2) Antiandrogens
142
Bicalutamide [X]
"Casodex Tablet" 50mg/tab
Usual Dose: PO, 50mg qd, combined with an LHRH analog
or orchiectomy.
XI. Antiinfective Agents
1. Penicillins
1) Natural Penicillins
NOTE: MU means million units.
Penicillin G Sodium (Benzylpenicillin Sodium, Aq. Penicillin)
[B]
"Penicillin G Sodium for Injection" 3 MU base/vial (Na
2.0mEq/MU)
Usual Dose: IM at conc. < 1 x 105 U/ml, intermittent IVF
over 0.5-1h or continuous IVF.
Adults & children > 12yr:
Endocarditis due to viridans Streptococci &
Streptococcus bovis: IV, 12-18MU/day in 6 doses or
via continuous IVF.
Endocarditis due to Enterococci: IV, 18-30MU/day in 6
doses or via continuous IVF.
Staphylococcal & streptococcal meningitis: IV,
15MU/day in divided doses q4h.
Neisseria meningitides meningitis: IM, 1-2MU q2h; or
continuous IVF, 20-30MU/day.
Neurosyphilis: IV, 2-4MU q4h, followed by penicillin G
benzathine 2.4MU/wk x 3wk.
Infants > 1mo & children < 12yr, 2.5-5 x 104 U/kg/day in
4 doses. Meningitis: 10-40 x 104 U/kg/day in 4-6 doses.
143
Neonates > 7 days, 7.5-20 x 104 U/kg/day in 3-4 doses.
Meningitis: 40 x 104 U/kg/day in 4 doses.
Neonates < 7 days, 5-10 x 104 U/kg/day in 2-3 doses.
Meningitis: 10-15 x 104 U/kg/day in 2-3 doses.
NOTE: rapid IV administration of large single doses ( 5MU)
or high daily dose may result in convulsions.
Penicillin G Benzathine (Benzathine Penicillin) [B]
"Retarpen for Injection" 2.4 MU penicillin G/vial (2g/vial)
Usual Dose: Deep IM only.
Gr. A Streptococcal URI: Adults, 1.2MU once.
Children > 1 mo, > 27kg, 1.2MU once; < 27kg, 0.6MU
once.
Neonates, 50000U/kg once.
Prophylaxis of recurrent rheumatic fever: Infant &
children, 25000-50000units/kg; adults, 1.2MU q3-4w.
Syphilis:
Adults:
Stage 1, 2 & latent < lyr, 2.4 MU once; > lyr, 2.4 MU
once/wk x 3wk; neurosyphilis, usual penicillin G
regimen followed by 2.4MU once/wk x 3wk.
Infants & children:
Early syphilis < lyr: 5 x 104 U/kg once, up to 2.4
MU/dose.
> lyr duration: 5 x 104 U/kg once/wk x 3wk.
2) Penicillinase-resistant Antistaphylococcal Penicillins
Flucloxacillin Sodium
"Flucloxin for Injection" 500mg/vial
144
Usual Dose:
IV 250 to 500 mg q6h over 3 to 4 minutes. IM, a dose of
250 mg q6h has been suggested. Higher doses are
indicated in more severe infections
Severe staphylococcal infections such as Septicemia and
Osteoarticular Infection, IV 2 g q6h. IV 1 g 6 times daily
used in combination with iv netilmicin in the treatment
of Staphylococcus aureus bacteremia
Children:
2 to 10 years of age, IVdoses of 125 to 250 mg q6h are
suggested. IM of 125 mg q6h has been recommended in
this age group. For children <2 years of age, one-half of
the above dose is suggested
Oxacillin Sodium [B]
"Prostaphlin for Injection" 500mg/vial (Na 2.8mEq/g
potency)
Usual Dose: Slow IV (< 100mg/ml) over 10min, IVF or
deep IM.
Adults & children > 40kg, 0.25- 1g q4-6h; endocarditis or
osteomyelitis, 1.5-2g q4h.
Children > 1mo & < 40kg, 50-200mg/kg/day in 4-6 doses,
max. 12g/day
Neonates > 1 wk, 25-50mg/kg q6-8h.
Neonates < 1 wk, 25-50mg/kg q8-12h.
Cloxacillin Sodium [B]
" Cloxacillin Capsule" 250mg/cap
Usual Dose: Adults: 2-4gm PO daily, given q6h.
Children: 50-100mg/kg/day PO, given q6h.
145
3) Aminopenicillins
Amoxicillin (Amoxicillin Trihydrate) [B]
" Amoxicillin(Supercillin) Capsule" 250mg/cap
" Amoxicillin Powder for Oral Suspension" 50mg/ml,
60ml/btl
Usual Dose: PO.
Adults & children > 20kg, 250-500mg q8h, max. 2-3g/day
Children > 1 mo & < 20kg, 20-40mg/kg/day in 3 doses.
4) β-lactam +β-lactamase Inhibitors
Amoxicillin and Clavulanate Potassium [B]
"Soonmelt Tablet" 250mg amoxicillin & 125mg clavulanic
acid/tab
"Augmentin Powder for Oral Suspension"
Syrup: 100ml/bot each 5 ml contain: amoxicillin trihydrate
125mg, clavulanic acid 31.25mg
"Augcin,Anbicyn for IV Injection" 1g amoxicillin & 200mg
clavulanic acid/vial
Usual Dose: Based on amoxicillin content.
PO
Tablet: Adults & children > 12yr, 1 tab bid.
Syrup:
Mild to moderate infections, 25/3.6mg/kg/day;
children 2-6yr, 2.5ml bid; 7-12yr, 5ml bid.
Serious infections, 45/6.4mg/kg/day; children 2-6yr,
5ml bid; 7-12yr, 10ml bid.
Slow IV or IVF over 30-40min.
146
Adults & children > 12yr, 1.0g amoxicillin q6-8h.
Children 3mo-12yr, 30mg amoxicillin/kg q6-8h.
Infants < 3mo, 30mg/kg q12h during the perinatal period;
increase to q8h thereafter.
Ampicillin Sodium and Sulbactam Sodium [B]
"Ansullina for Injection" 1g ampicillin & 500mg
sulbactam/vial (Na 5.0mEq/vial)
Usual Dose: Slow IV (over 10min), IVF over 15-30min or
deep IM.
Adults, 1.5-3g (1-2g A & 0.5-1g S) q6h.
Children, 150mg/kg/day (100mg/kg/day A &
50mg/kg/day S) q6-8h ; q12h for neonates < 7 days.
Max. Sulbactam < 4g/day.
Piperacillin Sodium [B]
" Picillina for Injection"2gm/vial,(1.85mEq Na+/gm)
Usual Dose:
Mild infection 100-200 mg/kg body wt. Severe infection
200-300 mg/kg body wt. Daily by IM or IV.
Piperacillin Sodium and Tazobactam Sodium [B]
"Tazocin Lyo-Injection, Pisutam,Tapimycin Injection " 2g
piperacillin & 0.25g tazobactam/vial (Na 2.35mEq/g potency)
Usual Dose: IVF (> 30min).
Adults & Children > 12 yr: piperacillin/tazobactam 4/0.5g
q8h or 3/0.375g q6h. Usual daily dose, 12/1.5g-16/2.0g.
Renal impairment:
Ccr 20-40ml/min: administer 2/0.25g q6h.
Ccr < 20ml/min: administer 2/0.25g q8h.
147
Hemodialysis: 2/0.25g q8h, with an additional dose of
0.75g after each dialysis.
2. Cephalosporins
1) First Generation Cephalosporins
Cefazolin Sodium [B]
" Cefazolin,Uzolin Injection" 1g /vial
Usual Dose: IV over 3-5min, intermittent or continuous IVF
or deep IM.
Adults, 0.25-2g q8h, up to 12g/day; children > 1mo,
25-50mg/kg/day in 3-4 doses, up to 100mg/kg/day, max.
6g/day.
Cefadroxil monohydrate [B]
"Cefadroxil Capsule" 500mg/cap
Usual Dose: PO.
Adult ：1-2 g daily in 1-2 doses.
Children ：30 mg/kg daily in 2 doses
Cephradine (as monohydrate) [B]
"S-60 Injection " 1g /vial
"Topcef Capsule" 500mg/cap
Usual Dose:
（1）PO.
Children  9 months: 25-50mg/kg/day q6h.
Adults: 250-1000mg q6-12h.
Renal Impairment:
Clcr 10-50ml/min: Administer 50% of dose.
Clcr < 10ml/min: Administer 25% of dose.
148
（2）IV/IM (Max. daily dose :  8 gm)
Adults:
Bone infections: 1g q6h
Pneumonia, skin and skin-structure infections and UTI: 0.5g
q6h. The total daily dose may be increased by using an
every-4-hour dosing interval or by increasing the dose
given 4 times daily.
Surgical prohylaxis: 1gm 30-90min prior to surgery. Then 1
gm may be administered q4-6h after the first dose
for 1 to 2 doses or up to 24 hours after the surgery
Adjust dosage in patients with renal impairment
Ccr > 20ml/min
500 mg q6h
5-20ml/min
250 mg q6h
< 5 ml/min
250 mg q12h
Children:
50-100mg/kg/d in 4 divided doses
Max. daily dose:  4gm/d
Cephalexin (Cephalexin Monohydrate) [B]
" Roles Injection" 1g /vial
Usual Dose: Inj: IV or IM
Children：50~100mg/kg/day
Adult：
Clcr
Dosage
(ml/min) (g/day)
50
20~5
2~8
3
5~20
1.5
0
149
<5
0.5
2) Second Generation Cephalosporins
Cefonicid sodium [B]
"Lisa for Injection" 1g /vial
Usual Dose:
Adult: 1 g by deep IM inj once daily.
Dose may be double in severe to 2 g.
Uncomplicated UTI 0.5 g once daily.
Cefuroxime Sodium [B]
" Cefuroxime for Injection" 750mg /vial (Na 2.4 meq/g
potency)
Usual Dose: IV over 3-5min, IVF over 15-60min or deep
IM.
Adults, 0.75-1.5g q6-8h.
Bacterial meningitis: Max. 3g q8h, children & infants >
3mo, 50-100mg/kg/day in 3-4 doses.
Bacterial meningitis: IV, initially, 200-240mg/kg/day in
3-4 doses, may reduce to 100mg/kg/day after
improvement.
Cefmetazole Sodium [B]
"Metacin for Injection" 500mg cefmetazole/vial (Na
2.12mEq/g potency)
Usual Dose: IV or IVF over 10-60min.
Adults, 1-2g q6-12h.
Children, 25-150mg/kg/day in 2-4 doses
150
3) Third Generation Cephalosporins
Ceftazidime (Ceftazidime Pentahydrate) [B]
"Unizid,Tatumcef,Sintum for Injection" 2g /vial
"Tatumcef for Injection" 1g /vial
Usual Dose: IV, IVF over 15-30min or deep IM (for adults
only).
Adults & children > 12yr, 1-2g q8-12h; max. 6g/day.
Infants & children 1mo-12yr, IV, 25-50mg/kg q8h; max.
6g/day. Neonates (0-4wk), IV, 30-50mg/kg q8-12h.
Dosage in hepatic impairment: No adjustment is needed.
Ceftriaxone Sodium [B]
"Sintrix for Injection" 1g ceftriaxone/vial (Na 3.6mEq/g
potency)
Usual Dose: IVF over 15-30min or deep IM.
Adults & children > 12yr: 1-2g/day in 1-2 doses; max.
4g/day.
Uncomplicated gonorrhea: 250mg single dose (IM).
Children < 12yr: Meningitis: 100mg/kg/day (max. 4g/day)
in 1-2 doses.
Serious infection other than meningitis: 50-75mg/kg/day
(max. 2g/day) in 1-2 doses.
Cefotaxime Sodium [B]
"Cetax for Injection" 0.5g cefotaxime/vial
Usual Dose: IV, IVF over 20-30min or continuous IVF or
deep IM.
Adults & children > 50kg, 1-2g q6-8h; severe infections,
151
2g q4h; max. 12g/day.
Children 1mo-12yr & < 50kg, 50-180mg/kg/day in 4-6
doses.
Neonates < lwk, 50mg/kg ql2h; 1-4wk, 50mg/kg q8h.
4) Fourth Generation Cephalosporins
Cefepime [B]
"Antifect for Injection" 1g cefepime/vial
Usual Dose: IM, IV
Children: 50mg/kg q8-12h; max. 2g/dose.
Adults:1-2g q8-12h.
UTI, uncomplicated: 500mg q12h.
Hemodialysis:0.5-1g q24h.
Peritoneal dialysis: give usually dose every 48h.
STORAGE: Protect from light.
3. Carbapenem
Imipenem and Cilastatin Sodium [C]
"Tienam,Penem for Injection" 500mg imipenem & 500mg
cilastatin/vial
Usual Dose: Based on imipenem content.
Intermittent IVF: Adults, 250mg-1g q6-8h; max. 4g/day;
Children 3mo-13yr, 15-25mg/kg q6h; max. 2g/day.
NOTE: For doses < 500mg, the infusion time should be
20-30min; for each 1g dose, infusion time should be over
40-60min.
Ertapenem Sodium [B]
152
"Invanz for Injection" 1g/vial
Usual Dose: IV/IM
Community acquired pneumonia: Adult,1g qd;
3 months to 12 years of age, 15mg/kg q12h; 13 years of
age and older, 1g qd for 10-14 days.
Infection of skin and/or subcutaneous tissue, complicated:
Adult,1g qd; 3 months to 12 years of age, 15mg/kg q12h,
13 years of age and older, 1g qd for7-14 days.
Infectious disease of abdomen, complicated: Adult, 1g qd;
3 months to 12 years of age, 15 mg/kg q12h; 13 years of
age and older, 1g qd for 5-14 days.
Pelvic infection, acute: Adult, 1g qd; 3 months to 12 years of
age, 15mg/kg bid; 13 years of age and older, 1g qd for
3-10 days.
Urinary tract infectious disease, complicated: Adult, 1g qd;
3 months to 12 years of age, 15mg/kg q12h; 13 years of
age and older, 1g qd for 10-14 days.
Note: IM, reconstitute with 3.2 mL lidocaine 1% (without
epinephrine); administer within 1 hour after preparation,
IV/IM, do not use diluents containing dextrose.
4. Macrolides
Clarithromycin [C]
" Klaricid Tablet" 500mg/tab
Usual Dose: PO.
Adults, 250-500mg q12h for 7-10 days.
Children, 15mg/kg/day q12h.
Helicobacter pylori infection: 250mg bid to 500mg tid.
153
Erythromycin Ethylsuccinate [B]
"Ilosone Capsule" 250mg erythromycin/cap
Usual Dose: PO.
Adults, 400mg q6h, up to 4g/day or more.
Children, 30-50mg/kg/day in 4 doses; dosage may be
doubled in severe infections.
Azithromycin Dihydrate [B]
"Zithromax Tablet" 250mg/tab
Usual Dose: PO.
Adults:
Respiratory tract infections & skin infections: Initially,
500mg qd x 1 day, then 250mg qd on days 2-5.
Uncomplicated Chlamydial infections: 1g as a single
dose or 500mg qd for 3 days.
Children:
Otitis media and community-acquired pneumonia in
children > 6mo: Initially 10mg/kg on day 1, max. 500mg,
then 5mg/kg, max. 250mg/day, qd on days 2-5 or
10mg/kg for 3 days.
Group A streptococcal pharyngitis or tonsillitis in
children > 2yr: 12mg/kg, max. 500mg/day, qd x 5
days.
NOTE: Avoid concomitant use with aluminium-or
magnesium-containing antacids.
5. Glycopeptides
Vancomycin HCl [C]
" U-Vanco for Injection" 500mg/vial
154
Usual Dose:
IVF > 1 hr with a conc. < 5mg/ml at a rate of < 10mg/min:
Adults, 500mg q6h or 1g ql2h.
Children, 40mg/kg/day in 4 doses.
Infants > 8 days & < 1 mo, initially 15mg/kg; followed
by 10mg/kg q8h.
Neonates < 8 days, initially 15mg/kg; followed by 10mg/kg
q12h.
PO:
Adults, 0.5-2g/day,in 3-4 doses x 7-10 days.
Children, 40mg/kg/day in 3-4 doses x 7-10 days; max.
2g/day.
NOTE: Oral vancomycin is not absorbed and thus not
effective for the treatment of systemic infections.
Teicoplanin [C]
"Targocid for Injection" 200mg/vial
Usual Dose: IV, intermittent IVF over 30min or IM.
Adults, initially, 400mg or 6mg/kg, followed by 200mg or
3mg/kg daily; for severe infection, 400mg q12h x 3
doses, followed by 400mg/day, up to 12mg/kg/day.
Children, initially, 10mg/kg q12h x 3 doses, followed by
6-10mg/kg/day.
Neonates, 16mg/kg on the first day, followed by
8mg/kg/day.
6. Lincosamides
Clindamycin HCl (Clindamycin HCl Hydrate) [B]
"Clincin Capsule" 150mg/cap
155
Usual Dose: PO, take with a full glass of water.
Adults, 150-450mg q6h.
Children, 8-25mg/kg/day in 3-4 doses. Minimum dose of
37.5mg tid should be given for children ≤ 10kg.
Clindamycin Phosphate [B]
" Clincin Injection" 300mg/2ml/amp
Usual Dose: Intermittent IVF over 10-60min (< 1.2g/hr) or
continuous IVF or IM (< 600mg).
Adults, 0.6-2.7g/day in 2-4 doses; max. 4.8g/day.
Children > 1mo, 15-40mg/kg/day in 3-4 doses.
Neonates < 1mo, 15-20mg/kg/day in 3-4 doses.
7. Tetracyclines
NOTE:
1. The use of tetracyclines during tooth development (last
half of pregnancy, infancy and childhood up to 8 years of
age) may cause permanent discoloration of the teeth.
Tetracyclines therefore should be avoided in this age
group.
2. Outdated tetracyclines may cause Fanconi-like syndrome
and SLE. It is therefore important to adhere strictly to the
expiration date and to avoid excessive heat and humidity
during storage.
Minocycline HCl [D]
"Cyclin Capsule" 100mg/cap
Usual Dose: PO.
Adult: Initial dose 200 mg; maintain dose 100 mg, q12h.
Children: Initial dose 4 mg/kg; maintain dose 2mg/kg,
156
q12h.
Doxycycline [D]
"Doxycycline Capsule" 100mg/cap
Usual Dose: PO.
Adults & children > 8yr & > 45kg, initially, 100mg q12h
x 1 day; maintenance, 100mg/day in 1-2 doses, up to
100mg q12h.
Children > 8yr & < 45kg, initially, 4.4mg/kg/day in 2
doses x 1 day; maintenance, 2.2mg/kg/day in 1-2 doses,
up to 4.4mg/kg/day.
Tetracycline [D] and Amphotericin B [B]
"Talsutin Vaginal Tablet" 100mg tetracycline & 50mg
amphotericin B/tab
Usual Dose: Intravaginally, 1-2 tab hs x 2wk.
Tetracycline HCl [D]
"TC(Tetracycline) Capsule" 250mg/cap
Usual Dose: PO, take on an empty stomach.
Adults, 1-2g/day in 2-4 doses.
Children > 8yr, 25-50mg/kg/day in 2-4 doses.
Tigecycline [D]
"Tygacil Lyophilized Powder for injection" 50mg/vial
Usual Dose:
Infection of skin and/or subcutaneous tissue: 100mg IV
followed by 50mg q12h IV; for 5 to 14 day.
Infection of abdomen, complicated: 100mg IV followed by
157
50mg q12h IV; for 5 to 14 days.
Severe hepatic impairment: 100mg IV followed by 25mg IV
q12h.
NOTE: Not recommended in patients under 18 years of age.
IV reconstituted solution should be yellow to orange in
color; if not, the solution should be discarded. Further dilute
reconstituted solution with NS or D5W to a maximum
concentration of 1mg/mL; use immediately.
8. Aminoglycosides
NOTE:
1. All aminoglycosides are potentially nephrotoxic and
ototoxic, both vestibular and auditory. Monitor serum
levels to assure adequate therapeutic level and to avoid
potentially toxic levels.
2. Amikacin, gentamicin, tobramycin and netilmicin should
be administered by slow intermittent IVF (over 30-60min)
or IM.
3. Dosage should be individualized. Use of ideal body
weight (IBW) for determining the mg/kg dose appears to
be more accurate than dosing on the basis of total body
weight.
4. In cases when empirical aminoglycoside dosing is needed,
the following dosage guidelines based on predictive
nomograms may be used.
NOTE :
1. Do not use in hemodialysis or peritoneal dialysis
patients or in children.
2. This method is not applicable to "single-daily dosing"
of aminoglycosides.
158
a. Select loading dose in mg/kg (IBW) to provide peak
plasma levels in the range listed below for the desired
aminoglycoside.
Drug
Usual loading dose Expected peak serum conc.
Gentamicin
1.0-2.5mg/kg
4-12mcg/ml
Amikacin
5.0-7.5mg/kg
15-40mcg/ml
b. Select maintenance dose (as percentage of loading
dose) to continue peak plasma levels indicated above,
according to desired dosing interval and the patient's
corrected creatinine clearance.
(140-age) x IBW
Clcr male ＝
Serum Creatinine x 72
Clcr female = 0.85 x Clcr male
159
% Loading Dose Required for Dosge Interval Selected
Ccr
Half-life
8hr
12hr
24hr
90ml/min
3.1hr
84%
80
3.4
80
91%
70
3.9
76
88
60
4.5
71
84
50
5.3
65
79
40
6.5
57
72
92%
30
8.4
48
63
86
25
9.9
43
57
81
20
11.9
37
50
75
17
13.6
33
46
70
15
15.1
31
42
67
12
17.9
27
37
61
10
20.4
24
34
56
7
25.9
19
28
47
5
31.5
16
23
41
2
46.8
11
16
30
0
69.3
8
11
21
(1) Alternatively, one half of the chosen loading dose may
be given at an interval approximately equal to the
estimated half-life.
(2) Dosage adjustment should be based on measured plasma
levels of aminoglycosides.
Amikacin Sulfate [D]
"Amikin Injection" 250mg/2ml/vial
Usual Dose & NOTE:
Traditional dose: 15 mg/kg/day q8-12h, max. 1.5 g/day.
160
Once daily dosing: 15-20mg/kg/day.
Sisomicin
"Sisogen Injection" 50mg/ml
Usual Dose
3 - 5 mg / Kg / day in 3 divided dose (IV, IM)
Gentamicin Sulfate [C]
" Gentamycin Injection" 80mg/2ml/Vial
Usual Dose & NOTE:
Traditional dosing: 3-6 mg/kg/day q8h
Once daily dosing: 4-7mg/kg/day
9. Sulfonamides, Sulfones and Trimethoprim
NOTE: Maintain an adequate urinary output to avoid
crystalluria.
Co-trimoxazole (Sulfamethoxazole and Trimethoprim) [C]
"Bacide Tablet" 400mg sulfamethoxazole & 80mg
trimethoprim/tab
Usual Dose: PO.
UTI, enteritis or bronchitis:
Adults, T 160mg (as co-trimoxazole) q12h.
Children > 2mo, T 7.5-8mg/kg/day in 2 doses.
Pneumocytis carinii:
Adults & children > 2mo, T 15-20mg/kg/day in 3-4
doses.
Prevention of P. carinii pneumonia in HIV patients:
160mg qd.
161
Sulfasalazine (Sulfasalazine, Salicylazosulfapyridine) [B, D
at term]
"Salazopyrin Tablet" 500mg/tab
Usual Dose: PO.
Adults, initially, 1-4g/day in 4 doses; maintenance, 2g/day
in 4 doses.
Children > 2yr, initially, 40-60mg/kg/day in3 -6 doses;
maintenance, 20-30mg/kg/day in 4 doses.
10. Quinolones
NOTE:
1.With fluoroquinolones, concomitant use or use within 2hr
with antacids containing di- or tri-valent cations should
be avoided.
2. Not recommended for use in pregnant women and
children < 18yr.
3. Fluoroquinolones should be given with full hydration.
Pipemidic acid
"Dolcol Tablet" 250mg/tab
Usual Dose: PO, 1-2 tab. bid.
Ciprofloxacin HCl [C]
"Superocin Tablet" 250mg/tab
Usual Dose: PO, 250-750mg q12h.
Ciprofloxacin Lactate [C]
"Cinolone Injection" 200mg/100ml/btl
"Seforce Injection" 400mg/200ml/btl
Usual Dose: IVF over 60min via large veins, 200-400mg
162
ql2h.
NOTE: Protect from light, full efficacy lasts for 3 days if
exposed to daylight.
Levofloxacin [C]
"Cravit Tablet" 500mg/tab
"Cravit Injection" 500mg/100ml/vial
Usual Dose: PO, IVF, Infuse over 60 minutes.
Acute bacterial exacerbation of chronic bronchitis: 500mg
qd for at least 7 days.
Community-acquired pneumonia: 500mg qd for 7-14
days.
Acute maxillary sinusitis: 500mg qd for 10-14 days.
Uncomplicated skin infections: 500mg qd for 7-10 days.
Complicated skin infections: 750mg qd for 7-14 days.
Uncomplicated urinary tract infections: 250mg qd for 3
days.
Complicated urinary infections, including acute
pyelonephritis: 250mg qd for 10 days.
Moxifloxacin [C]
"Avelox Infusion Solution" 400mg/250ml/btl
Usual Dose: PO and IVF.
Chronic bronchitis: 400mg QD for 5 days.
Community acquired pneumonia: 400mg QD for 7-14
days.
Acute sinusitis: 400mg QD for 10 days.
Skin/skin structure infection: 400mg QD for 7-21 days.
11. Miscellaneous Antibacterial Agents
163
Metronidazole
See "Flagyl(鹽野義) Tablet " 250mg/tab
" Flagyl(Anegyn) Injection" 500mg/l00ml/btl (Na
14mEq/btl)
Sulbactam[B]
" Maxtam Injection" 500mgl/vial
Usual Dose: IV or IM.
成人：0.5-1 g q6-12h. Max. 4 g/day.
小孩：50 mg/kg/day in 2-4 divided doses. Max. 80
mg/kg/day.
Chloramphenicol[C], Carbarsone
"Chlotin Vaginal Tablet" 100mg Chloramphenicol & 100mg
Carbarsone B/tab
Usual Dose: Intravaginally, 1 tab hs
12. Antituberculosis Agents
NOTE: In treating clinical tuberculosis and other
mycobacterial disease, these agents should not be given
alone to prevent rapid emergence of resistance.
Ethambutol HCl [B]
"EMB Tablet" 400mg/tab
Usual Dose: PO.
Adults, initial treatment, 15mg/kg qd.
Patients with previous treatment, 25mg/kg qd x 2mo;
followed by 15mg/kg qd.
Children > 6yr, 10- 15mg/kg/day.
164
NOTE: Visual testing should be performed prior to
initiating ethambutol therapy & periodically thereafter
(every month if dose > 15mg/kg/day).
Isoniazid (INAH) [C]
"Isoniazid, INAH Tablet" 100mg/tab
Usual Dose: PO.
Prevention of TB; given alone for 6-12mo:
Adults, 300mg qd or 15mg/kg (up to 900mg/day) twice
weekly.
Infants & children, 10-15mg/kg (up to 300mg) qd or
20-30mg/kg (up to 900mg) twice weekly (preferably
after daily therapy for 1 mo).
Treatment of TB:
Adults, 5-10mg/kg/day qd; max. 300mg/day.
If combined with other anti TB drugs & given
intermittently, 15mg/kg (up to 900mg) 2-3 times/wk.
Infants & children, 10-20mg/kg qd; max. 500mg/day.
If combined with Rifampin, 10mg/kg qd to minimize
the risk of hepatotoxicity.
If combined with other anti-TB drugs & given
intermittently, 20-40mg/kg (up to 900mg) 2-3
times/wk.
NOTE:
1. Antacids containing aluminum may interfere with
isoniazid absorption, separate doses by 2hr or more.
2. May cause peripheral neuritis and severe hepatitis
during long term use.
Pyrazinamide [C]
165
"PZA Tablet" 500mg/tab
Usual Dose: PO.
Adults, 15-30mg/kg/day, up to 2g/day. For INAH resistant
TB, 60mg/kg/day; max. 3g/day. If given twice weekly,
with other anti-TB drugs, 50-70mg/kg up to 4g. If given
3 times weekly with other anti-TB drugs, 50-70mg/kg
up to 3g.
Children, 15-30mg/kg/day, up to 2g/day; or 20-40mg /kg/
day for twice-weekly therapy, 50mg/kg, up to 2g/day.
NOTE: Pyrazinamide should always be administered with
other effective antituberculous drugs. It is administered
for the initial 2 months of a 6 month or longer treatment
regimen for drug susceptible patients. Patients with
concomitant HIV infection may require longer courses of
therapy.
Rifampin (Rifampicin) [C]
"RIF Capsule" 300mg/cap
Usual Dose: PO, take on an empty stomach.
Asymptomatic meningococcus carriers:
Adults, 600mg/day bid x 2 days or 600mg qd x 4 days.
Children  1mo: 10mg/kg bid x 2 days, or 10-20mg/kg
qd (up to 600mg) x 4 days.
Children < 1mo: 5mg/kg bid x 2 days, or 10-20mg/kg
(up to 600mg) x 4 days.
Prophylaxis of Haemophilus influenzae type b infection:
Adults & children, 20mg/kg 9up to 600mg) qd x 4 days.
Neonates  1mo, 10mg/kg qd x 4 days.
TB:
Adults, 10mg/kg (up to 600mg) qd.
166
Children, 10-20mg/kg (up to 600mg) qd, when used in
combination with INAH, limiting to 15mg/kg qd to
minimize the risk of hepatotoxicity.
Neonates < 1wk, max. 10mg/kg qd.
Rifampicin and Isoniazid [C]
"Rina Capsule "
Rifampicin 300mg, Isoniazid 150mg/cap
Usual Dose: PO, should be taken 30 minutes before a meal
or 2 hours after a meal; BW>50kg, (300/150) 2 tab qd.
13. Antifungal Agents
Fluconazole [C]
"Diflucan Injection" 100mg/50ml/vial
" Fluconazole Injection" 200mg/100ml/vial
Usual Dose: IVF (rate < 200mg/hr).
Candidal infections:
Oropharyngeal & esophageal candidiasis: 200mg on the
1st day, 100mg qd thereafter up to 400mg/day x > 3wk
and 2wk after symptoms resolved.
Systemic candidiasis: 400mg on the 1st day, 200mg qd
thereafter x > 4wk and 2wk after symptoms resolved.
Vulvovaginal candidiasis: 150mg qd.
Cryptococcal meningitis: 400mg on the 1st day,
200-400mg qd thereafter x 10-12wk after CSF is sterile.
Prevention of candidiasis in BMT patients: 400mg qd.
Pediatric dosage: Children, 3-12mg/kg qd, neonates
3-12mg/kg q3d.
167
Itraconazole [C]
"Sporanox Capsule" 100mg/cap
Usual Dose: PO, take with food to ensure maximal
absorption.
Aspergillosis: 200-400mg/day, up to 600mg/day.
Blastomycosis & nonmeningeal histoplasmosis: 200mg qd,
may increase by 100mg, up to 400mg/day.
Life-threatening infections: Initially, 200mg tid x 3-4 days,
then 200-400mg/day.
Onycomycosis: 200mg qd x 12wk.
Nystatin [C]
" Nystatin Vaginal Tablet" 100000U/tab
Usual Dose: Intravaginally, 1 tab hs
Sertaconazole Nitrate [C]
" Zalain Vaginal Tablet" 500mg/tab
Usual Dose: Intravaginally, 1 tab hs
14. Antiviral Agents
Acyclovir Sodium [C]
"Zovirax Tab" 200mg acyclovir/tab
Usual Dose: PO.
Herpes simplex virus genital infections:
Initial infection:
200mg q4h while awake (5 times/day) x 7-10 days or
400mg tid x 7-10 days.
Chronic suppressive therapy of recurrent herpes infections:
400mg bid or 200mg 3-5 times/day (up to 1yr).
168
Intermittent treatment of recurrence:
200mg q4h while awake (5 times/day) x 5 days; 400mg
q8h x 5 days or 800mg bid x 5 days.
Herpes zoster:
Adults & children ≧ 12yr, 800mg q4h 5 times/day x
7-10 days.
Chickenpox:
Adults & children ≧ 2yr, 20mg/kg (max. 800mg/dose)
qid x 5 days.
Amantadine Sulfate
See "Amantadine Tablet "
Lamivudine (3TC) [C]
"Zeffix Tablet" 100mg/tab
Usual Dose: 100mg qd.
Oseltamivir Phosphate [B]
"Tamiflu Capsule" 75mg/cap
Usual Dose: PO.
Adults, 75mg bid for 5 days, Ccr 10-30ml/min, 75mg qd
for 5 days; Ccr > 30ml/min, no dosage adjustment is
needed.
15. Antiprotozoals
Co-trimoxazole
See "Bacide Tablet" 400mg sulfamethoxazole & 80mg
trimethoprim/tab
169
Metronidazole [B]
" Flagyl(鹽野義) Tablet " 250mg/tab
" Flagyl(Anegyn) Injection" 500mg/l00ml/btl (Na 14mEq/btl)
Usual Dose:
Amebiasis: PO.
Adults, 500-750mg tid x 5-10 days.
Children, 30-50mg/kg/day in 3 doses x 5-10 days.
Anaerobic infections:
PO, 7.5mg/kg q6h, or 1-2g/day in 2-4 doses.
IVF over lhr, initially, 15mg/kg; maintenance, 7.5mg/kg
q6h. Daily dose may be given q8h or q12h due to long
half life; max. 4g/day.
Trichomoniasis: PO.
Adults, 2g once or 1g bid x 1 day or 500mg bid x 7 days.
If failure, repeat 500mg bid x 7 days; if 3rd failure,
2g/day x 3-5 days.
Children, 5mg/kg tid x 7-10 days; infants,
10-30mg/kg/day x 5-8 days.
STORAGE: Protect from light.
XII. Urologic Agents
1. Drugs For Urinary Retention
Bethanechol Chloride [C]
"Urecholine Tablet" 25mg/tab
Usual Dose: PO, 10-50mg bid-qid on an empty stomach.
S/P: Active or latent bronchial asthma, hyperthyroidism.
2. Drugs For Urinary Incontinence
170
Oxybutynin Chloride [B]
"Ditropan Tablet" 5mg/tab
Usual Dose:
Adults, 5mg bid to tid; max. 5mg qid.
Children > 5yr, 2.5mg bid; max. 5mg tid.
S/P: Angle-closure glaucoma, acute hemorrhage with
unstable CV status.
S/E: Constipation, drowsiness.
Propiverine Hydrochloride
"Urotrol Tablet" 15mg/tab
Usual Dose: PO.
Adults, 15mg bid-tid; may increased up to 60mg/day
Children 4.5-11yr, 0.2-0.4mg/kg/day in 2 divided doses.
Tolterodine Tartrate [C]
"Detrusitol,Uridin Tablet" 2mg/tab
Usual Dose: PO.
Bladder muscle dysfunction - overactive, with symptoms
of urinary frequency, urgency, or urge incontinence: 4 mg
qd; may adjust dose to 2 mg qd depending on tolerability
and response.
3. Agents for Impotence
Vardenafil [B]
"Levitra Film-coated Tablet" 20mg/tab
Usual Dose: PO, 10 mg 1 hr prior to sexual activity; max.
20 mg. Geriatrics (65 yr or old): initial, 5 mg once daily.
171
4. Adrenergic blocking agents
Tamsulosin HCl [C]
"Harnalidge D Tablet" 0.2mg/Tab
"Tamlosin SR Capsule" 0.2mg/cap
Usual Dose: PO.
Benign Prostatic Hyperplasia: 0.2 or 0.4mg once daily,
may increased to 0.8mg/day.
NOTE: Control release capsule, swallow whole, should not
be chewed.
Alfuzosine HCl
"Lafuzo XL Tablet" 10mg/Tab
Usual Dose: PO. 10 mg once daily.
5.Alkalizing agents
Potassium citrate monohydrate, Citric acidmonohydrate
"K-Citrate Granules " 5g/pk
Each gm contains:
Potassium citrate monohydrate ------------------------660mg
Citric acidmonohydrate -----------------------------200.4mg
Usual Dose: PO. 1 sachet in 180ml cold water or juice. qid.
pc or hs.
172
XIII. Antidotes in Poisoning
1. General Antidote
Activated Charcoal
"Carbomix Granules" 61.5g/btl
Usual Dose: PO.
Initially, adults, 30-100g; children, 15-30g; infants,
1-2g/kg; repeated q2-6h as one half the initial dose if
necessary.
NOTE: The powder should be mixed with sufficient water
(eg, 20-30g at least 240ml).
2. Speciflc Antidotes
Acetylcysteine Sodium [B]
See "Acetin Granule" 100mg/1.5g/pack
"Flutafin Granule" 100mg/5g/pack
Atropine Sulfate[C]
See "Atropine Sulfate Injection"
Flumazenil[C]
See "Anexate Injection"
Naloxone HCl [B]
" Naloxone Injection" 0.4mg/1ml/amp
Usual Dose:
Narcotic overdose: IV, IVF, IM or SC.
Adults, 0.4-2mg, may be repeated at 2-3min intervals;
173
children, initially, 0.01mg/kg.
Postoperative respiratory depression caused by narcotics:
IV, in increments of 0.1-0.2mg at 2-3min intervals until
the desired degree of reversal.
STORAGE: Protect from light.
Neostigmine Methylsulfate [C]
"Neostigmine Injection" 0.5mg/1ml/amp
Usual Dose:
Diagnosis of myasthenia gravis: IM.
Adults, 0.022mg/kg proceeded by atropine sulfate
0.011mg/kg IM.
Children, 0.025-0.04mg/kg preceded by atropine sulfate
0.011mg/kg SC.
Myasthenia gravis: IV, IM, SC, adults, 0.5-2.5mg;
children, 0.01-0.04mg/kg q2-3h as needed.
Neonatal myasthenia gravis: IM, 0.03mg/kg q2-4h; SC,
0.1-0.2mg.
Neuromuscular blockade reversal: Slow IV.
Adults, 0.5-2.5mg; repeated if necessary, totally not
exceed 5mg (0.6-1.2mg atropine sulfate should be
given to counteract the adverse muscarinic effects).
Neonates & infants, 0.04mg/kg with 0.02mg/kg atropine
sulfate.
Postoperative distention and urinary retention:
Prophylaxis: Adults, IM or SC, 0.25mg q4-6h for 2-3
days.
Treatment: Adults, IM or SC, 0.5-1mg, repeated q3-5h
for 5 doses after the bladder has been empties.
NOTE: IV route is hazardous.
174
STORAGE: Protect from light.
175
XIV. Enzymes
Serrapeptase (Serratiopeptidase)
"Danzen Tablet" 5mg (10,000units)/tab
Usual Dose: 5-10mg tidpc, swallowed whole.
Bromelain and L-Cysteine
"Broen-C Enteric-coated Tablet" Bromelain 20,000units,
L-Cysteine 20mg/tab
Usual Dose: PO, 3-6 tab/day in 3-4 divided dose.
176
XV. Miscellaneous
Nicotine-Resin complex(Nicorette) [X]
"Nicorette Tablet" 4mg/chewing gum
Usual Dose:
Starting the dose with 4mg/gum, usually 8-12 chewing
gums/day, lasting for at least 3 months. Stop treatment
when the daily consumption is down to 1-2 chewing
gums. Administered beyond one year is not
recommended.
Technique: Chew each piece of gum slowly in the
beginning. After 30 min all of the nicotine is released
from the gum.
Nicotine [D]
"Smokfree Nicotine TDDS" 31.2mg/15cm2/pc
Usual Dose:
Transdermal:
Weeks
Size
Healthy subjects Special subjects*
2-8 15cm2X1
12.5mg/day
8.3mg/day
2-4 10cm2X1
8.3mg/day
4.2mg/day
2-4
5cm2X1
4.2mg/day
*subject body weight < 45.5kg, cigerette used < 10 or
having cardiovascular disease
Sibutramine [C]
"Reductil Capsule" 10mg/cap
Usual Dose: PO.
Obesity: initially 10mg once daily, after 4wk may increase
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to max. dose 15mg once daily.
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B) DENTAL PREPARATIONS
I. Throat and Oral Cavity Preparations
Triamcinolone Acetonide [C]
"Nincort in Orabase" 0.1% Triamcinolone acetonide in
dental paste, 3.5 g/tube
Usual Dose:
Applied at night to permit steroid contact with the lesion
throughout the night, 2-3 times a day.
II. Dental Antiseptics
Chlorhexidine Gluconate [B]
"Parmason Gargle Solution" 0.2%, 2mg/ml, 200ml/btl
Usual Dose: Gargle 2-3 times daily, swishes for 30 sec, then
expectorants.
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C) DERMATOLOGICAL PREPARATIONS
I. Analgesics and Anti-inflammatory Agents
Etofenamate
"Teiria Gel" 5%,40g/tub
Piroxicam
"Focus Gel" 10mg/g, 40g/tube
II. Antipruritics
Zinc Oxide
"Zinc Oxide Ointment" 2%, 28.4g/tube
Usual Dose: Apply 2-3 daily.
"Calamine Lotion"100ml/btl
Each 100ml contains:
Calamine--------------------------------------------------------8g
Zinc Oxide------------------------------------------------8g
Menthol---------------------------------------------------------1g
Liquified Phenol---------------------------------------------1ml
Glycerin------------------------------------------------------2.5g
Calcium Hydroxide-----------------------------------------0.2g
Bentonite-------------------------------------------------------1g
Purified Water qs ad--------------------------------------100ml
Usual Dose: Shake well before use. Apply 2-3 times daily.
III. Keratolytics
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Urea
"Sinpharderm Cream" 10%, 30g/box
Usual Dose: Apply uniformly 3-4 times daily
Urea, Hydrocortisone
"Ureson Cream" 16gm/tube
Contain: 10% Urea + 1% Hydrocortisone
Usual Dose: Apply a thin layer to the affected areas 3-4
times daily.
Salicylic Acid and Lactic Acid [C]
"Duofilm Liquid" Salicylic acid 16.7%w/w, Lactic acid
16.7%/15ml/btl
Usual Dose: Apply in a thin film, 1-2 times daily.
IV. Antifungals
Naftifine HCl
"Jia Mei cream" 1% 10gm/tube
Usual Dose: Apply once daily. Continue for at least 2 wk
after clinical healing.
Undecylenic Acid Compound Oint
"UU oint"25gm/tube
Each gm contains: Undecylenic acid 50mg,
Zinc undecylenate 200mg
Usual Dose: Apply bid to thoroughly cleansed area.
Econazol Nitrate, Triamcinolone Acetonide
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"Ecosone Cream"5gm/tube
Each gm contains:
Econazole nitrate……………10mg
Triamcinolone acetonide……1mg
Usual Dose: Topical use twice daily.
Clotrimazole cream
" Cansen Cream"1%,20gm/tube
Usual Dose: Topical use twice daily.
V. Anti-infectives
1. Antivirals
Acyclovir [C]
"Acylote Topical Cream 5%" 3g/tube
Usual Dose: Apply 1/2 inch ribbon of cream per 4 in2 BSA,
6 times daily x 7 days.
NOTE: Avoid contact with eyes, mouth, vagina and other
mucous membranes.
2. Antibacterials, Antiseptics
Alcohol (Ethanol)
@75%, 95%
Beta-Iodine / Alc
Beta-Iodine
Beta-Iodine Scrub
Silver Sulfadiazine [B]
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"Sulfasil Cream 1%" 25g/tube
Usual Dose: Apply in a layer about 16mm thick to burned
areas by means of a sterile spatula or a sterile glove,
once-twice daily.
NOTE: Contraindicated in pregnant women approaching or
at term, except for the burn area covers more than 20% of
the body surface or the therapeutic benefit to the patient
outweigh the possible risk of the fetus.
Cadexomer Iodine
"Iodosorb Powder" 0.9%, 3g/pack
STORAGE: Protect from moisture and below 25℃.
3. Antibiotics
Fusidic Acid
" Conlifu oint" 2%, 5g/tube
Usual Dose: Apply twice daily x 7 days.
Treatment of acne: A longer period is needed.
Neomycin Sulfate
"Neomycin Sulfate Oint"0.5% 28gm/tube
Usual Dose: Apply 1-4 times daily to infected area or as
directed.
Neomycin Sulfate and Bacitracin Zinc
"Bacitracin-Neomycin Ointment" 30g/tube
Each g contains:
Neomycin Sulfate-----------------------------------------5mg
Bacitracin Zinc----------------------------------------12.5mg
Usual Dose: Apply 2-4 times daily.
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VI. Antipsoriatics
Polytar Liquid [C]
150ml/btl
Tar BP-------------------------------------------------------0.3%
Cade Oil BPC----------------------------------------------0.3%
Coal Tar BPC-----------------------------------------------0.1%
Arachis Oil Extract of Crude Coal Tar------------------0.3%
Oleyl Alcohol------------------------------------------------1%
Usual Dose: Rub shampoo liberally into wet hair and scalp
with optimal quantity, leave on 5 min, rinse thoroughly.
Seborrhoea, psoriasis, dandruff and itching scalp
Scalp cleansing: twice per week.
VII. Steroids
Clobetasol Propionate [C]
"Clobesol cream" 0.05%, 5g/tube
Usual Dose: Apply thinly qd-bid daily.
Diflucortolone Valerate
"Nerisone Fatty Ointment" 0.1%, 10g/tube
Usual Dose: Apply thinly 1-3 times daily.
Mometasone Furoate
" Elisone Cream" 0.1%, 1mg/gm, 5gm/tube
Usual Dose: Apply thinly on the affected skin once daily
Betamethasone Valerate
"Rinderon-V Cream"0.06%, 5g/tube
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Usual Dose: Apply thinly bid
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VIII. Scabicides and Pediculicides
Gamma benzene hexachloride
"Scabi Cream"10mg/g 10gm/tube
Usual Dose:
Adult apply to skin for 8-12h, then rinse.
Child apply to skin for 6-8h, then rinse.
IX. Miscellaneous
Heparinoid
"Hirudoid Gel" 40g/tube
each 100g contains 300mg heparinoid
Usual Dose: Vasculitis, scar, anti-inflammatory, 3-4 times
daily for 4 weeks.
Escin
" Aescin Gel "15mg/Gm；20Gm/Tube
Usual Dose:
Localised swelling resulting from injury or inflammatory
lesions. Superficial thrombophlebitis, varicose veins,
prevaricose states, 2-3 times daily
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D) ENT PREPARATIONS
I. Ear Drops
"Mycomb Otic Drops" 5ml/btl
Each ml contain:
Triamcinolone Acetonide----------------------------------1mg
Neomycin (as sulfate)------------------------------------2.5mg
Gramicidin-----------------------------------------------0.25mg
Nystatin------------------------------------------------100,000U
Chloroxylenol-----------------------------------------------3mg
Usual Dose: 2-3 gtt, 3-4 times daily.
Ofloxacin [C]
"Tarivid Otic Solution" 0.3%, 5ml/btl
Usual Dose: Adults & children > 12yr, 10 drops bid;
children 1-12yr, 5 drops bid.
Polymixin B sulphate, Neomycin sulphate, Lidocaine HCl
"Otozambon Ear Solution" 8ml/btl
Each ml contains:
Polymixin B Sulphate ------------------------------10000IU
Neomycin sulphate (eq. to neomycin base 3.75mg)-5mg
Lidocaine HCl-------------------------------------------40mg
Benzalkonium chloride-------------------------------0.1mg
Propylene glycol---------------------------------------0.44ml
Glycerol-----------------------------------------------0.265ml
Purified water to ------------------------------------------1ml
Usual Dose: Adult, 4-5 gtt bid-qid. Children, 2-3gtt tid-qid.
STORAGE: 8-15 C.
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II. Nasal Sprays or Drops
Fluticasone Propionate
See "Flixonase Nasal Spray"
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E) OPHTHALMIC PREPARATIONS
NOTE: Discard any remaining contents 4wk after opening the
bottle.
I. Agents for Glaucoma
Acetazolamide
See " Diamox Tablet"
Dorzolamide HCl [C]
"Trusopt Ophthalmic Solution" 2%, 5ml/btl
Usual Dose:
Monotherapy: 1 gtt tid.
Adjunctive therapy with an ophthalmic -blocker: 1gtt
bid.
STORAGE: Protect from light.
Latanoprost [C]
"Xalatan Ophthalmic Solution" 0.005%, 2.5ml/btl
Usual Dose: 1 gtt qd, in the evening.
NOTE: Latanoprost may increase the brown pigmentation
in the iris.
STORAGE: Protect from light. Unopened bottle at 2-25 C,
discard within 6 weeks of removing from sealed pouch.
Pilocarpine HCl [C]
"Pilocarpine Ophthalmic Solution" 2%, 10ml/btl
Usual Dose: 1-2 gtt tid-qid.
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Timolol Maleate [C]
"Timolol Ophthalmic Solution" 0.5%, 2.5ml/btl
Usual Dose: Timoptol: 1 gtt bid.
II. Mydriatics and Cycloplegics
Atropine Sulfate [C]
" Atropine Eye drops" 0.5 %, 10ml/btl
" Atropine Eye drops" 0.125 %, 10ml/btl
Usual Dose:
Treatment of acute iritis & uveitis—
Adults and children: instill 1 drop.
Treatment of cycloplegic refraction—
Adults: instill 1 to 2 drops 1 hour before refracting.
Children: instill 1 to 2 drops bid for 1 to 3 days before eye
examination and 1 hour before refraction.
STORAGE: Protect from light.
Tropicamide
"Mydriacyl Ophthalmic Solution"1%, 5ml/btl
Usual Dose:
Cycloplegia for refraction: 1-2 gtt, repeated in 5min.
Neostigmine Methylsulfate [C]
"O.N.S.D, Eye Drops"0.01% 10ml/btl
Usual Dose: 1-2 gtt tid-qid.
III. Ocular Anti-infectives and Anti-inflammatory agents
1. Ocular Antimicrobial Preparation
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Tetracycline HCl [D, B if topical used]
"Tetracycline HCl Ophthalmic Ointment" 1%, 5g/tube
Usual Dose: Apply q2h or oftener as needed.
Gentamicin Sulfate
"Gentamycin eye oint" 0.3%,3.5g/tube
Usual Dose: Oint, bid-tid.
Norfloxacin [C] and Disodium Edetate
"Baccidal Eye Drop" 3mg/ml, 5ml/btl
Usual Dose: 1 gtt tid.
Sulfamethoxazole (O.S.M.D.) [C]
"Kingmin Ophthalmic Solution" 4%, 15ml/btl
Usual Dose: 1-2 gtt several times daily.
Chloramphenicol
"Chloramphenicol eye drop" 0.25% 10ml/Bot
Usual Dose: Instill 1-2 drops in eye q4h until condition
improves, or instill qid depending on severity of
infection.
2. Steroids
Betamethasone [C] and Fradiomycin
"Rinderon-A Ointment" 3g/tube
Each g contains:
Betamethasone Disodium Phosphate---------------------1mg
Fradiomycin Sulfate--------------------------------------3.5mg
Usual Dose: Apply once to several times daily.
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Fluorometholone [C]
" Flumetholon Ophthalmic Suspension" 0.02%, 5ml/btl
Usual Dose: 1-2 gtt bid-qid.
NOTE: Shake before use.
Prednisolone acetate
"Pred-Forte" 1 %, 5 ml/Bot.
Usual Dose: Shake well before using. Instill 1-2 drops into
the conjunctival sac bid-qid.
Betamethasone,Neomycin
"EEN, Eye Drop" 5ml/btl
Each ml contains:
Betamethasone -------------------------------------------1mg
Neomycin ----------------------------------------- 5mg
Usual Dose: Instill 1-2 drops in the eye 3-5 times daily.
3. Ocular Antiallergic Agents
Antazoline HCl and Tetryzoline HCl [C]
"Spersallerg Eye Drops" 10ml/btl
Each ml contains:
Antazoline HCl--------------------------------------------0.5mg
Tetryzoline HCl-------------------------------------------0.4mg
Methylhydroxypropylcellulose-------------------------3.0mg
Benzalkonium Chloride-------------------------------- 0.15mg
Usual Dose:
Adults, acute phase, 1 gtt q3h; maintenance, 1 gtt bid-tid.
Children, 1-2 gtt qd.
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4. Miscellaneous Ophthalmic Preparations
Patear Eye Drop
@"Patear Eye Drop" 10ml/btl
Each ml contains:
Potassium Chloride -------------------------- 1.4mg
Sodium Chloride----------------------------------3.2mg
Boric Acid----------------------- ----------------9mg
Sodium Borate Decahydrate-----------------------------1mg
Monosodium Phosphate ----------------------0.4mg
Sodium Phosphate Monobasic--------------------------0.4mg
Benzalkonium Chloride----------------------------------0.1mg
Usual Dose: tid-qid or more frequently as needed
Carbomer
"Vidisic Gel" 0.2%, 10gm/tube
Usual Dose: Instill one drop into conjuctival sac 3-5 times or
more frequently during day and before retiring
for night.
Azapentacene Polysulfonate Sodium
"Quinax Sterile Ophthalmic Solution" 0.015%, 15ml/btl
Usual Dose: 2gtt, 3-5 times daily
Proparacaine HCl
"Alcaine Eye Drop" 0.5% 15ml/bot
Usual Dose:
Removal of foreign bodies & sutures, and for tonometry-instill 1-2 drops in each eye before operating
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For cataract extraction & glaucoma surgery—instill 1 drop
in each eye q 5-10 mins for 5-7
doses. (onset: 20 secs, duration:
15 mins.)
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