Postdoctoral/Research Associate positions (2) in the Chazin laboratory at Vanderbilt
University are available for highly motivated NMR structural biologists. One position is
for study of multi-domain proteins and multi-protein complexes involved in DNA
replication, damage response and repair. The focus is on NMR, SAXS and
computational studies of the structure and dynamics of replication protein A (RPA) and
its interaction with DNA primase and other genome maintenance factors. This position
requires a background in biomolecular NMR. The second position is for study of the role
of calprotectin in the innate immune response to infection by bacterial pathogens. The
focus in these studies is on x-ray crystallography, NMR and SAXS analysis of the
calprotectin (S100A8/A9) heterodimer and its interaction with the receptor for advanced
glycation end products (RAGE). In both positions there are opportunities to be involved
in the discovery of relevant small molecule inhibitors. These positions are excellent
opportunities to become experienced in the integrated applications of advanced
structural/dynamics methods at the cutting edge of medicine and biology. The laboratory
is well rounded and multi-disciplinary, with staff, students and postdocs whose research
efforts focus to different degrees on the wet lab and structural analysis. Moreover, our
laboratory has an extensive network of collaborators working on fundamental biology
and clinical applications. Applicants are expected to work well with others and will be
encouraged to develop their leadership potential. Compensation includes moving
expenses, a highly competitive salary and benefits. To apply, send a CV and a reference
list via e-mail to walter.chazin@vanderbilt.edu.